{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:29:04Z","timestamp":1791584944540,"version":"4.3.4"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Hertie Network of Excellence in Clinical Neuroscience, and funded by the Emmy-Noether Programme","award":["project ID SU 1548\/1-1"],"award-info":[{"award-number":["project ID SU 1548\/1-1"]}]},{"name":"Else Kr\u00f6ner Fresenius Stiftung"},{"name":"UNITE Glioblastoma","award":["SFB1389"],"award-info":[{"award-number":["SFB1389"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Isocitrate dehydrogenase (IDH)-wildtype Glioblastoma (GB) is the most prevalent primary malignant central nervous system (CNS) tumour in adults. The standard treatment regimen involves radiotherapy, which can cause radionecrotic (postactinic) changes as a late-onset treatment complication. While radiation is thought to mainly affect resident brain tissue, progressive GB and radionecrotic changes can be challenging to differentiate, as they may present with similar symptoms and appear alike on Magnetic Resonance Imaging (MRI). Therefore, histopathological examination remains the gold standard of diagnostics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The cohort comprised ten samples from 9 patients diagnosed with GB, all of whom underwent first-line standard of care treatment including surgery, radio- and chemotherapy with temozolomide. Subsequent radiological examination identified tumour progression in all patients, thus necessitating a second surgery. Following histopathological examination of the material collected from the second surgery, 4 patients were histologically diagnosed with tumour recurrence, 4 exhibited no evidence of recurrence but manifested with radionecrotic changes, and 1 patient demonstrated both. The spatial single cell transcriptomic profiling of the samples was conducted using the Xenium platform.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We generated a comprehensive spatial single cell transcriptomic atlas of progressive GB and brain tissue with radionecrotic changes. Tumour cells were detected in samples from both groups. The employment of the dataset revealed that progressive GB samples contained oligodendrocyte progenitor (OPC), and neural progenitor (NPC)-like and proliferating tumour cells with high epidermal growth factor receptor (EGFR) expression. Conversely, in samples with radionecrotic changes, tumour cells downregulated their EGFR expression even in the presence of gene amplification and did not show proliferation markers. Additionally, border-associated macrophages infiltrated the tissue and might have promoted gliosis in samples with radionecrotic changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study delineates a complex spatial architecture of brain tissue with post-treatment changes and its discrepancies from progressive GB, thus facilitating future research into novel treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noag026","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T12:45:31Z","timestamp":1769777131000},"page":"1150-1162","source":"Crossref","is-referenced-by-count":8,"title":["Spatial transcriptomics characterisation of radionecrotic changes in glioblastoma 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