{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:41:15Z","timestamp":1792435275945,"version":"4.5.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"am","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glioblastoma (GBM) is an aggressive brain tumor and an unmet clinical need due to its invasiveness and therapy resistance. These features are driven by glioblastoma stem-like cells (GSLCs), which exhibit remarkable functional heterogeneity. While transcriptional profiling has helped define this heterogeneity, it alone does not fully predict cellular behaviors. Because cell morphology is closely linked to function during neurodevelopment, we asked whether integrating morphological and transcriptomic identities could reveal clinically relevant roles of GSLCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We employed CellShape-seq, a customized spatial transcriptomics platform integrating cell morphology with transcriptome and applied it to patient-derived GBM organoids. To link GSLC transcriptome to function, we combined assembloid invasion assays, calcium imaging, pharmacological perturbations, and time-lapse microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified three GSLC morphological classes corresponding to distinct transcriptomic states and functional behaviors: nonpolar cells, which show differentiation and therapy sensitivity; elongated cells, which are blood-vessel associated, invasive, and chemoresistant; and multipolar cells, which form intercellular networks conveying therapy resistance. Importantly, morphological state remains stable throughout interphase and is readily inherited from mother to daughter cells. However, under pharmacological stress GSLCs show striking morphological plasticity. Namely, Temozolomide treatment is associated with GSLC elongation and branching, while YAP inhibition and gap-junction blockage result in a reduction of elongated and multipolar GSLCs, respectively. Finally, combined targeting of these morphoclass-specific vulnerabilities reduces viability in patient-derived organoids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings demonstrate that cell morphology provides critical insights into GSLC behaviors and establish a rationale for putative morphology-informed therapies to overcome resistance and improve outcomes in GBM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noag235","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:26:27Z","timestamp":1790425587000},"source":"Crossref","is-referenced-by-count":0,"title":["Stem cell morphology defines functional heterogeneity and therapeutic vulnerabilities in glioblastoma"],"prefix":"10.1093","author":[{"given":"Carlotta","family":"Barelli","sequence":"first","affiliation":[{"name":"Human Technopole , Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6361-5163","authenticated-orcid":false,"given":"Matteo","family":"Bonfanti","sequence":"additional","affiliation":[{"name":"Human Technopole , Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4312-1350","authenticated-orcid":false,"given":"Filippo","family":"Mirabella","sequence":"additional","affiliation":[{"name":"Human Technopole , Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3509-9699","authenticated-orcid":false,"given":"Dario","family":"Ricca","sequence":"additional","affiliation":[{"name":"Human Technopole , Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin","family":"Alizadehmohajer","sequence":"additional","affiliation":[{"name":"Human Technopole , Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5467-6212","authenticated-orcid":false,"given":"Roberta","family":"Bosotti","sequence":"additional","affiliation":[{"name":"Human Technopole , Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Bertani","sequence":"additional","affiliation":[{"name":"Human Technopole , Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2255-6195","authenticated-orcid":false,"given":"Viktoria","family":"Sokolova","sequence":"additional","affiliation":[{"name":"Human Technopole , Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1969-2126","authenticated-orcid":false,"given":"Alberto","family":"Campione","sequence":"additional","affiliation":[{"name":"Human Technopole , Milan,","place":["Italy"]},{"name":"Neurosurgery Unit, ASST Ovest Milanese\u2014Legnano Hospital , Legnano,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3767-3921","authenticated-orcid":false,"given":"Giovanni M","family":"Sicuri","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, ASST Ovest Milanese\u2014Legnano Hospital , Legnano,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clelia","family":"Peano","sequence":"additional","affiliation":[{"name":"Human Technopole , Milan,","place":["Italy"]},{"name":"Institute of Genetics and Biomedical Research, UoS of Milan, National Research Council , Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2489-1795","authenticated-orcid":false,"given":"Stefania","family":"Faletti","sequence":"additional","affiliation":[{"name":"Human Technopole , Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Stefini","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, ASST Ovest Milanese\u2014Legnano Hospital , Legnano,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8445-2906","authenticated-orcid":false,"given":"Nereo","family":"Kalebic","sequence":"additional","affiliation":[{"name":"Human Technopole , Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"key":"2026101914270755000_noag235-B1","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.jocn.2009.09.004","article-title":"Survival comparison between glioblastoma multiforme and other incurable cancers","volume":"17","author":"Tran","year":"2010","journal-title":"J Clin Neurosci"},{"key":"2026101914270755000_noag235-B2","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s11060-020-03451-6","article-title":"Trends in glioblastoma: outcomes over time and type of intervention: a systematic evidence based analysis","volume":"147","author":"Marenco-Hillembrand","year":"2020","journal-title":"J Neurooncol"},{"key":"2026101914270755000_noag235-B3","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.cell.2019.06.024","article-title":"An integrative model of cellular states, plasticity, and genetics for glioblastoma","volume":"178","author":"Neftel","year":"2019","journal-title":"Cell"},{"key":"2026101914270755000_noag235-B4","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.devcel.2021.12.007","article-title":"Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy","volume":"57","author":"Xie","year":"2022","journal-title":"Dev Cell"},{"key":"2026101914270755000_noag235-B5","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s43018-020-00159-4","article-title":"Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities","volume":"2","author":"Garofano","year":"2021","journal-title":"Nat Cancer"},{"key":"2026101914270755000_noag235-B6","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s43018-020-00154-9","article-title":"Gradient of developmental and injury response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity","volume":"2","author":"Richards","year":"2021","journal-title":"Nat Cancer"},{"key":"2026101914270755000_noag235-B7","doi-asserted-by":"publisher","first-page":"104044","DOI":"10.1016\/j.compbiomed.2020.104044","article-title":"Cellular morphological features are predictive markers of cancer cell state","volume":"126","author":"Alizadeh","year":"2020","journal-title":"Comput Biol Med"},{"key":"2026101914270755000_noag235-B8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13058-024-01796-8","article-title":"Cell morphology best predicts tumorigenicity and metastasis in vivo across multiple TNBC cell lines of different metastatic potential","volume":"26","author":"Conner","year":"2024","journal-title":"Breast Cancer Res"},{"key":"2026101914270755000_noag235-B9","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1093\/jnci\/djad243","article-title":"Morphological diversity of cancer cells predicts prognosis across tumor types","volume":"116","author":"Sali","year":"2024","journal-title":"J Natl Cancer Inst"},{"key":"2026101914270755000_noag235-B10","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nature16071","article-title":"Brain tumour cells interconnect to a functional and resistant network","volume":"528","author":"Osswald","year":"2015","journal-title":"Nature"},{"key":"2026101914270755000_noag235-B11","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1042\/BCJ20200710","article-title":"Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids","volume":"478","author":"Pinto","year":"2021","journal-title":"Biochem J"},{"key":"2026101914270755000_noag235-B12","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.stem.2019.11.015","article-title":"Outer radial glia-like cancer stem cells contribute to heterogeneity of glioblastoma","volume":"26","author":"Bhaduri","year":"2020","journal-title":"Cell Stem Cell"},{"key":"2026101914270755000_noag235-B13","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1038\/s41467-020-17186-5","article-title":"Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy","volume":"11","author":"Couturier","year":"2020","journal-title":"Nat