{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:45:50Z","timestamp":1770043550047,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000054","name":"the National Cancer Institute","doi-asserted-by":"crossref","award":["U10CA180868"],"award-info":[{"award-number":["U10CA180868"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000054","name":"the National Cancer Institute","doi-asserted-by":"crossref","award":["U10CA180822"],"award-info":[{"award-number":["U10CA180822"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000054","name":"the National Cancer Institute","doi-asserted-by":"crossref","award":["UG1CA189867"],"award-info":[{"award-number":["UG1CA189867"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000054","name":"the National Cancer Institute","doi-asserted-by":"crossref","award":["U24CA196067"],"award-info":[{"award-number":["U24CA196067"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01NR013707"],"award-info":[{"award-number":["1R01NR013707"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K07CA181480"],"award-info":[{"award-number":["K07CA181480"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Voices Against Brain Cancer Foundation and Genentech"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Glioblastoma (GBM) is an aggressive form of brain cancer in which treatment is associated with toxicities that can result in therapy discontinuation or death. This analysis investigated clinical and genetic markers of vascular toxicities in GBM patients during active treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In total, 591 non-Hispanic White GBM patients with clinical data were included in the analysis from NRG RTOG-0825. Genome-wide association studies (GWAS) were performed from genotyped blood samples (N\u2005=\u2005367) by occurrence of thrombosis or hypertension (grade\u2005\u2265\u20052). A clinical prediction model was produced for each vascular toxicity. Significant GWAS variants were then added to the clinical model as a single nucleotide polymorphism (SNP)-dose-effect variable to produce the final genetic models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Thrombosis and hypertension were experienced by 62 (11%) and 59 (10%) patients, respectively. Patients who experienced hypertension displayed improved survival over those without hypertension (median overall survival: 25.72 vs. 15.47 months, p\u2005=\u20050.002). The genetic model of thrombosis included corticosteroid use (odds ratio [OR]: 7.13, p\u2005=\u20050.02), absolute neutrophil count (OR: 1.008, p\u2005=\u20050.19), body surface area (OR: 18.87, p\u2005=\u20050.0008), and SNP-dose effect (3 variants; OR: 3.79, p\u2005&amp;lt;\u20050.0001). The genetic model of hypertension included bevacizumab use (OR: 0.97, p\u2005=\u20050.95) and the SNP-dose effect (6 variants; OR: 4.44, p\u2005&amp;lt;\u20050.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this study, germline variants were superior in predicting hypertension than clinical variables alone. Additionally, corticosteroid use was a considerable risk factor for thrombosis. Future investigations should confirm the hazard of corticosteroid use on thrombosis and the impact of bevacizumab in other malignancies after accounting for the genetic risk of hypertension.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/neuonc\/noae234","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T20:25:51Z","timestamp":1731615951000},"page":"767-778","source":"Crossref","is-referenced-by-count":4,"title":["Clinical and genetic markers of vascular toxicity in glioblastoma patients: Insights from NRG Oncology RTOG-0825"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2724-0851","authenticated-orcid":false,"given":"Joshua D","family":"Strauss","sequence":"first","affiliation":[{"name":"Texas Children\u2019s Cancer Center, Texas Children\u2019s Hospital , Houston, Texas ,","place":["USA"]},{"name":"Section of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine , Houston, Texas ,","place":["USA"]},{"name":"Department of Pediatrics, Center for Epidemiology and Population Health, Baylor College of Medicine , Houston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2556-9722","authenticated-orcid":false,"given":"Mark R","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Branch, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minesh","family":"Mehta","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Miami Cancer Institute , Miami, Florida ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine , Houston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renke","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zai Lab (US) LLC , Menlo Park, California ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa L","family":"Bondy","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health, Stanford University , Stanford, California ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik P","family":"Sulman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Laura and Isaac Perlmutter Cancer Center at NYU Langone , New York, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3163-480X","authenticated-orcid":false,"given":"Ying","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, M.D. Anderson Cancer Center , Houston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neuro-Oncology, M.D. Anderson Cancer Center , Houston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Vera","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Branch, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merideth M","family":"Wendland","sequence":"additional","affiliation":[{"name":"Willamette Valley Cancer Center , Eugene, Oregon ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker W","family":"Stieber","sequence":"additional","affiliation":[{"name":"Novant Health Forsyth Medical Center , Winston-Salem, North Carolina ,","place":["USA"]},{"name":"M.D. Anderson Cancer Center Department of Neuro-Oncology, , Houston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay K","family":"Puduvalli","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, M.D. Anderson Cancer Center , Houston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serah","family":"Choi","sequence":"additional","affiliation":[{"name":"Mary Hillman Jennings Radiation Oncology Center , Pittsburgh, Pennsylvania ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina L","family":"Martinez","sequence":"additional","affiliation":[{"name":"Neurology & Neurological Surgery, Thomas Jefferson University Hospital , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H Ian","family":"Robins","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Wisconsin Carbone Cancer Center , Madison, Wisconsin ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant K","family":"Hunter","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Intermountain Medical Center , Wilkes-Barre Township, Pennsylvania ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Fan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine , Houston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8478-2465","authenticated-orcid":false,"given":"Vivian A","family":"Guedes","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Branch, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-9860","authenticated-orcid":false,"given":"Melissa A","family":"Richard","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Cancer Center, Texas Children\u2019s Hospital , Houston, Texas ,","place":["USA"]},{"name":"Section of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine , Houston, Texas ,","place":["USA"]},{"name":"Department of Pediatrics, Center for Epidemiology and Population Health, Baylor College of Medicine , Houston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L","family":"Pugh","sequence":"additional","affiliation":[{"name":"American College of Radiology , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"NRG Oncology Statistics and Data Management Center , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2414-0492","authenticated-orcid":false,"given":"Terri S","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Branch, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8379-6088","authenticated-orcid":false,"given":"Michael E","family":"Scheurer","sequence":"additional","affiliation":[{"name":"Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine , Houston, Texas ,","place":["USA"]},{"name":"Department of Neuro-Oncology, M.D. Anderson Cancer Center , Houston, Texas ,","place":["USA"]},{"name":"Texas Children\u2019s Cancer Center, Texas Children\u2019s Hospital , Houston, Texas ,","place":["USA"]},{"name":"Section of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine , Houston, Texas ,","place":["USA"]},{"name":"Department of Pediatrics, Center for Epidemiology and Population Health, Baylor College of Medicine , Houston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"issue":"9","key":"2025030813452268100_CIT0001","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/ncpneuro0289","article-title":"Epidemiology and molecular pathology of glioma","volume":"2","author":"Schwartzbaum","year":"2006","journal-title":"Nat Clin Pract Neurol."},{"key":"2025030813452268100_CIT0002","first-page":"143","volume-title":"Epidemiology and Outcome of Glioblastoma","author":"Tamimi","year":"2017"},{"issue":"10","key":"2025030813452268100_CIT0003","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N Engl J Med."},{"issue":"5","key":"2025030813452268100_CIT0004","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1056\/NEJMra0708126","article-title":"Malignant gliomas in adults","volume":"359","author":"Wen","year":"2008","journal-title":"N Engl J Med."},{"key":"2025030813452268100_CIT0005","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.thromres.2015.11.027","article-title":"Recurrent venous thromboembolism in glioblastoma","volume":"137","author":"Edwin","year":"2016","journal-title":"Thromb Res."},{"issue":"7","key":"2025030813452268100_CIT0006","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1111\/jth.15739","article-title":"Incidence and determinants of thrombotic and bleeding complications in patients with glioblastoma","volume":"20","author":"Kaptein","year":"2022","journal-title":"J Thromb Haemost."