{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T11:44:20Z","timestamp":1793187860355,"version":"4.5.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malignant peripheral nerve sheath tumors (MPNSTs) are rare, aggressive sarcomas, with 40% associated with neurofibromatosis type 1 (NF1). Surgical excision is the main treatment for localized disease; however, local recurrence (LR) remains high. Radiotherapy (RTx) is increasingly used to enhance local control in STS, but its use remains controversial due to the potential for increased major wound complications and an increased risk of secondary malignancies in NF1 patients. This study investigated the use and impact of RTx on local control in MPNSTs, particularly in the NF1 setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Surgically treated primary MPNSTs from 1988 to 2019 in the MONACO multicenter cohort were included. Differences in demographics, treatment, and RTx use between NF1 and non-NF1 cases were examined. Factors influencing RTx administration and LR were assessed via multivariable analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 499 patients (33.1% NF1), 143 (28.7%) experienced LRs. Radiotherapy was administered to 56.3% of patients (57.0% in the NF1 group), with 27.3% receiving neoadjuvant and 72.7% adjuvant RTx. RTx was administered significantly more often to high-grade and extremity tumors. While RTx did not affect overall survival, it reduced LR risk in sporadic cases (hazard ratio [HR] 0.530; 95% confidence interval [CI], 0.354\u20130.793) but not in the NF1 subgroup (HR 1.00; 95% CI, 0.545\u20131.85). In NF1 patients, a microscopically positive margin (R1) was the only risk factor for LR development (HR 2.1; 95% CI, 1.19\u20133.79).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RTx is frequently used in the treatment of MPNSTs, regardless of NF1 status. While it may affect the LR rate in sporadic cases, its impact on NF1 patients is less clear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noaf186","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T11:33:48Z","timestamp":1754393628000},"page":"3214-3223","source":"Crossref","is-referenced-by-count":6,"title":["The role of radiotherapy in MPNST and the impact of NF1 status on outcomes: Insights from a multicenter cohort study"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5881-9316","authenticated-orcid":false,"given":"Christianne Y M N","family":"Jansma","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]},{"name":"Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J","family":"Gr\u00fcnhagen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta E","family":"Flucke","sequence":"additional","affiliation":[{"name":"Department of Pathology, Radboud University Medical Center , Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem-Bart M","family":"Slooff","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thijs","family":"van Dalen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas B","family":"Been","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Center Groningen , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han J","family":"Bonenkamp","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Radboud University Medical Center , Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique H M E","family":"Anten","sequence":"additional","affiliation":[{"name":"Department of Neurology, Maastricht University Medical Center+ , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8834-2202","authenticated-orcid":false,"given":"Martinus P G","family":"Broen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Maastricht University Medical Center+ , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc H A","family":"Bemelmans","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Maastricht University Medical Center+ , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos A M","family":"Bramer","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Amsterdam University Medical Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard R","family":"Schaap","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Amsterdam University Medical Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur J","family":"Kievit","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Amsterdam University Medical Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winan J","family":"van Houdt","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, The Netherlands Cancer Institute , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos","family":"van der Hage","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Leiden University Medical Center , Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel A J","family":"van de Sande","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Oncology, Leiden University Medical Center , Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Pendleton","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mayo Clinic , Rochester, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Spinner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mayo Clinic , Rochester, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2417-7794","authenticated-orcid":false,"given":"J