{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:51:48Z","timestamp":1793839908063,"version":"4.6.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Experimental Technology Center"},{"name":"College of Life Science and Health"},{"DOI":"10.13039\/100015257","name":"Northeastern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015257","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901163"],"award-info":[{"award-number":["81901163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371180"],"award-info":[{"award-number":["82371180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018635","name":"Thousand Young Talents Program of China","doi-asserted-by":"publisher","award":["QNQR-2021-02"],"award-info":[{"award-number":["QNQR-2021-02"]}],"id":[{"id":"10.13039\/501100018635","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Liaoning Xingliao Yingcai","award":["XLYC1907141"],"award-info":[{"award-number":["XLYC1907141"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472833"],"award-info":[{"award-number":["82472833"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SIP High-Quality Innovation Platform for Chronic Diseases","award":["YZCXPT2022203"],"award-info":[{"award-number":["YZCXPT2022203"]}]},{"name":"XJTLU Research Development Fund","award":["RDF-23-01-100"],"award-info":[{"award-number":["RDF-23-01-100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glioblastoma (GBM), the most prevalent and aggressive primary brain tumor in adults, has a median survival of merely 14 months. Current therapeutic approaches, including maximal safe resection, radiotherapy, and temozolomide-based chemotherapy, have limited efficacy owing to resistance and the high rate of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed H&amp;E-stained specimens from 65 patients with glioma using deep learning-based morphological classification and analyzed a mouse model through tissue clearing and 3D imaging. Integrated transcriptomic and single-cell RNA-seq analyses identified PTBP1 as a morphology regulator. We validated the function of PTBP1 through lentiviral knockdown in vitro and in orthotopic models and performed structure-based drug screening against PTBP1 with experimental validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We detected a clinically significant association between glioma cell morphology and patient survival times. Mechanistically, PTBP1, an RNA-binding protein abundantly expressed in glioma cells, regulated dual-specificity phosphatase 5 (DUSP5) expression post-transcriptionally and modulate ERK1\/2 phosphorylation dynamics, thus reducing glioma stem cell proliferation and enhancing differentiation into neuronal-like cells to suppress tumor growth. Importantly, we developed a nanotherapeutic strategy using A2-PLGA\/venetoclax; this strategy repurposes venetoclax, a known clinical drug for leukemia, as a PTBP1-targeting agent that effectively suppresses glioma progression in mouse models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings establish a novel PTBP1\/DUSP5\/ERK1\/2 axis governing glioma stem cell proliferation and differentiation and identify the A2-PLGA\/venetoclax nanoparticle as a mechanistically justified therapeutic candidate for glioblastoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noag068","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:42:28Z","timestamp":1774356148000},"page":"1694-1710","source":"Crossref","is-referenced-by-count":2,"title":["PTBP1 knockdown reprograms glioma stem cells into neuronal-like cells and suppresses tumorigenesis via the DUSP5-ERK1\/2 signaling pathway"],"prefix":"10.1093","volume":"28","author":[{"given":"Cunyu","family":"Li","sequence":"first","affiliation":[{"name":"College of Life and Health Sciences, Northeastern University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0561-1817","authenticated-orcid":false,"given":"Manyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Capital Medical University School of Basic Medicine & Chinese Institute for Brain Research , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6410-6503","authenticated-orcid":false,"given":"Songyi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Statistics and Mathematics, Zhejiang Gongshang University , Hangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suli","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life and Health Sciences, Northeastern University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9685-5481","authenticated-orcid":false,"given":"Guanwei","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life and Health Sciences, Northeastern University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2403-0865","authenticated-orcid":false,"given":"Tianqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyi","family":"Jin","sequence":"additional","affiliation":[{"name":"Academy of Pharmacy, Xi\u2019an Jiaotong-Liverpool University , Suzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6805-0426","authenticated-orcid":false,"given":"Xing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]},{"name":"Department of Neurosurgery, The First Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2961-0086","authenticated-orcid":false,"given":"Hu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Chinese Institute for Brain