{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:07:49Z","timestamp":1792786069540,"version":"4.5.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100010441","name":"Medical Faculty of Heidelberg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010441","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Else Kr\u00f6ner Fresenius Foundatio","award":["2023_EKMS.27"],"award-info":[{"award-number":["2023_EKMS.27"]}]},{"name":"German Consortium for Translational Cancer Research"},{"name":"Klinische Forschergruppe"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Else Kr\u00f6ner Fresenius Foundation","award":["2015_A_60"],"award-info":[{"award-number":["2015_A_60"]}]},{"name":"Else Kr\u00f6ner Fresenius Foundation","award":["2017_EKES.24"],"award-info":[{"award-number":["2017_EKES.24"]}]},{"DOI":"10.13039\/501100005972","name":"German Cancer Aid","doi-asserted-by":"publisher","award":["70112956"],"award-info":[{"award-number":["70112956"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Cancer Council","award":["KA 2679\/3-2"],"award-info":[{"award-number":["KA 2679\/3-2"]}]},{"name":"European Community","award":["MrgRT-DOS"],"award-info":[{"award-number":["MrgRT-DOS"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P0550530)"],"award-info":[{"award-number":["P0550530)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Novel radiotherapeutic modalities using carbon ions provide an increased relative biological effectiveness (RBE) compared to photons, delivering a higher biological dose while reducing radiation exposure for adjacent organs. This prospective phase 2 trial investigated bimodal radiotherapy using photons with carbon-ion (C12)-boost in patients with WHO grade 2 meningiomas following subtotal resection (Simpson grade 4 or 5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 33 patients were enrolled from July 2012 until July 2020. The study treatment comprised a C12-boost (18 Gy [RBE] in 6 fractions) applied to the macroscopic tumor in combination with photon radiotherapy (50 Gy in 25 fractions). The primary endpoint was the 3-year progression-free survival (PFS), and the secondary endpoints included overall survival, safety and treatment toxicities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>With a median follow-up of 42 months, the 3-year estimates of PFS, local PFS and overall survival were 80.3%, 86.7%, and 89.8%, respectively. Radiation-induced contrast enhancement (RICE) was encountered in 45%, particularly in patients with periventricularly located meningiomas. Patients exhibiting RICE were mostly either asymptomatic (40%) or presented immediate neurological and radiological improvement (47%) after the administration of corticosteroids or bevacizumab in case of radiation necrosis (3\/33). Treatment-associated complications occurred in 1 patient with radiation necrosis who died due to postoperative complications after resection of radiation necrosis. The study was prematurely terminated after recruiting 33 of the planned 40 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study demonstrates a bimodal approach utilizing photons with C12-boost may achieve a superior local PFS to conventional photon RT, but must be balanced against the potential risks of toxicities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noad244","type":"journal-article","created":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T18:26:31Z","timestamp":1702232791000},"page":"701-712","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy and toxicity of bimodal radiotherapy in WHO grade 2 meningiomas following subtotal resection with carbon ion boost: Prospective phase 2 MARCIE trial"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4925-7600","authenticated-orcid":false,"given":"Maximilian Y","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO) , Heidelberg , Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital , Heidelberg , Germany"},{"name":"Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sybren L N","family":"Maas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Leiden University Medical Center , Leiden , The Netherlands"},{"name":"Department of Pathology, Erasmus MC Cancer Institute, University Medical Center Rotterdam , Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Hinz","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ) , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian P","family":"Karger","sequence":"additional","affiliation":[{"name":"Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Sievers","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ) , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Eichkorn","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO) , Heidelberg , Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Meixner","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO) , Heidelberg , Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital , Heidelberg , Germany"},{"name":"Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Hoegen-Sassmannshausen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO) , Heidelberg , Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital , Heidelberg , Germany"},{"name":"Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"H\u00f6rner-Rieber","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO) , Heidelberg , Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital , Heidelberg , Germany"},{"name":"Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W","family":"Lischalk","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Perlmutter Cancer Center at New York University Langone Health at Long Island , New York, New York , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Seidensaal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO) , Heidelberg , Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital , Heidelberg , Germany"},{"name":"Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5231-9097","authenticated-orcid":false,"given":"Denise","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Klinikum Rechts der Isar, Technical University Munich , Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Jungk","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Heidelberg, Heidelberg University , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Unterberg","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Heidelberg, Heidelberg University , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Wick","sequence":"additional","affiliation":[{"name":"Department of Neurology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6171-634X","authenticated-orcid":false,"given":"Wolfgang","family":"Wick","sequence":"additional","affiliation":[{"name":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital , Heidelberg , Germany"},{"name":"Department of Neurology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ) , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"von Deimling","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ) , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5441-1962","authenticated-orcid":false,"given":"Felix","family":"Sahm","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ) , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Combs","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Klinikum Rechts der Isar, Technical University Munich , Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Herfarth","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO) , Heidelberg , Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital , Heidelberg , Germany"},{"name":"Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Debus","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO) , Heidelberg , Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital , Heidelberg , Germany"},{"name":"Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"},{"name":"Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO) , Heidelberg , Germany"},{"name":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital , Heidelberg , Germany"},{"name":"Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"2024040505534079100_CIT0001","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"Louis","year":"2016"},{"issue":"8","key":"2024040505534079100_CIT0002","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO Classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol"},{"issue":"6","key":"2024040505534079100_CIT0003","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization classification of tumors of the central nervous system: a summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol."},{"issue":"11","key":"2024040505534079100_CIT0004","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1093\/neuonc\/noab150","article-title":"EANO guideline on the diagnosis and management of meningiomas","volume":"23","author":"Goldbrunner","year":"2021","journal-title":"Neuro Oncol"},{"issue":"6","key":"2024040505534079100_CIT0005","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s00401-023-02642-5","article-title":"Independent prognostic impact of DNA methylation class and chromosome 1p loss in WHO grade 2 and 3 meningioma undergoing adjuvant high-dose radiotherapy: comprehensive molecular","volume":"146","author":"Maas","year":"2023","journal-title":"Acta Neuropathol."},{"issue":"2","key":"2024040505534079100_CIT0006","doi-asserted-by":"crossref","first-page":"e12970","DOI":"10.1111\/bpa.12970","article-title":"Prognostic impact of genetic alterations and methylation classes in meningioma","volume":"32","author":"Berghoff","year":"2022","journal-title":"Brain Pathol."},{"issue":"12","key":"2024040505534079100_CIT0007","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1038\/s41591-023-02586-z","article-title":"Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses","volume":"29","author":"Chen","year":"2023","journal-title":"Nat Med."},{"issue":"5","key":"2024040505534079100_CIT0008","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41588-022-01061-8","article-title":"Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities","volume":"54","author":"Choudhury","year":"2022","journal-title":"Nat Genet."},{"issue":"5","key":"2024040505534079100_CIT0009","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/neuonc\/noab213","article-title":"A molecularly integrated grade for meningioma","volume":"24","author":"Driver","year":"2022","journal-title":"Neuro Oncol"},{"issue":"34","key":"2024040505534079100_CIT0010","doi-asserted-by":"crossref","first-page":"JCO2100784","DOI":"10.1200\/JCO.21.00784","article-title":"Integrated molecular-morphologic meningioma classification: a multicenter retrospective analysis, retrospectively and prospectively validated","volume":"39","author":"Maas","year":"2021","journal-title":"J Clin Oncol."