{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:40:24Z","timestamp":1793324424661,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1093\/neuonc\/noq004","type":"journal-article","created":{"date-parts":[[2010,7,29]],"date-time":"2010-07-29T21:18:46Z","timestamp":1280438326000},"page":"844-854","source":"Crossref","is-referenced-by-count":28,"title":["Fatty acid synthase as a novel target for meningioma therapy"],"prefix":"10.1093","volume":"12","author":[{"given":"Daniela","family":"Haase","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schmidl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ewald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Kalff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Huebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimund","family":"Firsching","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerburg","family":"Keilhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Evert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Paulus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Gutmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Lal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mawrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,2,5]]},"reference":[{"key":"key\n\t\t\t\t20170508170512_NOQ004C1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO classification of tumours of the central nervous system","volume":"114","author":"Louis","year":"2007","journal-title":"Acta Neuropathol."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1212\/WNL.49.1.267","article-title":"Loss of merlin expression in sporadic meningiomas, ependymomas and schwannomas","volume":"49","author":"Gutmann","year":"1997","journal-title":"Neurology."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C3","doi-asserted-by":"crossref","first-page":"14719","DOI":"10.1073\/pnas.94.26.14719","article-title":"Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: toward a genetic model of meningioma progression","volume":"94","author":"Weber","year":"1997","journal-title":"Proc Natl Acad Sci USA."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C4","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0002-9440(10)61737-3","article-title":"Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas","volume":"159","author":"Bostrom","year":"2001","journal-title":"Am J Pathol."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11060-004-2749-0","article-title":"Molecular pathogenesis of meningiomas","volume":"70","author":"Perry","year":"2004","journal-title":"J Neurooncol."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C6","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1002\/cncr.10410","article-title":"The association between breast carcinoma and meningioma in women","volume":"94","author":"Custer","year":"2002","journal-title":"Cancer."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C7","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1093\/jnen\/59.10.872","article-title":"Merlin, DAL-1, and progesterone receptor expression in clinicopathologic subsets of meningioma: a correlative immunohistochemical study of 175 cases","volume":"59","author":"Perry","year":"2000","journal-title":"J Neuropathol Exp Neurol."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C8","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1158\/0008-5472.CAN-05-4673","article-title":"Fatty acid synthase and cancer: new application of an old pathway","volume":"66","author":"Kuhajda","year":"2006","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00004347-199701000-00008","article-title":"Expression of fatty acid synthase is closely linked to proliferation and stromal decidualization in cycling endometrium","volume":"16","author":"Pizer","year":"1997","journal-title":"Int J Gynecol Pathol."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C10","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nrc2222","article-title":"Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis","volume":"7","author":"Menendez","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"key\n\t\t\t\t20170508170512_NOQ004C11","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/sj.bjc.6603350","article-title":"Fatty acid synthase: a novel target for antiglioma therapy","volume":"95","author":"Zhao","year":"2006","journal-title":"Br J Cancer."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C12","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1158\/1078-0432.CCR-04-2550","article-title":"Different activation of mitogen-activated protein kinase and Akt signaling is associated with aggressive phenotype of human meningiomas","volume":"11","author":"Mawrin","year":"2005","journal-title":"Clin Cancer Res."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/labinvest.3700206","article-title":"Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat","volume":"85","author":"Evert","year":"2005","journal-title":"Lab Invest."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C14","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/labinvest.3700307","article-title":"Establishment of a benign meningioma cell line by hTERT-mediated immortalization","volume":"85","author":"Puttmann","year":"2005","journal-title":"Lab Invest."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C15","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.1158\/0008-5472.CAN-05-0240","article-title":"Meningioma transcript profiles reveal deregulated Notch signaling pathway","volume":"65","author":"Cuevas","year":"2005","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C16","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/ana.20201","article-title":"Functional significance of S6K overexpression in meningioma progression","volume":"56","author":"Surace","year":"2004","journal-title":"Ann Neurol."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C17","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1002\/1097-0142(19891201)64:11<2243::AID-CNCR2820641110>3.0.CO;2-S","article-title":"Establishment of a human malignant meningioma cell line with amplified c-myc oncogene","volume":"64","author":"Tanaka","year":"1989","journal-title":"Cancer."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C18","first-page":"175","article-title":"Short incubation with 2-methoxyestradiol kills malignant glioma cells independent of death receptor 5 upregulation","volume":"24","author":"Braeuninger","year":"2005","journal-title":"Clin Neuropathol."