{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:25:14Z","timestamp":1793157914769,"version":"4.5.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-CA226527"],"award-info":[{"award-number":["R01-CA226527"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01-NS122987"],"award-info":[{"award-number":["R01-NS122987"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pituitary neuroendocrine tumors (PitNETs) are the most common intracranial neuroendocrine tumors. PitNETs can be challenging to classify, and current recommendations include a large immunohistochemical panel to differentiate among 14 WHO-recognized categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we analyzed clinical, immunohistochemical, and DNA methylation data of 118 PitNETs to develop a clinicomolecular approach to classifying PitNETs and identifying epigenetic classes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CNS DNA methylation classifier has an excellent performance in recognizing PitNETs and distinguishing the 3 lineages when the calibrated score is\u2005\u2265\u20050.3. Unsupervised DNA methylation analysis separated PitNETs into 2 major clusters. The first was composed of silent gonadotrophs, which form a biologically distinct group of PitNETs characterized by clinical silencing, weak hormonal expression on immunohistochemistry, and simple copy number profile. The second major cluster was composed of corticotrophs and Pit1 lineage PitNETs, which could be further classified using DNA methylation into distinct subclusters that corresponded to clinically functioning and silent tumors and are consistent with transcription factor expression. Analysis of promoter methylation patterns correlated with lineage for corticotrophs and Pit1 lineage subtypes. However, the gonadotrophic genes did not show a distinct promoter methylation pattern in gonadotroph tumors compared to other lineages. Promoter of the NR5A1 gene, which encodes SF1, was hypermethylated across all PitNETs clinical and molecular subtypes including gonadotrophs with strong SF1 protein expression indicating alternative epigenetic regulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that classification of PitNETs may benefit from DNA methylation for clinicopathological stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noaf109","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T07:39:53Z","timestamp":1745307593000},"page":"2341-2354","source":"Crossref","is-referenced-by-count":12,"title":["DNA methylation profiling of pituitary neuroendocrine tumors identifies distinct clinical and pathological subtypes based on epigenetic differentiation"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0917-4759","authenticated-orcid":false,"given":"Sarra","family":"Belakhoua","sequence":"first","affiliation":[{"name":"Department of Pathology, NYU Grossman School of Medicine, NYU Langone Health , New York, New York 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varshini","family":"Vasudevaraja","sequence":"additional","affiliation":[{"name":"Department of Pathology, NYU Grossman School of Medicine, NYU Langone Health , New York, New York 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanel","family":"Schroff","sequence":"additional","affiliation":[{"name":"Department of Pathology, NYU Grossman School of Medicine, NYU Langone Health , New York, New York 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristyn","family":"Galbraith","sequence":"additional","affiliation":[{"name":"Department of Pathology, NYU Grossman School of Medicine, NYU Langone Health , New York, New York 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9249-5498","authenticated-orcid":false,"given":"Misha","family":"Movahed-Ezazi","sequence":"additional","affiliation":[{"name":"Department of Pathology, NYU Grossman School of Medicine, NYU Langone Health , New York, New York 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2839-9573","authenticated-orcid":false,"given":"Jonathan","family":"Serrano","sequence":"additional","affiliation":[{"name":"Department of Pathology, NYU Grossman School of Medicine, NYU Langone Health , New York, New York 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, NYU Grossman School of Medicine, NYU Langone Health , New York, New York 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Orringer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NYU Grossman School of Medicine, NYU Langone Health , New York, New York 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4221-0180","authenticated-orcid":false,"given":"John G","family":"Golfinos","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NYU Grossman School of Medicine, NYU Langone Health , New York, New York 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NYU Grossman School of Medicine, NYU Langone Health , New York, New York 