Commun"},{"key":"2026101914270755000_noag235-B14","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.tins.2020.07.009","article-title":"Basal progenitor morphology and neocortex evolution","volume":"43","author":"Kalebic","year":"2020","journal-title":"Trends Neurosci"},{"key":"2026101914270755000_noag235-B15","doi-asserted-by":"publisher","first-page":"e202402823","DOI":"10.26508\/lsa.202402823","article-title":"Morphoregulatory ADD3 underlies glioblastoma growth and formation of tumor\u2013tumor connections","volume":"8","author":"Barelli","year":"2025","journal-title":"Life Sci Alliance"},{"key":"2026101914270755000_noag235-B16","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.stem.2019.02.017","article-title":"Neocortical expansion due to increased proliferation of basal progenitors is linked to changes in their morphology","volume":"24","author":"Kalebic","year":"2019","journal-title":"Cell Stem Cell"},{"key":"2026101914270755000_noag235-B17","doi-asserted-by":"publisher","first-page":"116276","DOI":"10.1016\/j.celrep.2025.116276","article-title":"Adducins regulate morphology and fate of neural progenitors during neocortical neurogenesis","volume":"44","author":"Ossola","year":"2025","journal-title":"Cell Rep"},{"key":"2026101914270755000_noag235-B18","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1101\/gr.276059.121","article-title":"Identification of phenotype-specific networks from paired gene expression\u2013cell shape imaging data","volume":"32","author":"Barker","year":"2022","journal-title":"Genome Res"},{"key":"2026101914270755000_noag235-B19","doi-asserted-by":"publisher","first-page":"eaaw6938","DOI":"10.1126\/sciadv.aaw6938","article-title":"Single-cell morphology encodes metastatic potential","volume":"6","author":"Wu","year":"2020","journal-title":"Sci Adv"},{"key":"2026101914270755000_noag235-B20","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.cell.2019.11.036","article-title":"A patient-derived glioblastoma organoid model and biobank recapitulates inter- and intra-tumoral heterogeneity","volume":"180","author":"Jacob","year":"2020","journal-title":"Cell"},{"key":"2026101914270755000_noag235-B21","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1158\/0008-5472.CAN-12-1881","article-title":"A tumorigenic MLL-homeobox network in human glioblastoma stem cells","volume":"73","author":"Gallo","year":"2013","journal-title":"Cancer Res"},{"key":"2026101914270755000_noag235-B22","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.ccell.2017.02.013","article-title":"m6A demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation program","volume":"31","author":"Zhang","year":"2017","journal-title":"Cancer Cell"},{"key":"2026101914270755000_noag235-B23","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jim.2009.06.008","article-title":"ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays","volume":"347","author":"Hu","year":"2009","journal-title":"J Immunol Methods"},{"key":"2026101914270755000_noag235-B24","doi-asserted-by":"publisher","author":"Fazzari","year":"2024","DOI":"10.1101\/2024.07.24.604840"},{"key":"2026101914270755000_noag235-B25","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1038\/s41587-022-01251-z","article-title":"Integrative spatial analysis of cell morphologies and transcriptional states with MUSE","volume":"40","author":"Bao","year":"2022","journal-title":"Nat Biotechnol"},{"key":"2026101914270755000_noag235-B26","doi-asserted-by":"publisher","first-page":"026105","DOI":"10.1063\/1.5143779","article-title":"Cell shape, and not 2D migration, predicts extracellular matrix-driven 3D cell invasion in breast cancer","volume":"4","author":"Baskaran","year":"2020","journal-title":"APL Bioeng"},{"key":"2026101914270755000_noag235-B27","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.yexcr.2016.08.001","article-title":"Time-lapse phenotyping of invasive glioma cells ex vivo reveals subtype-specific movement patterns guided by tumor core signaling","volume":"349","author":"Fayzullin","year":"2016","journal-title":"Exp Cell Res"},{"key":"2026101914270755000_noag235-B28","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.3390\/ijms20051137","article-title":"Cd99 expression in Glioblastoma molecular subtypes and role in migration and invasion","volume":"20","author":"Cardoso","year":"2019","journal-title":"IJMS"},{"key":"2026101914270755000_noag235-B29","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1177\/1947601912473603","article-title":"Overexpression of CD99 increases the migration and invasiveness