{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:31:22Z","timestamp":1792103482389,"version":"4.4.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172820"],"award-info":[{"award-number":["82172820"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Shanghai","award":["22ZR1466200"],"award-info":[{"award-number":["22ZR1466200"]}]},{"name":"Clinical Research Special Funding of the Shanghai Municipal Health Commission","award":["202340112"],"award-info":[{"award-number":["202340112"]}]},{"name":"Research Funds for the Central Universities","award":["22120250457"],"award-info":[{"award-number":["22120250457"]}]},{"name":"Research Funds for the Central Universities","award":["22120240228"],"award-info":[{"award-number":["22120240228"]}]},{"name":"Key Disciplines Group Construction Project of Shanghai Pudong New Area Health Commission","award":["PWZxq2022-10"],"award-info":[{"award-number":["PWZxq2022-10"]}]},{"name":"Key Discipline Construction Project of Shanghai East Hospital","award":["2024-DFZD-003S"],"award-info":[{"award-number":["2024-DFZD-003S"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Temozolomide (TMZ) resistance remains the major obstacle in the treatment of glioblastoma (GBM). We previously found that the super-enhancer (SE) complex is involved in the regulation of genes related to tumor biology, but its mechanisms in mediating TMZ resistance in GBM remain poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Comprehensive in vitro and in vivo functional experiments were conducted using patient-derived cells (PDCs), patient-derived organoids, and PDCs xenograft models. Cleavage Under Targets and Tagmentation, chromatin immunoprecipitation, co-immunoprecipitation, mass spectrometry, protein fragment complementation assay, dual-luciferase reporter assay, fluorescence polarization assay, and surface plasmon resonance assay were employed to unravel the molecular mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that SOX2 is significantly upregulated in TMZ-resistant PDCs and associated with the poor prognosis of recurrent GBM patients. Moreover, inhibition of SOX2 enhanced TMZ-induced apoptosis and DNA damage response, thereby promoting TMZ chemosensitivity. Mechanically, we identified PDGFB as a novel SE-associated oncogene mediated by SOX2. SE complex SOX2 and HDAC1 were recruited together to the SE region of PDGFB, synergistically triggering the PDGFB-MAPK\/PI3K signaling axis and ultimately promoting TMZ resistance. Notably, virtual screening targeting the critical interaction domain between SOX2 and HDAC1 identified the FDA-approved drug fluvastatin as a potent SOX2 inhibitor that effectively sensitizes GBM cells to TMZ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Targeting the SE complex enhances TMZ chemosensitivity in GBM, providing a promising therapeutic avenue to overcome drug resistance and improve clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noaf219","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T12:06:57Z","timestamp":1757678817000},"page":"55-69","source":"Crossref","is-referenced-by-count":5,"title":["Co-activation of the super-enhancer complex SOX2 and HDAC1 confers temozolomide resistance by promoting PDGFB transcription in glioblastoma"],"prefix":"10.1093","volume":"28","author":[{"given":"Han","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai, 200120, (H.X., T.J., C.Z., M.C., R.W., Y.W., J.W., H.W., J.Y., S.X., M.L., J.Z., C.Z.)","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongjie","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai, 200120, (H.X., T.J., C.Z., M.C., R.W., Y.W., J.W., H.W., J.Y., S.X., M.L., J.Z., C.Z.)","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai, 200120, (H.X., T.J., C.Z., M.C., R.W., Y.W., J.W., H.W., J.Y., S.X., M.L., J.Z., C.Z.)","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai, 200120, (H.X., T.J., C.Z., M.C., R.W., Y.W., J.W., H.W., J.Y., S.X., M.L., J.Z., C.Z.)","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Advanced Study, Tongji University , Shanghai, 20092, (J.Z.)","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyao","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute for Advanced Study, Tongji University , Shanghai, 20092, (J.Z.)","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Advanced Study, Tongji University , Shanghai, 20092, (J.Z.)","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghao","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Advanced Study, Tongji University , Shanghai, 20092, (J.Z.)","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai, 200120, (H.X., T.J., C.Z., M.C., R.W., Y.W., J.W., H.W., J.Y., S.X., M.L., J.Z., C.Z.)","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai, 200120, (H.X., T.J., C.Z., M.C., R.W., Y.W., J.W., H.W., J.Y., S.X., M.L., J.Z., C.Z.)","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai, 200120, (H.X., T.J., C.Z., M.C., R.W., Y.W., J.W., H.W., J.Y., S.X., M.L., J.Z., C.Z.)","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3155-6768","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai, 200120, (H.X., T.J., C.Z., M.C., R.W., Y.W., J.W., H.W., J.Y., S.X., M.L., J.Z., C.Z.)","place":["China"]},{"name":"State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China"},{"name":"Institute