{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:50:19Z","timestamp":1789145419133,"version":"build-2803163510"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Childhood craniopharyngioma (cCP) has excellent survival, but quality of life may be severely hampered by hypothalamic dysfunction. We aimed to evaluate treatment and hypothalamic outcomes of a Dutch cCP cohort, and evaluate the effect of centralization of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was performed, including cCP patients diagnosed between 2004 and 2021. Treatment characteristics and hypothalamic outcomes were evaluated and compared before and since centralization of care in May 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 87 cCP patients. Cyst drainage\/fenestration was performed in 29.9%, limited resection in 27.6%, near-total resection in 16.1%, and gross total resection (GTR) in 25.4%. Radiotherapy was given in 46.0%. After a median follow-up of 6.5 years, hypothalamic obesity (HO) was present in 24.7% and panhypopituitarism with diabetes insipidus in 71.3%. Higher body mass index (BMI) SDS at diagnosis and Muller grade II at last magnetic resonance imaging of follow-up were associated with overweight\/obesity. No association was found between extensiveness of resection and overweight\/obesity at last follow-up. When comparing before and after centralization of care, rates of GTR remained similar, but BMI outcomes changed; mean \u0394BMI SDS 1 year after diagnosis from 1.12 (SD 1.15) to 0.81 (SD 1.24), and HO after 1 year decreased from 33.3% to 12.0% (P = .067), and after 2 years from 28.6% to 6.7% (P = NS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In our nationwide cohort, GTR was performed in a relatively low percentage of patients and extensiveness of resection was no longer associated with HO at follow-up. A trend toward improvement of BMI is observed since centralization of care, which needs further exploration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noad112","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T02:51:50Z","timestamp":1688007110000},"page":"2250-2261","source":"Crossref","is-referenced-by-count":23,"title":["Treatment and outcome of the Dutch Childhood Craniopharyngioma Cohort study: First results after centralization of care"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-6592","authenticated-orcid":false,"given":"Jiska","family":"Van Schaik","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht , Utrecht , The Netherlands"},{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for pediatric oncology , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette Y N","family":"Schouten-van Meeteren","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for pediatric oncology , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Vos-Kerkhof","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for pediatric oncology , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert O","family":"Janssens","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Medical Center Utrecht , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio L","family":"Porro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Medical Center Utrecht , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Fiocco","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for pediatric oncology , Utrecht , The Netherlands"},{"name":"Department of Mathematics and Statistics, Institute of Mathematics, Leiden University , Leiden , Netherlands"},{"name":"Department of Biomedical Data Science, Section Medical Statistics, Leiden University Medical Center , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boudewijn","family":"Bakker","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht , Utrecht , The Netherlands"},{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for pediatric oncology , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim J E","family":"Tissing","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for pediatric oncology , Utrecht , The Netherlands"},{"name":"Department of Pediatric Oncology\/Hematology, University of Groningen, University Medical Center Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eelco W","family":"Hoving","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Princess M\u00e1xima Center for pediatric oncology , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke M","family":"van Santen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Wilhelmina Children\u2019s Hospital, University Medical Center Utrecht , Utrecht , The Netherlands"},{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for pediatric oncology , Utrecht , The 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