{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:30:09Z","timestamp":1787009409048,"version":"build-2736575974"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15NS130456-01 to Y.Z., R01CA220551"],"award-info":[{"award-number":["R15NS130456-01 to Y.Z., R01CA220551"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173263"],"award-info":[{"award-number":["82173263"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Choroid plexus (CP) tumors are rare brain neoplasms that mainly affect the pediatric population. Unlike benign CP papilloma (CPP), CP carcinoma (CPC) is an aggressive cancer with a dismal survival rate. Despite chromosome-wide rearrangements, drivers of most CP tumors remain elusive except recurrent alterations in TP53. Studies of signaling dysregulation may bring biological understanding of these malignancies. Previous studies implicated NOTCH signaling in CP tumors; we developed mouse models of CP tumors driven by NOTCH activation and Trp53 loss, respectively. This work examined the role of the transcription factor SOX2 in CP development and tumorigenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multi-omics approaches were used to characterize cellular heterogeneity in NOTCH-driven CP tumors. SOX2 functions in the molecular signature of tumor cells were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Single-cell transcriptomics and epigenetics methods identified diverse cell populations in tumors that resemble normal CP, such as epithelial and glial groups. Pseudotime trajectory analysis indicated that NOTCH-driven CP tumor arises from bipotential glial progenitors and retains a progenitor-like signature characterized by an enhanced SOX2 profile. SOX2 inactivation attenuated progenitor-like features and blunted tumor growth. Integrative omics studies revealed SOX2 binding to genes expressed in progenitors in the rhombic lip, including LIM homeobox transcription factors LMX1A and LMX1B. Consistently, SOX2 maintains progenitor identity through regulating their expression in CP tumors and during development, whereas LMX1A and LMX1B support SOX2 functions in tumor cell proliferation. Furthermore, spatial transcriptomics revealed aberrant SOX2 and LMX1A expression in human CP tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SOX2-LMX1 signaling maintains progenitor identity in CP development and tumor formation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noaf085","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T06:26:31Z","timestamp":1742711191000},"page":"2006-2022","source":"Crossref","is-referenced-by-count":4,"title":["SOX2 commands LIM homeobox transcription factors in choroid plexus development and tumorigenesis"],"prefix":"10.1093","volume":"27","author":[{"given":"Lukas J","family":"Faltings","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine , Shanghai ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Zahran","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heena","family":"Jalili","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Siluveru","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahek","family":"Chaudry","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah M","family":"Wachsmuth","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navjot","family":"Guru","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Schoof","sequence":"additional","affiliation":[{"name":"Institute for Neuropathology, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]},{"name":"Research Institute Children\u2019s Cancer Center , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noreen","family":"Mian","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohyun","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Zahran","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Arts and Science, Adelphi University , Garden City, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhi","family":"Modi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maheen","family":"Umer","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Q","family":"Virga","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Tao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8731-1121","authenticated-orcid":false,"given":"Ulrich","family":"Sch\u00fcller","sequence":"additional","affiliation":[{"name":"Institute for Neuropathology, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]},{"name":"Research Institute Children\u2019s Cancer Center , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine , Shanghai ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2315-8452","authenticated-orcid":false,"given":"Haotian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine , Old Westbury, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"issue":"3","key":"2025091918573190600_CIT0001","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.devcel.2020.01.027","article-title":"Emergence and developmental roles of the cerebrospinal fluid system","volume":"52","author":"Fame","year":"2020","journal-title":"Dev Cell."