{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:55:52Z","timestamp":1789181752588,"version":"build-2803163510"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neurocognition can be severely affected in pediatric brain tumor survivors. We analyzed the association of cognitive functioning with radiotherapy dose, postoperative cerebellar mutism syndrome (pCMS), hydrocephalus, intraventricular methotrexate (MTX) application, tumor localization, and biology in pediatric survivors of a posterior fossa tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Subdomain-specific neurocognitive outcome data from 279 relapse-free survivors of the HIT-2000 trial (241 medulloblastoma and 38 infratentorial ependymoma) using the Neuropsychological Basic Diagnostic tool based on Cattell\u2013Horn\u2013Carroll\u2019s model for intelligence were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cognitive performance 5.14 years (mean; range\u2005=\u20051.52\u201313.02) after diagnosis was significantly below normal for all subtests. Processing speed and psychomotor abilities were most affected. Influencing factors were domain-specific: CSI-dose had a strong impact on most subtests. pCMS was associated with psychomotor abilities (\u03b2 = \u20130.25 to \u20130.16) and processing speed (\u03b2 = \u20130.32). Postoperative hydrocephalus correlated with crystallized intelligence (\u03b2 = \u20130.20) and short-term memory (\u03b2 = \u20130.15), age with crystallized intelligence (\u03b2 = 0.15) and psychomotor abilities (\u03b2 = \u20130.16 and \u03b2 = \u20130.17). Scores for fluid intelligence (\u03b2 = \u20130.23), short-term memory (\u03b2 = \u20130.17) and visual processing (\u03b2 = \u20130.25) declined, and scores for selective attention improved (\u03b2 = 0.29) with time after diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The dose of CSI was strongly associated with neurocognitive outcomes. Low psychomotor abilities and processing speed both in patients treated with and without CSI suggest a strong contribution of the tumor and its surgery on these functions. Future research therefore should analyze strategies to both reduce CSI dose and toxicity caused by other treatment modalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noae092","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T10:14:28Z","timestamp":1716891268000},"page":"2113-2124","source":"Crossref","is-referenced-by-count":14,"title":["Risk factors for domain-specific neurocognitive outcome in pediatric survivors of a brain tumor in the posterior fossa\u2014Results of the HIT 2000 trial"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3302-2719","authenticated-orcid":false,"given":"Martin","family":"Mynarek","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf , Hamburg ,","place":["Germany"]},{"name":"Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Rossius","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Guiard","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital Rostock , Rostock ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Ottensmeier","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, University Children\u2019s Hospital Wuerzburg , Wuerzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"von Hoff","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf , Hamburg ,","place":["Germany"]},{"name":"Department of Pediatric Hematology and Oncology, Charit\u00e9\u2014University Medicine , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Obrecht-Sturm","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3888-1360","authenticated-orcid":false,"given":"Lisa","family":"Bu\u00dfenius","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Department for General Pediatrics and Pediatric Hematology and Oncology, University Children\u2019s Hospital Oldenburg , Oldenburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4197-6264","authenticated-orcid":false,"given":"Andre O","family":"von Bueren","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology and Obstetrics, University Hospital of Geneva , Geneva ,","place":["Switzerland"]},{"name":"Department of Pediatrics, Gynecology and Obstetrics, University of Geneva , Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas U","family":"Gerber","sequence":"additional","affiliation":[{"name":"Department of Oncology, University Children\u2019s Hospital , Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Traunwieser","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf , Hamburg ,","place":["Germany"]},{"name":"Paediatrics and Adolescent Medicine, University of Augsburg , Augsburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8952-1819","authenticated-orcid":false,"given":"Rolf-Dieter","family":"Kortmann","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Leipzig , Leipzig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3544-319X","authenticated-orcid":false,"given":"Monika","family":"Warmuth-Metz","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Neuroradiology, University Hospital Wuerzburg , Wuerzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Bison","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital Augsburg , Augsburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich-W","family":"Thomale","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Charit\u00e9-Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Krauss","sequence":"additional","affiliation":[{"name":"Department for Neurosurgery, University Hospital Wuerzburg , Wuerzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0763-6506","authenticated-orcid":false,"given":"Torsten","family":"Pietsch","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, Brain Tumor Reference Center of the German Society for Neuropathology and Neuroanatomy (DGNN), University of Bonn, DZNE German Center for Neurodegenerative Diseases , Bonn ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C","family":"Clifford","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle University , Newcastle Upon Tyne ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan M","family":"Pfister","sequence":"additional","affiliation":[{"name":"Hopp Children\u2019s Cancer Center Heidelberg (KiTZ) , Heidelberg ,","place":["Germany"]},{"name":"Division of Pediatric Neurooncology (B062), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg ,","place":["Germany"]},{"name":"Department of Pediatric Hematology and Oncology, Heidelberg University Hospital , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Sturm","sequence":"additional","affiliation":[{"name":"Hopp Children\u2019s Cancer Center Heidelberg (KiTZ) , Heidelberg ,","place":["Germany"]},{"name":"Division of Pediatric Neurooncology (B062), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) , Heidelberg ,","place":["Germany"]},{"name":"Department of Pediatric Hematology and Oncology, Heidelberg University Hospital , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5441-1962","authenticated-orcid":false,"given":"Felix","family":"Sahm","sequence":"additional","affiliation":[{"name":"Hopp Children\u2019s Cancer Center Heidelberg (KiTZ) , Heidelberg ,","place":["Germany"]},{"name":"Clinical Cooperation Unit Neuropathology (B300), German Cancer Research Center (DKFZ) , Heidelberg ,","place":["Germany"]},{"name":"Department of Neuropathology, Heidelberg University Hospital , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Tischler","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf , Hamburg ,","place":["Germany"]},{"name":"Paediatrics and Adolescent Medicine, University of Augsburg , Augsburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5446-9571","authenticated-orcid":false,"given":"Stefan","family":"Rutkowski","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"2024110422225101600_CIT0001","volume-title":"Lehrbuch der Klinischen Kinderneuropsychologie - Grundlagen, Syndrome, Diagnostik und Intervention","author":"Heubrock","year":"2000"},{"issue":"2","key":"2024110422225101600_CIT0002","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO classification of tumours of the central nervous system","volume":"114","author":"Louis","year":"2007","journal-title":"Acta Neuropathol."},{"issue":"2","key":"2024110422225101600_CIT0003","first-page":"82","article-title":"Core deficits and quality of survival after childhood medulloblastoma: a review","volume":"4","author":"Chevignard","year":"2017","journal-title":"Neurooncol Pract.."},{"issue":"8","key":"2024110422225101600_CIT0004","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1200\/JCO.2001.19.8.2302","article-title":"Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis","volume":"19","author":"Palmer","year":"2001","journal-title":"J Clin Oncol."},{"issue":"24","key":"2024110422225101600_CIT0005","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1200\/JCO.20.02730","article-title":"Children\u2019s oncology group phase III trial of reduced-dose and reduced-volume radiotherapy with chemotherapy for newly diagnosed average-risk medulloblastoma","volume":"39","author":"Michalski","year":"2021","journal-title":"J Clin Oncol."},{"issue":"4","key":"2024110422225101600_CIT0006","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.ejpn.2019.05.009","article-title":"The European society of paediatric oncology Ependymoma-II program Core-Plus model: development and initial implementation of a cognitive test protocol for an international brain tumour trial","volume":"23","author":"Thomas","year":"2019","journal-title":"Eur J Paediatr Neurol."},{"issue":"6","key":"2024110422225101600_CIT0007","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ejpn.2015.07.011","article-title":"Strategies to improve the quality of survival for childhood brain tumour survivors","volume":"19","author":"Tallen","year":"2015","journal-title":"Eur J Paediatr Neurol."},{"issue":"2","key":"2024110422225101600_CIT0008","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ejpn.2014.12.003","article-title":"Quality of survival assessment in European childhood brain tumour trials, for children aged 5 years and over","volume":"19","author":"Limond","year":"2015","journal-title":"Eur J Paediatr Neurol."},{"issue":"16","key":"2024110422225101600_CIT0009","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1200\/JCO.20.02327","article-title":"Addressing neurocognitive late effects in pediatric cancer survivors: current approaches and future opportunities","volume":"39","author":"Hocking","year":"2021","journal-title":"J Clin Oncol."