Henk","family":"Coert","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9980-8613","authenticated-orcid":false,"given":"Cornelis","family":"Verhoef","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5530-7259","authenticated-orcid":false,"given":"Walter","family":"Taal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus MC Cancer Institute , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"issue":"10","key":"2026021901461776900_CIT0001","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1177\/014556131109001015","article-title":"Report of a case of malignant peripheral nerve sheath tumor of the neck with an early local recurrence","volume":"90","author":"Edizer","year":"2011","journal-title":"Ear Nose Throat J"},{"issue":"3","key":"2026021901461776900_CIT0002","first-page":"3072","article-title":"Recurrent epithelioid malignant peripheral nerve sheath tumor with neurofibromatosis type 1: a case report and literature review","volume":"18","author":"Du","year":"2019","journal-title":"Oncolo Lett"},{"issue":"4","key":"2026021901461776900_CIT0003","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.soc.2016.05.009","article-title":"Malignant peripheral nerve sheath tumor","volume":"25","author":"James","year":"2016","journal-title":"Surg Oncol Clin N Am."},{"issue":"4","key":"2026021901461776900_CIT0004","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/neuonc\/noaa280","article-title":"A Bayesian approach for diagnostic accuracy of malignant peripheral nerve sheath tumors: a systematic review and meta-analysis","volume":"23","author":"Martin","year":"2021","journal-title":"Neuro-Oncology."},{"issue":"3","key":"2026021901461776900_CIT0005","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s11060-021-03936-y","article-title":"Diagnostic value of 18F-FDG PET-CT in detecting malignant peripheral nerve sheath tumors among adult and pediatric neurofibromatosis type 1 patients","volume":"156","author":"Geitenbeek","year":"2022","journal-title":"J Neurooncol."},{"issue":"17","key":"2026021901461776900_CIT0006","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1200\/JCO.2015.65.3576","article-title":"Distinctive cancer associations in patients with neurofibromatosis type 1","volume":"34","author":"Uusitalo","year":"2016","journal-title":"J Clin Oncol"},{"issue":"4","key":"2026021901461776900_CIT0007","first-page":"324","article-title":"Radiation therapy in management of sporadic and neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors","volume":"4","author":"Kahn","year":"2014","journal-title":"Front Oncol."},{"issue":"5","key":"2026021901461776900_CIT0008","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/COC.0000000000000303","article-title":"Malignant peripheral nerve sheath tumors: a single institution\u2019s experience using combined surgery and radiation therapy","volume":"41","author":"Bishop","year":"2018","journal-title":"Am J Clin Oncol."},{"issue":"35","key":"2026021901461776900_CIT0009","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.suronc.2020.09.011","article-title":"Malignant peripheral nerve sheath tumors\u2013outcomes and prognostic factors based on the reference center experience","volume":"35","author":"Sobczuk","year":"2020","journal-title":"Surg Oncol."},{"issue":"Suppl 1","key":"2026021901461776900_CIT0010","first-page":"i40","article-title":"Diagnosis and management of malignant peripheral nerve sheath tumors: current practice and future perspectives","volume":"2","author":"Prudner","year":"2020","journal-title":"Neurooncol. Adv.."},{"issue":"11","key":"2026021901461776900_CIT0011","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.annonc.2021.07.006","article-title":"EURACAN and GENTURIS. Electronic address: clinicalguidelines@ esmo. org. Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"32","author":"Gronchi","year":"2021","journal-title":"Ann Oncol."},{"issue":"20","key":"2026021901461776900_CIT0012","doi-asserted-by":"crossref","first-page":"17739","DOI":"10.1007\/s00432-023-05449-9","article-title":"The role of radiotherapy in the management of malignant peripheral nerve sheath tumors: a single-center retrospective cohort study","volume":"149","author":"Roohani","year":"2023","journal-title":"J Cancer Res Clin Oncol."},{"issue":"2","key":"2026021901461776900_CIT0013","first-page":"95","article-title":"WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition","volume":"46","author":"Jo","year":"2014","journal-title":"Pathology (Phila)."},{"key":"2026021901461776900_CIT0014","first-page":"281","article-title":"Grading of patients for surgical procedures","author":"Saklad","year":"1941"},{"issue":"5","key":"2026021901461776900_CIT0015","first-page":"575","article-title":"Conference statement. National Institutes of Health Consensus Development Conference","volume":"45","author":"Neurofibromatosis","year":"1988","journal-title":"Arch Neurol."},{"issue":"10","key":"2026021901461776900_CIT0016","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.5858\/2006-130-1448-GOSTSR","article-title":"Grading of soft tissue sarcomas: review and update","volume":"130","author":"Coindre","year":"2006","journal-title":"Arch Pathol Lab Med"},{"issue":"434","key":"2026021901461776900_CIT0017","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1080\/01621459.1996.10476908","article-title":"Multiple imputation after 18+ years","volume":"91","author":"Rubin","year":"1996","journal-title":"J Am Stat Assoc."