{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:55:27Z","timestamp":1792695327589,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008235","name":"School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008235","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Readmission following endoscopic endonasal transsphenoidal surgery (EETS) for pituitary neuroendocrine tumor (PitNET) and other sellar pathology is most commonly due to delayed hyponatremia. Studies suggest postoperative fluid restriction (FR) reduces delayed hyponatremia. We present a prospective randomized controlled study evaluating post-EETS FR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>300 participants were scheduled for EETS (2016\u20132023) at a single institution. Patients with CKD, CHF, arginine vasopressin deficiency on postoperative day (POD) 3, chronic hyponatremia, and untreated adrenal insufficiency or hypothyroidism were excluded. Groups included control (ad-lib, n\u2005=\u200594), moderate FR (1.8 L\/day or 2 L\/day weight\u2005&amp;gt;\u2005100 kg, n\u2005=\u200539), and strict FR (1 L\/day or 1.2 L\/day weight\u2005&amp;gt;\u2005100 kg, n\u2005=\u200562) from POD 3\u201314. Incidence of overall, moderate, and severe hyponatremia (Na\u2005&amp;lt;\u2005135, 125\u2013129, and &amp;lt;125 mEq\/L), readmission rates, fluid intake, and thirst were evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The incidence of overall hyponatremia was 31.9%, 28.2%, and 21.0% in control, moderate FR, and strict FR groups, and the incidence of severe hyponatremia was 7.4%, 5.1%, and 0% in control, moderate FR, and strict FR groups. Nadir Na level was higher (1.81 mEq\/L; 95% CI, 0.34 to 3.27; P\u2005=\u2005.02) and severe hyponatremia occurred less frequently (95% CI, 0.00 to 1.02; P\u2005=\u2005.04) in the strict FR vs. control group. Readmission was lower in the strict FR (1.6%, n\u2005=\u20051) vs. control group (6.4%, n\u2005=\u20056).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Postoperative FR decreases rates of delayed hyponatremia and related readmission compared to patients drinking ad-lib. Further studies are needed to assess the optimal volume and duration of FR after EETS.<\/jats:p>\n                  <jats:p>Trial registration number: NCT03636568<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/neuonc\/noaf069","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T09:16:32Z","timestamp":1741943792000},"page":"1746-1757","source":"Crossref","is-referenced-by-count":8,"title":["Postoperative fluid restriction to prevent delayed hyponatremia after endoscopic transsphenoidal surgery"],"prefix":"10.1093","volume":"27","author":[{"given":"Doriann","family":"Klaassen","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine , St. Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinghei","family":"Mok","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Washington 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Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan M","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Neurosurgery of Saint Louis , St. Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Chicoine","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Missouri-Columbia , Columbia, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph G","family":"Dacey","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Washington University School of Medicine , St. Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyssa F","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Washington University in St Louis , St. Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua W","family":"Osbun","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Washington University School of Medicine , St. Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith M","family":"Rich","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Washington University School of Medicine , St. Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren T","family":"Roland","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Washington University in St Louis , St. Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Washington University in St Louis , St. Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J","family":"Zipfel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Washington University in St Louis , St. Louis, Missouri ,","place":["USA"]},{"name":"Department of Neurological Surgery, Washington University School of Medicine , St. Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongliang","family":"Luo","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Washington University School of Medicine , St. Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1751-8493","authenticated-orcid":false,"given":"Albert H","family":"Kim","sequence":"additional","affiliation":[{"name":"The Brain Tumor Center, Siteman Cancer 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