},{"issue":"1","key":"2025030813452268100_CIT0007","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11060-020-03404-z","article-title":"Hypertension and proteinuria as clinical biomarkers of response to bevacizumab in glioblastoma patients","volume":"147","author":"Carvalho","year":"2020","journal-title":"J Neurooncol."},{"issue":"9","key":"2025030813452268100_CIT0008","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1002\/cncr.29234","article-title":"Bevacizumab-induced hypertension is a predictive marker for improved outcomes in patients with recurrent glioblastoma treated with bevacizumab","volume":"121","author":"Zhong","year":"2015","journal-title":"Cancer."},{"issue":"8","key":"2025030813452268100_CIT0009","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJMoa1308573","article-title":"A randomized trial of bevacizumab for newly diagnosed glioblastoma","volume":"370","author":"Gilbert","year":"2014","journal-title":"N Engl J Med."},{"issue":"15","key":"2025030813452268100_CIT0010","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1093\/bioinformatics\/bti499","article-title":"Prediction error estimation: a comparison of resampling methods","volume":"21","author":"Molinaro","year":"2005","journal-title":"Bioinformatics."},{"issue":"10","key":"2025030813452268100_CIT0011","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1182\/blood-2007-10-116327","article-title":"Development and validation of a predictive model for chemotherapy-associated thrombosis","volume":"111","author":"Khorana","year":"2008","journal-title":"Blood."},{"issue":"10","key":"2025030813452268100_CIT0012","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1182\/bloodadvances.2021006484","article-title":"Validation of the Khorana score for predicting venous thromboembolism in 40 218 patients with cancer initiating chemotherapy","volume":"6","author":"Overvad","year":"2022","journal-title":"Blood Adv."},{"issue":"6","key":"2025030813452268100_CIT0013","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.3324\/haematol.2018.209114","article-title":"The Khorana score for prediction of venous thromboembolism in cancer patients: a systematic review and meta-analysis","volume":"104","author":"Mulder","year":"2019","journal-title":"Haematologica."},{"issue":"2","key":"2025030813452268100_CIT0014","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ejvs.2006.10.006","article-title":"Obesity and thrombosis","volume":"33","author":"Darvall","year":"2007","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"6","key":"2025030813452268100_CIT0015","doi-asserted-by":"crossref","first-page":"e0158017","DOI":"10.1371\/journal.pone.0158017","article-title":"Corticosteroid use and complications in a US inflammatory bowel disease cohort","volume":"11","author":"Waljee","year":"2016","journal-title":"PLoS One."},{"issue":"4","key":"2025030813452268100_CIT0016","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1159\/000070197","article-title":"High-dose corticosteroid treatment is associated with an increased risk of developing cerebral venous thrombosis","volume":"49","author":"Stolz","year":"2003","journal-title":"Eur Neurol."},{"key":"2025030813452268100_CIT0017","doi-asserted-by":"crossref","first-page":"1076029621993573","DOI":"10.1177\/1076029621993573","article-title":"Venous thromboembolism, corticosteroids and COVID-19: a systematic review and meta-analysis","volume":"27","author":"Sarfraz","year":"2021","journal-title":"Clin Appl Thromb Hemost"},{"issue":"11","key":"2025030813452268100_CIT0018","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1002\/ajh.25603","article-title":"Predicting venous thromboembolism in multiple myeloma: development and validation of the IMPEDE VTE score","volume":"94","author":"Sanfilippo","year":"2019","journal-title":"Am J Hematol."},{"issue":"Pt 5","key":"2025030813452268100_CIT0019","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1093\/brain\/aww046","article-title":"Corticosteroids compromise survival in glioblastoma","volume":"139","author":"Pitter","year":"2016","journal-title":"Brain."},{"issue":"1","key":"2025030813452268100_CIT0020","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11060-019-03146-7","article-title":"Impact of overall corticosteroid exposure during chemoradiotherapy on lymphopenia and survival of glioblastoma patients","volume":"143","author":"Hui","year":"2019","journal-title":"J Neurooncol."},{"issue":"33","key":"2025030813452268100_CIT0021","doi-asserted-by":"crossref","first-page":"e2203437119","DOI":"10.1073\/pnas.2203437119","article-title":"Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2\u2013induced lung exudative vasculitis and predicts COVID-19 severity","volume":"119","author":"Iwamura","year":"2022","journal-title":"Proc Natl Acad Sci USA."},{"issue":"5","key":"2025030813452268100_CIT0022","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.3390\/ijms23052440","article-title":"The platelet collagen receptor GPVI is cleaved by Tspan15\/ADAM10 and Tspan33\/ADAM10 molecular scissors","volume":"23","author":"Koo","year":"2022","journal-title":"Int J Mol Sci."