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Pacione","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NYU Grossman School of Medicine, NYU Langone Health , New York, New York 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6024-9236","authenticated-orcid":false,"given":"Nidhi","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Medicine, NYU Grossman School of Medicine, NYU Langone Health , New York, New York 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0752-0917","authenticated-orcid":false,"given":"Matija","family":"Snuderl","sequence":"additional","affiliation":[{"name":"Laura and Isaac Perlmutter Cancer Center, NYU Langone Health , New York, New York 10016 ,","place":["USA"]},{"name":"Department of Pathology, NYU Grossman School of Medicine, NYU Langone Health , New York, New York 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"issue":"5563","key":"2025101514180137200_CIT0001","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1126\/science.1062736","article-title":"Pituitary development: regulatory codes in mammalian organogenesis","volume":"295","author":"Scully","year":"2002","journal-title":"Science."},{"key":"2025101514180137200_CIT0002","doi-asserted-by":"crossref","first-page":"113344","DOI":"10.1016\/j.ygcen.2019.113344","article-title":"Gonadotrope plasticity at cellular, population and structural levels: a comparison between fishes and mammals","volume":"287","author":"Fontaine","year":"2020","journal-title":"Gen Comp Endocrinol."},{"issue":"11","key":"2025101514180137200_CIT0003","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nrc926","article-title":"The pathogenesis of pituitary tumours","volume":"2","author":"Asa","year":"2002","journal-title":"Nat Rev Cancer."},{"issue":"11","key":"2025101514180137200_CIT0004","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/cr.2016.114","article-title":"The genome-wide mutational landscape of pituitary adenomas","volume":"26","author":"Song","year":"2016","journal-title":"Cell Res."},{"issue":"6","key":"2025101514180137200_CIT0005","doi-asserted-by":"crossref","first-page":"R235","DOI":"10.1530\/EJE-19-0602","article-title":"Somatic and germline mutations in the pathogenesis of pituitary adenomas","volume":"181","author":"Vandeva","year":"2019","journal-title":"Eur J Endocrinol."},{"issue":"5","key":"2025101514180137200_CIT0006","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nrendo.2011.40","article-title":"Pathogenesis of pituitary tumors","volume":"7","author":"Melmed","year":"2011","journal-title":"Nat Rev Endocrinol."},{"issue":"1","key":"2025101514180137200_CIT0007","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s12022-022-09703-7","article-title":"Overview of the 2022 WHO Classification of Pituitary Tumors","volume":"33","author":"Asa","year":"2022","journal-title":"Endocr Pathol."},{"issue":"4","key":"2025101514180137200_CIT0008","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/s41379-018-0167-7","article-title":"GATA3 immunoreactivity expands the transcription factor profile of pituitary neuroendocrine tumors","volume":"32","author":"Mete","year":"2019","journal-title":"Mod Pathol."},{"issue":"7697","key":"2025101514180137200_CIT0009","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature26000","article-title":"DNA methylation-based classification of central nervous system tumours","volume":"555","author":"Capper","year":"2018","journal-title":"Nature."},{"issue":"5","key":"2025101514180137200_CIT0010","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.humpath.2007.10.004","article-title":"Role of Ki-67 proliferation index and p53 expression in predicting progression of pituitary adenomas","volume":"39","author":"Gejman","year":"2008","journal-title":"Hum Pathol."},{"key":"2025101514180137200_CIT0011","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-4939-7659-1_2","article-title":"Whole genome DNA methylation analysis of human glioblastoma using Illumina BeadArrays","volume":"1741","author":"Serrano","year":"2018","journal-title":"Methods Mol Biol."},{"issue":"10","key":"2025101514180137200_CIT0012","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays","volume":"30","author":"Aryee","year":"2014","journal-title":"Bioinformatics."},{"issue":"18","key":"2025101514180137200_CIT0013","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics."},{"issue":"7","key":"2025101514180137200_CIT0014","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrg3230","article-title":"Functions of DNA methylation: islands, start sites, gene bodies and beyond","volume":"13","author":"Jones","year":"2012","journal-title":"Nat Rev Genet."},{"issue":"2","key":"2025101514180137200_CIT0015","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1530\/JOE-12-0229","article-title":"Pituitary development: a complex, temporal regulated process dependent on specific transcriptional factors","volume":"215","author":"De Moraes","year":"2012","journal-title":"J Endocrinol."