{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:22:02Z","timestamp":1783405322288,"version":"3.54.6"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"American Society of Clinical Oncology\u2019s Conquer Cancer Foundation","award":["2019CDA-7743456038"],"award-info":[{"award-number":["2019CDA-7743456038"]}]},{"name":"National Institute of Health","award":["T32CA092203"],"award-info":[{"award-number":["T32CA092203"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In a recent randomized controlled trial, caregivers of patients diagnosed with primary malignant brain tumors (PMBT) who received NeuroCARE\u2014a 6-session, cognitive-behavioral, telehealth intervention\u2014demonstrated improved anxiety and depression symptoms at 11 weeks post-randomization compared to caregivers assigned to usual care (UC). We explored whether these intervention effects were mediated by improvements in coping and self-efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined data from caregivers of patients with PMBT randomized to receive either NeuroCARE or UC (N\u2009=\u2009120). Participants completed assessments of anxiety and depression symptoms (Hospital Anxiety and Depression Scale), coping (Measure of Current Status), and self-efficacy (Lewis Cancer Self-Efficacy Scale) at baseline, 11 weeks, and 16 weeks. We conducted 4 simple mediation regression models using the Preacher &amp; Hayes bootstrapping method to examine whether improvements in coping or self-efficacy from baseline to 11 weeks mediated intervention effects on 11-week anxiety or depression symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The sample (N\u2009=\u2009120; Mage\u2009=\u200953 years) predominantly consisted of participants who self-identified as female (82.5%), White (91.7%), and spouses\/partners (70.0%) caring for a patient with glioblastoma (84%). Improvements in 11-week anxiety symptoms in caregivers assigned to NeuroCARE were mediated by improved coping (indirect effect = \u22121.44, SE\u2009=\u20090.49, 95% CI [\u22122.50, \u22120.54]) and self-efficacy (indirect effect=\u22121.29, SE\u2009=\u20090.42, 95% CI [\u22122.16, \u22120.52]). Similarly, improvements in 11-week depression symptoms were mediated by improved coping (indirect effect=-1.43, SE\u2009=\u20090.38, 95% CI [\u22122.21, \u22120.74]) and self-efficacy (indirect effect\u2009=\u2009\u22120.95, SE\u2009=\u20090.32, 95% CI [\u22121.60, \u22120.36]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The NeuroCARE intervention improves mood by enhancing coping skills and improving caregivers\u2019 self-efficacy in caregivers of patients with PMBT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noag070","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:50:54Z","timestamp":1776430254000},"page":"1741-1752","source":"Crossref","is-referenced-by-count":0,"title":["Improved coping and self-efficacy drive improvements in mood among caregivers of patients with primary malignant brain tumors: Results 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Massachusetts,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Corveleyn","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute , Boston, Massachusetts,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4479-0350","authenticated-orcid":false,"given":"Timothy","family":"Sannes","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Massachusetts Chan Medical School , Worcester, Massachusetts,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7268-5921","authenticated-orcid":false,"given":"Jennifer S","family":"Temel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mass General Brigham , Boston, Massachusetts,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0979-4076","authenticated-orcid":false,"given":"Joseph A","family":"Greer","sequence":"additional","affiliation":[{"name":"Mass General Brigham Cancer Institute , Boston, Massachusetts,","place":["USA"]},{"name":"Harvard Medical School , Boston, Massachusetts,","place":["USA"]},{"name":"Department of Psychiatry, Mass General Brigham , Boston, Massachusetts,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3556-1495","authenticated-orcid":false,"given":"Areej","family":"El-Jawahri","sequence":"additional","affiliation":[{"name":"Mass General Brigham Cancer Institute , Boston, Massachusetts,","place":["USA"]},{"name":"Harvard Medical School , Boston, Massachusetts,","place":["USA"]},{"name":"Department of Medicine, Mass General Brigham , Boston, 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