{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:35:16Z","timestamp":1785328516466,"version":"3.55.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100008221","name":"Cure Starts Now Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008221","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Cure Starts Now Australia"},{"DOI":"10.13039\/100019369","name":"Brooke Healey Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019369","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wayland Villars Foundation"},{"name":"Aidan\u2019s Avengers"},{"name":"Aubreigh\u2019s Army"},{"name":"Austin Strong"},{"DOI":"10.13039\/501100006641","name":"Cure Brain Cancer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006641","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011187","name":"Jeffrey Thomas Hayden Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011187","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Laurie\u2019s Love Foundation"},{"name":"Love Chloe Foundation"},{"DOI":"10.13039\/100003156","name":"Musella Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003156","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pray Hope Believe"},{"DOI":"10.13039\/100010080","name":"Reflections Of Grace","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010080","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Storm the Heavens Fund"},{"name":"Whitley\u2019s Wishes"},{"name":"Gabriella\u2019s Smile Foundation"},{"name":"The Gold Hope Project"},{"DOI":"10.13039\/501100019893","name":"The Isabella and Marcus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019893","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lauren\u2019s Fight for Cure"},{"DOI":"10.13039\/501100016057","name":"Robert Connor Dawes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016057","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ryan\u2019s Hope"},{"name":"Benny\u2019s World"},{"name":"Lily Larue Foundation"},{"name":"Marlee\u2019s Mission"},{"name":"RUN DIPG"},{"name":"American Childhood Cancer Organization"},{"name":"The DIPG Collaborative"},{"name":"Snapgrant.com"},{"name":"Kyler Strong Foundation"},{"name":"Keris Kares"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Children\u2005\u226436 months with diffuse intrinsic pontine glioma (DIPG) have increased long-term survival (LTS, overall survival (OS)\u2005\u226524 months). Understanding distinguishing characteristics in this population is critical to improving outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients\u2005\u226436 months at diagnosis enrolled on the International DIPG Registry (IDIPGR) with central imaging confirmation were included. Presentation, clinical course, imaging, pathology and molecular findings were analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 1183 patients in IDIPGR, 40 were eligible (median age: 29 months). Median OS was 15 months. Twelve patients (30%) were LTS, 3 (7.5%) very long-term survivors\u2005\u22655 years. Among 8 untreated patients, median OS was 2 months. Patients enrolled in the registry but excluded from our study by central radiology review or tissue diagnosis had median OS of 7 months. All but 1 LTS received radiation. Among 32 treated patients, 1-, 2-, 3-, and 5-year OS rates were 68.8%, 31.2%, 15.6% and 12.5%, respectively. LTS had longer duration of presenting symptoms (P\u2005=\u2005.018). No imaging features were predictive of outcome. Tissue and genomic data were available in 18 (45%) and 10 patients, respectively. Among 9 with known H3K27M status, 6 had a mutation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Children\u2005\u226436 months demonstrated significantly more LTS, with an improved median OS of 15 months; 92% of LTS received radiation. Median OS in untreated children was 2 months, compared to 17 months for treated children. LTS had longer duration of symptoms. Excluded patients demonstrated a lower OS, contradicting the hypothesis that children\u2005\u226436 months with DIPG show improved outcomes due to misdiagnosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/neuonc\/noac123","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T19:11:52Z","timestamp":1652123512000},"page":"2190-2199","source":"Crossref","is-referenced-by-count":11,"title":["Characteristics of children \u226436 months of age with DIPG: A report from the international DIPG registry"],"prefix":"10.1093","volume":"24","author":[{"given":"Allison L","family":"Bartlett","sequence":"first","affiliation":[{"name":"Brain Tumor Center, Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio , USA"},{"name":"Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5522-8112","authenticated-orcid":false,"given":"Adam","family":"Lane","sequence":"additional","affiliation":[{"name":"Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooklyn","family":"Chaney","sequence":"additional","affiliation":[{"name":"Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy Yanez","family":"Escorza","sequence":"additional","affiliation":[{"name":"Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3269-7303","authenticated-orcid":false,"given":"Katie","family":"Black","sequence":"additional","affiliation":[{"name":"Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Cochrane","sequence":"additional","affiliation":[{"name":"Brain Tumor Center, Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio , USA"},{"name":"University of Cincinnati College of Medicine , Cincinnati, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Minturn","sequence":"additional","affiliation":[{"name":"Division of Oncology, Children\u2019s Hospital of Philadelphia and Perelman School of Medicine , Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2112-5251","authenticated-orcid":false,"given":"Ute","family":"Bartels","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Oncology, University of Toronto and The Hospital for Sick Children , Toronto, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Dana Farber Cancer Institute\/Boston Children\u2019s Hospital , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Hansford","sequence":"additional","affiliation":[{"name":"Children\u2019s Cancer Centre, Royal Children\u2019s Hospital; Murdoch Children\u2019s Research Institute; University of Melbourne , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Children\u2019s Cancer Institute Australia, Lowy Cancer Research Centre, UNSW and Kids Cancer Centre, Sydney\u2019s Children Hospital , Randwick, Sydney NSW , Australia"},{"name":"School of Women\u2019s and Children\u2019s Health, University of New South Wales , Sydney , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Diez","sequence":"additional","affiliation":[{"name":"FLENI (Fundacion para Lucha contra las Enfermedes Neurologicas de Infantes ), Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Goldman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Center for Cancer and Blood Disorders, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago , Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Packer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Neuroscience and Behavioral Medicine, Children\u2019s National Hospital , Washington, DC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Kieran","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dana-Farber\/Boston Children\u2019s Cancer and Blood Disorders Center and Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8084-2720","authenticated-orcid":false,"given":"Mariko","family":"DeWire-Schottmiller","sequence":"additional","affiliation":[{"name":"Brain Tumor Center, Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1394-7167","authenticated-orcid":false,"given":"Craig","family":"Erker","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dalhousie University and IWK Health Center , Halifax, Nova Scotia , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Monje-Deisseroth","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurosurgery, Pediatrics, and Pathology, Stanford University School of Medicine , Stanford, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Wagner","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Kentucky Children\u2019s Hospital, University of Kentucky , Lexington, Kentucky , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0825-7615","authenticated-orcid":false,"given":"Carl","family":"Koschmann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, C.S. Mott Children\u2019s Hospital and University of Michigan School of Medicine , Ann Arbor, Michigan , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0753-2176","authenticated-orcid":false,"given":"Kathleen","family":"Dorris","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado School of Medicine , Aurora, Colorado , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie-Schin","family":"Shih","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health , Indianapolis, Indiana , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Hassall","sequence":"additional","affiliation":[{"name":"Queensland Children\u2019s Hospital , Brisbane, Queensland , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvan","family":"Samson","sequence":"additional","affiliation":[{"name":"Department of Hematology-Oncology, Universit\u00e9 de Montr\u00e9al and CHU Sainte-Justine , Montr\u00e9al, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Child Neurology, Stanford University , Palo Alto, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacie S","family":"Wang","sequence":"additional","affiliation":[{"name":"Children\u2019s Cancer Centre, Royal Children\u2019s Hospital; Murdoch Children\u2019s Research Institute; University of Melbourne , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Tsui","sequence":"additional","affiliation":[{"name":"Starship Blood and Cancer Centre, Starship Children\u2019s Health , Auckland , New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Sevlever","sequence":"additional","affiliation":[{"name":"FLENI (Fundacion para Lucha contra las Enfermedes Neurologicas de Infantes ), Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Zhu","sequence":"additional","affiliation":[{"name":"Brain Tumor Center, Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio , USA"},{"name":"Department of Electrical Engineering and Computer Science, University of Cincinnati College of Engineering and Applied Science , Cincinnati, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Dexheimer","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Cincinnati Children\u2019s Hospital Medical Center and University of Cincinnati , Cincinnati, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Asher","sequence":"additional","affiliation":[{"name":"Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-7675","authenticated-orcid":false,"given":"Christine","family":"Fuller","sequence":"additional","affiliation":[{"name":"Department of Pathology, Upstate Medical University , Syracuse, New York , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0564-0181","authenticated-orcid":false,"given":"Rachid","family":"Drissi","sequence":"additional","affiliation":[{"name":"Center for Childhood Cancer & Blood Disorders, Nationwide Children\u2019s Hospital , Columbus, Ohio , USA"},{"name":"The Ohio State University College of Medicine , Columbus, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaise","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Radiology, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8602-4737","authenticated-orcid":false,"given":"James","family":"Leach","sequence":"additional","affiliation":[{"name":"Division of Radiology, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5693-035X","authenticated-orcid":false,"given":"Maryam","family":"Fouladi","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Medicine , Columbus, Ohio , USA"},{"name":"Pediatric Neuro-Oncology Program, Nationwide Children\u2019s Hospital , Columbus, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"2022120109000476500_CIT0001","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3389\/fonc.2015.00237","article-title":"DIPG in children - what can we learn from the past?","volume":"5","author":"Vanan","year":"2015","journal-title":"Front Oncol."