},{"issue":"7","key":"2025101514180137200_CIT0016","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1158\/1078-0432.CCR-16-0790","article-title":"Landscape of genomic alterations in pituitary adenomas","volume":"23","author":"Bi","year":"2017","journal-title":"Clin Cancer Res"},{"issue":"1","key":"2025101514180137200_CIT0017","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/MED.0b013e328320d845","article-title":"Genetics and molecular pathology of neuroendocrine gastrointestinal and pancreatic tumors (gastroenteropancreatic neuroendocrine tumors)","volume":"16","author":"Oberg","year":"2009","journal-title":"Curr Opin Endocrinol Diabetes Obes."},{"issue":"5","key":"2025101514180137200_CIT0018","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.beem.2009.05.004","article-title":"The pathophysiology of pituitary adenomas","volume":"23","author":"Dworakowska","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab."},{"issue":"1","key":"2025101514180137200_CIT0019","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13073-023-01267-3","article-title":"Single-cell transcriptomic analysis reveals tumor cell heterogeneity and immune microenvironment features of pituitary neuroendocrine tumors","volume":"16","author":"Yan","year":"2024","journal-title":"Genome Med."},{"issue":"1","key":"2025101514180137200_CIT0020","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1101\/gad.947102","article-title":"DNA methylation patterns and epigenetic memory","volume":"16","author":"Bird","year":"2002","journal-title":"Genes Dev."},{"issue":"7","key":"2025101514180137200_CIT0021","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1210\/jc.2018-00688","article-title":"Clinical and pathological aspects of silent pituitary adenomas","volume":"104","author":"Drummond","year":"2019","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2025101514180137200_CIT0022","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11102-017-0855-1","article-title":"Histopathological classification of non-functioning pituitary neuroendocrine tumors","volume":"21","author":"Manojlovic-Gacic","year":"2018","journal-title":"Pituitary"},{"issue":"1","key":"2025101514180137200_CIT0023","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00401-024-02686-1","article-title":"Pituitary neuroendocrine tumors with PIT1\/SF1 co-expression show distinct clinicopathological and molecular features","volume":"147","author":"Dottermusch","year":"2024","journal-title":"Acta Neuropathol."},{"issue":"1","key":"2025101514180137200_CIT0024","doi-asserted-by":"crossref","first-page":"e12870","DOI":"10.1111\/nan.12870","article-title":"Unveiling the identities of null cell tumours: epigenomics corroborate subtle histological cues in pituitary neuroendocrine tumour\/adenoma classification","volume":"49","author":"Dottermusch","year":"2023","journal-title":"Neuropathol Appl Neurobiol."},{"issue":"6","key":"2025101514180137200_CIT0025","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1007\/s11102-021-01164-1","article-title":"Double adenomas of the pituitary reveal distinct lineage markers, copy number alterations, and epigenetic profiles","volume":"24","author":"Hagel","year":"2021","journal-title":"Pituitary"},{"issue":"1","key":"2025101514180137200_CIT0026","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00401-020-02149-3","article-title":"Genome-wide DNA methylation profiles distinguish silent from non-silent ACTH adenomas","volume":"140","author":"Ricklefs","year":"2020","journal-title":"Acta Neuropathol."},{"issue":"1","key":"2025101514180137200_CIT0027","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ccell.2019.11.002","article-title":"Pangenomic classification of pituitary neuroendocrine tumors","volume":"37","author":"Neou","year":"2020","journal-title":"Cancer Cell"},{"issue":"3","key":"2025101514180137200_CIT0028","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s12022-021-09671-4","article-title":"The pangenomic classification of pituitary neuroendocrine tumors: quality histopathology is required for accurate translational research","volume":"32","author":"Mete","year":"2021","journal-title":"Endocr Pathol."},{"issue":"2","key":"2025101514180137200_CIT0029","doi-asserted-by":"crossref","first-page":"100934","DOI":"10.1016\/j.xcrm.2023.100934","article-title":"Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET","volume":"4","author":"Zhang","year":"2023","journal-title":"Cell Rep Med"},{"issue":"11","key":"2025101514180137200_CIT0030","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1093\/neuonc\/noab102","article-title":"Single-cell transcriptome and genome analyses of pituitary neuroendocrine tumors","volume":"23","author":"Cui","year":"2021","journal-title":"Neuro Oncol"},{"issue":"12","key":"2025101514180137200_CIT0031","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/s41422-022-00736-5","article-title":"Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumors","volume":"32","author":"Zhang","year":"2022","journal-title":"Cell Res."