Research , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology , Shenzhen,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4554-4610","authenticated-orcid":false,"given":"Sijin","family":"Wu","sequence":"additional","affiliation":[{"name":"Academy of Pharmacy, Xi\u2019an Jiaotong-Liverpool University , Suzhou,","place":["China"]},{"name":"Ministry of Education Engineering Research Center of RNA Medicine and Cell Therapy Technology, , Suzhou, (S.W.)","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3905-7325","authenticated-orcid":false,"given":"Hangjin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center for Data Science, Zhejiang University , Hangzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anhua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9977-5620","authenticated-orcid":false,"given":"Shuang","family":"Hao","sequence":"additional","affiliation":[{"name":"College of Life and Health Sciences, Northeastern University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,28]]},"reference":[{"key":"2026070701515400500_noag068-B1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41572-024-00516-y","article-title":"Glioma","volume":"10","author":"Weller","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"2026070701515400500_noag068-B2","doi-asserted-by":"publisher","first-page":"4503","DOI":"10.1038\/s41467-024-48757-5","article-title":"Glioblastoma disrupts cortical network activity at multiple spatial and temporal scales","volume":"15","author":"Meyer","year":"2024","journal-title":"Nat Commun"},{"key":"2026070701515400500_noag068-B3","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1038\/s41467-023-37306-1","article-title":"IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1\/HER2-CREB signaling axis","volume":"14","author":"Lin","year":"2023","journal-title":"Nat Commun"},{"key":"2026070701515400500_noag068-B4","doi-asserted-by":"publisher","first-page":"5551","DOI":"10.1038\/s41467-021-25892-x","article-title":"SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1\/PTBP2 switching and RBFOX2 activity","volume":"12","author":"Kim","year":"2021","journal-title":"Nat Commun"},{"key":"2026070701515400500_noag068-B5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nature16071","article-title":"Brain tumour cells interconnect to a functional and resistant network","volume":"528","author":"Osswald","year":"2015","journal-title":"Nature"},{"key":"2026070701515400500_noag068-B6","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/nature03128","article-title":"Identification of human brain tumour initiating cells","volume":"432","author":"Singh","year":"2004","journal-title":"Nature"},{"key":"2026070701515400500_noag068-B7","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.trecan.2020.01.009","article-title":"Glioblastoma stem cells: driving resilience through chaos","volume":"6","author":"Prager","year":"2020","journal-title":"Trends Cancer"},{"key":"2026070701515400500_noag068-B8","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.cell.2019.06.024","article-title":"An integrative model of cellular states, plasticity, and genetics for glioblastoma","volume":"178","author":"Neftel","year":"2019","journal-title":"Cell"},{"key":"2026070701515400500_noag068-B9","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.stem.2017.06.004","article-title":"ASCL1 reorganizes chromatin to direct neuronal fate and suppress tumorigenicity of glioblastoma stem cells","volume":"21","author":"Park","year":"2017","journal-title":"Cell Stem Cell"},{"key":"2026070701515400500_noag068-B10","doi-asserted-by":"publisher","first-page":"860","DOI":"10.20892\/j.issn.2095-3941.2020.0499","article-title":"Transcription factor-based gene therapy to treat glioblastoma through direct neuronal conversion","volume":"18","author":"Wang","year":"2021","journal-title":"Cancer Biol Med"},{"key":"2026070701515400500_noag068-B11","doi-asserted-by":"publisher","first-page":"3522","DOI":"10.1158\/0008-5472.CAN-24-1388","article-title":"Neuroendocrine differentiation in prostate cancer requires ASCL1","volume":"84","author":"Rodarte","year":"2024","journal-title":"Cancer Res"},{"key":"2026070701515400500_noag068-B12","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1016\/j.jtho.2020.09.009","article-title":"SCLC subtypes defined by ASCL1, NEUROD1, POU2F3, and YAP1: a comprehensive immunohistochemical and histopathologic characterization","volume":"15","author":"Baine","year":"2020","journal-title":"J Thorac Oncol"},{"key":"2026070701515400500_noag068-B13","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.lungcan.2020.05.012","article-title":"NEUROD1 is highly expressed in extensive-disease small cell lung cancer and promotes tumor cell migration","volume":"146","author":"Ikematsu","year":"2020","journal-title":"Lung Cancer"},{"key":"2026070701515400500_noag068-B14","doi-asserted-by":"publisher","DOI":"10.1007\/s44178-022-00014-9","article-title":"MET fusions and splicing variants convergently define a subgroup of glioma sensitive to MET inhibitors","volume":"1","author":"Zhang","year":"2022","journal-title":"Holist Integ Oncol"},{"key":"2026070701515400500_noag068-B15","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1080\/10717544.2018.1534897","article-title":"Self-assembled angiopep-2 modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles delivery TMZ for glioma synergistic TMZ and RT therapy","volume":"26","author":"Zong","year":"2019","journal-title":"Drug Deliv"},{"key":"2026070701515400500_noag068-B16","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/s41422-018-0049-z","article-title":"Tissue clearing of both hard and soft tissue organs with the PEGASOS method","volume":"28","author":"Jing","year":"2018","journal-title":"Cell Res"},{"key":"2026070701515400500_noag068-B17","doi-asserted-by":"publisher","first-page":"2955","DOI":"10.1016\/j.neuron.2024.06.017","article-title":"Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs","volume":"112","author":"Nakanishi","year":"2024","journal-title":"Neuron"},{"key":"2026070701515400500_noag068-B18","doi-asserted-by":"publisher","first-page":"8385","DOI":"10.1038\/s41467-024-52425-z","article-title":"Prohibitin 2 orchestrates long noncoding RNA and gene transcription to accelerate tumorigenesis","volume":"15","author":"Ding","year":"2024","journal-title":"Nat Commun"},{"key":"2026070701515400500_noag068-B19","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.ymthe.2019.09.003","article-title":"A NeuroD1 AAV-Based gene therapy for functional brain repair after ischemic injury through In vivo astrocyte-to-neuron conversion","volume":"28","author":"Chen","year":"2020","journal-title":"Mol Ther"},{"key":"2026070701515400500_noag068-B20","doi-asserted-by":"publisher","first-page":"4690","DOI":"10.1016\/j.cell.2024.07.033","article-title":"Schwann cell-secreted PGE2 promotes sensory neuron excitability during development","volume":"187","author":"Kantarci","year":"2024","journal-title":"Cell"},{"key":"2026070701515400500_noag068-B21","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.molcel.2007.06.016","article-title":"Crossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1","volume":"27","author":"Spellman","year":"2007","journal-title":"Mol Cell"},{"key":"2026070701515400500_noag068-B22","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1093\/brain\/awp153","article-title":"Splicing factors PTBP1 and PTBP2 \u00adpromote proliferation and migration of glioma cell lines","volume":"132","author":"Cheung","year":"2009","journal-title":"Brain"},{"key":"2026070701515400500_noag068-B23","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s41586-024-07526-6","article-title":"In vitro reconstitution of epigenetic reprogramming in the human germ line","volume":"631","author":"Murase","year":"2024","journal-title":"Nature"},{"key":"2026070701515400500_noag068-B24","doi-asserted-by":"publisher","first-page":"218","DOI":"10.15252\/embj.201489456","article-title":"Dusp5 negatively regulates IL33-mediated eosinophil survival and function","volume":"34","author":"Holmes","year":"2015","journal-title":"Embo J"},{"key":"2026070701515400500_noag068-B25","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1038\/s41388-022-02302-0","article-title":"Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6","volume":"41","author":"Kidger","year":"2022","journal-title":"Oncogene"},{"key":"2026070701515400500_noag068-B26","doi-asserted-by":"publisher","DOI":"10.1172\/JCI182100","article-title":"PTBP1 variants displaying altered nucleocytoplasmic distribution are responsible for a neurodevelopmental disorder with skeletal dysplasia","volume":"135","author":"Masson","year":"2025","journal-title":"Journal of Clinical Investigation"},{"key":"2026070701515400500_noag068-B27","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1038\/s41419-022-05359-7","article-title":"LncRNA SFTA1P promotes cervical cancer progression by interaction with PTBP1 to facilitate TPM4 mRNA degradation","volume":"13","author":"Luo","year":"2022","journal-title":"Cell Death Dis"},{"key":"2026070701515400500_noag068-B28","doi-asserted-by":"publisher","first-page":"29619","DOI":"10.1039\/c9ra05763c","article-title":"In vitro and in silico determination of glutaminyl cyclase inhibitors","volume":"9","author":"Tran","year":"2019","journal-title":"RSC Adv"},{"key":"2026070701515400500_noag068-B29","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1021\/js980402t","article-title":"Rapid calculation of polar molecular surface area and its \u00adapplication to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration","volume":"88","author":"Clark","year":"1999","journal-title":"J Pharm Sci"},{"key":"2026070701515400500_noag068-B30","doi-asserted-by":"publisher","first-page":"3606","DOI":"10.1038\/s41467-022-31340-1","article-title":"Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression","volume":"13","author":"Comba","year":"2022","journal-title":"Nat Commun"},{"key":"2026070701515400500_noag068-B31","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1093\/neuonc\/noac233","article-title":"TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane \u00adblebbing","volume":"25","author":"Demirdizen","year":"2023","journal-title":"Neuro Oncol"},{"key":"2026070701515400500_noag068-B32","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.molcel.2022.12.014","article-title":"PTBP1-activated co-transcriptional splicing controls epigenetic status of pluripotent stem cells","volume":"83","author":"Iannone","year":"2023","journal-title":"Mol Cell"},{"key":"2026070701515400500_noag068-B33","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1007\/s11010-023-04905-x","article-title":"PTBP1 