{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:15:24Z","timestamp":1791641724544,"version":"4.3.4"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Giorgio Foundation"},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1R01CA258384"],"award-info":[{"award-number":["1R01CA258384"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35NS097211"],"award-info":[{"award-number":["R35NS097211"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R50CA233164"],"award-info":[{"award-number":["R50CA233164"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016618","name":"Gilbert Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY002687"],"award-info":[{"award-number":["P30EY002687"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Washington University Genome Engineering"},{"name":"Cancer Center Support","award":["P30-CA091842"],"award-info":[{"award-number":["P30-CA091842"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>With the recognition that noncancerous cells function as critical regulators of brain tumor growth, we recently demonstrated that neurons drive low-grade glioma initiation and progression. Using mouse models of neurofibromatosis type 1 (NF1)-associated optic pathway glioma (OPG), we showed that Nf1 mutation induces neuronal hyperexcitability and midkine expression, which activates an immune axis to support tumor growth, such that high-dose lamotrigine treatment reduces Nf1-OPG proliferation. Herein, we execute a series of complementary experiments to address several key knowledge gaps relevant to future clinical translation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We leverage a collection of Nf1-mutant mice that spontaneously develop OPGs to alter both germline and retinal neuron-specific midkine expression. Nf1-mutant mice harboring several different NF1 patient-derived germline mutations were employed to evaluate neuronal excitability and midkine expression. Two distinct Nf1-OPG preclinical mouse models were used to assess lamotrigine effects on tumor progression and growth in vivo.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We establish that neuronal midkine is both necessary and sufficient for Nf1-OPG growth, demonstrating an obligate relationship between germline Nf1 mutation, neuronal excitability, midkine production, and Nf1-OPG proliferation. We show anti-epileptic drug (lamotrigine) specificity in suppressing neuronal midkine production. Relevant to clinical translation, lamotrigine prevents Nf1-OPG progression and suppresses the growth of existing tumors for months following drug cessation. Importantly, lamotrigine abrogates tumor growth in two Nf1-OPG strains using pediatric epilepsy clinical dosing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Together, these findings establish midkine and neuronal hyperexcitability as targetable drivers of Nf1-OPG growth and support the use of lamotrigine as a potential chemoprevention or chemotherapy agent for children with NF1-OPG.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/neuonc\/noae054","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T17:11:27Z","timestamp":1712941887000},"page":"1496-1508","source":"Crossref","is-referenced-by-count":20,"title":["<i>NF1<\/i> mutation-driven neuronal hyperexcitability sets a threshold for tumorigenesis and therapeutic targeting of murine optic glioma"],"prefix":"10.1093","volume":"26","author":[{"given":"Corina","family":"Anastasaki","sequence":"first","affiliation":[{"name":"Departments of Neurology, Washington University School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jit","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Washington University School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua P","family":"Koleske","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Washington University School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqing","family":"Gao","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Washington University School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L","family":"Bozeman","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Washington University School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe M","family":"Kernan","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Washington University School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara I","family":"Marco Y Marquez","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Washington University School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Kang","family":"Chen","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Washington University School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin E","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Washington University School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor J","family":"Blair","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Washington University School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis J","family":"Dietzen","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Washington University School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Kesterson","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center, Louisiana State University , Baton Rouge, Louisiana , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3127-5045","authenticated-orcid":false,"given":"David H","family":"Gutmann","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Washington University School of Medicine , St. Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"issue":"Suppl 10","key":"2024080523472385100_CIT0001","doi-asserted-by":"crossref","first-page":"x1","DOI":"10.1093\/neuonc\/nou327","article-title":"Alex\u2019s lemonade stand foundation infant and childhood primary brain and central nervous system tumors diagnosed in the United States in 2007-2011","volume":"16","author":"Ostrom","year":"2015","journal-title":"Neuro Oncol"},{"issue":"8","key":"2024080523472385100_CIT0002","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.braindev.2019.04.003","article-title":"Brain gliomas, hydrocephalus and idiopathic aqueduct stenosis in children with neurofibromatosis type 1","volume":"41","author":"Glombova","year":"2019","journal-title":"Brain Dev."},{"issue":"Pt 1","key":"2024080523472385100_CIT0003","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/brain\/awg016","article-title":"Prognostic factors of CNS tumours in neurofibromatosis 1 (NF1): a retrospective study of 104 patients","volume":"126","author":"Guillamo","year":"2003","journal-title":"Brain."},{"issue":"6","key":"2024080523472385100_CIT0004","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/neuonc\/nos076","article-title":"Visual outcomes in children with neurofibromatosis type 1-associated optic pathway glioma following chemotherapy: a multicenter retrospective analysis","volume":"14","author":"Fisher","year":"2012","journal-title":"Neuro Oncol"},{"issue":"2","key":"2024080523472385100_CIT0005","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jaapos.2009.11.020","article-title":"Optic pathway gliomas in patients with neurofibromatosis type 1: follow-up of 44 patients","volume":"14","author":"Segal","year":"2010","journal-title":"J AAPOS."},{"issue":"3","key":"2024080523472385100_CIT0006","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000458525","article-title":"Endocrine long-term follow-up of children with neurofibromatosis type 1 and optic pathway glioma","volume":"87","author":"Sani","year":"2017","journal-title":"Horm Res Paediatr"},{"issue":"3","key":"2024080523472385100_CIT0007","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/ana.21107","article-title":"Optic pathway gliomas in neurofibromatosis-1: controversies and recommendations","volume":"61","author":"Listernick","year":"2007","journal-title":"Ann Neurol."},{"key":"2024080523472385100_CIT0008","doi-asserted-by":"crossref","first-page":"766","DOI":"10.3389\/fneur.2020.00766","article-title":"The visual acuity outcome and relevant factors affecting visual improvement in pediatric sporadic chiasmatic-hypothalamic glioma patients who received surgery","volume":"11","author":"Liao","year":"2020","journal-title":"Front Neurol."},{"issue":"1","key":"2024080523472385100_CIT0009","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1038\/s41467-022-30466-6","article-title":"Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1","volume":"13","author":"Anastasaki","year":"2022","journal-title":"Nat Commun."},{"issue":"7862","key":"2024080523472385100_CIT0010","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41586-021-03580-6","article-title":"NF1 mutation drives neuronal activity-dependent initiation of optic glioma","volume":"594","author":"Pan","year":"2021","journal-title":"Nature."},{"issue":"4","key":"2024080523472385100_CIT0011","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.stemcr.2020.03.007","article-title":"Human iPSC-derived neurons and cerebral organoids establish differential effects of germline NF1 gene mutations","volume":"14","author":"Anastasaki","year":"2020","journal-title":"Stem Cell Rep."},{"issue":"9","key":"2024080523472385100_CIT0012","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1093\/hmg\/ddw039","article-title":"NF1 germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1","volume":"25","author":"Toonen","year":"2016","journal-title":"Hum Mol Genet."},{"issue":"3","key":"2024080523472385100_CIT0013","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ng0794-353","article-title":"Tumour predisposition in mice heterozygous for a targeted mutation in Nf1","volume":"7","author":"Jacks","year":"1994","journal-title":"Nat Genet."},{"issue":"24","key":"2024080523472385100_CIT0014","first-page":"8573","article-title":"Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity","volume":"63","author":"Bajenaru","year":"2003","journal-title":"Cancer Res."