{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:32:10Z","timestamp":1770723130339,"version":"3.49.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1093\/neuonc\/nor068","type":"journal-article","created":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T01:15:45Z","timestamp":1308791745000},"page":"961-973","source":"Crossref","is-referenced-by-count":29,"title":["Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides"],"prefix":"10.1093","volume":"13","author":[{"given":"Wei Ying","family":"Yue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Jason","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusta","family":"Fernando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick","family":"Domann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlan R.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,6,22]]},"reference":[{"issue":"6429","key":"key\n\t\t\t\t20170508175126_NOR068C1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/363515a0","article-title":"Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2","volume":"363","author":"Rouleau","year":"1993","journal-title":"Nature"},{"issue":"5","key":"key\n\t\t\t\t20170508175126_NOR068C2","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0092-8674(93)90406-G","article-title":"A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor","volume":"72","author":"Trofatter","year":"1993","journal-title":"Cell"},{"issue":"6","key":"key\n\t\t\t\t20170508175126_NOR068C3","first-page":"1649","article-title":"Universal absence of merlin, but not other ERM family members, in schwannomas","volume":"151","author":"Stemmer-Rachamimov","year":"1997","journal-title":"Am J Pathol"},{"issue":"1","key":"key\n\t\t\t\t20170508175126_NOR068C4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/00019052-200302000-00004","article-title":"Neurofibromatosis 2","volume":"16","author":"Baser","year":"2003","journal-title":"Curr Opin Neurol"},{"issue":"4","key":"key\n\t\t\t\t20170508175126_NOR068C5","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S1097-2765(03)00382-4","article-title":"Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1","volume":"12","author":"Kissil","year":"2003","journal-title":"Mol Cell"},{"issue":"2","key":"key\n\t\t\t\t20170508175126_NOR068C6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0006-291X(03)00124-4","article-title":"Merlin suppresses the SRE-dependent transcription by inhibiting the activation of Ras-ERK pathway","volume":"302","author":"Lim","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"key\n\t\t\t\t20170508175126_NOR068C7","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/ncb1152","article-title":"MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation","volume":"6","author":"Chadee","year":"2004","journal-title":"Nat Cell Biol"},{"issue":"6","key":"key\n\t\t\t\t20170508175126_NOR068C8","first-page":"1493","article-title":"Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation","volume":"23","author":"Fraenzer","year":"2003","journal-title":"Int J Oncol"},{"issue":"11","key":"key\n\t\t\t\t20170508175126_NOR068C9","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1093\/hmg\/ddg146","article-title":"Upregulation of the Rac1\/JNK signaling pathway in primary human schwannoma cells","volume":"12","author":"Kaempchen","year":"2003","journal-title":"Hum Mol Genet"},{"issue":"52","key":"key\n\t\t\t\t20170508175126_NOR068C10","doi-asserted-by":"crossref","first-page":"18200","DOI":"10.1073\/pnas.0405971102","article-title":"Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L","volume":"101","author":"Rong","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"key\n\t\t\t\t20170508175126_NOR068C11","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1073\/pnas.0510651103","article-title":"Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf\/Raf-1 complex and inhibition by the NF2 tumor suppressor protein","volume":"103","author":"Chadee","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"issue":"19","key":"key\n\t\t\t\t20170508175126_NOR068C12","doi-asserted-by":"crossref","first-page":"7932","DOI":"10.1158\/0008-5472.CAN-08-0866","article-title":"Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2","volume":"68","author":"Yi","year":"2008","journal-title":"Cancer Res"},{"issue":"6","key":"key\n\t\t\t\t20170508175126_NOR068C13","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1128\/MCB.01392-08","article-title":"The neurofibromatosis 2 protein, merlin, regulates glial cell growth in an ErbB2- and Src-dependent manner","volume":"29","author":"Houshmandi","year":"2009","journal-title":"Mol Cell Biol"},{"issue":"1","key":"key\n\t\t\t\t20170508175126_NOR068C14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.expneurol.2009.04.019","article-title":"PAK kinase regulates Rac GTPase and is a potential target in human schwannomas","volume":"218","author":"Flaiz","year":"2009","journal-title":"Exp Neurol"},{"issue":"15","key":"key\n\t\t\t\t20170508175126_NOR068C15","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1128\/MCB.01581-08","article-title":"NF2\/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth","volume":"29","author":"James","year":"2009","journal-title":"Mol Cell Biol"},{"issue":"5","key":"key\n\t\t\t\t20170508175126_NOR068C16","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1083\/jcb.200703010","article-title":"Contact-dependent inhibition of EGFR signaling by Nf2\/Merlin","volume":"177","author":"Curto","year":"2007","journal-title":"J Cell Biol"},{"issue":"4","key":"key\n\t\t\t\t20170508175126_NOR068C17","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/ng930","article-title":"Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology","volume":"31","author":"Fernandez-Valle","year":"2002","journal-title":"Nat Genet"},{"issue":"3","key":"key\n\t\t\t\t20170508175126_NOR068C18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1083\/jcb.200307132","article-title":"Krox-20 inhibits Jun-NH2-terminal kinase\/c-Jun to control Schwann cell proliferation and