{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:30:07Z","timestamp":1787009407912,"version":"build-2736575974"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R03CA272955, R01CA284531"],"award-info":[{"award-number":["R03CA272955, R01CA284531"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD112081"],"award-info":[{"award-number":["R01HD112081"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Children born with a congenital anomaly have a higher risk of developing a brain tumor during childhood or adolescence, but the co-occurrence between specific types of congenital anomalies and specific types of childhood brain tumors (CBTs) is not well described. This study characterized the associations between specific congenital anomalies and CBTs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We leveraged a population-based registry linkage study of births (1990\u20132018), congenital anomalies, and cancer from 9 states (n\u2005=\u200522,599,099 births). Congenital anomalies were classified as major structural without a known chromosomal or genetic syndrome, chromosomal, neurofibromatosis, and\/or tuberous sclerosis complex. CBT classification was based on the International Classification of Childhood Cancer for children diagnosed\u2005&amp;lt;\u200520 years. Cox regression analyses were conducted separately by congenital anomaly for anomaly-CBT combinations with at least 5 co-occurring cases. We conducted analyses for any CBT and separately for astrocytoma, atypical teratoid\/rhabdoid tumor, ependymoma, medulloblastoma, mixed and unspecified gliomas, and primitive neuroectodermal tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 6,247 children diagnosed with a CBT. Having any major structural anomaly was associated with risk of any CBT and across all subgroups (aHR range: 1.48\u20133.69) except ependymoma, particularly among children diagnosed with a tumor by 1 year of age. Of the 66 anomaly-CBT combinations analyzed, 42 were significant (P\u2005&amp;lt;\u2005.05), including 25 in an earlier version of this study and 16 novel associations (aHR range: 1.46\u2013525). Anomaly\u2013CBT associations also differed by astrocytoma histology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We observed consistent evidence that having a structural congenital anomaly increases risk of developing a CBT, particularly in infancy, which may provide insights into etiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noaf087","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T06:26:50Z","timestamp":1742711210000},"page":"1910-1922","source":"Crossref","is-referenced-by-count":2,"title":["Co-occurrence of congenital anomalies and childhood brain tumors in 22 million live births"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8498-0020","authenticated-orcid":false,"given":"Thanh T","family":"Hoang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine , Houston, Texas ,","place":["USA"]},{"name":"Texas Children's Cancer and Hematology Center, Texas Children's Hospital , Houston, Texas ,","place":["USA"]},{"name":"The Dan L. 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Duncan Comprehensive Cancer Center, Baylor College of Medicine , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2884-2835","authenticated-orcid":false,"given":"Charles","family":"Shumate","sequence":"additional","affiliation":[{"name":"Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services , Austin, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1600-3700","authenticated-orcid":false,"given":"Tania A","family":"Desrosiers","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8318-4049","authenticated-orcid":false,"given":"Wendy N","family":"Nembhard","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences and Arkansas Center for Birth Defects Research and Prevention , Little Rock, Arkansas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7415-5350","authenticated-orcid":false,"given":"Mahsa","family":"Yazdy","sequence":"additional","affiliation":[{"name":"Massachusetts Center for Birth Defects Research and Prevention, Division for Surveillance, Research, and Promotion of Perinatal Health, Massachusetts Department of Public Health , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Nestoridi","sequence":"additional","affiliation":[{"name":"Massachusetts Center for Birth Defects Research and Prevention, Division for Surveillance, Research, and Promotion of Perinatal Health, Massachusetts Department of Public Health , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2690-385X","authenticated-orcid":false,"given":"Amanda E","family":"Janitz","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences , Oklahoma City, Oklahoma ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3489-401X","authenticated-orcid":false,"given":"Russell S","family":"Kirby","sequence":"additional","affiliation":[{"name":"Chiles Center, College of Public Health, University of South Florida , Tampa, Florida ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0077-6023","authenticated-orcid":false,"given":"Jason L","family":"Salemi","sequence":"additional","affiliation":[{"name":"Chiles Center, College of Public Health, University of South Florida , Tampa, Florida ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Paul","family":"Tanner","sequence":"additional","affiliation":[{"name":"Chiles Center, College of Public Health, University of South Florida , Tampa, Florida ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7618-7009","authenticated-orcid":false,"given":"Tiffany M","family":"Chambers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine , Houston, Texas ,","place":["USA"]},{"name":"Texas Children's Cancer and Hematology Center, Texas Children's Hospital , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7009-3466","authenticated-orcid":false,"given":"Michael D","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine , Houston, Texas ,","place":["USA"]},{"name":"Texas Children's Cancer and Hematology Center, Texas Children's Hospital , Houston, Texas ,","place":["USA"]},{"name":"The Dan L. 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