},{"key":"2024110422225101600_CIT0010","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejpn.2019.10.002","article-title":"Quality of survival assessment in European childhood brain tumour trials, for children below the age of 5 years","volume":"25","author":"Limond","year":"2020","journal-title":"Eur J Paediatr Neurol."},{"issue":"3","key":"2024110422225101600_CIT0011","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/pbc.22568","article-title":"A quantitative meta-analysis of neurocognitive sequelae in survivors of pediatric brain tumors","volume":"55","author":"Robinson","year":"2010","journal-title":"Pediatr Blood Cancer."},{"issue":"5","key":"2024110422225101600_CIT0012","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/dmcn.12020","article-title":"Neurocognitive consequences of a paediatric brain tumour and its treatment: a meta-analysis","volume":"55","author":"De Ruiter","year":"2013","journal-title":"Dev Med Child Neurol."},{"issue":"1","key":"2024110422225101600_CIT0013","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1017\/S1355617712000987","article-title":"Neurocognitive late effects of pediatric brain tumors of the posterior fossa: a quantitative review","volume":"19","author":"Robinson","year":"2013","journal-title":"J Int Neuropsychol Soc"},{"issue":"4","key":"2024110422225101600_CIT0014","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.pediatrneurol.2014.06.011","article-title":"Long-term cognitive sequelae after pediatric brain tumor related to medical risk factors, age, and sex","volume":"51","author":"Olsson","year":"2014","journal-title":"Pediatr Neurol."},{"issue":"6","key":"2024110422225101600_CIT0015","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/pbc.24947","article-title":"Prognostic factors that increase the risk for reduced white matter volumes and deficits in attention and learning for survivors of childhood cancers","volume":"61","author":"Reddick","year":"2014","journal-title":"Pediatr Blood Cancer."},{"issue":"6","key":"2024110422225101600_CIT0016","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1017\/S1355617712000793","article-title":"Working memory performance among childhood brain tumor survivors","volume":"18","author":"Conklin","year":"2012","journal-title":"J Int Neuropsychol Soc."},{"issue":"1","key":"2024110422225101600_CIT0017","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ejpn.2015.11.001","article-title":"Executive function deficits in pediatric cerebellar tumor survivors","volume":"20","author":"Koustenis","year":"2016","journal-title":"Eur J Paediatr Neurol."},{"issue":"0","key":"2024110422225101600_CIT0018","first-page":"JCO.19.03057","article-title":"Nonmetastatic medulloblastoma of early childhood: results from the prospective clinical trial HIT-2000 and an extended validation cohort","volume":"0","author":"Mynarek","year":"2020","journal-title":"J Clin Oncol."},{"issue":"6","key":"2024110422225101600_CIT0019","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S1470-2045(18)30204-3","article-title":"Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial","volume":"19","author":"Robinson","year":"2018","journal-title":"Lancet Oncol."},{"issue":"9","key":"2024110422225101600_CIT0020","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1002\/pbc.26042","article-title":"Clinical, pathological, and molecular characterization of infant medulloblastomas treated with sequential high-dose chemotherapy","volume":"63","author":"Lafay-Cousin","year":"2016","journal-title":"Pediatr Blood Cancer"},{"issue":"24","key":"2024110422225101600_CIT0021","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.1158\/1078-0432.CCR-23-0348","article-title":"A Pilot Study omitting radiation in the treatment of children with newly diagnosed wnt-activated medulloblastoma","volume":"29","author":"Cohen","year":"2023","journal-title":"Clin Cancer Res."},{"issue":"19","key":"2024110422225101600_CIT0022","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.1158\/1078-0432.CCR-22-0758","article-title":"Omission of upfront craniospinal irradiation in patients with low-risk WNT-pathway medulloblastoma is associated with unacceptably high risk of neuraxial failure","volume":"28","author":"Gupta","year":"2022","journal-title":"Clin Cancer Res."},{"issue":"23","key":"2024110422225101600_CIT0023","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.3390\/cancers13236077","article-title":"SIOP PNET5 MB Trial: history and concept of a molecularly stratified clinical trial of risk-adapted therapies for standard-risk medulloblastoma","volume":"13","author":"Mynarek","year":"2021","journal-title":"Cancers"},{"issue":"1","key":"2024110422225101600_CIT0024","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00401-014-1300-4","article-title":"Improved health-related quality of life outcomes associated with SHH subgroup medulloblastoma in SIOP-UKCCSG PNET3 trial survivors","volume":"128","author":"Bull","year":"2014","journal-title":"Acta Neuropathol."},{"issue":"34","key":"2024110422225101600_CIT0025","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1200\/JCO.2016.66.9077","article-title":"Intellectual outcome in molecular subgroups of medulloblastoma","volume":"34","author":"Moxon-Emre","year":"2016","journal-title":"J Clin Oncol."