{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:20:53Z","timestamp":1791872453028,"version":"4.3.4"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Central nervous system (CNS) tumors lead to cancer-related mortality in children. Genetic ancestry-associated cancer prevalence and outcomes have been studied but are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed genetic ancestry prediction in 1,452 pediatric patients with paired normal and tumor whole genome sequencing from the Open Pediatric Cancer (OpenPedCan) project to evaluate the influence of reported race and ethnicity and ancestry-based genetic superpopulations on tumor histology, molecular subtype, survival, and treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Predicted superpopulations included African (AFR, N\u2005=\u2005153), Admixed American (AMR, N\u2005=\u2005222), East Asian (EAS, N\u2005=\u200567), European (EUR, N\u2005=\u2005968), and South Asian (SAS, N\u2005=\u200542). Reported race and ethnicity and ancestry-based genetic superpopulations were non-randomly associated (P\u2005&amp;lt;\u2005.001). Patients with an atypical teratoid rhabdoid tumor or meningioma were enriched for AFR ancestry (OR\u2005=\u20052.6, FDR\u2005=\u20050.01; OR\u2005=\u20052.9, FDR\u2005=\u20050.01, respectively). Among KIAA1549::BRAF fusion-positive low-grade glioma (LGG) diagnoses, EAS and SAS patients disproportionately harbored exon 15:09 breakpoints (FDR\u2005&amp;lt;\u20050.05), and AMR patients demonstrated rare breakpoints, which were associated with lesser degree of surgical resection and worse event-free survival (EFS) versus other breakpoints (hazard ratio (HR)\u2005=\u20054.6, P\u2005=\u2005.03). Non-EUR and AMR patients with germ cell tumors and SHH-activated medulloblastoma, respectively, exhibited worse EFS relative to EUR patients (HR\u2005=\u200512.1, P\u2005&amp;lt;\u2005.01; HR\u2005=\u20055.2, P\u2005=\u2005.03) and AFR patients with LGG (HR\u2005=\u200516.4, P\u2005&amp;lt;\u2005.01) or ependymoma (HR\u2005=\u20055.5, P\u2005=\u2005.02) had worse overall survival compared to EUR patients. We observed a higher frequency of clinical trial enrollment among AMR patients across tumor histologies (OR\u2005=\u20052.0, P \u2264 .01), but increased utilization of photon versus proton radiation relative to other superpopulations (OR\u2005=\u20050.55, P=\u2005.04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Genetic ancestry-associated differences exist across pediatric CNS tumor histological and molecular subtypes from PBTA and PNOC. Further investigation into genetic and socioeconomic factors contributing to these observed inequities is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noaf017","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T15:19:42Z","timestamp":1737472782000},"page":"1356-1371","source":"Crossref","is-referenced-by-count":6,"title":["Genetic ancestry superpopulations show distinct prevalence and outcomes across pediatric central nervous system tumors from the Pediatric Brain Tumor Atlas and Pediatric Neuro-Oncology Consortium"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3478-0784","authenticated-orcid":false,"given":"Ryan J","family":"Corbett","sequence":"first","affiliation":[{"name":"Division of Oncology, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Division of Neurosurgery, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1549-2688","authenticated-orcid":false,"given":"Cricket C","family":"Gullickson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6883-0691","authenticated-orcid":false,"given":"Zhuangzhuang","family":"Geng","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6782-1442","authenticated-orcid":false,"given":"Miguel A","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2406-2735","authenticated-orcid":false,"given":"Chuwei","family":"Zhong","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7414-9516","authenticated-orcid":false,"given":"Nicholas","family":"Van Kuren","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Chroni","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4928-090X","authenticated-orcid":false,"given":"Christopher","family":"Blackden","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0625-666X","authenticated-orcid":false,"given":"Ammar S","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Plisiewicz","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania 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,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1655-3860","authenticated-orcid":false,"given":"Tom B","family":"Davidson","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of University of Southern California, Children\u2019s Hospital of Los Angeles , Los Angeles, California 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C","family":"Resnick","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0571-2889","authenticated-orcid":false,"given":"Angela J","family":"Waanders","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Northwestern University Feinberg School of Medicine , Chicago, Illinois ,","place":["USA"]},{"name":"Division of Hematology, Oncology, Neuro-Oncology, and Stem Cell Transplant, Ann & Robert H Lurie Children\u2019s Hospital of Chicago , Chicago, Iliinois ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3042-9521","authenticated-orcid":false,"given":"Sebastian M","family":"Waszak","sequence":"additional","affiliation":[{"name":"Laboratory of Computational Neuro-Oncology, Swiss Institute for Experimental Cancer Research, School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne , Lausanne ,","place":["Switzerland"]},{"name":"Department of Neurology, University of California, San Francisco , San Francisco, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3452-5150","authenticated-orcid":false,"given":"Sabine","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, San Francisco , San Francisco, California 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