},{"issue":"11","key":"2025030813452268100_CIT0023","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1161\/ATVBAHA.121.316108","article-title":"Platelet GPVI (glycoprotein VI) and thrombotic complications in the venous system","volume":"41","author":"Perrella","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol."},{"issue":"1","key":"2025030813452268100_CIT0024","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/1477-7819-11-306","article-title":"Correlation of bevacizumab-induced hypertension and outcomes of metastatic colorectal cancer patients treated with bevacizumab: a systematic review and meta-analysis","volume":"11","author":"Cai","year":"2013","journal-title":"World J Surg Oncol."},{"issue":"7","key":"2025030813452268100_CIT0025","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/cam4.701","article-title":"Retrospective analysis of bevacizumab-induced hypertension and clinical outcome in patients with colorectal cancer and lung cancer","volume":"5","author":"Nakaya","year":"2016","journal-title":"Cancer Medicine"},{"issue":"1","key":"2025030813452268100_CIT0026","first-page":"227","article-title":"Hypertension as a predictive marker for bevacizumab in metastatic breast cancer: results from a retrospective matched-pair analysis","volume":"34","author":"Gampenrieder","year":"2014","journal-title":"Anticancer Res."},{"issue":"8","key":"2025030813452268100_CIT0027","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1161\/HYPERTENSIONAHA.123.21119","article-title":"Bevacizumab-induced hypertension in glioblastoma patients and its potential as a modulator of treatment response","volume":"80","author":"Scheer","year":"2023","journal-title":"Hypertension."},{"key":"2025030813452268100_CIT0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biochi.2019.06.014","article-title":"Increasing evidence of pathogenic role of the Mediator (MED) complex in the development of cardiovascular diseases","volume":"165","author":"Napoli","year":"2019","journal-title":"Biochimie."},{"issue":"3","key":"2025030813452268100_CIT0029","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/hmg\/ddu478","article-title":"Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension","volume":"24","author":"Lu","year":"2014","journal-title":"Hum Mol Genet."},{"key":"2025030813452268100_CIT0030","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3389\/fphys.2013.00247","article-title":"Pathophysiological roles of FGF signaling in the heart","volume":"4","author":"Itoh","year":"2013","journal-title":"Front Physiol."},{"issue":"2","key":"2025030813452268100_CIT0031","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/ije\/dyv077","article-title":"A genome-wide association study of body mass index across early life and childhood","volume":"44","author":"Warrington","year":"2015","journal-title":"Int J Epidemiol."},{"issue":"15","key":"2025030813452268100_CIT0032","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1182\/blood.2019003251","article-title":"RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival","volume":"136","author":"DeHelian","year":"2020","journal-title":"Blood."},{"issue":"1","key":"2025030813452268100_CIT0033","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bcmd.2008.07.003","article-title":"Platelet function in hypertension","volume":"42","author":"El Haouari","year":"2009","journal-title":"Blood Cells Mol Dis."},{"issue":"6","key":"2025030813452268100_CIT0034","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/bjc.2014.430","article-title":"Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100","volume":"111","author":"Schneider","year":"2014","journal-title":"Br J Cancer."},{"issue":"19","key":"2025030813452268100_CIT0035","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1158\/1078-0432.CCR-17-1523","article-title":"Identification of a genomic region between SLC29A1 and HSP90AB1 associated with risk of bevacizumab-induced hypertension: CALGB 80405 (Alliance)","volume":"24","author":"Li","year":"2018","journal-title":"Clin Cancer Res"},{"issue":"2","key":"2025030813452268100_CIT0036","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41416-021-01557-w","article-title":"Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients","volume":"126","author":"Quintanilha","year":"2022","journal-title":"Br J Cancer."}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/advance-article-pdf\/doi\/10.1093\/neuonc\/noae234\/60938190\/noae234.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/27\/3\/767\/60938190\/noae234.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/27\/3\/767\/60938190\/noae234.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T13:45:47Z","timestamp":1741441547000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article\/27\/3\/767\/7902170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,16]]},"references-count":36,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,11,16]]},"published-print":{"date-parts":[[2025,3,7]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/noae234","relation":{},"ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,3]]},"published":{"date-parts":[[2024,11,16]]}}}