},{"issue":"3","key":"2022120109000476500_CIT0002","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s11060-013-1189-0","article-title":"Clinico-radiologic characteristics of long-term survivors of diffuse intrinsic pontine glioma","volume":"114","author":"Jackson","year":"2013","journal-title":"J Neurooncol."},{"key":"2022120109000476500_CIT0003","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3389\/fonc.2015.00148","article-title":"Future clinical trials in DIPG: bringing epigenetics to the clinic","volume":"5","author":"Morales La Madrid","year":"2015","journal-title":"Front Oncol."},{"issue":"3","key":"2022120109000476500_CIT0004","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1470-2045(06)70615-5","article-title":"Diffuse brainstem glioma in children: critical review of clinical trials","volume":"7","author":"Hargrave","year":"2006","journal-title":"Lancet Oncol."},{"issue":"19","key":"2022120109000476500_CIT0005","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1200\/JCO.2017.75.9308","article-title":"Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries","volume":"36","author":"Hoffman","year":"2018","journal-title":"J Clin Oncol."},{"issue":"24","key":"2022120109000476500_CIT0006","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.1002\/cncr.24663","article-title":"Outcome and prognostic features in pediatric gliomas: a review of 6212 cases from the Surveillance, Epidemiology, and End Results database","volume":"115","author":"Qaddoumi","year":"2009","journal-title":"Cancer."},{"issue":"1","key":"2022120109000476500_CIT0007","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/neuonc\/nou104","article-title":"Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria","volume":"17","author":"Jansen","year":"2015","journal-title":"Neuro Oncol."},{"issue":"3","key":"2022120109000476500_CIT0008","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/cncr.23584","article-title":"Young age may predict a better outcome for children with diffuse pontine glioma","volume":"113","author":"Broniscer","year":"2008","journal-title":"Cancer."},{"issue":"2","key":"2022120109000476500_CIT0009","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s11060-017-2372-5","article-title":"The international diffuse intrinsic pontine glioma registry: an infrastructure to accelerate collaborative research for an orphan disease","volume":"132","author":"Baugh","year":"2017","journal-title":"J Neurooncol."},{"issue":"11","key":"2022120109000476500_CIT0010","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/neuonc\/noaa140","article-title":"MR imaging features of diffuse intrinsic pontine glioma and relationship to overall survival: report from the International DIPG Registry","volume":"22","author":"Leach","year":"2020","journal-title":"Neuro Oncol."},{"issue":"2","key":"2022120109000476500_CIT0011","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO classification of tumours of the central nervous system","volume":"114","author":"Louis","year":"2007","journal-title":"Acta Neuropathol."},{"issue":"6, Neuro-oncology","key":"2022120109000476500_CIT0012","first-page":"1531","article-title":"2016 World Health Organization Classification of Central Nervous System Tumors","volume":"23","author":"Wen","year":"2017","journal-title":"Continuum (Minneap Minn)."},{"issue":"7","key":"2022120109000476500_CIT0013","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nrclinonc.2012.87","article-title":"Paediatric and adult malignant glioma: close relatives or distant cousins?","volume":"9","author":"Jones","year":"2012","journal-title":"Nat Rev Clin Oncol."},{"issue":"1","key":"2022120109000476500_CIT0014","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11060-017-2514-9","article-title":"External validation of the diffuse intrinsic pontine glioma survival prediction model: a collaborative report from the International DIPG Registry and the SIOPE DIPG Registry","volume":"134","author":"Veldhuijzen van Zanten","year":"2017","journal-title":"J Neurooncol."},{"issue":"1","key":"2022120109000476500_CIT0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11060-017-2546-1","article-title":"Survival rates and prognostic predictors of high grade brain stem gliomas in childhood: a systematic review and meta-analysis","volume":"135","author":"Hassan","year":"2017","journal-title":"J Neurooncol."},{"issue":"2","key":"2022120109000476500_CIT0016","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1586\/14737140.2015.974563","article-title":"A twenty-year review of diagnosing and treating children with diffuse intrinsic pontine glioma in The Netherlands","volume":"15","author":"Veldhuijzen van Zanten","year":"2015","journal-title":"Expert Rev Anticancer Ther."},{"issue":"3","key":"2022120109000476500_CIT0017","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s11060-006-9133-1","article-title":"Treatment options in childhood pontine gliomas","volume":"79","author":"Wagner","year":"2006","journal-title":"J Neurooncol."},{"key":"2022120109000476500_CIT0018","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ejca.2016.12.007","article-title":"Survival benefit for patients with diffuse intrinsic pontine glioma (DIPG) undergoing re-irradiation at first progression: A matched-cohort analysis on behalf of the SIOP-E-HGG\/DIPG working group","volume":"73","author":"Janssens","year":"2017","journal-title":"Eur J Cancer."