},{"issue":"14","key":"2024080523472385100_CIT0015","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1128\/MCB.22.14.5100-5113.2002","article-title":"Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation","volume":"22","author":"Bajenaru","year":"2002","journal-title":"Mol Cell Biol."},{"issue":"6","key":"2024080523472385100_CIT0016","doi-asserted-by":"crossref","first-page":"e3559","DOI":"10.21769\/BioProtoc.3559","article-title":"Optic nerve crush in mice to study retinal ganglion cell survival and regeneration","volume":"10","author":"Cameron","year":"2020","journal-title":"Bio Protoc"},{"issue":"5","key":"2024080523472385100_CIT0017","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1158\/0008-5472.CAN-07-5916","article-title":"Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma","volume":"68","author":"Hegedus","year":"2008","journal-title":"Cancer Res."},{"issue":"1","key":"2024080523472385100_CIT0018","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1038\/s41467-020-15770-3","article-title":"Midkine activation of CD8(+) T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth","volume":"11","author":"Guo","year":"2020","journal-title":"Nat Commun."},{"issue":"9","key":"2024080523472385100_CIT0019","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.0013-9580.2004.40903.x","article-title":"Lamotrigine versus valproic acid as first-line monotherapy in newly diagnosed typical absence seizures: an open-label, randomized, parallel-group study","volume":"45","author":"Coppola","year":"2004","journal-title":"Epilepsia."},{"issue":"6","key":"2024080523472385100_CIT0020","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0022-3476(95)70047-1","article-title":"Lamotrigine for the treatment of epilepsy in childhood","volume":"127","author":"Besag","year":"1995","journal-title":"J Pediatr."},{"issue":"3","key":"2024080523472385100_CIT0021","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1535-7511.2005.05303.x","article-title":"Making sense of lamotrigine serum levels","volume":"5","author":"Abou-Khalil","year":"2005","journal-title":"Epilepsy Curr"},{"issue":"Suppl 1","key":"2024080523472385100_CIT0022","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1097\/WNO.0000000000000550","article-title":"Optic pathway gliomas in neurofibromatosis type 1: An update: surveillance, treatment indications, and biomarkers of vision","volume":"37","author":"de Blank","year":"2017","journal-title":"J Neuroophthalmol."},{"issue":"21 Suppl 1","key":"2024080523472385100_CIT0023","first-page":"S15","article-title":"Functional outcome measures for NF1-associated optic pathway glioma clinical trials","volume":"81","author":"Fisher","year":"2013","journal-title":"Neurology."},{"issue":"2","key":"2024080523472385100_CIT0024","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/ana.24093","article-title":"Sex is a major determinant of neuronal dysfunction in neurofibromatosis type 1","volume":"75","author":"Diggs-Andrews","year":"2014","journal-title":"Ann Neurol."},{"issue":"1","key":"2024080523472385100_CIT0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1084\/jem.20160447","article-title":"Estrogen activation of microglia underlies the sexually dimorphic differences in Nf1 optic glioma-induced retinal pathology","volume":"214","author":"Toonen","year":"2017","journal-title":"J Exp Med."},{"issue":"6","key":"2024080523472385100_CIT0026","first-page":"808","article-title":"Defining the temporal course of murine neurofibromatosis-1 optic gliomagenesis reveals a therapeutic window to attenuate retinal dysfunction","volume":"19","author":"Toonen","year":"2017","journal-title":"Neuro Oncol"},{"issue":"4","key":"2024080523472385100_CIT0027","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.ajo.2014.06.017","article-title":"Reproducibility of circumpapillary retinal nerve fiber layer measurements using handheld optical coherence tomography in sedated children","volume":"158","author":"Avery","year":"2014","journal-title":"Am J Ophthalmol."},{"issue":"1","key":"2024080523472385100_CIT0028","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40478-020-00902-z","article-title":"Pediatric low-grade glioma in the era of molecular diagnostics","volume":"8","author":"Ryall","year":"2020","journal-title":"Acta Neuropathol Commun"},{"issue":"21","key":"2024080523472385100_CIT0029","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1200\/JCO.2011.36.6054","article-title":"Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children\u2019s Oncology Group","volume":"30","author":"Ater","year":"2012","journal-title":"J Clin Oncol."