as a potential regulator of disease","volume":"479","author":"Yu","year":"2024","journal-title":"Mol Cell Biochem"},{"key":"2026070701515400500_noag068-B34","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/s41048-018-0066-y","article-title":"PTB\/nPTB: master regulators of neuronal fate in mammals","volume":"4","author":"Hu","year":"2018","journal-title":"Biophys Rep"},{"key":"2026070701515400500_noag068-B35","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1101\/gad.1558107","article-title":"A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons","volume":"21","author":"Boutz","year":"2007","journal-title":"Genes Dev"},{"key":"2026070701515400500_noag068-B36","doi-asserted-by":"publisher","first-page":"7647","DOI":"10.1158\/0008-5472.CAN-04-1910","article-title":"Aberrant and alternative splicing in cancer","volume":"64","author":"Venables","year":"2004","journal-title":"Cancer Res"},{"key":"2026070701515400500_noag068-B37","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1158\/0008-5472.CAN-24-1412","article-title":"PTBP1 lactylation promotes glioma stem cell maintenance through PFKFB4-Driven glycolysis","volume":"85","author":"Zhou","year":"2025","journal-title":"Cancer Res"},{"key":"2026070701515400500_noag068-B38","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.neuron.2021.11.023","article-title":"Direct neuronal reprogramming: fast forward from new concepts toward therapeutic approaches","volume":"110","author":"Bocchi","year":"2022","journal-title":"Neuron"},{"key":"2026070701515400500_noag068-B39","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.cell.2012.11.045","article-title":"Direct conversion of fibroblasts to neurons by reprogramming PTB-Regulated MicroRNA circuits","volume":"152","author":"Xue","year":"2013","journal-title":"Cell"},{"key":"2026070701515400500_noag068-B40","doi-asserted-by":"publisher","DOI":"10.1172\/JCI173789","article-title":"RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma","volume":"134","author":"Song","year":"2024","journal-title":"J.\u00a0Clin. Invest"},{"key":"2026070701515400500_noag068-B41","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.trecan.2022.10.010","article-title":"Neuronal and tumourigenic boundaries of glioblastoma plasticity","volume":"9","author":"De Silva","year":"2023","journal-title":"Trends Cancer"},{"key":"2026070701515400500_noag068-B42","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/s41580-020-0255-7","article-title":"ERK signalling: a master regulator of cell behaviour, life and fate","volume":"21","author":"Lavoie","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026070701515400500_noag068-B43","doi-asserted-by":"publisher","first-page":"11124","DOI":"10.1038\/ncomms11124","article-title":"Early ERK1\/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming","volume":"7","author":"Prieto","year":"2016","journal-title":"Nat Commun"},{"key":"2026070701515400500_noag068-B44","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1038\/s41419-022-05499-w","article-title":"BAF53A drives colorectal cancer development by regulating DUSP5-mediated ERK phosphorylation","volume":"13","author":"Yang","year":"2022","journal-title":"Cell Death Dis"},{"key":"2026070701515400500_noag068-B45","doi-asserted-by":"publisher","first-page":"693670","DOI":"10.3389\/fonc.2021.693670","article-title":"Treatment of central nervous system relapse in acute promyelocytic leukemia by venetoclax: a case report","volume":"11","author":"Zhang","year":"2021","journal-title":"Front Oncol"},{"key":"2026070701515400500_noag068-B46","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.7150\/jca.81795","article-title":"Venetoclax penetrates the blood brain barrier: a pharmacokinetic analysis in pediatric leukemia patients","volume":"14","author":"Badawi","year":"2023","journal-title":"J Cancer"},{"key":"2026070701515400500_noag068-B47","doi-asserted-by":"publisher","first-page":"e14528","DOI":"10.1111\/cns.14528","article-title":"Self-assembled nanoparticles of natural \u00adbioactive molecules enhance the delivery and efficacy of paclitaxel in glioblastoma","volume":"30","author":"Li","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"2026070701515400500_noag068-B48","doi-asserted-by":"publisher","first-page":"123138","DOI":"10.1016\/j.biomaterials.2025.123138","article-title":"Advanced nanoparticle engineering for precision therapeutics of brain diseases","volume":"318","author":"Ismail","year":"2025","journal-title":"Biomaterials"}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/advance-article-pdf\/doi\/10.1093\/neuonc\/noag068\/67631335\/noag068.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/28\/7\/1694\/67631335\/noag068.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/28\/7\/1694\/67631335\/noag068.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:52:02Z","timestamp":1783403522000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article\/28\/7\/1694\/8554160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,28]]},"references-count":48,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,3,28]]},"published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/noag068","relation":{},"ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,3,28]]}}}