{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:59:22Z","timestamp":1790272762574,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic Inc","doi-asserted-by":"crossref","award":["2018-KOT-001"],"award-info":[{"award-number":["2018-KOT-001"]}],"id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiation therapy (RT) offers pain relief for patients with symptomatic spine metastases. This study compares pain response and quality of life (QOL) between conventional RT or RT and radiofrequency ablation\/percutaneous vertebral augmentation (RFA\/PVA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-center, prospective, randomized phase 2 trial (NCT04375891) enrolled patients with spine metastasis (T5-L5, with 1-2 index sites amenable to RFA) and a minimum Numeric Pain Rating Scale (NPRS) of 5. After stratifying by tumor type (radioresistant vs. radiosensitive), patients were randomized (1:2) to RT or RT+RFA\/PVA. The primary endpoint was 3-month pain response. Secondary endpoints included rapidity and duration of pain response, adverse events, and QOL measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study terminated after enrolling and randomizing 63 patients (79% of planned accrual; 21 RT alone, 42 RT+RFA\/PVA). The median baseline NPRS was 10 (interquartile range [IQR] 8-10) for RT and 9 (7.5-10) for RT+RFA\/PVA. The primary endpoint of pain control 3 months after treatment was similar between the RT and RT+RFA\/PVA arms (50% vs. 48%, P\u2009=\u2009.92). Complete pain response rates at 3 months were also similar in the RT and RT+RFA\/PVA arms (17% vs. 21%, P\u2009=\u2009.77). The 3-month median NPRS reduction was \u22124 (IQR, \u22126 to \u22121) in both the RT and the RT+RFA\/PVA arms. Secondary efficacy endpoints and toxicity rates were comparable. Overall QOL measures including FACT-G, BPI, and EQ-5D scores were also similar between the two treatment arms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The addition of RFA\/PVA to conventional RT for patients with symptomatic spine metastases did not improve pain control or QOL measures at 3 months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noaf231","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T11:57:57Z","timestamp":1759492677000},"page":"241-250","source":"Crossref","is-referenced-by-count":2,"title":["Radiation therapy alone versus radiation therapy plus radiofrequency ablation\/vertebral augmentation for painful spine metastasis: A phase 2 randomized controlled 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