{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:54:50Z","timestamp":1790909690935,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001442"],"award-info":[{"award-number":["UL1TR001442"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The hippocampus comprises discrete anatomic subfields subserving different components of memory. We evaluated longitudinal, dose-dependent volumetric changes in hippocampal subfields after fractionated radiotherapy (RT) and determined their associations with verbal and visuospatial memory performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty-nine adults with primary brain tumors received fractionated RT in a prospective clinical trial. High-resolution 3D volumetric MRI and memory tests were obtained at baseline and 3, 6, and 12 months post-RT. Bilateral hippocampi and their 38 subfields were segmented using robust automated parcellation. Linear mixed-effects models analyzed (1) time-dependent atrophy, (2) dose-volume relationships, and (3) subfield-memory associations at the same timepoint, corrected for multiple comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Multiple left- and right-sided hippocampal subfields demonstrated significant atrophy at 3, 6, and 12 months post-RT (all P \u2009\u2264\u2009 .05). Dose-dependent atrophy was significant at 12 months (P = .01) in the left hippocampus and across all time points in the right (all P\u2009\u2264\u2009.05). Eight right-sided and 1 left-sided subfield exhibited dose-dependent atrophy across all time points (all P\u2009\u2264\u2009.05). Greater left hippocampal tail and molecular layer volumes were associated with higher verbal memory scores, while greater volumes of multiple right-sided subfields predicted better visuospatial memory performance (all P\u2009\u2264\u2009.05, \ud835\udefd &amp;gt; 0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fractionated RT induces progressive, dose-related atrophy in discrete hippocampal subfields, with earlier and steeper dose-response curves in right-sided subfields. Higher volumes within multiple left and right-sided subfields were associated with better verbal and visuospatial memory, respectively. Subfield-sparing planning objectives may optimize cognitive outcomes in primary brain tumor patients when hippocampal avoidance is not feasible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noag195","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:31:14Z","timestamp":1787837474000},"source":"Crossref","is-referenced-by-count":0,"title":["Volumetric changes in hippocampal subfields and memory performance after fractionated brain radiation therapy"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3618-5310","authenticated-orcid":false,"given":"Hieu","family":"Nguyen","sequence":"first","affiliation":[{"name":"School of Medicine, University of California San Diego , La Jolla, California,","place":["USA (H.N., A.C., S.U.)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2554-1535","authenticated-orcid":false,"given":"Austin 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J.A.H-G.)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Christofferson","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California San Diego , La Jolla, California,","place":["USA (H.N., A.C., S.U.)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan","family":"Karunamuni","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine and Applied Sciences, University of California San Diego , La Jolla, California,","place":["USA (A.B.H., J.S.K., C.P., R.K., K.R.T., A.S., C.R.M., J.A.H-G.)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1506-4870","authenticated-orcid":false,"given":"Kathryn R","family":"Tringale","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine and Applied Sciences, University of California San Diego , La Jolla, California,","place":["USA (A.B.H., J.S.K., C.P., R.K., K.R.T., A.S., 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