},{"issue":"124","key":"2026021901461776900_CIT0018","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejca.2019.10.014","article-title":"A nationwide cohort study on treatment and survival in patients with malignant peripheral nerve sheath tumours","volume":"124","author":"Martin","year":"2020","journal-title":"Eur J Cancer"},{"issue":"1","key":"2026021901461776900_CIT0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/6406439","article-title":"Oncological treatment considerations differ across surgical subspecialties treating malignant peripheral nerve sheath tumors: an international survey","volume":"2020","author":"Martin","year":"2020","journal-title":"Sarcoma"},{"issue":"6","key":"2026021901461776900_CIT0020","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.ctrv.2012.10.005","article-title":"Isolated limb perfusion of soft tissue sarcomas: a comprehensive review of literature","volume":"39","author":"Seinen","year":"2013","journal-title":"Cancer Treat Rev."},{"issue":"6","key":"2026021901461776900_CIT0021","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/00000658-199612000-00011","article-title":"Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas: the cumulative multicenter European experience","volume":"224","author":"Eggermont","year":"1996","journal-title":"Ann Surg."},{"issue":"6","key":"2026021901461776900_CIT0022","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/S1470-2045(17)30334-0","article-title":"Histotype-tailored neoadjuvant chemotherapy versus standard chemotherapy in patients with high-risk soft-tissue sarcomas (ISG-STS 1001): an international, open-label, randomised, controlled, phase 3, multicentre trial","volume":"18","author":"Gronchi","year":"2017","journal-title":"Lancet Oncol."},{"issue":"105","key":"2026021901461776900_CIT0023","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejca.2018.09.028","article-title":"Impact of perioperative chemotherapy and radiotherapy in patients with primary extremity soft tissue sarcoma: retrospective analysis across major histological subtypes and major reference centres","volume":"105","author":"Callegaro","year":"2018","journal-title":"Eur J Cancer (Oxford, England : 1990)"},{"issue":"6","key":"2026021901461776900_CIT0024","doi-asserted-by":"crossref","first-page":"758","DOI":"10.6004\/jnccn.2016.0078","article-title":"Soft tissue sarcoma, version 2.2016, NCCN clinical practice guidelines in oncology","volume":"14","author":"Von Mehren","year":"2016","journal-title":"J Nat Compr Canc Netw"},{"issue":"56","key":"2026021901461776900_CIT0025","doi-asserted-by":"crossref","first-page":"101818","DOI":"10.1016\/j.eclinm.2022.101818","article-title":"ERN GENTURIS tumour surveillance guidelines for individuals with neurofibromatosis type 1","volume":"56","author":"Carton","year":"2023","journal-title":"EClinicalMedicine"},{"issue":"1","key":"2026021901461776900_CIT0026","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1200\/JCO.1998.16.1.197","article-title":"Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity","volume":"16","author":"Yang","year":"1998","journal-title":"J Clin Oncol."},{"issue":"2","key":"2026021901461776900_CIT0027","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0360-3016(98)00223-5","article-title":"Malignant peripheral nerve sheath tumor: analysis of treatment outcome","volume":"42","author":"Wong","year":"1998","journal-title":"Int J Radiation Oncol Biol Phys"},{"issue":"2","key":"2026021901461776900_CIT0028","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/neuonc\/nos287","article-title":"Survival meta-analyses for&gt; 1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1","volume":"15","author":"Kolberg","year":"2013","journal-title":"Neuro-Oncology."},{"issue":"1","key":"2026021901461776900_CIT0029","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/(SICI)1096-9896(200001)190:1<31::AID-PATH505>3.0.CO;2-#","article-title":"Cytogenetic characterization of peripheral nerve sheath tumours: a report of the CHAMP study group","volume":"190","author":"Mertens","year":"2000","journal-title":"J Pathol."},{"issue":"1","key":"2026021901461776900_CIT0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/00005072-199501000-00008","article-title":"Alterations at chromosome 17 loci in peripheral nerve sheath tumors","volume":"54","author":"Lothe","year":"1995","journal-title":"J Neuropathol Exp Neurol."},{"issue":"4","key":"2026021901461776900_CIT0031","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/(SICI)1098-2264(199908)25:4<362::AID-GCC8>3.0.CO;2-Q","article-title":"Analysis of chromosomal imbalances in sporadic and NF1-associated peripheral nerve sheath tumors by comparative genomic hybridization","volume":"25","author":"Mechtersheimer","year":"1999","journal-title":"Genes Chromosomes Cancer."},{"issue":"2","key":"2026021901461776900_CIT0032","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/(SICI)1097-0215(19991008)83:2<171::AID-IJC5>3.0.CO;2-S","article-title":"Computer-assisted cytogenetic analysis of 51 malignant peripheral-nerve-sheath tumors: sporadic vs. neurofibromatosis-type-1-associated malignant schwannomas","volume":"83","author":"Plaat","year":"1999","journal-title":"Int J Cancer."