},{"issue":"6","key":"2025101514180137200_CIT0032","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1210\/clinem\/dgac703","article-title":"Integrating methylome and transcriptome signatures expands the molecular classification of the pituitary tumors","volume":"108","author":"Silva-Junior","year":"2023","journal-title":"J Clin Endocrinol Metab."},{"issue":"8","key":"2025101514180137200_CIT0033","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1093\/neuonc\/noab044","article-title":"DNA methylation-based signatures classify sporadic pituitary tumors according to clinicopathological features","volume":"23","author":"Mosella","year":"2021","journal-title":"Neuro Oncol"},{"issue":"1","key":"2025101514180137200_CIT0034","first-page":"vdad076","article-title":"Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors\u2014a prospective study and guidelines for clinical testing","volume":"5","author":"Galbraith","year":"2023","journal-title":"Neurooncol Adv."},{"issue":"1","key":"2025101514180137200_CIT0035","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.1038\/s41467-020-19012-4","article-title":"Single-cell transcriptomics identifies divergent developmental lineage trajectories during human pituitary development","volume":"11","author":"Zhang","year":"2020","journal-title":"Nat Commun."},{"issue":"10","key":"2025101514180137200_CIT0036","doi-asserted-by":"crossref","first-page":"110467","DOI":"10.1016\/j.celrep.2022.110467","article-title":"Single nucleus transcriptome and chromatin accessibility of postmortem human pituitaries reveal diverse stem cell regulatory mechanisms","volume":"38","author":"Zhang","year":"2022","journal-title":"Cell Rep"},{"issue":"8","key":"2025101514180137200_CIT0037","doi-asserted-by":"crossref","first-page":"e13169","DOI":"10.1111\/jne.13169","article-title":"Aggressive corticotroph tumors and carcinomas","volume":"34","author":"Lasolle","year":"2022","journal-title":"J Neuroendocrinol."},{"issue":"1","key":"2025101514180137200_CIT0038","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00401-024-02836-5","article-title":"Genome-wide methylation profiling differentiates benign from aggressive and metastatic pituitary neuroendocrine tumors","volume":"148","author":"Jotanovic","year":"2024","journal-title":"Acta Neuropathol."},{"key":"2025101514180137200_CIT0039","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/msb.2009.93","article-title":"A global view of protein expression in human cells, tissues, and organs","volume":"5","author":"Ponten","year":"2009","journal-title":"Mol Syst Biol."},{"issue":"1","key":"2025101514180137200_CIT0040","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00401-024-02736-8","article-title":"Genome-wide loss of heterozygosity predicts aggressive, treatment-refractory behavior in pituitary neuroendocrine tumors","volume":"147","author":"Lin","year":"2024","journal-title":"Acta Neuropathol."},{"issue":"1","key":"2025101514180137200_CIT0041","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s40478-020-01067-5","article-title":"Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis","volume":"8","author":"Lasolle","year":"2020","journal-title":"Acta Neuropathol Commun"},{"issue":"3","key":"2025101514180137200_CIT0042","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S2213-8587(23)00382-0","article-title":"A proposed clinical classification for pituitary neoplasms to guide therapy and prognosis","volume":"12","author":"Ho","year":"2024","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"11","key":"2025101514180137200_CIT0043","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41574-023-00883-8","article-title":"Pituitary adenoma or neuroendocrine tumour: the need for an integrated prognostic classification","volume":"19","author":"Ho","year":"2023","journal-title":"Nat Rev Endocrinol."}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/advance-article-pdf\/doi\/10.1093\/neuonc\/noaf109\/63024755\/noaf109.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/27\/9\/2341\/63024755\/noaf109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/27\/9\/2341\/63024755\/noaf109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:18:16Z","timestamp":1760552296000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article\/27\/9\/2341\/8121431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":43,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,4,29]]},"published-print":{"date-parts":[[2025,10,14]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/noaf109","relation":{},"ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2025,4,29]]}}}