},{"issue":"10","key":"2024080523472385100_CIT0030","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1093\/neuonc\/noab047","article-title":"A phase II trial of selumetinib in children with recurrent optic pathway and hypothalamic low-grade glioma without NF1: a Pediatric Brain Tumor Consortium study","volume":"23","author":"Fangusaro","year":"2021","journal-title":"Neuro Oncol"},{"key":"2024080523472385100_CIT0031","first-page":"PO.19.00298","article-title":"Outcomes of BRAF V600E pediatric gliomas treated with targeted BRAF inhibition","volume":"4","author":"Nobre","year":"2020","journal-title":"JCO Precis Oncol"},{"issue":"25","key":"2024080523472385100_CIT0032","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1200\/JCO.2016.71.8726","article-title":"Therapeutic and prognostic implications of BRAF V600E in pediatric low-grade gliomas","volume":"35","author":"Lassaletta","year":"2017","journal-title":"J Clin Oncol."},{"issue":"1","key":"2024080523472385100_CIT0033","first-page":"vdac182","article-title":"Integrated response analysis of pediatric low-grade gliomas during and after targeted therapy treatment","volume":"5","author":"Tsai","year":"2023","journal-title":"Neurooncol Adv"},{"issue":"1","key":"2024080523472385100_CIT0034","doi-asserted-by":"crossref","first-page":"7122","DOI":"10.1038\/s41467-021-27455-6","article-title":"Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia","volume":"12","author":"Chatterjee","year":"2021","journal-title":"Nat Commun."},{"issue":"7-8","key":"2024080523472385100_CIT0035","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1101\/gad.310797.117","article-title":"Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth","volume":"32","author":"Pan","year":"2018","journal-title":"Genes Dev."},{"key":"2024080523472385100_CIT0036","doi-asserted-by":"crossref","first-page":"105230","DOI":"10.1016\/j.bioorg.2021.105230","article-title":"Voltage gated sodium channel inhibitors as anticonvulsant drugs: a systematic review on recent developments and structure activity relationship studies","volume":"115","author":"Pal","year":"2021","journal-title":"Bioorg Chem."},{"issue":"9","key":"2024080523472385100_CIT0037","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1097\/EJA.0000000000000449","article-title":"Propofol, but not ketamine or midazolam, exerts neuroprotection after ischaemic injury by inhibition of Toll-like receptor 4 and nuclear factor kappa-light-chain-enhancer of activated B-cell signalling: a combined in vitro and animal study","volume":"33","author":"Ulbrich","year":"2016","journal-title":"Eur J Anaesthesiol."},{"issue":"24","key":"2024080523472385100_CIT0038","doi-asserted-by":"crossref","first-page":"13604","DOI":"10.3390\/ijms222413604","article-title":"Lamotrigine attenuates neuronal excitability, depresses GABA synaptic inhibition, and modulates theta rhythms in rat hippocampus","volume":"22","author":"Kazmierska-Grebowska","year":"2021","journal-title":"Int J Mol Sci."},{"key":"2024080523472385100_CIT0039","doi-asserted-by":"crossref","first-page":"106106","DOI":"10.1016\/j.nbd.2023.106106","article-title":"Lamotrigine rescues neuronal alterations and prevents seizure-induced memory decline in an Alzheimer\u2019s disease mouse model","volume":"181","author":"Rizzello","year":"2023","journal-title":"Neurobiol Dis."},{"issue":"4","key":"2024080523472385100_CIT0040","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/IAE.0b013e31815ec2da","article-title":"Neuroprotective effects of oral lamotrigine administration on rabbit retinas after pars plana vitrectomy and silicone oil injection","volume":"28","author":"Guizzo","year":"2008","journal-title":"Retina."},{"issue":"8","key":"2024080523472385100_CIT0041","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.cell.2023.02.002","article-title":"Cancer neuroscience: state of the field, emerging directions","volume":"186","author":"Winkler","year":"2023","journal-title":"Cell."},{"issue":"1","key":"2024080523472385100_CIT0042","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2165\/00003495-200060010-00003","article-title":"Newer anticonvulsants: comparative review of drug interactions and adverse effects","volume":"60","author":"Sabers","year":"2000","journal-title":"Drugs."},{"issue":"19","key":"2024080523472385100_CIT0043","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.2165\/00003495-200363190-00009","article-title":"Lamotrigine: a review of its use in bipolar disorder","volume":"63","author":"Goldsmith","year":"2003","journal-title":"Drugs."},{"issue":"5","key":"2024080523472385100_CIT0044","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1592\/phco.26.5.699","article-title":"Lamotrigine-induced toxic epidermal necrolysis in three patients treated for bipolar disorder","volume":"26","author":"Varghese","year":"2006","journal-title":"Pharmacotherapy."},{"issue":"7986","key":"2024080523472385100_CIT0045","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41586-023-06678-1","article-title":"Glioma synapses recruit mechanisms of adaptive plasticity","volume":"623","author":"Taylor","year":"2023","journal-title":"Nature."