{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:30:08Z","timestamp":1787009408702,"version":"build-2736575974"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Craniopharyngioma (CP) in adults is a rare benign tumor associated with many morbidities, with limited contemporary studies to define treatment, and follow-up guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single-center retrospective study was conducted on patients aged \u2265 18 years from 2006\u20132018 with CP and who were treated with proton therapy (PT). Late toxicity was defined as a minimum of 18 months from diagnosis. Overall survival (OS), local recurrence-free survival (LRFS), and toxicity were characterized using Kaplan\u2013Meier and Cox regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety-one patients met the criteria, with a median age of 37 years (range 18\u201382 years). PT was conducted after tumor resection in 88 patients (97%), in 64 patients (70.3%) as an adjuvant strategy and in 27 (29.7%) after recurrent disease. Three patients received exclusive PT. A median MRI follow-up of 39 months revealed 35.2% complete response, 49.5% partial response, and 9.9% stable disease. Five patients developed local recurrence (LR). The pattern of failure study showed that these five LR were within the GTV volume. The 5-year LRFS was 92.0% [CI 95% 84.90\u201399.60]. All the patients were alive at the end of the follow-up. Patients requiring treatment adaptation during PT tend to have a higher risk of LR (P = .084). Endocrinopathy was the most frequent grade \u2265 2 late toxicity. Among patients who were symptom-free before the start of treatment, none developed hearing toxicity but four (9.8%) developed visual disorders and 10 (11.3%) symptomatic memory impairment. Patients with large tumors had a higher risk of developing symptomatic memory impairment (P = .029).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adults with CP treated with PT have favorable survival outcomes, with acceptable late toxicity. Prospective quality-of-life and neurocognitive studies are needed to define late adverse effects better.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noac210","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T08:31:41Z","timestamp":1661329901000},"page":"710-719","source":"Crossref","is-referenced-by-count":20,"title":["Proton therapy for adult craniopharyngioma: Experience of a single institution in 91 consecutive patients"],"prefix":"10.1093","volume":"25","author":[{"given":"Arnaud","family":"Beddok","sequence":"first","affiliation":[{"name":"Institut Curie, PSL Research University, Radiation Oncology Department, Proton Therapy Centre, Centre Universitaire , 91898 Orsay , France"},{"name":"Institut Curie, PSL Research University, University Paris Saclay, Inserm LITO , 91898 Orsay , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Scher","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, Radiation Oncology Department, Proton Therapy Centre, Centre Universitaire , 91898 Orsay , France"},{"name":"Hartmann Oncology Radiotherapy Group , 4 Rue Kleber, 92309 Levallois-Perret , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2493-5815","authenticated-orcid":false,"given":"Claire","family":"Alapetite","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, Radiation Oncology Department, Proton Therapy Centre, Centre Universitaire , 91898 Orsay , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Baussart","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sorbonne Universit\u00e9, AP-HP, H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re, Charles Foix , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghita","family":"Bentahila","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, Radiation Oncology Department, Proton Therapy Centre, Centre Universitaire , 91898 Orsay , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6564-6388","authenticated-orcid":false,"given":"Franck","family":"Bielle","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Sorbonne Universit\u00e9, AP-HP, H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re, Charles Foix , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Bolle","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, Radiation Oncology Department, Proton Therapy Centre, Centre Universitaire , 91898 Orsay , France"},{"name":"Department of Radiation Oncology, Gustave Roussy , Villejuif, Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remi","family":"Dendale","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, Radiation Oncology Department, Proton Therapy Centre, Centre Universitaire , 91898 Orsay , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Dureau","sequence":"additional","affiliation":[{"name":"Department of statistics, Institut Curie , Saint-Cloud , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Goudjl","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, Radiation Oncology Department, Proton Therapy Centre, Centre Universitaire , 91898 Orsay , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Helfre","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, Radiation Oncology Department, Proton Therapy Centre, Centre Universitaire , 91898 Orsay , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Mammar","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, Radiation Oncology Department, Proton Therapy Centre, Centre Universitaire , 91898 Orsay , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Nichelli","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Sorbonne Universit\u00e9, AP-HP, H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re, Charles Foix , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Calugaru","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, Radiation Oncology Department, Proton Therapy Centre, Centre Universitaire , 91898 Orsay , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Feuvret","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, AP-HP, H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re, Charles Foix, Sorbonne Universit\u00e9 , Paris , France"},{"name":"Department of Radiation Therapy, East Group Hospital, Hospices Civils de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"issue":"2","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00381-012-1926-2","article-title":"A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma","volume":"29","author":"Clark","year":"2013","journal-title":"Childs Nerv Syst."