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C19","first-page":"1189","article-title":"Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer","volume":"56","author":"Pizer","year":"1996","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C20","first-page":"153","article-title":"Increased fatty acid synthase is a therapeutic target in mesothelioma","volume":"7","author":"Gabrielson","year":"2001","journal-title":"Clin Cancer Res."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C21","doi-asserted-by":"crossref","first-page":"7794","DOI":"10.1128\/MCB.23.21.7794-7808.2003","article-title":"Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)\/Akt by a PKCzeta-dependent mechanism","volume":"23","author":"Powell","year":"2003","journal-title":"Mol Cell Biol."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C22","doi-asserted-by":"crossref","first-page":"36608","DOI":"10.1074\/jbc.M406499200","article-title":"Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt\/protein kinase B","volume":"279","author":"Stratford","year":"2004","journal-title":"J Biol Chem."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C23","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.1073\/pnas.91.14.6379","article-title":"Fatty acid synthesis: a potential selective target for antineoplastic therapy","volume":"91","author":"Kuhajda","year":"1994","journal-title":"Proc Natl Acad Sci USA."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C24","first-page":"4589","article-title":"Apoptosis of androgen-independent prostate cell line induced by inhibition of fatty acid synthesis","volume":"17","author":"Furuya","year":"1997","journal-title":"Anticancer Res."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C25","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/oxfordjournals.jbchem.a122739","article-title":"Binding site of cerulenin in fatty acid synthetase","volume":"105","author":"Funabashi","year":"1989","journal-title":"J Biochem."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C26","first-page":"1493","article-title":"Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53","volume":"61","author":"Li","year":"2001","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C27","first-page":"7330","article-title":"Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells","volume":"63","author":"Zhou","year":"2003","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C28","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.biopha.2007.08.020","article-title":"Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells","volume":"61","author":"Ho","year":"2007","journal-title":"Biomed Pharmacother."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C29","first-page":"411","article-title":"Inhibition of tumor-associated fatty acid synthase activity enhances vinorelbine (Navelbine)-induced cytotoxicity and apoptotic cell death in human breast cancer cells","volume":"12","author":"Menendez","year":"2004","journal-title":"Oncol Rep."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C30","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1073\/pnas.97.7.3450","article-title":"Synthesis and antitumor activity of an inhibitor of fatty acid synthase","volume":"97","author":"Kuhajda","year":"2000","journal-title":"Proc Natl Acad Sci USA."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/sj.onc.1208174","article-title":"Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice","volume":"24","author":"Alli","year":"2005","journal-title":"Oncogene."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C32","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1038\/sj.onc.1208463","article-title":"Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells","volume":"24","author":"Wang","year":"2005","journal-title":"Oncogene."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C33","first-page":"L381","article-title":"Hormonal regulation and cellular localization of fatty acid synthase in human fetal lung","volume":"277","author":"Wagle","year":"1999","journal-title":"Am J Physiol."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C34","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1177\/002215540004800505","article-title":"Fatty acid synthase is expressed mainly in adult hormone-sensitive cells or cells with high lipid metabolism and in proliferating fetal cells","volume":"48","author":"Kusakabe","year":"2000","journal-title":"J Histochem Cytochem."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C35","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1158\/0008-5472.CAN-07-1796","article-title":"Specific genes expressed in association with progesterone receptors in meningioma","volume":"68","author":"Claus","year":"2008","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C36","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1046\/j.1365-2559.2003.01712.x","article-title":"Hormone receptors in non-malignant meningiomas correlate with apoptosis, cell proliferation and recurrence-free survival","volume":"43","author":"Konstantinidou","year":"2003","journal-title":"Histopathology."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C37","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0014-4827(02)00023-X","article-title":"Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c","volume":"282","author":"Yang","year":"2003","journal-title":"Exp Cell Res."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C38","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/path.1760","article-title":"High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt\/PKB","volume":"206","author":"Van de","year":"2005","journal-title":"J Pathol."},{"key":"key\n\t\t\t\t20170508170512_NOQ004C39","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1158\/0008-5472.CAN-06-2201","article-title":"Activation of Akt predicts poor outcome in neuroblastoma","volume":"67","author":"Opel","year":"2007","journal-title":"Cancer Res."}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/12\/8\/844\/16662880\/noq004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T19:54:27Z","timestamp":1503518067000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-lookup\/doi\/10.1093\/neuonc\/noq004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,5]]},"references-count":39,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2010,2,5]]},"published-print":{"date-parts":[[2010,8]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/noq004","relation":{},"ISSN":["1523-5866","1522-8517"],"issn-type":[{"value":"1523-5866","type":"electronic"},{"value":"1522-8517","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2,5]]}}}