{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:52:47Z","timestamp":1785851567027,"version":"3.56.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010441","name":"Medical Faculty of Heidelberg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010441","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Else Kr\u00f6ner Fresenius Foundation","award":["2023_EKMS.27"],"award-info":[{"award-number":["2023_EKMS.27"]}]},{"name":"German Consortium for Translational Cancer Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Meningiomas represent the most common primary intracranial tumors in adults, with World Health Organization (WHO) grade 1 typically associated with favorable outcomes following gross total resection (GTR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective study included patients with CNS WHO grade 1 meningioma and available DNA methylation profiles (n\u2005=\u2005210). Clinical tumor characteristics and treatment course (eg, surgical resection, extent of resection, radiotherapy [RT]) were evaluated. Integrated Scores (InS) were calculated based on methylation family using the DKFZ brain tumor classifier, CNS WHO grading, and chromosomal losses, categorized as low, intermediate, or high. Survival analyses employed Kaplan\u2013Meier and Cox regression methods, with local PFS defined as the primary endpoint.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In newly diagnosed cases, GTR was associated with a 93.0% 3-year progression-free survival (PFS), compared to 69.3% following subtotal resection (STR). Stratification by IntS showed that patients in the IntS-low group had superior outcomes: 3-year PFS of 93.4 after GTR and 77.4% after STR. In contrast, patients with IntS-intermediate\/high profiles showed significantly worse outcomes, with PFS of 85.9% after GTR and 40.0% after STR. Following tumor recurrence, particularly those with IntS-intermediate\/high, postoperative RT after STR may improve 3-year PFS to 88.9%, compared to much lower PFS rates in newly diagnosed cases managed without adjuvant RT after STR (3-year PFS: 40.0%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our findings highlight the combined impact of both the extent of resection and molecular risk profile on prognosis in newly diagnosed cases. While conservative management is feasible in lower-risk primary cases, recurrent or higher-risk patients may benefit from early postoperative RT.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/neuonc\/noaf125","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T16:28:36Z","timestamp":1748363316000},"page":"2370-2381","source":"Crossref","is-referenced-by-count":3,"title":["Postoperative radiotherapy in subtotally resected recurrent WHO grade 1 meningiomas with intermediate-\/high-risk molecular profiles"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4925-7600","authenticated-orcid":false,"given":"Maximilian Y","family":"Deng","sequence":"first","affiliation":[{"name":"Hopp Children\u2019s Cancer Center Heidelberg (KiTZ) , Heidelberg ,","place":["Germany"]},{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sybren L N","family":"Maas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasmus MC Cancer Institute, University Medical Center Rotterdam , Rotterdam ,","place":["The Netherlands"]},{"name":"Department of Pathology, Leiden University Medical Center , Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnes","family":"Anil","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital, Heidelberg University , Heidelberg ,","place":["Germany"]},{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg 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Heidelberg University , Heidelberg ,","place":["Germany"]},{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Seidensaal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital, Heidelberg University , Heidelberg ,","place":["Germany"]},{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"H\u00f6rner-Rieber","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Hospital D\u00fcsseldorf , D\u00fcsseldorf ,","place":["Germany"]},{"name":"Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ) , Heidelberg ,","place":["Germany"]},{"name":"Department of Radiation Oncology, Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital, Heidelberg University , Heidelberg ,","place":["Germany"]},{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg University , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan M","family":"Pfister","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) , Heidelberg ,","place":["Germany"]},{"name":"Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg , Heidelberg ,","place":["Germany"]},{"name":"Hopp Children\u2019s Cancer Center Heidelberg (KiTZ) , Heidelberg 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