},{"issue":"1","key":"2026021901461776900_CIT0033","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/path.1101","article-title":"Frequent genomic imbalances in chromosomes 17, 19, and 22q in peripheral nerve sheath tumours detected by comparative genomic hybridization analysis","volume":"197","author":"Koga","year":"2002","journal-title":"J Pathol."},{"issue":"3","key":"2026021901461776900_CIT0034","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1750-3639.2004.tb00067.x","article-title":"Gene expression profiling reveals unique molecular subtypes of neurofibromatosis type I-associated and sporadic malignant peripheral nerve sheath tumors","volume":"14","author":"Watson","year":"2004","journal-title":"Brain Pathol."},{"issue":"4","key":"2026021901461776900_CIT0035","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/gcc.2870100405","article-title":"TP53 mutations are frequent in malignant NFI tumors","volume":"10","author":"Legius","year":"1994","journal-title":"Genes Chromosomes Cancer."},{"issue":"7","key":"2026021901461776900_CIT0036","first-page":"908","article-title":"Malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1: a clinicopathologic and molecular study of 17 patients","volume":"137","author":"Leroy","year":"2001","journal-title":"Arch Dermatol."},{"issue":"6","key":"2026021901461776900_CIT0037","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/labinvest.3780293","article-title":"Rb and TP53 pathway alterations in sporadic and NF1-related malignant peripheral nerve sheath tumors","volume":"81","author":"Birindelli","year":"2001","journal-title":"Lab Invest"},{"issue":"1A","key":"2026021901461776900_CIT0038","first-page":"183","article-title":"The p53 gene in soft tissue sarcomas: prognostic value of DNA sequencing versus immunohistochemistry","volume":"18","author":"Taubert","year":"1998","journal-title":"Anticancer Res."},{"issue":"2","key":"2026021901461776900_CIT0039","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1046\/j.1365-2559.2001.01176.x","article-title":"Malignant peripheral nerve sheath tumours: high Ki67 labelling index is the significant prognostic indicator","volume":"39","author":"Watanabe","year":"2001","journal-title":"Histopathology."},{"issue":"2","key":"2026021901461776900_CIT0040","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/1098-2264(2000)9999:9999<::AID-GCC1079>3.0.CO;2-5","article-title":"Biallelic inactivation of TP53 rarely contributes to the development of malignant peripheral nerve sheath tumors","volume":"30","author":"Lothe","year":"2001","journal-title":"Genes Chromosomes Cancer."},{"issue":"6","key":"2026021901461776900_CIT0041","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1097\/SLA.0b013e3181a77e9a","article-title":"Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome","volume":"249","author":"Zou","year":"2009","journal-title":"Ann Surg."},{"issue":"3","key":"2026021901461776900_CIT0042","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1245\/s10434-011-1978-7","article-title":"Malignant peripheral nerve sheath tumors (MPNST): the Mayo Clinic experience","volume":"19","author":"Stucky","year":"2012","journal-title":"Ann Surg Oncol."},{"issue":"16","key":"2026021901461776900_CIT0043","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJM198810203191601","article-title":"Tumors of the brain and nervous system after radiotherapy in childhood","volume":"319","author":"Ron","year":"1988","journal-title":"N Engl J Med."},{"issue":"4","key":"2026021901461776900_CIT0044","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1136\/jmg.2005.036319","article-title":"Malignant transformation and new primary tumours after therapeutic radiation for benign disease: substantial risks in certain tumour prone syndromes","volume":"43","author":"Evans","year":"2006","journal-title":"J Med Genet."},{"issue":"5","key":"2026021901461776900_CIT0045","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/jmg.39.5.311","article-title":"Malignant peripheral nerve sheath tumours in neurofibromatosis 1","volume":"39","author":"Evans","year":"2002","journal-title":"J Med Genet."},{"issue":"105","key":"2026021901461776900_CIT0046","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.wneu.2017.06.010","article-title":"Radiation-induced malignant peripheral nerve sheath tumors: a systematic review","volume":"105","author":"Yamanaka","year":"2017","journal-title":"World Neurosurg"},{"issue":"2","key":"2026021901461776900_CIT0047","doi-asserted-by":"crossref","first-page":"zrae024","DOI":"10.1093\/bjsopen\/zrae024","article-title":"Local recurrence in malignant peripheral nerve sheath tumours: multicentre cohort study","volume":"8","author":"Jansma","year":"2024","journal-title":"BJS Open"}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/advance-article-pdf\/doi\/10.1093\/neuonc\/noaf186\/64000548\/noaf186.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/27\/12\/3214\/64000548\/noaf186.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/27\/12\/3214\/64000548\/noaf186.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:46:32Z","timestamp":1771483592000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article\/27\/12\/3214\/8230197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,9]]},"references-count":47,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,8,9]]},"published-print":{"date-parts":[[2025,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/noaf186","relation":{},"ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,8,9]]}}}