},{"issue":"3","key":"2025091918573190600_CIT0002","doi-asserted-by":"crossref","first-page":"e1900186","DOI":"10.1002\/bies.201900186","article-title":"Brain ventricular system and cerebrospinal fluid development and function: light at the end of the tube: a primer with latest insights","volume":"42","author":"Fame","year":"2020","journal-title":"Bioessays."},{"issue":"11","key":"2025091918573190600_CIT0003","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1016\/j.cell.2021.04.003","article-title":"A cellular and spatial map of the choroid plexus across brain ventricles and ages","volume":"184","author":"Dani","year":"2021","journal-title":"Cell."},{"issue":"2","key":"2025091918573190600_CIT0004","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ydbio.2004.10.011","article-title":"Roof plate-dependent patterning of the vertebrate dorsal central nervous system","volume":"277","author":"Chizhikov","year":"2005","journal-title":"Dev Biol."},{"issue":"6","key":"2025091918573190600_CIT0005","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00018-022-04314-1","article-title":"Regulation of choroid plexus development and its functions","volume":"79","author":"Kompanikova","year":"2022","journal-title":"Cell Mol Life Sci."},{"issue":"8","key":"2025091918573190600_CIT0006","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1242\/dev.099002","article-title":"Msx1 and Msx2 act as essential activators of Atoh1 expression in the murine spinal cord","volume":"141","author":"Duval","year":"2014","journal-title":"Development."},{"issue":"15","key":"2025091918573190600_CIT0007","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1242\/dev.01915","article-title":"Direct and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation","volume":"132","author":"Currle","year":"2005","journal-title":"Development."},{"issue":"19","key":"2025091918573190600_CIT0008","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1242\/dev.003095","article-title":"Molecularly and temporally separable lineages form the hindbrain roof plate and contribute differentially to the choroid plexus","volume":"134","author":"Hunter","year":"2007","journal-title":"Development."},{"issue":"23","key":"2025091918573190600_CIT0009","doi-asserted-by":"crossref","first-page":"10725","DOI":"10.1073\/pnas.0910786107","article-title":"Lmx1a regulates fates and location of cells originating from the cerebellar rhombic lip and telencephalic cortical hem","volume":"107","author":"Chizhikov","year":"2010","journal-title":"Proc Natl Acad Sci USA."},{"issue":"22","key":"2025091918573190600_CIT0010","doi-asserted-by":"crossref","first-page":"dev190173","DOI":"10.1242\/dev.190173","article-title":"ZFP423 regulates early patterning and multiciliogenesis in the hindbrain choroid plexus","volume":"147","author":"Casoni","year":"2020","journal-title":"Development."},{"issue":"36","key":"2025091918573190600_CIT0011","doi-asserted-by":"crossref","first-page":"11377","DOI":"10.1523\/JNEUROSCI.0969-09.2009","article-title":"Overlapping function of Lmx1a and Lmx1b in anterior hindbrain roof plate formation and cerebellar growth","volume":"29","author":"Mishima","year":"2009","journal-title":"J Neurosci."},{"issue":"5","key":"2025091918573190600_CIT0012","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1242\/dev.090860","article-title":"The transcription factor Otx2 regulates choroid plexus development and function","volume":"140","author":"Johansson","year":"2013","journal-title":"Development."},{"issue":"10","key":"2025091918573190600_CIT0013","doi-asserted-by":"crossref","first-page":"dev192054","DOI":"10.1242\/dev.192054","article-title":"MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus","volume":"148","author":"Kaiser","year":"2021","journal-title":"Development."},{"issue":"2","key":"2025091918573190600_CIT0014","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.ydbio.2010.01.032","article-title":"Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus","volume":"340","author":"Nielsen","year":"2010","journal-title":"Dev Biol."},{"issue":"15","key":"2025091918573190600_CIT0015","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1242\/dev.033795","article-title":"Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus","volume":"136","author":"Huang","year":"2009","journal-title":"Development."},{"issue":"1","key":"2025091918573190600_CIT0016","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41467-021-27602-z","article-title":"Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate","volume":"13","author":"Parichha","year":"2022","journal-title":"Nat Commun."},{"issue":"8","key":"2025091918573190600_CIT0017","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1038\/s41418-022-00950-z","article-title":"Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development","volume":"29","author":"Li","year":"2022","journal-title":"Cell Death Differ."},{"issue":"12","key":"2025091918573190600_CIT0018","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1038\/s41418-019-0332-7","article-title":"Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis","volume":"26","author":"Wildung","year":"2019","journal-title":"Cell Death Differ."