of human malignant glioma cells","volume":"3","author":"Seol","year":"2012","journal-title":"Genes Cancer"},{"key":"2026101914270755000_noag235-B30","doi-asserted-by":"publisher","first-page":"2994","DOI":"10.1016\/j.celrep.2016.11.056","article-title":"Clonal variation in drug and radiation response among glioma-initiating cells is linked to proneural-mesenchymal transition","volume":"17","author":"Segerman","year":"2016","journal-title":"Cell Rep"},{"key":"2026101914270755000_noag235-B31","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.neo.2014.06.003","article-title":"Mechanisms of glioma formation: iterative perivascular glioma growth and invasion leads to tumor progression, VEGF-independent vascularization, and resistance to antiangiogenic therapy","volume":"16","author":"Baker","year":"2014","journal-title":"Neoplasia"},{"key":"2026101914270755000_noag235-B32","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1091\/mbc.E15-08-0565","article-title":"Mechanical confinement triggers glioma linear migration dependent on formin FHOD3","volume":"27","author":"Monzo","year":"2016","journal-title":"Mol Biol Cell"},{"key":"2026101914270755000_noag235-B33","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s10555-021-09997-9","article-title":"Glioma: molecular signature and crossroads with tumor microenvironment","volume":"41","author":"Barthel","year":"2022","journal-title":"Cancer Metastasis Rev"},{"key":"2026101914270755000_noag235-B34","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1177\/2472555218764623","article-title":"Spontaneous glioblastoma spheroid infiltration of early-stage cerebral organoids models brain tumor invasion","volume":"23","author":"da Silva","year":"2018","journal-title":"SLAS Discovery"},{"key":"2026101914270755000_noag235-B35","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/s41568-022-00475-0","article-title":"Disconnecting multicellular networks in brain tumours","volume":"22","author":"Venkataramani","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"2026101914270755000_noag235-B36","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/s41586-022-05520-4","article-title":"Autonomous rhythmic activity in glioma networks drives brain tumour growth","volume":"613","author":"Hausmann","year":"2023","journal-title":"Nature"},{"key":"2026101914270755000_noag235-B37","doi-asserted-by":"publisher","first-page":"e101230","DOI":"10.15252\/embj.2018101230","article-title":"The wnt\/Ca(2+) pathway is involved in interneuronal communication mediated by tunneling nanotubes","volume":"38","author":"Vargas","year":"2019","journal-title":"Embo J"},{"key":"2026101914270755000_noag235-B38","doi-asserted-by":"publisher","first-page":"10142","DOI":"10.1073\/pnas.1808066115","article-title":"Metabolic regulation and glucose sensitivity of cortical radial glial cells","volume":"115","author":"Rash","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026101914270755000_noag235-B39","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1152\/jn.00060.2009","article-title":"Direct actions of carbenoxolone on synaptic transmission and neuronal membrane properties","volume":"102","author":"Tovar","year":"2009","journal-title":"J Neurophysiol"},{"key":"2026101914270755000_noag235-B40","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nature24014","article-title":"Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma","volume":"549","author":"Venkatesh","year":"2017","journal-title":"Nature"},{"key":"2026101914270755000_noag235-B41","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/s41586-019-1564-x","article-title":"Glutamatergic synaptic input to glioma cells drives brain tumour progression","volume":"573","author":"Venkataramani","year":"2019","journal-title":"Nature"},{"key":"2026101914270755000_noag235-B42","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1093\/neuonc\/nox070","article-title":"Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas","volume":"19","author":"Weil","year":"2017","journal-title":"Neuro Oncol"},{"key":"2026101914270755000_noag235-B43","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1093\/jnci\/djm044","article-title":"Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide","volume":"99","author":"Keshelava","year":"2007","journal-title":"J Natl Cancer Inst"},{"key":"2026101914270755000_noag235-B44","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1093\/neuonc\/noab244","article-title":"Anti-invasive efficacy and survival benefit of the YAP-TEAD inhibitor verteporfin in preclinical glioblastoma