{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T21:16:34Z","timestamp":1768598194440,"version":"3.49.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100007188","name":"Uniformed Services University of the Health Sciences","doi-asserted-by":"publisher","award":["HU00012220063"],"award-info":[{"award-number":["HU00012220063"]}],"id":[{"id":"10.13039\/100007188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["75D30119C06056"],"award-info":[{"award-number":["75D30119C06056"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["75N91022P00827"],"award-info":[{"award-number":["75N91022P00827"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Comprehensive analysis of brain tumor incidence and survival in the Veteran population has been lacking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Veteran data were obtained from the Veterans Health Administration (VHA) Medical Centers via VHA Corporate Data Warehouse. Brain tumor statistics on the overall US population were generated from the Central Brain Tumor Registry of the US data. Cases were individuals (\u226518 years) with a primary brain tumor, diagnosed between 2004 and 2018. The average annual age-adjusted incidence rates (AAIR) and 95% confidence intervals were estimated per 100 000 population and Kaplan\u2013Meier survival curves evaluated overall survival outcomes among Veterans.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The Veteran population was primarily white (78%), male (93%), and between 60 and 64 years old (18%). Individuals with a primary brain tumor in the general US population were mainly female (59%) and between 18 and 49 years old (28%). The overall AAIR of primary brain tumors from 2004 to 2018 within the Veterans Affairs cancer registry was 11.6. Nonmalignant tumors were more common than malignant tumors (AAIR:7.19 vs 4.42). The most diagnosed tumors in Veterans were nonmalignant pituitary tumors (AAIR:2.96), nonmalignant meningioma (AAIR:2.62), and glioblastoma (AAIR:1.96). In the Veteran population, survival outcomes became worse with age and were lowest among individuals diagnosed with glioblastoma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Differences between Veteran and US populations can be broadly attributed to demographic composition differences of these groups. Prior to this, there have been no reports on national-level incidence rates and survival outcomes for Veterans. These data provide vital information that can drive efforts to understand disease burden and improve outcomes for individuals with primary brain tumors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/neuonc\/noad182","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T21:46:07Z","timestamp":1695419167000},"page":"387-396","source":"Crossref","is-referenced-by-count":5,"title":["Brain tumors in United States military veterans"],"prefix":"10.1093","volume":"26","author":[{"given":"John R","family":"Bihn","sequence":"first","affiliation":[{"name":"VA Boston Healthcare System , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3296-8652","authenticated-orcid":false,"given":"Gino","family":"Cioffi","sequence":"additional","affiliation":[{"name":"Trans Divisional Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute , Bethesda, Maryland , USA"},{"name":"Central Brain Tumor Registry of the United States , Hinsdale, Illinois , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin A","family":"Waite","sequence":"additional","affiliation":[{"name":"Trans Divisional Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute , Bethesda, Maryland , USA"},{"name":"Central Brain Tumor Registry of the United States , Hinsdale, Illinois , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7212-035X","authenticated-orcid":false,"given":"Carol","family":"Kruchko","sequence":"additional","affiliation":[{"name":"Central Brain Tumor Registry of the United States , Hinsdale, Illinois , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corey","family":"Neff","sequence":"additional","affiliation":[{"name":"Central Brain Tumor Registry of the United States , Hinsdale, Illinois , USA"},{"name":"Department of Neurosurgery, Duke University School of Medicine , Durham, North Carolina , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mackenzie","family":"Price","sequence":"additional","affiliation":[{"name":"Central Brain Tumor Registry of the United States , Hinsdale, Illinois , USA"},{"name":"Department of Neurosurgery, Duke University School of Medicine , Durham, North Carolina , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quinn T","family":"Ostrom","sequence":"additional","affiliation":[{"name":"Central Brain Tumor Registry of the United States , Hinsdale, Illinois , USA"},{"name":"Department of Neurosurgery, Duke University School of Medicine , Durham, North Carolina , USA"},{"name":"The Preston Robert Tisch Brain Tumor Center, Duke University School of Medicine , Durham, North Carolina , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlin N","family":"Swinnerton","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danne C","family":"Elbers","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System , Boston, Massachusetts , USA"},{"name":"Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Mooney","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System , Boston, Massachusetts , USA"},{"name":"Department of Neurosurgery, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Rachlin","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thor D","family":"Stein","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System , Boston, Massachusetts , USA"},{"name":"Boston University, Chobanian and Avedisian School of Medicine , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary T","family":"Brophy","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System , Boston, Massachusetts , USA"},{"name":"Boston University, Chobanian and Avedisian School of Medicine , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nhan V","family":"Do","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System , Boston, Massachusetts , USA"},{"name":"Boston University, Chobanian and Avedisian School of Medicine , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan E","family":"Ferguson","sequence":"additional","affiliation":[{"name":"VA Boston Healthcare System , Boston, Massachusetts , USA"},{"name":"Boston University, Chobanian and Avedisian School of Medicine , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S","family":"Priemer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Uniformed Services University School of Medicine , Bethesda, Maryland , USA"},{"name":"Henry M. Jackson Foundation for The Advancement of Military Medicine , Bethesda, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P","family":"Perl","sequence":"additional","affiliation":[{"name":"Department of Pathology, Uniformed Services University School of Medicine , Bethesda, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A","family":"Hickman","sequence":"additional","affiliation":[{"name":"Henry M. Jackson Foundation for The Advancement of Military Medicine , Bethesda, Maryland , USA"},{"name":"Human Oncology and Pathogenesis Program, Sloan Kettering Institute , New York, New York , USA"},{"name":"Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of Health Sciences , Bethesda, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burt","family":"Nabors","sequence":"additional","affiliation":[{"name":"Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham , Birmingham, Alabama , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Rusiecki","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Biostatistics, Uniformed Services University School of Medicine , Bethesda, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill 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