{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T21:17:55Z","timestamp":1776374275584,"version":"3.51.2"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"U.S. was supported by the Deutsche Forschungsgemeinschaft"},{"name":"F\u00f6rdergemeinschaft Kinderkrebszentrum Hamburg"},{"DOI":"10.13039\/100010124","name":"Erich und Gertrud Roggenbuck-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010124","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The 2 most prevalent types of spinal ependymal tumors are myxopapillary ependymomas (MPE) and spinal ependymomas (SP-EPN). Based on molecular data from bulk tumor samples, we previously identified clinically relevant subtypes with poor (MPE-A; SP-EPN-A) and favorable progression-free survival (MPE-B; SP-EPN-B). However, detailed cellular composition, molecular heterogeneity, and features of tumor progression are largely unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed singlenucleus transcriptomic sequencing of 25 formalin-fixed and paraffin-embedded spinal ependymal tumors, including all MPE and SP-EPN subtypes and 6 paired primary and relapsed MPE-A.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ependymoma subtypes presented with a broad, but comparable tumor microenvironment. Furthermore, neoplastic cells demonstrated inter- and intratumoral heterogeneity regarding cancer cell state composition. Overall, MPE tumors exhibited a significantly higher abundance of the astrocytic state, whereas a ciliated state was more prevalent in SP-EPN. Also, transcriptome-inferred copy number variation (CNV) profiles revealed tumor cell clusters with distinct chromosomal alterations across tumors, suggesting subclonal neoplastic growth. Compared to normal human spinal cord cell populations, MPE tumor cells displayed similarities to astrocytes and ependymal cells, whereas SP-EPN exclusively matched ependymal cells. Myxopapillary ependymomas of type A demonstrated a distinct profile, being similar to the roof and floor plate of the developing spinal cord. Paired primary and relapsed MPE-A revealed mostly similar histology, epigenetics, CNV profiles, and cellular composition of neoplastic cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Single-nucleus transcriptomic sequencing provides valuable insights into the molecular composition of spinal ependymoma types and subtypes and may pave the way for a better understanding of tumor evolution and identification of therapeutic targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noaf210","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T11:29:41Z","timestamp":1757417381000},"page":"86-98","source":"Crossref","is-referenced-by-count":1,"title":["Single-nucleus transcriptomics of spinal ependymoma subtypes recognizes intratumoral heterogeneity"],"prefix":"10.1093","volume":"28","author":[{"given":"Karoline","family":"Hack","sequence":"first","affiliation":[{"name":"Research Institute Children\u2019s Cancer Center (K.H., C.K., M.S., U.S.)","place":["Germany"]},{"name":"Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf (K.H., C.K., M.S., U.S.)","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia-Larissa","family":"Jauch-Speer","sequence":"additional","affiliation":[{"name":"Single Cell Core Facility, University Medical \u00adCenter Hamburg-Eppendorf (S.-L.J.)","place":["Germany"]},{"name":"III. 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