},{"issue":"Article 66","key":"2025091918573190600_CIT0019","first-page":"1","article-title":"Transport of thyroid hormones via the choroid plexus into the brain: the roles of transthyretin and thyroid hormone transmembrane transporters","volume":"9","author":"Richardson","year":"2015","journal-title":"Front Neurosci."},{"issue":"8","key":"2025091918573190600_CIT0020","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol."},{"issue":"2","key":"2025091918573190600_CIT0021","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00381-010-1269-9","article-title":"Choroid plexus tumors in children less than 36 months: the Canadian Pediatric Brain Tumor Consortium (CPBTC) experience","volume":"27","author":"Lafay-Cousin","year":"2011","journal-title":"Childs Nerv Sys."},{"issue":"1","key":"2025091918573190600_CIT0022","first-page":"vdaa168","article-title":"Outcome and molecular analysis of young children with choroid plexus carcinoma treated with non-myeloablative therapy: results from the SJYC07 trial","volume":"3","author":"Liu","year":"2021","journal-title":"Neurooncol Adv."},{"issue":"3","key":"2025091918573190600_CIT0023","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s11060-021-03942-0","article-title":"Final results of the Choroid Plexus Tumor study CPT-SIOP-2000","volume":"156","author":"Wolff","year":"2022","journal-title":"J Neurooncol."},{"issue":"4","key":"2025091918573190600_CIT0024","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/neuonc\/noaa267","article-title":"The genetic landscape of choroid plexus tumors in children and adults","volume":"23","author":"Thomas","year":"2021","journal-title":"Neuro Oncol."},{"issue":"1","key":"2025091918573190600_CIT0025","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1158\/1078-0432.CCR-14-1324","article-title":"Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups","volume":"21","author":"Merino","year":"2015","journal-title":"Clin Cancer Res."},{"issue":"6","key":"2025091918573190600_CIT0026","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1093\/neuonc\/noac274","article-title":"Molecular heterogeneity of pediatric choroid plexus carcinomas determines the distinctions in clinical course and prognosis","volume":"25","author":"Zaytseva","year":"2023","journal-title":"Neuro Oncol."},{"issue":"6","key":"2025091918573190600_CIT0027","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/neuonc\/nov322","article-title":"Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups","volume":"18","author":"Thomas","year":"2016","journal-title":"Neuro Oncol."},{"issue":"8","key":"2025091918573190600_CIT0028","first-page":"1055","article-title":"Notch receptors in human choroid plexus tumors","volume":"28","author":"Beschorner","year":"2013","journal-title":"Histol Histopathol."},{"issue":"1","key":"2025091918573190600_CIT0029","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11060-023-04484-3","article-title":"Multi-omics analyses of choroid plexus carcinoma cell lines reveal potential targetable pathways and alterations","volume":"166","author":"Hesham","year":"2024","journal-title":"J Neurooncol."},{"issue":"6","key":"2025091918573190600_CIT0030","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.ajpath.2018.02.009","article-title":"Mice expressing myc in neural precursors develop choroid plexus and ciliary body tumors","volume":"188","author":"Shannon","year":"2018","journal-title":"Am J Pathol."},{"issue":"2","key":"2025091918573190600_CIT0031","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.bbrc.2017.11.192","article-title":"A new genetically engineered mouse model of choroid plexus carcinoma","volume":"496","author":"El Nagar","year":"2018","journal-title":"Biochem Biophys Res Commun."},{"issue":"1","key":"2025091918573190600_CIT0032","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s40478-019-0739-x","article-title":"c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism","volume":"7","author":"Merve","year":"2019","journal-title":"Acta Neuropathol Commun."},{"issue":"4","key":"2025091918573190600_CIT0033","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/ncb3327","article-title":"Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells","volume":"18","author":"Li","year":"2016","journal-title":"Nat Cell Biol."},{"issue":"1","key":"2025091918573190600_CIT0034","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/neuonc\/noae176","article-title":"Activation of Wnt\/beta-catenin signaling is critical for the tumorigenesis of choroid plexus","volume":"27","author":"Ho","year":"2025","journal-title":"Neuro Oncol."},{"issue":"Pt 1","key":"2025091918573190600_CIT0035","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.semcancer.2019.08.007","article-title":"SOX2 in development and cancer biology","volume":"67","author":"Novak","year":"2020","journal-title":"Semin Cancer Biol."},{"issue":"2","key":"2025091918573190600_CIT0036","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.3892\/ol.2017.6326","article-title":"Increased NG2 and SOX2 expression is associated with high-grade choroid plexus tumors","volume":"14","author":"Zhao","year":"2017","journal-title":"Oncol Lett."