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In this study, we analyzed the survival of adults with glioma in relation to their antibody measurements to 4 common herpes viral infections, including VZV, measured post-diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analyzed IgG antibody measurements to VZV, cytomegalovirus (CMV), herpes simplex virus 1\/2 (HSV), and Epstein-Barr virus (EBV) collected from 1378 adults with glioma diagnosed between 1991 and 2010. Blood was obtained a median of 3 months after surgery. Associations of patient IgG levels with overall survival were estimated using Cox models adjusted for age, sex, self-reported race, surgery type, dexamethasone usage at blood draw, and tumor grade. Models were stratified by recruitment series and meta-analyzed to account for time-dependent treatment effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>VZV antibody seropositivity was associated with improved survival outcomes in adults with glioma (Hazard ratio, HR = 0.70, 95% Confidence Interval 0.54\u20130.90, P = .006). Amongst cases who were seropositive for VZV antibodies, survival was significantly improved for those above the 25th percentile of continuous reactivity measurements versus those below (HR = 0.76, 0.66\u20130.88, P = .0003). Antibody seropositivity to EBV was separately associated with improved survival (HR = 0.71, 0.53\u20130.96, P = .028). Antibody positivity to 2 other common viruses (CMV, HSV) was not associated with altered survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Low levels of VZV or EBV antibodies are associated with poorer survival outcomes for adults with glioma. Differential immune response rather than viral exposure may explain these findings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/neuonc\/noac283","type":"journal-article","created":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T22:48:10Z","timestamp":1673131690000},"page":"1047-1057","source":"Crossref","is-referenced-by-count":16,"title":["Antibodies to varicella-zoster virus and three other herpesviruses and survival in adults with glioma"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9870-9998","authenticated-orcid":false,"given":"Geno","family":"Guerra","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco , San Francisco, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2728-6083","authenticated-orcid":false,"given":"Lucie","family":"McCoy","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco , San Francisco, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen M","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco , San Francisco, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terri","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco , San Francisco, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9854-7404","authenticated-orcid":false,"given":"Annette M","family":"Molinaro","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco , San Francisco, California , USA"},{"name":"Department of Epidemiology and Biostatistics, University of California San Francisco , San Francisco, California , USA"},{"name":"Weill Institute for Neurosciences, University of California San Francisco , San Francisco, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph L","family":"Wiemels","sequence":"additional","affiliation":[{"name":"Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California , Los Angeles, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John K","family":"Wiencke","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco , San Francisco, California , USA"},{"name":"Department of Epidemiology and Biostatistics, University of California San Francisco , San Francisco, California , USA"},{"name":"Institute of Human Genetics, University of California San Francisco , San Francisco, California , USA"},{"name":"Weill Institute for Neurosciences, University of California San Francisco , San Francisco, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Wrensch","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco , San Francisco, California , USA"},{"name":"Institute of Human Genetics, University of California San Francisco , San Francisco, California , USA"},{"name":"Weill Institute for Neurosciences, University of California San Francisco , San Francisco, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen S","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California San Francisco , San Francisco, California , USA"},{"name":"Department of Epidemiology and Biostatistics, University of California San Francisco , San Francisco, California , USA"},{"name":"Weill Institute for Neurosciences, 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