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Ras-related C3 botulinum toxin substrate 1 (RAC1), a low molecular weight GTPase involved in cytoskeletal regulation and cell migration, is established to facilitate tumorigenesis in other neoplasia, but RAC1 is unexplored in MB and has no targeted therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined RAC1 activity in Sonic Hedgehog (SHH)-subtype MB using human and mouse Ptch1\u2212\/\u2212 cell models, RNAi knockdown, pharmacologic inhibition with GYS32661, transcript profiling, chromatin immunoprecipitation, and cytotoxicity assays in primary human astrocytes. We also determined the efficacy, brain penetration, and toxicity of GYS32661 in orthotopic spheroid Ptch1\u2212\/\u2212 mouse and rat models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>RAC1 activity was markedly increased in the MB tissue compared to the normal cerebellum. RAC1 depletion suppressed the proliferation and migration of SHH-MB cells. Mechanistically, RAC1 regulated GLI1 and GLI2 expression and bound the upstream loci of GLI1 and DNMT1, revealing a novel mechanism of SHH transcriptional regulation. GYS32661, a brain-permeable RAC1 inhibitor, was not toxic to normal astrocytes, suppressed SHH-MB tumor growth, and improved survival in vivo without toxicity in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RAC1 functions as a critical transcriptional regulator of SHH signaling and epigenetic mediators in medulloblastoma, highlighting its potential as a druggable target in SHH-dependent MB. Our findings also characterize the RAC1 inhibitor GYS32661 as a promising drug candidate for the treatment of SHH-MB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noag057","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:40:35Z","timestamp":1773981635000},"page":"1527-1540","source":"Crossref","is-referenced-by-count":0,"title":["RAC1 regulates Sonic Hedgehog-medulloblastoma growth via GLI-mediated transcription"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2768-4196","authenticated-orcid":false,"given":"Nitish","family":"Jangde","sequence":"first","affiliation":[{"name":"Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Georgetown University , Washington, 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