},{"issue":"4","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s11102-021-01127-6","article-title":"Descriptive epidemiology of craniopharyngiomas in the United States","volume":"24","author":"Momin","year":"2021","journal-title":"Pituitary."},{"issue":"5","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00701-020-04265-1","article-title":"Surgical management of craniopharyngiomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section","volume":"162","author":"Cossu","year":"2020","journal-title":"Acta Neurochir (Wien)."},{"issue":"4","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/17446651.2020.1770081","article-title":"Craniopharyngioma treatment: an updated summary of important clinicopathological concepts","volume":"15","author":"Prieto","year":"2020","journal-title":"Expert Rev Endocrinol Metab"},{"key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jss.2018.01.029","article-title":"Comparing survival outcomes of gross total resection and subtotal resection with radiotherapy for craniopharyngioma: a meta-analysis","volume":"226","author":"Wang","year":"2018","journal-title":"J Surg Res"},{"issue":"4","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/neuros\/nyx570","article-title":"Adult craniopharyngioma: case series, systematic review, and meta-analysis","volume":"83","author":"Dandurand","year":"2018","journal-title":"Neurosurgery."},{"issue":"6","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1210\/jc.2012-3928","article-title":"Childhood craniopharyngioma: hypothalamus-sparing surgery decreases the risk of obesity","volume":"98","author":"Elowe-Gruau","year":"2013","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0360-3016(02)02799-2","article-title":"Craniopharyngioma: the St. Jude Children\u2019s Research Hospital experience 1984\u20132001","volume":"53","author":"Merchant","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"2","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.ijrobp.2010.11.027","article-title":"Dosimetric comparison of three-dimensional conformal proton radiotherapy, intensity-modulated proton therapy, and intensity-modulated radiotherapy for treatment of pediatric craniopharyngiomas","volume":"82","author":"Boehling","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"11","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3390\/cancers10110401","article-title":"Dosimetric comparison of proton radiation therapy, volumetric modulated arc therapy, and three-dimensional conformal radiotherapy based on intracranial tumor location","volume":"10","author":"Adeberg","year":"2018","journal-title":"Cancers (Basel)"},{"issue":"1","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.radonc.2018.05.001","article-title":"Radiation dose constraints for organs at risk in neuro-oncology; the European Particle Therapy Network consensus","volume":"128","author":"Lambrecht","year":"2018","journal-title":"Radiother Oncol."},{"key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.radonc.2022.01.018","article-title":"The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation","volume":"168","author":"De Roeck","year":"2022","journal-title":"Radiother Oncol"},{"issue":"5","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0360-3016(99)00550-7","article-title":"Patterns of local-regional recurrence following parotid-sparing conformal and segmental intensity-modulated radiotherapy for head and neck cancer","volume":"46","author":"Dawson","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"2023040607123634200_","volume-title":"R: a language and environment for statistical computing","author":"R Core Team.","year":"2021"},{"issue":"4","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/17446651.2020.1770081","article-title":"Craniopharyngioma treatment: an updated summary of important clinicopathological concepts","volume":"15","author":"Prieto","year":"2020","journal-title":"Expert Rev Endocrinol Metab."},{"issue":"3","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s11060-011-0540-6","article-title":"Incidence of craniopharyngioma in Denmark (n = 189) and estimated world incidence of craniopharyngioma in children and adults","volume":"104","author":"Nielsen","year":"2011","journal-title":"J Neurooncol."},{"issue":"5","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s00381-021-05094-y","article-title":"Characteristics and overall survival in pediatric versus adult craniopharyngioma: a population-based study","volume":"37","author":"Lehrich","year":"2021","journal-title":"Childs Nerv Syst."},{"issue":"2","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3171\/jns.1995.83.2.0206","article-title":"Papillary craniopharyngioma: a clinicopathological study of 48 cases","volume":"83","author":"Crotty","year":"1995","journal-title":"J Neurosurg."},{"issue":"3","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3171\/jns.1972.36.3.0299","article-title":"Craniopharyngiomas in children and adults","volume":"36","author":"Hoff","year":"1972","journal-title":"J Neurosurg."},{"issue":"4","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1365-2265.2005.02231.x","article-title":"Craniopharyngiomas in children and adults: systematic analysis of 121 cases with long-term follow-up","volume":"62","author":"Karavitaki","year":"2005","journal-title":"Clin Endocrinol (Oxf)."},{"key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fendo.2012.00046","article-title":"Craniopharyngioma in adults","volume":"3","author":"Zoicas","year":"2012","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3171\/jns.2002.97.1.0003","article-title":"Craniopharyngioma in adults and children: a study of 122 surgical cases","volume":"97","author":"Van Effenterre","year":"2002","journal-title":"J Neurosurg."},{"issue":"8","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/COC.0000000000000378","article-title":"The role of definitive radiotherapy in craniopharyngioma: a SEER analysis","volume":"41","author":"Zhang","year":"2018","journal-title":"Am J Clin Oncol."