{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:59:57Z","timestamp":1793066397669,"version":"4.5.0"},"reference-count":133,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Penn State Department of Neurosurgery"},{"name":"Tara Leah Witmer Memorial Fund"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F30CA250193"],"award-info":[{"award-number":["F30CA250193"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01CA245705"],"award-info":[{"award-number":["P01CA245705"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Glioblastoma (GBM) is among the deadliest malignancies facing modern oncology. While our understanding of certain aspects of GBM biology has significantly increased over the last decade, other aspects, such as the role of bioactive metals in GBM progression, remain understudied. Iron is the most abundant transition metal found within the earth\u2019s crust and plays an intricate role in human physiology owing to its ability to participate in oxidation\u2013reduction reactions. The importance of iron homeostasis in human physiology is apparent when examining the clinical consequences of iron deficiency or iron overload. Despite this, the role of iron in GBM progression has not been well described. Here, we review and synthesize the existing literature examining iron\u2019s role in GBM progression and patient outcomes, as well as provide a survey of iron\u2019s effects on the major cell types found within the GBM microenvironment at the molecular and cellular level. Iron represents an accessible target given the availability of already approved iron supplements and chelators. Improving our understanding of iron\u2019s role in GBM biology may pave the way for iron-modulating approaches to improve patient outcomes.<\/jats:p>","DOI":"10.1093\/neuonc\/noad136","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T08:43:31Z","timestamp":1691138611000},"page":"2136-2149","source":"Crossref","is-referenced-by-count":23,"title":["A closer look at the role of iron in glioblastoma"],"prefix":"10.1093","volume":"25","author":[{"given":"Ganesh","family":"Shenoy","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Penn State College of Medicine , Hershey, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0481-8240","authenticated-orcid":false,"given":"James R","family":"Connor","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Penn State College of Medicine , Hershey, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"key":"2023120821465814500_CIT0001","doi-asserted-by":"crossref","first-page":"v1","DOI":"10.1093\/neuonc\/noac202","article-title":"CBTRUS Statistical Report: primary brain and other central nervous system tumors diagnosed in the United States in 2015\u20132019","volume":"24","author":"Ostrom","year":"2022","journal-title":"Neuro-Oncol."},{"issue":"3","key":"2023120821465814500_CIT0002","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1021\/ar500345f","article-title":"Exploration of earth-abundant transition metals (Fe, Co, and Ni) as catalysts in unreactive chemical bond activations","volume":"48","author":"Su","year":"2015","journal-title":"Acc Chem Res."},{"issue":"1","key":"2023120821465814500_CIT0003","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1134\/S001670290601006X","article-title":"Abundances of chemical elements in the 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