},{"issue":"2","key":"2022120109000476500_CIT0019","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000120511","article-title":"Brain stem gliomas: a classification system based on magnetic resonance imaging","volume":"16","author":"Barkovich","year":"1990","journal-title":"Pediatr Neurosurg."},{"issue":"4","key":"2022120109000476500_CIT0020","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/neuonc\/noq200","article-title":"MRI as a central component of clinical trials analysis in brainstem glioma: a report from the Pediatric Brain Tumor Consortium (PBTC)","volume":"13","author":"Poussaint","year":"2011","journal-title":"Neuro Oncol"},{"issue":"1-2","key":"2022120109000476500_CIT0021","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/pr.2013.194","article-title":"Children are not just little adults: recent advances in understanding of diffuse intrinsic pontine glioma biology","volume":"75","author":"Schroeder","year":"2014","journal-title":"Pediatr Res."},{"issue":"3","key":"2022120109000476500_CIT0022","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00401-012-0998-0","article-title":"K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas","volume":"124","author":"Khuong-Quang","year":"2012","journal-title":"Acta Neuropathol."},{"issue":"3","key":"2022120109000476500_CIT0023","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/ng.1102","article-title":"Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas","volume":"44","author":"Wu","year":"2012","journal-title":"Nat Genet."},{"issue":"1","key":"2022120109000476500_CIT0024","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26751","article-title":"Molecular alterations in pediatric brainstem gliomas","volume":"65","author":"Porkholm","year":"2018","journal-title":"Pediatr Blood Cancer."},{"issue":"3","key":"2022120109000476500_CIT0025","doi-asserted-by":"crossref","first-page":"e28102","DOI":"10.1002\/pbc.28102","article-title":"Indolent course of brainstem tumors with K27M-H3.3 mutation","volume":"67","author":"Baroni","year":"2020","journal-title":"Pediatr Blood Cancer."},{"issue":"5","key":"2022120109000476500_CIT0026","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ccell.2017.03.011","article-title":"Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma","volume":"31","author":"Nagaraja","year":"2017","journal-title":"Cancer Cell."},{"issue":"4","key":"2022120109000476500_CIT0027","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.ccell.2017.08.017","article-title":"Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma","volume":"32","author":"Mackay","year":"2017","journal-title":"Cancer Cell."},{"issue":"27","key":"2022120109000476500_CIT0028","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1200\/JCO.2014.59.9217","article-title":"Pediatric Brain Tumors: Innovative Genomic Information Is Transforming the Diagnostic and Clinical Landscape","volume":"33","author":"Gajjar","year":"2015","journal-title":"J Clin Oncol."},{"issue":"1","key":"2022120109000476500_CIT0029","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/neuonc\/noy145","article-title":"Characterization of the immune microenvironment of diffuse intrinsic pontine glioma: implications for development of immunotherapy","volume":"21","author":"Lieberman","year":"2019","journal-title":"Neuro Oncol."},{"issue":"6","key":"2022120109000476500_CIT0030","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/CCO.0000000000000577","article-title":"Diffuse intrinsic pontine glioma: molecular landscape and emerging therapeutic targets","volume":"31","author":"Aziz-Bose","year":"2019","journal-title":"Curr Opin Oncol."},{"issue":"1","key":"2022120109000476500_CIT0031","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40478-018-0553-x","article-title":"Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma","volume":"6","author":"Lin","year":"2018","journal-title":"Acta Neuropathol Commun."},{"issue":"7","key":"2022120109000476500_CIT0032","doi-asserted-by":"crossref","first-page":"e28338","DOI":"10.1002\/pbc.28338","article-title":"Tumor mutational burden and driver mutations: Characterizing the genomic landscape of pediatric brain tumors","volume":"67","author":"Patel","year":"2020","journal-title":"Pediatr Blood Cancer."},{"issue":"10","key":"2022120109000476500_CIT0033","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1093\/neuonc\/noz077","article-title":"Immunotherapy for pediatric brain tumors: past and present","volume":"21","author":"Foster","year":"2019","journal-title":"Neuro Oncol."},{"issue":"9","key":"2022120109000476500_CIT0034","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1093\/neuonc\/noaa058","article-title":"Pharmacologic inhibition of lysine-specific demethylase 1 as a therapeutic and immune-sensitization strategy in pediatric high-grade glioma","volume":"22","author":"Bailey","year":"2020","journal-title":"Neuro Oncol."},{"issue":"1","key":"2022120109000476500_CIT0035","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40478-020-01107-0","article-title":"A pilot radiogenomic study of DIPG reveals distinct subgroups with unique clinical trajectories and therapeutic targets","volume":"9","author":"Zhu","year":"2021","journal-title":"Acta Neuropathol Commun."}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/advance-article-pdf\/doi\/10.1093\/neuonc\/noac123\/45418291\/noac123.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/24\/12\/2190\/47369168\/noac123.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/24\/12\/2190\/47369168\/noac123.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T09:01:11Z","timestamp":1669885271000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article\/24\/12\/2190\/6585024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,12]]},"references-count":35,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,5,12]]},"published-print":{"date-parts":[[2022,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/noac123","relation":{},"ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,12,1]]},"published":{"date-parts":[[2022,5,12]]}}}