{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:52:06Z","timestamp":1793411526141,"version":"4.5.0"},"reference-count":101,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T00:00:00Z","timestamp":1666396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This systematic review provides updated insights, from the published literature in the past 5 years, based on the 2017 European Association of Neuro-Oncology (EANO) guidelines for palliative care in adults with malignant brain tumors. It provides an overview of palliative care options, including during the end-of-life phase for patients with malignant brain tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature search was conducted from 2016 to 2021 focusing on four main topics: (1) symptom management, (2) caregiver needs, (3) early palliative care, and (4) care in the end-of-life phase. An international panel of palliative care experts in neuro-oncology synthesized the literature and reported the most relevant updates. A total of 140 articles were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>New insights include that: Hippocampal avoidance and stereotactic radiosurgery results in a lower risk of neurocognitive decline in patients with brain metastases; levetiracetam is more efficacious in reducing seizures than valproic acid as first-line monotherapy antiseizure drug (ASD) in glioma patients; lacosamide and perampanel seem well-tolerated and efficacious add-on ASDs; and a comprehensive framework of palliative and supportive care for high-grade glioma patients and their caregivers was proposed. No pharmacological agents have been shown in randomized controlled trials to significantly improve fatigue or neurocognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Since the 2017 EANO palliative care guidelines, new insights have been reported regarding symptom management and end-of-life care, however, most recommendations remain unchanged. Early palliative care interventions are essential to define goals of care and minimize symptom burden in a timely fashion. Interventional studies that address pain, fatigue, and psychiatric symptoms as well as (the timing of) early palliative care are urgently needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noac216","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T16:11:00Z","timestamp":1662480660000},"page":"447-456","source":"Crossref","is-referenced-by-count":82,"title":["Palliative care and end-of-life care in adults with malignant brain tumors"],"prefix":"10.1093","volume":"25","author":[{"given":"Johan A F","family":"Koekkoek","sequence":"first","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center , Leiden , The Netherlands"},{"name":"Department of Neurology, Haaglanden Medical Center , The Hague , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim B","family":"van der Meer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center , Leiden , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pace","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Unit, IRCCS Regina Elena National Cancer Institute , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6181-2895","authenticated-orcid":false,"given":"Caroline","family":"Hertler","sequence":"additional","affiliation":[{"name":"Competence Center Palliative Care, Department of Radiation Oncology, University Hospital Zurich and University of Zurich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Harrison","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, BC Cancer, The University of British Colombia , Vancouver , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather E","family":"Leeper","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health , Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A","family":"Forst","sequence":"additional","affiliation":[{"name":"Division of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Jalali","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Apollo Proton Cancer Center , Chennai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Oliver","sequence":"additional","affiliation":[{"name":"International Brain Tumour Alliance , Tadworth , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Philip","sequence":"additional","affiliation":[{"name":"Department of Medicine, St. Vincent\u2019s Hospital Melbourne, University of Melbourne , Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9949-4722","authenticated-orcid":false,"given":"Martin J B","family":"Taphoorn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center , Leiden , The Netherlands"},{"name":"Department of Neurology, Haaglanden Medical Center , The Hague , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9157-9895","authenticated-orcid":false,"given":"Linda","family":"Dirven","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center , Leiden , The Netherlands"},{"name":"Department of Neurology, 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