},{"issue":"6500","key":"2025091918573190600_CIT0037","doi-asserted-by":"crossref","first-page":"eaaz5626","DOI":"10.1126\/science.aaz5626","article-title":"Human CNS barrier-forming organoids with cerebrospinal fluid production","volume":"369","author":"Pellegrini","year":"2020","journal-title":"Science."},{"issue":"2","key":"2025091918573190600_CIT0038","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jsb.2011.12.023","article-title":"Cryo X-ray microscope with flat sample geometry for correlative fluorescence and nanoscale tomographic imaging","volume":"177","author":"Schneider","year":"2012","journal-title":"J Struct Biol."},{"issue":"1","key":"2025091918573190600_CIT0039","doi-asserted-by":"crossref","first-page":"15764","DOI":"10.1038\/s41598-018-33592-8","article-title":"EzColocalization: an ImageJ plugin for visualizing and measuring colocalization in cells and organisms","volume":"8","author":"Stauffer","year":"2018","journal-title":"Sci Rep."},{"issue":"14","key":"2025091918573190600_CIT0040","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1158\/0008-5472.CAN-16-1836","article-title":"ATOH1 promotes leptomeningeal dissemination and metastasis of sonic hedgehog subgroup medulloblastomas","volume":"77","author":"Grausam","year":"2017","journal-title":"Cancer Res."},{"issue":"W1","key":"2025091918573190600_CIT0041","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next-generation web server for deep-sequencing data analysis","volume":"44","author":"Ramirez","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"Web Server issue","key":"2025091918573190600_CIT0042","doi-asserted-by":"crossref","first-page":"W202","DOI":"10.1093\/nar\/gkp335","article-title":"MEME SUITE: tools for motif discovery and searching","volume":"37","author":"Bailey","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"2025091918573190600_CIT0043","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1158\/0008-5472.CAN-13-1942","article-title":"Sox2 is required to maintain cancer stem cells in a mouse model of high-grade oligodendroglioma","volume":"74","author":"Favaro","year":"2014","journal-title":"Cancer Res."},{"issue":"1","key":"2025091918573190600_CIT0044","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ccr.2014.05.005","article-title":"Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma","volume":"26","author":"Vanner","year":"2014","journal-title":"Cancer Cell."},{"issue":"1","key":"2025091918573190600_CIT0045","doi-asserted-by":"crossref","first-page":"10811","DOI":"10.1038\/s41598-019-46948-5","article-title":"Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ","volume":"9","author":"Hurtado","year":"2019","journal-title":"Sci Rep."},{"issue":"17","key":"2025091918573190600_CIT0046","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1242\/dev.037341","article-title":"Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis","volume":"136","author":"Smith","year":"2009","journal-title":"Development."},{"issue":"15","key":"2025091918573190600_CIT0047","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1242\/dev.02441","article-title":"The roof plate regulates cerebellar cell-type specification and proliferation","volume":"133","author":"Chizhikov","year":"2006","journal-title":"Development."},{"issue":"9","key":"2025091918573190600_CIT0048","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1523\/JNEUROSCI.4987-09.2010","article-title":"Essential roles of Notch signaling in maintenance of neural stem cells in developing and adult brains","volume":"30","author":"Imayoshi","year":"2010","journal-title":"J Neurosci."},{"issue":"2","key":"2025091918573190600_CIT0049","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ydbio.2007.12.006","article-title":"Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis","volume":"314","author":"Elsen","year":"2008","journal-title":"Dev Biol."},{"issue":"1","key":"2025091918573190600_CIT0050","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41392-020-00242-3","article-title":"Functional characterization of SOX2 as an anticancer target","volume":"5","author":"Zhang","year":"2020","journal-title":"Signal Transduct Target Ther."}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/advance-article-pdf\/doi\/10.1093\/neuonc\/noaf085\/62602555\/noaf085.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/27\/8\/2006\/62602555\/noaf085.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/27\/8\/2006\/62602555\/noaf085.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T22:57:43Z","timestamp":1758322663000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article\/27\/8\/2006\/8092873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":50,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,3,25]]},"published-print":{"date-parts":[[2025,9,17]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/noaf085","relation":{},"ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,3,25]]}}}