for Advanced Study, Tongji University , Shanghai, 20092, (J.Z.)","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0605-7273","authenticated-orcid":false,"given":"Chunlong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai, 200120, (H.X., T.J., C.Z., M.C., R.W., Y.W., J.W., H.W., J.Y., S.X., M.L., J.Z., C.Z.)","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"2026030516314375600_noaf219-B1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12943-025-02273-2","article-title":"Distant origin of glioblastoma recurrence: neural stem cells in the subventricular zone serve as a source of tumor reconstruction after primary resection","volume":"24","author":"Li","year":"2025","journal-title":"Mol Cancer"},{"key":"2026030516314375600_noaf219-B2","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1001\/jama.2023.0023","article-title":"Glioblastoma and other primary brain malignancies in adults: a review","volume":"329","author":"Schaff","year":"2023","journal-title":"JAMA"},{"key":"2026030516314375600_noaf219-B3","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/neuonc\/noac242","article-title":"A novel compound EPIC-0412 reverses temozolomide resistance via inhibiting DNA repair\/MGMT in glioblastoma","volume":"25","author":"Zhao","year":"2023","journal-title":"Neuro Oncol"},{"key":"2026030516314375600_noaf219-B4","doi-asserted-by":"crossref","first-page":"e2309290","DOI":"10.1002\/advs.202309290","article-title":"Histone H3K9 lactylation confers temozolomide resistance in glioblastoma via LUC7L2-Mediated MLH1 intron retention","volume":"11","author":"Yue","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"2026030516314375600_noaf219-B5","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1093\/neuonc\/noad102","article-title":"EPIC-0307-mediated selective disruption of PRADX-EZH2 interaction and enhancement of temozolomide sensitivity to glioblastoma via inhibiting DNA repair and MGMT","volume":"25","author":"Xin","year":"2023","journal-title":"Neuro Oncol"},{"key":"2026030516314375600_noaf219-B6","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/neuonc\/noae065","article-title":"Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia","volume":"26","author":"Xie","year":"2024","journal-title":"Neuro Oncol"},{"key":"2026030516314375600_noaf219-B7","doi-asserted-by":"crossref","first-page":"eadh1436","DOI":"10.1126\/sciadv.adh1436","article-title":"Enhanced TP53 reactivation disrupts MYC transcriptional program and overcomes venetoclax resistance in acute myeloid leukemias","volume":"9","author":"Nishida","year":"2023","journal-title":"Sci Adv"},{"key":"2026030516314375600_noaf219-B8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s13046-023-02763-5","article-title":"Super-enhancers complexes zoom in transcription in cancer","volume":"42","author":"Wang","year":"2023","journal-title":"J Exp Clin Cancer Res"},{"key":"2026030516314375600_noaf219-B9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41419-023-05892-z","article-title":"Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progression","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis"},{"key":"2026030516314375600_noaf219-B10","doi-asserted-by":"crossref","first-page":"387","DOI":"10.7150\/ijbs.86385","article-title":"KLF7 promotes colon adenocarcinoma progression through the PDGFB signaling pathway","volume":"20","author":"Zhang","year":"2024","journal-title":"Int J Biol Sci"},{"key":"2026030516314375600_noaf219-B11","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.1038\/s41467-020-20136-w","article-title":"Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors","volume":"11","author":"Wang","year":"2020","journal-title":"Nat Commun"},{"key":"2026030516314375600_noaf219-B12","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1038\/s41467-022-31331-2","article-title":"MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma","volume":"13","author":"Tao","year":"2022","journal-title":"Nat Commun"},{"key":"2026030516314375600_noaf219-B13","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1158\/1940-6207.CAPR-19-0211","article-title":"Fluvastatin inhibits HMG-CoA reductase and prevents non-small cell lung carcinogenesis","volume":"12","author":"Zhang","year":"2019","journal-title":"Cancer Prev Res (Phila)"},{"key":"2026030516314375600_noaf219-B14","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1158\/0008-5472.CAN-20-2642","article-title":"Mevalonate pathway inhibition slows breast cancer metastasis via reduced N-glycosylation abundance and branching","volume":"81","author":"Yu","year":"2021","journal-title":"Cancer Res"},{"key":"2026030516314375600_noaf219-B15","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.eururo.2024.05.026","article-title":"Integrative drug screening and multiomic characterization of patient-derived bladder cancer organoids reveal novel molecular correlates of gemcitabine response","volume":"86","author":"Merrill","year":"2024","journal-title":"Eur Urol"},{"key":"2026030516314375600_noaf219-B16","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.stem.2024.08.010","article-title":"The landscape of drug sensitivity and resistance in sarcoma","volume":"31","author":"Al