},{"issue":"3","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s11060-022-03983-z","article-title":"Disease control after radiotherapy for adult craniopharyngioma: clinical outcomes from a large single-institution series","volume":"157","author":"Rutenberg","year":"2022","journal-title":"J Neurooncol"},{"issue":"3","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.ijrobp.2008.05.010","article-title":"Surveillance of craniopharyngioma cyst growth in children treated with proton radiotherapy","volume":"73","author":"Winkfield","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"6","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"E15","DOI":"10.3171\/2016.9.FOCUS16298","article-title":"A quantitative analysis of craniopharyngioma cyst expansion during and after radiation therapy and surgical implications","volume":"41","author":"Lamiman","year":"2016","journal-title":"Neurosurg Focus"},{"key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"e615","DOI":"10.1016\/j.wneu.2020.05.258","article-title":"Utility of interval imaging during focused radiation therapy for residual cystic craniopharyngiomas","volume":"141","author":"Moorthy","year":"2020","journal-title":"World Neurosurg"},{"issue":"5","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.ijrobp.2021.02.045","article-title":"Proton radiation therapy for pediatric craniopharyngioma","volume":"110","author":"Jimenez","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.wneu.2020.05.173","article-title":"Creative and innovative methods and techniques for the challenges in the management of adult craniopharyngioma","volume":"142","author":"Takami","year":"2020","journal-title":"World Neurosurg"},{"issue":"1","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3322\/caac.21707","article-title":"Magnetic resonance linear accelerator technology and adaptive radiation therapy: an overview for clinicians","volume":"72","author":"Hall","year":"2022","journal-title":"CA Cancer J Clin."},{"issue":"2","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s11060-020-03432-9","article-title":"Clinical outcomes following proton therapy for adult craniopharyngioma: a single-institution cohort study","volume":"147","author":"Rutenberg","year":"2020","journal-title":"J Neurooncol."},{"issue":"1","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41572-019-0125-9","article-title":"Craniopharyngioma","volume":"5","author":"M\u00fcller","year":"2019","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/pbc.21530","article-title":"Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models of dose characteristics and their relationship to cognitive function","volume":"51","author":"Merchant","year":"2008","journal-title":"Pediatr Blood Cancer."},{"key":"2023040607123634200_","first-page":"e26772","article-title":"Comparison of academic achievement scores after proton and photon therapy in children and young adults with craniopharyngioma","volume":"64","author":"Merchant","year":"2017","journal-title":"Pediatr Blood Cancer"},{"issue":"2","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000377727","article-title":"Proton radiotherapy for midline central nervous system lesions: a class solution","volume":"89","author":"Estabrook","year":"2015","journal-title":"Oncology."},{"issue":"2","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"e281","DOI":"10.1016\/j.ijrobp.2011.01.005","article-title":"On the benefits and risks of proton therapy in pediatric craniopharyngioma","volume":"82","author":"Beltran","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.radonc.2019.08.002","article-title":"Temporal lobe sparing radiotherapy with photons or protons for cognitive function preservation in paediatric craniopharyngioma","volume":"142","author":"Toussaint","year":"2020","journal-title":"Radiother Oncol"},{"key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3389\/fonc.2019.00991","article-title":"Evaluation of the hippocampal normal tissue complication model in a prospective cohort of low grade glioma patients-an analysis within the EORTC 22033 clinical trial","volume":"9","author":"Jaspers","year":"2019","journal-title":"Front Oncol"},{"issue":"34","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1200\/JCO.2014.57.2909","article-title":"Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial","volume":"32","author":"Gondi","year":"2014","journal-title":"J Clin Oncol."},{"issue":"28","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1200\/JCO.21.01632","article-title":"Hippocampal avoidance prophylactic cranial irradiation: a new standard of care?","volume":"39","author":"Brown","year":"2021","journal-title":"J Clin Oncol."},{"issue":"2","key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.radonc.2018.05.027","article-title":"Cognitive impairment and morphological changes after radiation therapy in brain tumors: a review","volume":"128","author":"Jacob","year":"2018","journal-title":"Radiother Oncol."},{"issue":"1","key":"2023040607123634200_","first-page":"vdaa141","article-title":"Medical debulking with BRAF\/MEK inhibitors in aggressive BRAF-mutant craniopharyngioma","volume":"2","author":"Di Stefano","year":"2020","journal-title":"Neurooncol Adv"},{"key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"882381","DOI":"10.3389\/fendo.2022.882381","article-title":"Neoadjuvant B-RAF and MEK inhibitor targeted therapy for adult papillary craniopharyngiomas: a new treatment paradigm","volume":"13","author":"Calvanese","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2023040607123634200_","doi-asserted-by":"crossref","first-page":"(12):5751","DOI":"10.1210\/jc.2019-01299","article-title":"The medical therapy of craniopharyngiomas: the way ahead","volume":"104","author":"Alexandraki","year":"2019","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/advance-article-pdf\/doi\/10.1093\/neuonc\/noac210\/46091692\/noac210.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/25\/4\/710\/49775529\/noac210.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/25\/4\/710\/49775529\/noac210.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T22:56:51Z","timestamp":1700953011000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article\/25\/4\/710\/6674791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,25]]},"references-count":44,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,8,25]]},"published-print":{"date-parts":[[2023,4,6]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/noac210","relation":{},"ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,4,1]]},"published":{"date-parts":[[2022,8,25]]}}}