models","volume":"24","author":"Barrette","year":"2022","journal-title":"Neuro Oncol"},{"key":"2026101914270755000_noag235-B45","doi-asserted-by":"publisher","first-page":"3602","DOI":"10.1038\/s41467-024-47985-z","article-title":"VC-resist glioblastoma cell state: vessel co-option as a key driver of chemoradiation resistance","volume":"15","author":"Pichol-Thievend","year":"2024","journal-title":"Nat Commun"},{"key":"2026101914270755000_noag235-B46","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1093\/neuonc\/now297","article-title":"VDAC1 is a molecular target in glioblastoma, with its depletion leading to reprogrammed metabolism and reversed oncogenic properties","volume":"19","author":"Arif","year":"2017","journal-title":"Neuro Oncol"},{"key":"2026101914270755000_noag235-B47","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.1016\/j.cell.2022.06.054","article-title":"Glioblastoma hijacks neuronal mechanisms for brain invasion","volume":"185","author":"Venkataramani","year":"2022","journal-title":"Cell"},{"key":"2026101914270755000_noag235-B48","doi-asserted-by":"publisher","first-page":"e56328","DOI":"10.1371\/journal.pone.0056328","article-title":"IDH1-associated primary glioblastoma in young adults displays differential patterns of tumour and vascular morphology","volume":"8","author":"Popov","year":"2013","journal-title":"PLoS One"},{"key":"2026101914270755000_noag235-B49","doi-asserted-by":"publisher","DOI":"10.1002\/mog2.66","article-title":"The hidden architects of glioblastoma multiforme: Glioma stem cells","volume":"3","author":"Sahoo","year":"2024","journal-title":"MedComm \u2013 Oncol"},{"key":"2026101914270755000_noag235-B50","doi-asserted-by":"publisher","first-page":"6809105","DOI":"10.1155\/2016\/6809105","article-title":"Glioblastoma stem cells microenvironment: the paracrine roles of the niche in drug and radioresistance","volume":"2016","author":"Fidoamore","year":"2016","journal-title":"Stem Cells Int"},{"key":"2026101914270755000_noag235-B51","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/s42003-022-03175-5","article-title":"Deciphering tissue structure and function using spatial transcriptomics","volume":"5","author":"Walker","year":"2022","journal-title":"Commun Biol"},{"key":"2026101914270755000_noag235-B52","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/nbt.3445","article-title":"Electrophysiological, transcriptomic and morphologic profiling of single neurons using patch-seq","volume":"34","author":"Cadwell","year":"2016","journal-title":"Nat Biotechnol"},{"key":"2026101914270755000_noag235-B53","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/neuonc\/noaf205","article-title":"Extracellular matrix stiffness conditions glioblastoma cells for long-term migration: mechanical memory as a driver of invasion and recurrence in glioblastoma","volume":"28","author":"Suarez-Meade","year":"2026","journal-title":"Neuro Oncol"},{"key":"2026101914270755000_noag235-B54","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1002\/1878-0261.13786","article-title":"Tonabersat enhances temozolomide-mediated cytotoxicity in glioblastoma by disrupting intercellular connectivity through connexin 43 inhibition","volume":"19","author":"Schmidt","year":"2025","journal-title":"Mol Oncol"},{"key":"2026101914270755000_noag235-B55","doi-asserted-by":"publisher","first-page":"5527","DOI":"10.1038\/s41598-018-23592-z","article-title":"Blocking distinct interactions between glioblastoma cells and their tissue microenvironment: a novel multi-targeted therapeutic approach","volume":"8","author":"Mettang","year":"2018","journal-title":"Sci Rep"},{"key":"2026101914270755000_noag235-B56","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s00424-010-0849-6","article-title":"Connexin 43 mimetic peptide Gap26 confers protection to intact heart against myocardial ischemia injury","volume":"460","author":"Hawat","year":"2010","journal-title":"Pflugers Arch"}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/advance-article-pdf\/doi\/10.1093\/neuonc\/noag235\/71409393\/noag235.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/advance-article-pdf\/doi\/10.1093\/neuonc\/noag235\/71409393\/noag235.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:27:39Z","timestamp":1792434459000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/advance-article\/doi\/10.1093\/neuonc\/noag235\/8837427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,26]]},"references-count":56,"URL":"https:\/\/doi.org\/10.1093\/neuonc\/noag235","relation":{},"ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,26]]},"article-number":"noag235"}}