{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T10:03:54Z","timestamp":1781345034771,"version":"3.54.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>\u201cPrimary papillary epithelial tumor of the sella (PPETS)\u201d is a recently described rare tumor entity of the central nervous system (CNS) with stereotypic location in the sella. Comprehensive molecular investigations and epigenetic profiles of PPETS have not been performed to date.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We report a comprehensive clinical, histopathologic, and molecular assessment of 5 PPETS cases in comparison with a cohort composed of 7 choroid plexus papilloma (CPP), 7 central neurocytoma (CN), 15 posterior pituitary tumor (PPT) including 4 pituicytoma, 6 granular cell tumors of the sellar region (GCT), and 5 spindle cell oncocytoma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>All PPETS had good outcomes. Immunohistochemically, PPETS tumors showed positive staining with TTF1, EMA, AE1\/AE3, MAP2, and Vimentin, but were negatively stained with Syn, GFAP, CgA, and S100, and sporadically stained with Ki-67. In unsupervised hierarchical clustering and t-distributed stochastic neighbor embedding analyses of DNA-methylation data, PPETS and PPT tumors formed a distinct cluster irrespective of their histologic types. However, PPETS tumors did not cluster together with CPP and CN samples. Similar findings were obtained when our samples were projected into the reference cohort of the brain tumor classifier. Substantial fractions of the PPETS and PPT tumors shared broadly similar chromosomal copy number alterations. No mutations were detected using targeted next-generation sequencing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Though more cases are needed to further elucidate the molecular pathogenesis of these tumors, our findings indicate that PPETS and PPT tumors may constitute a single neurooncological entity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/neuonc\/noad067","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T14:26:47Z","timestamp":1681482407000},"page":"1487-1497","source":"Crossref","is-referenced-by-count":14,"title":["Primary papillary epithelial tumor of the sella and posterior pituitary tumor show similar (epi)genetic features and constitute a single neuro-oncological entity"],"prefix":"10.1093","volume":"25","author":[{"given":"Jing","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Pathology, Sanbo Brain Hospital, Capital Medical University , Haidian District, Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zejun","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sanbo Brain Hospital, Capital Medical University , Haidian District, Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sanbo Brain Hospital, Capital Medical University , Haidian District, Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuping","family":"Gui","sequence":"additional","affiliation":[{"name":"The Department of Pathology, Chinese PLA General Hospital (301 Hospital) , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing Neurosurgical Institute, Capital 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