},{"issue":"7874","key":"2024040505534079100_CIT0011","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41586-021-03850-3","article-title":"A clinically applicable integrative molecular classification of meningiomas","volume":"597","author":"Nassiri","year":"2021","journal-title":"Nature."},{"issue":"7","key":"2024040505534079100_CIT0012","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/neuonc\/noz061","article-title":"DNA methylation profiling to predict recurrence risk in meningioma: development and validation of a nomogram to optimize clinical management","volume":"21","author":"Nassiri","year":"2019","journal-title":"Neuro Oncol"},{"issue":"5","key":"2024040505534079100_CIT0013","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S1470-2045(17)30155-9","article-title":"DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis","volume":"18","author":"Sahm","year":"2017","journal-title":"Lancet Oncol."},{"issue":"5","key":"2024040505534079100_CIT0014","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/neuonc\/nou025","article-title":"Adjuvant radiotherapy for atypical and malignant meningiomas: a systematic review","volume":"16","author":"Kaur","year":"2014","journal-title":"Neuro Oncol"},{"issue":"4","key":"2024040505534079100_CIT0015","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.ijrobp.2019.11.028","article-title":"High-risk meningioma: initial outcomes from NRG Oncology\/RTOG 0539","volume":"106","author":"Rogers","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"1","key":"2024040505534079100_CIT0016","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3171\/2014.7.JNS131644","article-title":"Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review","volume":"122","author":"Rogers","year":"2015","journal-title":"J Neurosurg."},{"issue":"2","key":"2024040505534079100_CIT0017","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0360-3016(98)90035-9","article-title":"Ensuring local control in meningiomas","volume":"15","author":"Salazar","year":"1988","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"1","key":"2024040505534079100_CIT0018","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1136\/jnnp.20.1.22","article-title":"The recurrence of intracranial meningiomas after surgical treatment","volume":"20","author":"Simpson","year":"1957","journal-title":"J Neurol Neurosurg Psychiatry."},{"issue":"3","key":"2024040505534079100_CIT0019","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3171\/2015.9.JNS15754","article-title":"The Simpson grading revisited: aggressive surgery and its place in modern meningioma management","volume":"125","author":"Gousias","year":"2016","journal-title":"J Neurosurg."},{"issue":"9","key":"2024040505534079100_CIT0020","doi-asserted-by":"crossref","first-page":"e383","DOI":"10.1016\/S1470-2045(16)30321-7","article-title":"EANO guidelines for the diagnosis and treatment of meningiomas","volume":"17","author":"Goldbrunner","year":"2016","journal-title":"Lancet Oncol."},{"issue":"12","key":"2024040505534079100_CIT0021","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/s42254-021-00368-5","article-title":"Physics and biomedical challenges of cancer therapy with accelerated heavy ions","volume":"3","author":"Durante","year":"2021","journal-title":"Nat Rev Phys."},{"issue":"1114","key":"2024040505534079100_CIT0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1259\/bjr.20200183","article-title":"Particle therapy in the future of precision therapy","volume":"93","author":"Schaub","year":"2020","journal-title":"Brit J Radiol"},{"issue":"3","key":"2024040505534079100_CIT0023","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s11060-020-03464-1","article-title":"Carbon ion radiotherapy for skull base chordomas and chondrosarcomas: a systematic review and meta-analysis of local control, survival, and toxicity outcomes","volume":"147","author":"Lu","year":"2020","journal-title":"J Neurooncol."},{"issue":"1","key":"2024040505534079100_CIT0024","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijrobp.2006.08.027","article-title":"Carbon ion radiotherapy of skull base chondrosarcomas","volume":"67","author":"Schulz-Ertner","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"2","key":"2024040505534079100_CIT0025","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s00066-022-02002-4","article-title":"Proton and carbon ion beam treatment with active raster scanning method in 147 patients with skull base chordoma at the Heidelberg Ion Beam Therapy Center-a single-center experience","volume":"199","author":"Mattke","year":"2023","journal-title":"Strahlenther Onkol."},{"issue":"1","key":"2024040505534079100_CIT0026","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.radonc.2009.12.029","article-title":"Carbon ion radiation therapy for high-risk meningiomas","volume":"95","author":"Combs","year":"2010","journal-title":"Radiother Oncol."},{"issue":"11","key":"2024040505534079100_CIT0027","doi-asserted-by":"crossref","first-page":"109861","DOI":"10.1016\/j.radonc.2023.109861","article-title":"Fractionated radiotherapy for surgically resected intracranial meningiomas: a multicentre retrospective cohort study","volume":"188","author":"Wang","year":"2023","journal-title":"Radiother Oncol."},{"issue":"1","key":"2024040505534079100_CIT0028","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s004110050055","article-title":"Computation of cell survival in heavy ion beams for therapy. The model and its approximation","volume":"36","author":"Scholz","year":"1997","journal-title":"Radiat Environ Biophys."