},{"issue":"7775","key":"2024080523472385100_CIT0046","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/s41586-019-1564-x","article-title":"Glutamatergic synaptic input to glioma cells drives brain tumour progression","volume":"573","author":"Venkataramani","year":"2019","journal-title":"Nature."},{"issue":"7961","key":"2024080523472385100_CIT0047","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41586-023-06036-1","article-title":"Glioblastoma remodelling of human neural circuits decreases survival","volume":"617","author":"Krishna","year":"2023","journal-title":"Nature."},{"issue":"2","key":"2024080523472385100_CIT0048","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1158\/1535-7163.MCT-10-0654","article-title":"Interpreting mammalian target of rapamycin and cell growth inhibition in a genetically engineered mouse model of Nf1-deficient astrocytes","volume":"10","author":"Banerjee","year":"2011","journal-title":"Mol Cancer Ther."},{"key":"2024080523472385100_CIT0049","doi-asserted-by":"crossref","first-page":"1074726","DOI":"10.3389\/fonc.2022.1074726","article-title":"Response and resistance to BRAF(V600E) inhibition in gliomas: Roadblocks ahead","volume":"12","author":"Capogiri","year":"2022","journal-title":"Front Oncol."},{"issue":"7793","key":"2024080523472385100_CIT0050","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41586-020-1952-2","article-title":"PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis","volume":"578","author":"Yu","year":"2020","journal-title":"Nature."},{"issue":"1","key":"2024080523472385100_CIT0051","doi-asserted-by":"crossref","first-page":"14616","DOI":"10.1038\/s41598-021-94272-8","article-title":"Serum midkine as non-invasive biomarker for detection and prognosis of non-small cell lung cancer","volume":"11","author":"Stern","year":"2021","journal-title":"Sci Rep."},{"issue":"5","key":"2024080523472385100_CIT0052","doi-asserted-by":"crossref","first-page":"368","DOI":"10.5455\/medarh.2022.76.368-372","article-title":"Association between serum midkine level and gastric precancerous lesion in patients with gastritis","volume":"76","author":"Siregar","year":"2022","journal-title":"Med Arch"},{"issue":"1","key":"2024080523472385100_CIT0053","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13000-021-01150-y","article-title":"Diagnostic performance of midkine ratios in fine-needle aspirates for evaluation of cytologically indeterminate thyroid nodules","volume":"16","author":"Zhou","year":"2021","journal-title":"Diagn Pathol."},{"issue":"8","key":"2024080523472385100_CIT0054","first-page":"1792","article-title":"Differential expression of pleiotrophin and midkine in advanced neuroblastomas","volume":"55","author":"Nakagawara","year":"1995","journal-title":"Cancer Res."},{"issue":"1","key":"2024080523472385100_CIT0055","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0304-3940(97)00619-8","article-title":"Increased expression of midkine during the progression of human astrocytomas","volume":"233","author":"Mishima","year":"1997","journal-title":"Neurosci Lett."},{"issue":"10","key":"2024080523472385100_CIT0056","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1038\/sj.bjc.6600938","article-title":"Correlation of elevated level of blood midkine with poor prognostic factors of human neuroblastomas","volume":"88","author":"Ikematsu","year":"2003","journal-title":"Br J Cancer."},{"issue":"12","key":"2024080523472385100_CIT0057","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1212\/WNL.0b013e31826aac73","article-title":"Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore","volume":"79","author":"Dong","year":"2012","journal-title":"Neurology."},{"issue":"10","key":"2024080523472385100_CIT0058","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1111\/epi.13087","article-title":"The HLA-A*2402\/Cw*0102 haplotype is associated with lamotrigine-induced maculopapular eruption in the Korean population","volume":"56","author":"Moon","year":"2015","journal-title":"Epilepsia."}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/advance-article-pdf\/doi\/10.1093\/neuonc\/noae054\/57116378\/noae054.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/26\/8\/1496\/58739955\/noae054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/26\/8\/1496\/58739955\/noae054.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T23:49:38Z","timestamp":1722901778000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article\/26\/8\/1496\/7637150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,12]]},"references-count":58,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,4,12]]},"published-print":{"date-parts":[[2024,8,5]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/noae054","relation":{},"ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,8]]},"published":{"date-parts":[[2024,4,12]]}}}