},{"issue":"22","key":"2024110422225101600_CIT0026","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1200\/JCO.2005.06.117","article-title":"Cognitive and adaptive outcome in low-grade pediatric cerebellar astrocytomas: evidence of diminished cognitive and adaptive functioning in National Collaborative Research Studies (CCG 9891\/POG 9130)","volume":"23","author":"Beebe","year":"2005","journal-title":"J Clin Oncol."},{"issue":"26","key":"2024110422225101600_CIT0027","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1200\/JCO.2011.39.8719","article-title":"Hyperfractionated versus conventional radiotherapy followed by chemotherapy in standard-risk medulloblastoma: results from the randomized multicenter HIT-SIOP PNET 4 trial","volume":"30","author":"Lannering","year":"2012","journal-title":"J Clin Oncol."},{"issue":"34","key":"2024110422225101600_CIT0028","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1200\/JCO.2016.67.2428","article-title":"Treatment of children and adolescents with metastatic medulloblastoma and prognostic relevance of clinical and biologic parameters","volume":"34","author":"von Bueren","year":"2016","journal-title":"J Clin Oncol."},{"key":"2024110422225101600_CIT0029","first-page":"i24","article-title":"Risk-adapted treatment for non-metastatic ependymoma: preliminary results of the non-randomized prospective phase II clinical trial HIT2000 [abstract]","volume":"16","author":"von Hoff","year":"2014","journal-title":"Neuro-Oncology."},{"issue":"5","key":"2024110422225101600_CIT0030","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.ijrobp.2015.04.023","article-title":"Neuropsychological outcome of children treated for standard risk medulloblastoma in the PNET4 European randomized controlled trial of hyperfractionated versus standard radiation therapy and maintenance chemotherapy","volume":"92","author":"Camara-Costa","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"6","key":"2024110422225101600_CIT0031","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.adro.2020.09.018","article-title":"Evaluation of prognostic factors and role of participation in a randomized trial or a prospective registry in pediatric and adolescent nonmetastatic medulloblastoma","volume":"5","author":"Dietzsch","year":"2020","journal-title":"Adv Radiat Oncol"},{"issue":"suppl 1","key":"2024110422225101600_CIT0032","first-page":"i24","article-title":"Risk-adapted treatment for non-metastatic ependymoma: preliminary results of the non-randomized prospective phase II clinical trial HIT2000 [abstract]","volume":"16","author":"von Hoff","year":"2014","journal-title":"Neuro-Oncology."},{"key":"2024110422225101600_CIT0033","volume-title":"Contemporary Intellectual Assessment, Third Edition: Theories, Tests, and Issues","author":"Flanagan","year":"2012","edition":"3"},{"key":"2024110422225101600_CIT0034","volume-title":"Essentials of Cross-Battery Assessment","author":"Flanagan","year":"2013"},{"issue":"3","key":"2024110422225101600_CIT0035","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ejpn.2014.12.019","article-title":"Neuropsychological short assessment of disease- and treatment-related intelligence deficits in children with brain tumours","volume":"19","author":"Ottensmeier","year":"2015","journal-title":"Eur J Paediatr Neurol."},{"issue":"1","key":"2024110422225101600_CIT0036","first-page":"vdaa094","article-title":"Long-term cognitive deficits in pediatric low-grade glioma (LGG) survivors reflect pretreatment conditions-report from the German LGG studies","volume":"2","author":"Traunwieser","year":"2020","journal-title":"Neurooncol Adv."},{"issue":"7697","key":"2024110422225101600_CIT0037","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature26000","article-title":"DNA methylation-based classification of central nervous system tumours","volume":"555","author":"Capper","year":"2018","journal-title":"Nature."},{"issue":"1","key":"2024110422225101600_CIT0038","doi-asserted-by":"crossref","first-page":"13421","DOI":"10.1038\/s41598-017-13644-1","article-title":"Minimal methylation classifier (MIMIC): a novel method for derivation and rapid diagnostic detection of disease-associated DNA methylation signatures","volume":"7","author":"Schwalbe","year":"2017","journal-title":"Sci Rep."},{"issue":"12","key":"2024110422225101600_CIT0039","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/S1470-2045(18)30532-1","article-title":"Prognostic effect of whole chromosomal aberration signatures in standard-risk, non-WNT\/non-SHH medulloblastoma: a retrospective, molecular analysis of the HIT-SIOP PNET 4 trial","volume":"19","author":"Goschzik","year":"2018","journal-title":"Lancet Oncol."},{"key":"2024110422225101600_CIT0040","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988"},{"issue":"1","key":"2024110422225101600_CIT0041","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"Power primer","volume":"112","author":"Cohen","year":"1992","journal-title":"Psychol Bull."},{"issue":"1","key":"2024110422225101600_CIT0042","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Ser B: Stat Methodol"},{"issue":"9","key":"2024110422225101600_CIT0043","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1093\/neuonc\/noab030","article-title":"Clinical features, neurologic recovery, and risk factors of postoperative posterior fossa syndrome and delayed recovery: a prospective study","volume":"23","author":"Khan","year":"2021","journal-title":"Neuro-Oncology."