{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:21:42Z","timestamp":1793020902474,"version":"4.5.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Stereotactic radiosurgery (SRS) is used to treat recurrent or residual nonfunctioning pituitary neuroendocrine tumors (NFPA). The objective of the study was to assess imaging and development of new pituitary hormone deficiency.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients treated with single-session SRS for a NFPA were included in this retrospective, multicenter study. Tumor control and new pituitary dysfunction were evaluated using Cox analysis and Kaplan\u2013Meier curves.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 869 patients (male 476 [54.8%], median age at SRS 52.5 years [Interquartile range (IQR): 18.9]) were treated using a median margin dose of 14Gy (IQR: 4) for a median tumor volume of 3.4 cc (IQR: 4.3). With a median radiological follow-up of 3.7 years (IQR: 4.8), volumetric tumor reduction occurred in 451 patients (51.9%), stability in 364 (41.9%) and 54 patients (6.2%) showed tumor progression.<\/jats:p>\n                  <jats:p>The probability of tumor control was 95.5% (95% Confidence Interval [CI]: 93.8\u201397.3) and 88.8% (95%CI: 85.2\u201392.5) at 5 and 10 years, respectively. A margin dose &amp;gt;14 Gy was associated with tumor control (Hazard Ratio [HR]:0.33, 95% CI: 0.18\u20130.60, P &amp;lt; 0.001). The probability of new hypopituitarism was 9.9% (95% CI: 7.3\u201312.5) and 15.3% (95% CI: 11\u201319.4) at 5 and 10 years, respectively. A maximum point dose &amp;gt;10 Gy in the pituitary stalk was associated with new pituitary hormone deficiency (HR: 3.47, 95% CI: 1.95\u20136.19). The cumulative probability of new cortisol, thyroid, gonadotroph, and growth hormone deficiency was 8% (95% CI: 3.9\u201311.9), 8.3% (95% CI: 3.9\u201312.5), 3.5% (95% CI: 1.7\u20135.2), and 4.7% (95% CI: 1.9\u20137.4), respectively at 10 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>SRS provides long-term tumor control with a 15.3% risk of hypopituitarism at 10 years.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/neuonc\/noad215","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T16:05:07Z","timestamp":1702569907000},"page":"715-723","source":"Crossref","is-referenced-by-count":18,"title":["Stereotactic radiosurgery for nonfunctioning pituitary tumor: A multicenter study of new pituitary hormone deficiency"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1333-2533","authenticated-orcid":false,"given":"Chloe","family":"Dumot","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of Virginia , Charlottesville, Virginia , USA"},{"name":"Department of Neurological Surgery, Hospices civils de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Mantziaris","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Virginia , Charlottesville, Virginia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Dayawansa","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Virginia , Charlottesville, Virginia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selcuk","family":"Peker","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Koc University School of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavuz","family":"Samanci","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Koc University School of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M","family":"Nabeel","sequence":"additional","affiliation":[{"name":"Gamma Knife Center Cairo, Nasser Institute Hospital , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael A","family":"Reda","sequence":"additional","affiliation":[{"name":"Gamma Knife Center Cairo, Nasser Institute Hospital , Cairo , Egypt"},{"name":"Departments of Neurosurgery, Ain Shams University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameh R","family":"Tawadros","sequence":"additional","affiliation":[{"name":"Gamma Knife Center Cairo, Nasser Institute Hospital , Cairo , Egypt"},{"name":"Departments of Neurosurgery, Ain Shams University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Abdelkarim","sequence":"additional","affiliation":[{"name":"Gamma Knife Center Cairo, Nasser Institute Hospital , Cairo , Egypt"},{"name":"Departments of Clinical Oncology, Ain Shams University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr M N","family":"El-Shehaby","sequence":"additional","affiliation":[{"name":"Gamma Knife Center Cairo, Nasser Institute Hospital , Cairo , Egypt"},{"name":"Departments of Neurosurgery, Ain Shams University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem M","family":"Emad","sequence":"additional","affiliation":[{"name":"Gamma Knife Center Cairo, Nasser Institute Hospital , Cairo , Egypt"},{"name":"Department of Radiation Oncology, National Cancer Institute, Cairo University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Ragab","family":"Abdelsalam","sequence":"additional","affiliation":[{"name":"Neurosurgery Department, Military Medical Academy , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Liscak","sequence":"additional","affiliation":[{"name":"Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital , Prague , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaromir","family":"May","sequence":"additional","affiliation":[{"name":"Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital , Prague , Czech Republic"},{"name":"Department of Neurosurgery, University of Miami , Miami, 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Miami, Florida , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital , Prague , Czech Republic"},{"name":"Department of Neurosurgery, University of Miami , Miami, Florida , USA"},{"name":"Department of Radiation Oncology, James Cancer Hospital at The Ohio State University , Columbus, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Universite\u0301 de Sherbrooke, Centre de recherche du CHUS , Sherbrooke, Quebec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Nicolas","family":"Tourigny","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Universite\u0301 de Sherbrooke, Centre de recherche du CHUS , Sherbrooke, Quebec , 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