{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T05:36:23Z","timestamp":1794029783028,"version":"4.8.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The oncological role of resection in elderly patients with glioblastoma remains controversial. We evaluated the value of resection in patients \u226565 years with (1) newly diagnosed and (2) recurrent glioblastoma by comparing the prognostic relevance of extent of resection to patients &amp;lt;65 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The international RANO resect group retrospectively collected patients with newly diagnosed and recurrent IDH-wildtype glioblastoma from ten neuro-oncological centers. Associations of residual tumor with molecular and clinical markers and survival were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1260 patients with newly diagnosed glioblastoma were identified, including 512 patients \u226565 years. Lower postoperative contrast-enhancing tumor volumes were favorably associated with survival on uni- and multivariate analyses; however, the associations with outcome were more pronounced in younger patients. Only in patients &amp;lt;65 years, supramaximal resection was associated with more favorable survival (40 vs 20 months, P\u2009=\u2009.001). In 310 patients with first recurrence (\u226565 years: 92), maximal resection of contrast-enhancing tumor was associated with favorable outcomes, particularly in younger patients. Neither older nor younger patients had favorable outcome associations of supramaximal resection in the recurrent setting. All findings were confirmed in propensity-score-matched analyses to minimize confounding effects of inherent differences in demographic and clinical markers (including second-line treatments) between older and younger patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While complete contrast-enhancing tumor resection is prognostic for favorable outcomes in older patients, associations of supramaximal resection with improved outcomes were only retained in younger patients with newly diagnosed disease. Those findings support stratified surgical approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noaf239","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T12:13:58Z","timestamp":1759925638000},"page":"470-484","source":"Crossref","is-referenced-by-count":8,"title":["Associations of supramaximal resection with outcome in glioblastoma across age groups: A report of the RANO\n                    <i>resect<\/i>\n                    group"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7153-7994","authenticated-orcid":false,"given":"Nico","family":"Teske","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Uniklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen, (N.T., O.S., P.K.)","place":["Germany"]},{"name":"Department of Neurosurgery, LMU University Hospital of the Ludwig-Maximilians-University Munich , Munich, (N.T., J.-C.T., P.K.)","place":["Germany"]},{"name":"\u00adGerman Cancer Consortium (DKTK), Partner Site, Munich , (N.T., J.-C.T., P.K.)","place":["\u00adGermany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8041-8399","authenticated-orcid":false,"given":"Antonio","family":"Dono","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, McGovern Medical School at UT Health Houston , Houston, Texas,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob S","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Division of Neuro-Oncology, University of San Francisco , San Francisco, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie T","family":"J\u00fcnger","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Cologne , Cologne,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Youssef","sequence":"additional","affiliation":[{"name":"Division of Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School , \u00adBoston, Massachusetts,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levin","family":"H\u00e4ni","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical Center\u2014University of Freiburg , Freiburg, (L.H., J.B., O.S.)","place":["Germany"]},{"name":"Department of Neurosurgery, Inselspital, Bern University Hospital, and University of Bern , Bern, (L.H.)","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Sciortino","sequence":"additional","affiliation":[{"name":"Neurosurgical Oncology Unit, IRCCS Galeazzi Sant\u2019Ambrogio , Milan, (T.S.)","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8087-5293","authenticated-orcid":false,"given":"Francesco","family":"Bruno","sequence":"additional","affiliation":[{"name":"\u00adDivision of Neuro-Oncology, Department of Neuroscience, University of Turin , Turin, (F.B., R.R.)","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8291-0136","authenticated-orcid":false,"given":"Jorg","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Neuro-Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School , Boston, Massachusetts, (J.D.)","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Y","family":"Mau","sequence":"additional","affiliation":[{"name":"Department of \u00adNeuroOncology, Moffitt Cancer Center , Tampa, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1748-174X","authenticated-orcid":false,"given":"Michael","family":"Weller","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital and\u00a0\u00adUniversity of Zurich , Zurich, (M.W.)","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical Center\u2014University of Freiburg , Freiburg, (L.H., J.B., O.S.)","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4699-260X","authenticated-orcid":false,"given":"Shawn","family":"Hervey-Jumper","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Division of Neuro-Oncology, University of San Francisco , San Francisco, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette M","family":"Molinaro","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Division of Neuro-Oncology, University of San Francisco , San Francisco, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3521-364X","authenticated-orcid":false,"given":"Susan M","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Division of Neuro-Oncology, University of San Francisco , San Francisco, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"van den Bent","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus MC Cancer Institute , Rotterdam, (M.v.d.B.)","place":["The \u00adNetherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Vogelbaum","sequence":"additional","affiliation":[{"name":"Department of \u00adNeuroOncology, Moffitt Cancer Center , Tampa, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0466-6646","authenticated-orcid":false,"given":"Maximilian I","family":"Ruge","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Cologne , Cologne,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2552-6546","authenticated-orcid":false,"given":"Daniel P","family":"Cahill","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts, (D.P.C.)","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9134-1537","authenticated-orcid":false,"given":"Roberta","family":"Rud\u00e0","sequence":"additional","affiliation":[{"name":"\u00adDivision of Neuro-Oncology, Department of Neuroscience, University of Turin , Turin, (F.B., R.R.)","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Bello","sequence":"additional","affiliation":[{"name":"Division of Neuro-Oncology, Department of Oncology and Hemato-Oncology, University of Milan , Milan, (L.B.)","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan J","family":"Grau","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Cologne , Cologne,","place":["Germany"]},{"name":"Klinikum Fulda, Academic Hospital of Marburg University , Fulda, (S.J.G)","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Schnell","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Uniklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen, (N.T., O.S., P.K.)","place":["Germany"]},{"name":"Department of Neurosurgery, Medical Center\u2014University of Freiburg , Freiburg, (L.H., J.B., O.S.)","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond Y","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, Massachusetts, (R.Y.H.)","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0774-7700","authenticated-orcid":false,"given":"Patrick 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