Shihabi","year":"2024","journal-title":"Cell Stem Cell"},{"key":"2026030516314375600_noaf219-B17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/s13046-023-02843-6","article-title":"Albumin-bound paclitaxel augment temozolomide treatment sensitivity of glioblastoma cells by disrupting DNA damage repair and promoting ferroptosis","volume":"42","author":"Qu","year":"2023","journal-title":"J Exp Clin Cancer Res"},{"key":"2026030516314375600_noaf219-B18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12943-025-02267-0","article-title":"Glioblastoma multiforme: insights into pathogenesis, key signaling pathways, and therapeutic strategies","volume":"24","author":"Pouyan","year":"2025","journal-title":"Mol Cancer"},{"key":"2026030516314375600_noaf219-B19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41392-021-00855-2","article-title":"EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma","volume":"7","author":"Gai","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"2026030516314375600_noaf219-B20","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/neuonc\/noaa214","article-title":"EIF4A3-induced circular RNA ASAP1 promotes tumorigenesis and temozolomide resistance of glioblastoma via NRAS\/MEK1\/ERK1-2 signaling","volume":"23","author":"Wei","year":"2021","journal-title":"Neuro Oncol"},{"key":"2026030516314375600_noaf219-B21","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12943-020-1137-5","article-title":"DNA-methylation-mediated activating of lncRNA SNHG12 promotes temozolomide resistance in glioblastoma","volume":"19","author":"Lu","year":"2020","journal-title":"Mol Cancer"},{"key":"2026030516314375600_noaf219-B22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12943-024-02066-z","article-title":"Super-enhancer omics in stem cell","volume":"23","author":"Ma","year":"2024","journal-title":"Mol Cancer"},{"key":"2026030516314375600_noaf219-B23","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1016\/j.molcel.2021.06.014","article-title":"Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer","volume":"81","author":"Einstein","year":"2021","journal-title":"Mol Cell"},{"key":"2026030516314375600_noaf219-B24","doi-asserted-by":"crossref","first-page":"100963","DOI":"10.1016\/j.drup.2023.100963","article-title":"Targeting myc-driven stress addiction in colorectal cancer","volume":"69","author":"Saeed","year":"2023","journal-title":"Drug Resist Updat"},{"key":"2026030516314375600_noaf219-B25","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/j.molcel.2021.04.015","article-title":"Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300\/CBP inhibition","volume":"81","author":"Hogg","year":"2021","journal-title":"Mol Cell"},{"key":"2026030516314375600_noaf219-B26","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/s42255-022-00616-7","article-title":"Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma","volume":"4","author":"Liu","year":"2022","journal-title":"Nat Metab"},{"key":"2026030516314375600_noaf219-B27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12943-020-01185-7","article-title":"Noncoding RNAs in gastric cancer: implications for drug resistance","volume":"19","author":"Wei","year":"2020","journal-title":"Mol Cancer"},{"key":"2026030516314375600_noaf219-B28","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/s41588-021-00859-2","article-title":"Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence","volume":"53","author":"Wu","year":"2021","journal-title":"Nat Genet"},{"key":"2026030516314375600_noaf219-B29","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1038\/s41467-018-06081-9","article-title":"Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression","volume":"9","author":"Jiang","year":"2018","journal-title":"Nat Commun"},{"key":"2026030516314375600_noaf219-B30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12943-022-01605-w","article-title":"MARCKSL1-2 reverses docetaxel-resistance of lung adenocarcinoma cells by recruiting SUZ12 to suppress HDAC1 and elevate miR-200b","volume":"21","author":"Jiang","year":"2022","journal-title":"Mol Cancer"},{"key":"2026030516314375600_noaf219-B31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41588-019-0541-5","article-title":"ARID1A influences HDAC1\/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response","volume":"52","author":"Nagarajan","year":"2020","journal-title":"Nat Genet"},{"key":"2026030516314375600_noaf219-B32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41392-021-00857-0","article-title":"Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications","volume":"7","author":"Lopez-Bertoni","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"2026030516314375600_noaf219-B33","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1158\/0008-5472.CAN-20-2489","article-title":"Reprogramming transcription factors Oct4 and Sox2 induce a BRD-Dependent immunosuppressive transcriptome in GBM-Propagating cells","volume":"81","author":"Ma","year":"2021","journal-title":"Cancer Res"},{"key":"2026030516314375600_noaf219-B34","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1093\/neuonc\/noad018","article-title":"Lysine-specific histone demethylase 1A (KDM1A\/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma","volume":"25","author":"Alejo","year":"2023","journal-title":"Neuro