{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:28:18Z","timestamp":1792794498796,"version":"4.5.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"The Gustave Roussy Foundatio","id":[{"id":"https:\/\/ror.org\/05rfnt234","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Fondation ARC"},{"name":"French Society of Childhood and Adolescent Cancer"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Optic pathway gliomas (OPGs) represent 5% of childhood brain tumors. Successive relapses lead to multiple treatments exposing to late complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included patients treated at Gustave Roussy (GR) between January 1980 and December 2015 for OPG, before 18 years old and alive at 5 years from diagnosis. Mortality and physical health conditions data were extracted from medical data files and updated, thanks to the GR long-term follow-up program and French national mortality registry for patients included in the French Childhood Cancer Survivor Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 182 5-year OPG-childhood survivors in the analysis (sex ratio M\/F 0.8, 35% with neurofibromatosis type 1 [NF1]). With a median follow-up of 17.2 years (range\u2005=\u20055\u201341), we registered 82 relapses, 9 second malignancies, and 15 deaths as first events after 5 years, resulting in 20-year conditional overall survival (C-OS) and late events-free survival of 79.9% (95% confidence interval [CI]\u2005=\u200571\u201386) and 43.5% (95% CI\u2005=\u200536\u201351), respectively. Radiotherapy exposure in NF1 patients (hazard ratio [HR] = 6, 95% CI = 1.7\u201321.2) and hypothalamic involvement (HR = 3.2, 95% CI = 1.4\u20137.3) were significantly associated with C-OS in multivariable analyses. Ninety-five percent of 5-year OPG survivors suffered from any health condition, especially visual acuity \u201c&amp;lt;1\/10\u201d (n\u2005=\u2005109), pituitary deficiency (n\u2005=\u2005106), and neurocognitive impairment (n\u2005=\u200589). NF1 (HR 2.1) was associated with precocious puberty. With a median time post-diagnosis of 4.2 years, 33 cerebrovascular events were observed in 21 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Late relapses, second malignancies, and cerebrovascular diseases are severe late events resulting in premature mortality. Morbidity is high and needs after-cancer care to improve quality of life. Risk factors could be considered to better stratify long-term follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noae045","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T18:37:31Z","timestamp":1709836651000},"page":"1310-1324","source":"Crossref","is-referenced-by-count":18,"title":["Very long-term outcomes of pediatric patients treated for optic pathway gliomas: A longitudinal cohort study"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5259-0181","authenticated-orcid":false,"given":"Alice","family":"Morin","sequence":"first","affiliation":[{"name":"Department of Children and Adolescents Oncology, Gustave Roussy, Paris-Saclay University , Villejuif , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigue","family":"Allodji","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Group, INSERM Unit 1018 , Villejuif , 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