{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:08:32Z","timestamp":1788847712894,"version":"build-2803163510"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Bavarian Cancer Research Center","award":["TLG024\/04-Joha"],"award-info":[{"award-number":["TLG024\/04-Joha"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rhabdoid tumors (RT) are among the most aggressive pediatric malignancies, characterized by early onset in life, loss of SWI\/SNF complex members (SMARCB1 or SMARCA4), and dismal outcomes despite multimodal therapy. Refractory and relapsing RT remain almost uniformly fatal, and targeted or immune-based approaches have yet to demonstrate clinical benefit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To explore novel therapeutic vulnerabilities, we systematically investigated the expression of clinically actionable surface proteins that could serve as targets for antibody-drug conjugates (ADCs), radiopharmaceutical therapy (RPT), or cellular immunotherapies. Based on large-scale transcriptomic analyses, we prioritized FAP (fibroblast activation protein), CXCR4 (chemokine receptor 4), and IL13RA2 (interleukin receptor 13 RA2) and performed comprehensive protein-level validation by immunohistochemistry in an unprecedented cohort of 60 rhabdoid tumors spanning all molecular subgroups (ATRT-TYR, ATRT-SHH, ATRT-MYC, and eMRT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Integrating these data with spatial and single-nucleus transcriptomic profiling, we identified subgroup- and cell-type-specific expression patterns, including heterogeneous FAP distribution between stromal and tumor compartments and a distinct IL13RA2-positive rhabdoid cell population with melanosomal and stem-like features: Overall 51\/60 tumors demonstrated positivity, defined as immunohistochemical H-score above or at least equal to 10, for FAP in the stroma and 34\/60 tumors for CXCR4, indicating that a substantial fraction of rhabdoid tumors may be amenable to targeted therapies directed against these epitopes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings define a set of biologically and clinically relevant surface targets in RT and provide a translational blueprint for rational ADC and RPT target development in pediatric cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noag133","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:32:23Z","timestamp":1780399943000},"page":"2263-2278","source":"Crossref","is-referenced-by-count":0,"title":["Spatial dissection of antibody-drug conjugate\/radiopharmaceutical therapy targets defines heterogeneous expression landscapes and therapeutic implications in rhabdoid tumors"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0070-3158","authenticated-orcid":false,"given":"Nic G","family":"Reitsam","sequence":"first","affiliation":[{"name":"Else Kroener Fresenius Center for Digital Health, Technical University Dresden , Dresden,","place":["Germany"]},{"name":"Department of Pathology, Faculty of Medicine, University of Augsburg , Augsburg,","place":["Germany"]},{"name":"Bavarian Cancer Research Center (BZKF) , Augsburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7488-6885","authenticated-orcid":false,"given":"Victoria E","family":"Fincke","sequence":"additional","affiliation":[{"name":"Bavarian Cancer Research Center (BZKF) , Augsburg,","place":["Germany"]},{"name":"Swabian Childrens\u2019 Cancer Center, Faculty of Medicine, University of Augsburg , Augsburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Daniela","family":"Hernandez Ramirez","sequence":"additional","affiliation":[{"name":"Bavarian Cancer Research Center (BZKF) , Augsburg,","place":["Germany"]},{"name":"Swabian Childrens\u2019 Cancer Center, Faculty of Medicine, University of Augsburg , Augsburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9009-3383","authenticated-orcid":false,"given":"Marlena","family":"Mucha","sequence":"additional","affiliation":[{"name":"Bavarian Cancer Research Center (BZKF) , Augsburg,","place":["Germany"]},{"name":"Swabian Childrens\u2019 Cancer Center, Faculty of Medicine, University of Augsburg , Augsburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8168-2271","authenticated-orcid":false,"given":"Eva","family":"Sipos","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Augsburg , Augsburg,","place":["Germany"]},{"name":"Bavarian Cancer Research Center (BZKF) , Augsburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Siebenh\u00fcter","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Augsburg , Augsburg,","place":["Germany"]},{"name":"Bavarian Cancer Research Center (BZKF) , Augsburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-8856","authenticated-orcid":false,"given":"Johanna S","family":"Enke","sequence":"additional","affiliation":[{"name":"Department of Nuclear 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