{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:36:53Z","timestamp":1783456613687,"version":"3.55.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:00:00Z","timestamp":1732320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["10070012010006"],"award-info":[{"award-number":["10070012010006"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011676","name":"Elekta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011676","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000770","name":"University of Manchester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000770","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Advanced MR imaging, such as diffusion-weighted (DWI) and dynamic contrast-enhanced (DCE) imaging, may provide valuable noninvasive information on intrinsic tumor biology. This study aims to evaluate apparent diffusion coefficient (ADC) and DCE-MRI-derived microvascular parameter values (Ktrans, ve, and vp) as potential imaging predictors for future sporadic vestibular schwannoma (VS) growth.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this prospective cohort study, patients with newly diagnosed unilateral sporadic VS and an initial wait-and-scan strategy were enrolled between January 2021 and January 2023. Patients underwent a single timepoint comprehensive MRI protocol, including DWI and DCE-MRI sequences. The estimated values of ADC, Ktrans, ve, and vp were calculated using established pipelines on a voxelwise basis within the delineated tumor region of interest. Associations of the estimated parameter values with volumetric growth were evaluated in uni- and multivariable logistic regression and survival analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 110 analyzed patients, 70 (64%) exhibited growth during follow-up. A significant correlation was primarily observed between the DCE-MRI-derived parameters and VS growth. The combination of mean Ktrans (P\u2005&amp;lt;\u2005.001) and ve (P\u2005&amp;lt;\u2005.001) tumor values provided an internally validated model with an AUC of 0.85 for growth, yielding a sensitivity of 89% and specificity of 73% at the optimized cutoff value. Only the mean ADC values were found to be significantly higher in shrinking tumors (P\u2005=\u2005.04).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The strongly significant correlation observed between VS growth and Ktrans and ve tumor values indicate the great potential of the noninvasive DCE-MRI for individualized VS management in clinical practice. External validation is needed to further substantiate these findings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/neuonc\/noae252","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T18:18:52Z","timestamp":1732385932000},"page":"1116-1127","source":"Crossref","is-referenced-by-count":7,"title":["Dynamic contrast-enhanced and diffusion-weighted MR imaging for predicting tumor growth of sporadic vestibular schwannomas: A prospective study"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8098-1692","authenticated-orcid":false,"given":"Sammy M","family":"Schouten","sequence":"first","affiliation":[{"name":"Mental Health & Neuroscience Research Institute, Maastricht University , Maastricht , the","place":["Netherlands"]},{"name":"Gamma Knife Center, Elisabeth-TweeSteden Hospital , Tilburg ,","place":["the Netherlands"]},{"name":"Dutch Academic Alliance Skull Base Pathology Radboudumc\/MUMC+ , Nijmegen ,","place":["the Netherlands"]},{"name":"Maastricht University Medical Center+ , Maastricht ,","place":["the Netherlands"]},{"name":"Radboud University Medical Center , Nijmegen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6831-6990","authenticated-orcid":false,"given":"Daniel","family":"Lewis","sequence":"additional","affiliation":[{"name":"Geoffrey Jefferson Brain Research Centre, University of Manchester , Manchester ,","place":["UK"]},{"name":"Division of Cancer Sciences, University of Manchester , Manchester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Cornelissen","sequence":"additional","affiliation":[{"name":"The Video Coding and Architecture Group, Eindhoven University of Technology , Eindhoven ,","place":["the Netherlands"]},{"name":"Gamma Knife Center, Elisabeth-TweeSteden Hospital , Tilburg ,","place":["the 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G","family":"Jansen","sequence":"additional","affiliation":[{"name":"Dutch Academic Alliance Skull Base Pathology Radboudumc\/MUMC+ , Nijmegen ,","place":["the Netherlands"]},{"name":"Radboud University Medical Center , Nijmegen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jef J S","family":"Mulder","sequence":"additional","affiliation":[{"name":"Dutch Academic Alliance Skull Base Pathology Radboudumc\/MUMC+ , Nijmegen ,","place":["the Netherlands"]},{"name":"Radboud University Medical Center , Nijmegen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me J","family":"Waterval","sequence":"additional","affiliation":[{"name":"Mental Health & Neuroscience Research Institute, Maastricht University , Maastricht , the","place":["Netherlands"]},{"name":"Dutch Academic Alliance Skull Base Pathology Radboudumc\/MUMC+ , Nijmegen ,","place":["the Netherlands"]},{"name":"Maastricht University Medical Center+ , Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alida A","family":"Postma","sequence":"additional","affiliation":[{"name":"Mental Health & Neuroscience Research Institute, Maastricht University , Maastricht , the","place":["Netherlands"]},{"name":"Dutch Academic Alliance Skull Base Pathology Radboudumc\/MUMC+ , Nijmegen ,","place":["the Netherlands"]},{"name":"Maastricht University Medical Center+ , Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Pathmanaban","sequence":"additional","affiliation":[{"name":"Geoffrey Jefferson Brain Research Centre, University of Manchester , Manchester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Coope","sequence":"additional","affiliation":[{"name":"Geoffrey Jefferson Brain Research Centre, University of Manchester , Manchester 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