{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:15:26Z","timestamp":1793297726507,"version":"4.5.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Improving the surgical outcomes for commonly occurring spinal neoplasms of extradural and intradural extramedullary origins requires precise intraoperative diagnosis provided by highly trained neuropathologists.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Through a retrospective study of n\u2005=\u2005319 patient specimens, verified where appropriate by learning curve analysis to be sufficient for statistically significant observations, we aimed to assess the utility of 10-second picosecond infrared laser mass spectrometry (MS; PIRL-MS) for non-subjective diagnosis of major spinal tumor types of metastatic carcinoma, schwannoma, and meningiomas.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The sensitivity and specificity values of spinal tumor-type diagnosis (based on n\u2005=\u2005182 independent specimens) were (93%\u2005\u00b1\u20051)% and (97%\u2005\u00b1\u20052)%, respectively. This classification utilizes n\u2005=\u200541 cellular lipids including phosphatidylcholines, sphingomyelins, phosphatidylethanolamines, and ceramides whose identities were established using high-resolution tandem MS. Furthermore, the accuracy of diagnosis of a model that contained n\u2005=\u200597 meningioma and n\u2005=\u2005106 schwannoma was not drastically influenced by the presence of n\u2005=\u200554 additional intradural extramedullary spinal neoplasms of myxopapillary ependymoma, neurofibroma, paraganglioma, and solitary fibrous tumor types in the differential diagnosis, confirming the generalizability and robustness of the identified molecular array in rendering correct classification even in the presence of data not seen previously by the model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The identified lipids form a \u201cmolecular array\u201d for robust diagnosis of meningioma and schwannoma tumors by non-pathologists in a manner similar to genomic, transcriptomic, or methylomic arrays used to diagnose brain cancer types, albeit on a much faster timescale of seconds as opposed to hours.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/neuonc\/noaf047","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T04:37:46Z","timestamp":1740112666000},"page":"2060-2072","source":"Crossref","is-referenced-by-count":5,"title":["A molecular array for 10-second diagnosis of common spinal tumor types with picosecond infrared laser mass spectrometry"],"prefix":"10.1093","volume":"27","author":[{"given":"Alexa","family":"Fiorante","sequence":"first","affiliation":[{"name":"Department of Medical Biophysics, University of Toronto , Toronto, Ontario ,","place":["Canada"]},{"name":"Princess Margaret Cancer Centre, University Health Network , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Woolman","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics, University of Toronto , Toronto, Ontario ,","place":["Canada"]},{"name":"Princess Margaret Cancer Centre, University Health Network , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G","family":"Munoz","sequence":"additional","affiliation":[{"name":"Keenan Research Center for Biomedical Science & The Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital , Toronto, Ontario ,","place":["Canada"]},{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taira","family":"Kiyota","sequence":"additional","affiliation":[{"name":"Drug Discovery Group, Ontario Institute for Cancer Research (OICR) , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan Anna","family":"Ye","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine","family":"Farahmand","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darah","family":"Vlaminck","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics, University of Toronto , Toronto, Ontario ,","place":["Canada"]},{"name":"Princess Margaret Cancer Centre, University Health Network , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis O","family":"Talbot","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunit","family":"Das","sequence":"additional","affiliation":[{"name":"Keenan Research Center for Biomedical Science & The Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital , Toronto, Ontario ,","place":["Canada"]},{"name":"Department of Surgery, University of Toronto , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorcha","family":"Kellett","sequence":"additional","affiliation":[{"name":"Keenan Research Center for Biomedical Science & The Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Giuffrida","sequence":"additional","affiliation":[{"name":"Keenan Research Center for Biomedical Science & The Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6637-4502","authenticated-orcid":false,"given":"Gelareh","family":"Zadeh","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Toronto , Toronto, Ontario ,","place":["Canada"]},{"name":"Princess Margaret Cancer Centre, University Health Network , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J","family":"Ginsberg","sequence":"additional","affiliation":[{"name":"Keenan Research Center for Biomedical Science & The Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital , Toronto, Ontario ,","place":["Canada"]},{"name":"Department of Surgery, University of Toronto , Toronto, Ontario ,","place":["Canada"]},{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Aman","sequence":"additional","affiliation":[{"name":"Leslie Dan, Faculty of Pharmacy, University of Toronto , Toronto, Ontario ,","place":["Canada"]},{"name":"Drug Discovery Group, Ontario Institute for Cancer Research (OICR) , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8013-6893","authenticated-orcid":false,"given":"Arash","family":"Zarrine-Afsar","sequence":"additional","affiliation":[{"name":"Keenan Research Center for Biomedical Science & The Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital , Toronto, Ontario ,","place":["Canada"]},{"name":"Department of Surgery, University of Toronto , Toronto, Ontario ,","place":["Canada"]},{"name":"Department of Medical Biophysics, University of Toronto , Toronto, Ontario ,","place":["Canada"]},{"name":"Princess Margaret Cancer Centre, 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