},{"issue":"1","key":"2024110422225101600_CIT0044","doi-asserted-by":"crossref","first-page":"e0227693","DOI":"10.1371\/journal.pone.0227693","article-title":"Treatment of children under 4 years of age with medulloblastoma and ependymoma in the HIT2000\/HIT-REZ 2005 trials: neuropsychological outcome 5 years after treatment","volume":"15","author":"Ottensmeier","year":"2020","journal-title":"PLoS One."},{"issue":"21","key":"2024110422225101600_CIT0045","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1200\/JCO.20.01687","article-title":"Predictors of cognitive performance among infants treated for brain tumors: findings from a multisite, prospective, longitudinal trial","volume":"39","author":"Ali","year":"2021","journal-title":"J Clin Oncol."},{"issue":"5","key":"2024110422225101600_CIT0046","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/neuonc\/noz010","article-title":"Trajectories of psychosocial and cognitive functioning in pediatric patients with brain tumors treated with radiation therapy","volume":"21","author":"Willard","year":"2019","journal-title":"Neuro-Oncology."},{"issue":"2","key":"2024110422225101600_CIT0047","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1017\/S1355617709090249","article-title":"The effects of treatment for posterior fossa brain tumors on selective attention","volume":"15","author":"Mabbott","year":"2009","journal-title":"J Int Neuropsychol Soc"},{"key":"2024110422225101600_CIT0048","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1007\/978-94-007-1333-8_75","article-title":"Cerebellum and cognition","volume-title":"Handbook of the Cerebellum and Cerebellar Disorders","author":"Steinlin","year":"2013"},{"key":"2024110422225101600_CIT0049","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-662-59288-5","volume-title":"Neuropsychologische Therapie mit Kindern und Jugendlichen","author":"Pletschko","year":"2020"},{"issue":"6","key":"2024110422225101600_CIT0050","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3171\/2014.10.PEDS14209","article-title":"The accuracy of linear indices of ventricular volume in pediatric hydrocephalus: technical note","volume":"15","author":"Ragan","year":"2015","journal-title":"J Neurosurg Pediatr"},{"issue":"3","key":"2024110422225101600_CIT0051","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/pbc.25804","article-title":"Effect of sensorineural hearing loss on neurocognitive functioning in pediatric brain tumor survivors","volume":"63","author":"Orgel","year":"2016","journal-title":"Pediatr Blood Cancer."},{"issue":"7","key":"2024110422225101600_CIT0052","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1093\/neuonc\/noab018","article-title":"The impact of socioeconomic status (SES) on cognitive outcomes following radiotherapy for pediatric brain tumors: a prospective, longitudinal trial","volume":"23","author":"Torres","year":"2021","journal-title":"Neuro-Oncology."},{"issue":"1","key":"2024110422225101600_CIT0053","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1200\/JCO.21.01480","article-title":"Association between brain substructure dose and cognitive outcomes in children with medulloblastoma treated on SJMB03: a step toward substructure-informed planning","volume":"40","author":"Acharya","year":"2021","journal-title":"J Clin Oncol."},{"issue":"3","key":"2024110422225101600_CIT0054","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/neuonc\/noaa217","article-title":"Intellectual changes after radiation for children with brain tumors: which brain structures are most important","volume":"23","author":"Tsang","year":"2021","journal-title":"Neuro-Oncology."},{"issue":"16","key":"2024110422225101600_CIT0055","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1200\/JCO.20.02338","article-title":"Cognitive risk in survivors of pediatric brain tumors","volume":"39","author":"Oyefiade","year":"2021","journal-title":"J Clin Oncol."},{"issue":"5","key":"2024110422225101600_CIT0056","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1200\/JCO.19.01706","article-title":"Superior intellectual outcomes after proton radiotherapy compared with photon radiotherapy for pediatric medulloblastoma","volume":"38","author":"Kahalley","year":"2020","journal-title":"J Clin Oncol."}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/advance-article-pdf\/doi\/10.1093\/neuonc\/noae092\/58689524\/noae092.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/26\/11\/2113\/60416301\/noae092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/26\/11\/2113\/60416301\/noae092.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T17:23:16Z","timestamp":1730740996000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article\/26\/11\/2113\/7687860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,5]]},"references-count":56,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,6,5]]},"published-print":{"date-parts":[[2024,11,4]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/noae092","relation":{},"ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,11]]},"published":{"date-parts":[[2024,6,5]]}}}