Oncol"},{"key":"2026030516314375600_noaf219-B35","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1158\/0008-5472.CAN-24-2492","article-title":"Stabilization of RUNX1 induced by O-GlcNAcylation promotes PDGF-BB-Mediated resistance to CDK4\/6 inhibitors in breast cancer","volume":"85","author":"Zhou","year":"2025","journal-title":"Cancer Res"},{"key":"2026030516314375600_noaf219-B36","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41392-020-00222-7","article-title":"FGF\/FGFR signaling in health and disease","volume":"5","author":"Xie","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"2026030516314375600_noaf219-B37","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1158\/1078-0432.CCR-21-1943","article-title":"Activation of PI3K\/AKT pathway is a potential mechanism of treatment resistance in small cell lung cancer","volume":"28","author":"Jin","year":"2022","journal-title":"Clin Cancer Res"},{"key":"2026030516314375600_noaf219-B38","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1158\/2159-8290.CD-22-0787","article-title":"Blocking genomic instability prevents acquired resistance to MAPK inhibitor therapy in melanoma","volume":"13","author":"Dharanipragada","year":"2023","journal-title":"Cancer Discov"},{"key":"2026030516314375600_noaf219-B39","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/s43018-022-00431-9","article-title":"Ectopic JAK-STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance","volume":"3","author":"Deng","year":"2022","journal-title":"Nat Cancer"},{"key":"2026030516314375600_noaf219-B40","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1126\/science.abn7570","article-title":"Mechanism-based design of agents that selectively target drug-resistant glioma","volume":"377","author":"Lin","year":"2022","journal-title":"Science"},{"key":"2026030516314375600_noaf219-B41","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.1038\/s41467-023-39845-z","article-title":"Lysine methylation promotes NFAT5 activation and determines temozolomide efficacy in glioblastoma","volume":"14","author":"Li","year":"2023","journal-title":"Nat Commun"},{"key":"2026030516314375600_noaf219-B42","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/neuonc\/noab003","article-title":"PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O6-methylguanine DNA damage in glioblastoma","volume":"23","author":"Wu","year":"2021","journal-title":"Neuro Oncol"},{"key":"2026030516314375600_noaf219-B43","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s13045-021-01164-5","article-title":"Combination strategies to maximize the benefits of cancer immunotherapy","volume":"14","author":"Zhu","year":"2021","journal-title":"J Hematol Oncol"},{"key":"2026030516314375600_noaf219-B44","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41374-021-00707-1","article-title":"Fluvastatin sensitizes pancreatic cancer cells toward radiation therapy and suppresses radiation- and\/or TGF-\u03b2-induced tumor-associated fibrosis","volume":"102","author":"Mohapatra","year":"2022","journal-title":"Lab Invest"},{"key":"2026030516314375600_noaf219-B45","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1038\/s41467-024-47080-3","article-title":"Nanoparticles targeting mutant p53 overcome chemoresistance and tumor recurrence in non-small cell lung cancer","volume":"15","author":"Bi","year":"2024","journal-title":"Nat Commun"},{"key":"2026030516314375600_noaf219-B46","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s12943-021-01464-x","article-title":"Epigenetic modulation of antitumor immunity for improved cancer immunotherapy","volume":"20","author":"Dai","year":"2021","journal-title":"Mol Cancer"},{"key":"2026030516314375600_noaf219-B47","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15072020","article-title":"Phase I study of a combination of fluvastatin and celecoxib in children with relapsing\/refractory low-grade or high-grade glioma (FLUVABREX)","volume":"15","author":"Leblond","year":"2023","journal-title":"Cancers (Basel)"},{"key":"2026030516314375600_noaf219-B48","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41392-023-01642-x","article-title":"Smart nanoparticles for cancer therapy","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2026030516314375600_noaf219-B49","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12943-023-01849-0","article-title":"Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics","volume":"22","author":"Gajbhiye","year":"2023","journal-title":"Mol Cancer"}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/advance-article-pdf\/doi\/10.1093\/neuonc\/noaf219\/64274372\/noaf219.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/28\/1\/55\/64274372\/noaf219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/28\/1\/55\/64274372\/noaf219.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T21:31:54Z","timestamp":1772746314000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article\/28\/1\/55\/8254369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,15]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,9,15]]},"published-print":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/noaf219","relation":{},"ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,9,15]]}}}