},{"issue":"1","key":"2024040505534079100_CIT0029","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/neuonc\/noy137","article-title":"Proposed response assessment and endpoints for meningioma clinical trials: report from the response assessment in neuro-oncology working group","volume":"21","author":"Huang","year":"2019","journal-title":"Neuro Oncol"},{"issue":"8","key":"2024040505534079100_CIT0030","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.radonc.2022.06.006","article-title":"Results of a prospective randomized trial on long-term effectiveness of protons and carbon ions in prostate cancer: LEM I and alpha\/beta = 2 Gy overestimates the RBE","volume":"173","author":"Eichkorn","year":"2022","journal-title":"Radiother Oncol."},{"issue":"10","key":"2024040505534079100_CIT0031","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s00066-022-01994-3","article-title":"DEGRO practical guideline for central nervous system radiation necrosis part 1: classification and a multistep approach for diagnosis","volume":"198","author":"Bernhardt","year":"2022","journal-title":"Strahlenther Onkol."},{"issue":"11","key":"2024040505534079100_CIT0032","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00066-022-01973-8","article-title":"DEGRO practical guideline for central nervous system radiation necrosis part 2: treatment","volume":"198","author":"Bernhardt","year":"2022","journal-title":"Strahlenther Onkol."},{"issue":"1","key":"2024040505534079100_CIT0033","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1186\/1471-2407-10-615","article-title":"Treatment of patients with atypical meningiomas Simpson grade 4 and 5 with a carbon ion boost in combination with postoperative photon radiotherapy: the MARCIE trial","volume":"10","author":"Combs","year":"2010","journal-title":"BMC Cancer"},{"issue":"7697","key":"2024040505534079100_CIT0034","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature26000","article-title":"DNA methylation-based classification of central nervous system tumours","volume":"555","author":"Capper","year":"2018","journal-title":"Nature."},{"issue":"1","key":"2024040505534079100_CIT0035","first-page":"vdac123","article-title":"A multi-institutional phase II trial of bevacizumab for recurrent and refractory meningioma","volume":"4","author":"Kumthekar","year":"2022","journal-title":"Neurooncol Adv"},{"issue":"1","key":"2024040505534079100_CIT0036","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11060-012-0886-4","article-title":"Atypical and anaplastic meningiomas treated with bevacizumab","volume":"109","author":"Nayak","year":"2012","journal-title":"J Neurooncol."},{"issue":"3","key":"2024040505534079100_CIT0037","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ijrobp.2020.03.013","article-title":"Late contrast enhancing brain lesions in proton-treated patients with low-grade glioma: clinical evidence for increased periventricular sensitivity and variable RBE","volume":"107","author":"Bahn","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"5","key":"2024040505534079100_CIT0038","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.radonc.2022.05.005","article-title":"Radiation-induced contrast enhancement following proton radiotherapy for low-grade glioma depends on tumor characteristics and is rarer in children than adults","volume":"172","author":"Eichkorn","year":"2022","journal-title":"Radiother Oncol."},{"issue":"1","key":"2024040505534079100_CIT0039","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0360-3016(91)90171-Y","article-title":"Tolerance of normal tissue to therapeutic irradiation","volume":"21","author":"Emami","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"5","key":"2024040505534079100_CIT0040","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1667\/3063","article-title":"Radiation tolerance of the rat spinal cord after single and split doses of photons and carbon ions","volume":"160","author":"Debus","year":"2003","journal-title":"Radiat Res."},{"issue":"1","key":"2024040505534079100_CIT0041","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrclinonc.2009.183","article-title":"Charged particles in radiation oncology","volume":"7","author":"Durante","year":"2010","journal-title":"Nat Rev Clin Oncol."},{"issue":"1","key":"2024040505534079100_CIT0042","first-page":"vdad059","article-title":"Analysis of recurrence probability following radiotherapy in patients with CNS WHO grade 2 meningioma using integrated molecular-morphologic classification","volume":"5","author":"Deng","year":"2023","journal-title":"Neurooncol Adv"}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/advance-article-pdf\/doi\/10.1093\/neuonc\/noad244\/56280973\/noad244.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/26\/4\/701\/57158504\/noad244.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/26\/4\/701\/57158504\/noad244.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T01:54:38Z","timestamp":1712282078000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article\/26\/4\/701\/7469300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,11]]},"references-count":42,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,12,11]]},"published-print":{"date-parts":[[2024,4,5]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/noad244","relation":{},"ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4,1]]},"published":{"date-parts":[[2023,12,11]]}}}