death","volume":"164","author":"Parkinson","year":"2004","journal-title":"J Cell Biol"},{"issue":"21","key":"key\n\t\t\t\t20170508175126_NOR068C19","doi-asserted-by":"crossref","first-page":"8572","DOI":"10.1523\/JNEUROSCI.21-21-08572.2001","article-title":"Transforming growth factor beta (TGFbeta) mediates Schwann cell death in vitro and in vivo: examination of c-Jun activation, interactions with survival signals, and the relationship of TGFbeta-mediated death to Schwann cell differentiation","volume":"21","author":"Parkinson","year":"2001","journal-title":"J Neurosci"},{"issue":"3","key":"key\n\t\t\t\t20170508175126_NOR068C20","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1046\/j.1471-4159.2001.00110.x","article-title":"Insulin-like growth factor-I and Bcl-X(L) inhibit c-jun N-terminal kinase activation and rescue Schwann cells from apoptosis","volume":"76","author":"Cheng","year":"2001","journal-title":"J Neurochem"},{"issue":"6","key":"key\n\t\t\t\t20170508175126_NOR068C21","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/MLG.0b013e318163f920","article-title":"Effects of ErbB2 signaling on the response of vestibular schwannoma cells to gamma-irradiation","volume":"118","author":"Hansen","year":"2008","journal-title":"Laryngoscope"},{"issue":"6","key":"key\n\t\t\t\t20170508175126_NOR068C22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/glia.20316","article-title":"Constitutive neuregulin-1\/ErbB signaling contributes to human vestibular schwannoma proliferation","volume":"53","author":"Hansen","year":"2006","journal-title":"Glia"},{"issue":"9","key":"key\n\t\t\t\t20170508175126_NOR068C23","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1097\/MAO.0b013e3181f20655","article-title":"MicroRNA-21 overexpression contributes to vestibular schwannoma cell proliferation and survival","volume":"31","author":"Cioffi","year":"2010","journal-title":"Otol Neurotol"},{"issue":"1","key":"key\n\t\t\t\t20170508175126_NOR068C24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/mao.0b013e31815dbb11","article-title":"Lipid raft localization of erbB2 in vestibular schwannoma and Schwann cells","volume":"29","author":"Brown","year":"2008","journal-title":"Otol Neurotol"},{"issue":"13","key":"key\n\t\t\t\t20170508175126_NOR068C25","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.1158\/0008-5472.CAN-07-5849","article-title":"Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannoma","volume":"68","author":"Ammoun","year":"2008","journal-title":"Cancer Res"},{"issue":"1","key":"key\n\t\t\t\t20170508175126_NOR068C26","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/mao.0b013e31816021f7","article-title":"Phosphatidylinositol 3-kinase\/AKT pathway activation in human vestibular schwannoma","volume":"29","author":"Jacob","year":"2008","journal-title":"Otol Neurotol"},{"issue":"6","key":"key\n\t\t\t\t20170508175126_NOR068C27","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/j.1365-2559.2009.03440.x","article-title":"Activation of ERK, AKT and JNK signalling pathways in human schwannomas in situ","volume":"55","author":"Hilton","year":"2009","journal-title":"Histopathology"},{"issue":"1","key":"key\n\t\t\t\t20170508175126_NOR068C28","doi-asserted-by":"crossref","first-page":"H99","DOI":"10.1152\/ajpheart.00901.2004","article-title":"EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1\/Waf1 upregulation and endothelial apoptosis","volume":"289","author":"Nuntharatanapong","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"key\n\t\t\t\t20170508175126_NOR068C29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1158\/1541-7786.MCR-06-0233","article-title":"Mitochondrial c-Jun NH2-terminal kinase prevents the accumulation of reactive oxygen species and reduces necrotic damage in neural tumor cells that lack trophic support","volume":"5","author":"Lopez-Sanchez","year":"2007","journal-title":"Mol Cancer Res"},{"issue":"13","key":"key\n\t\t\t\t20170508175126_NOR068C30","doi-asserted-by":"crossref","first-page":"10987","DOI":"10.1074\/jbc.M107565200","article-title":"Identification of the critical features of a small peptide inhibitor of JNK activity","volume":"277","author":"Barr","year":"2002","journal-title":"J Biol Chem"},{"issue":"1","key":"key\n\t\t\t\t20170508175126_NOR068C31","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2174\/1568007053005145","article-title":"Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy","volume":"4","author":"Kuan","year":"2005","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"issue":"5326","key":"key\n\t\t\t\t20170508175126_NOR068C32","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1126\/science.277.5326.693","article-title":"A cytoplasmic inhibitor of the JNK signal transduction pathway","volume":"277","author":"Dickens","year":"1997","journal-title":"Science"},{"issue":"6805","key":"key\n\t\t\t\t20170508175126_NOR068C33","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"issue":"6","key":"key\n\t\t\t\t20170508175126_NOR068C34","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/cne.21430","article-title":"Prosurvival and proapoptotic intracellular signaling in rat spiral ganglion neurons in vivo after the loss of hair cells","volume":"503","author":"Alam","year":"2007","journal-title":"J Comp Neurol"},{"issue":"9","key":"key\n\t\t\t\t20170508175126_NOR068C35","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.cellsig.2007.04.009","article-title":"Oxyl radicals, redox-sensitive signalling cascades and antioxidants","volume":"19","author":"Genestra","year":"2007","journal-title":"Cell Signal"},{"issue":"4","key":"key\n\t\t\t\t20170508175126_NOR068C36","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1074\/jbc.M109641200","article-title":"Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis","volume":"277","author":"Nakamura","year":"2002","journal-title":"J Biol Chem"},{"issue":"6","key":"key\n\t\t\t\t20170508175126_NOR068C37","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nprot.2008.56","article-title":"The selective detection of mitochondrial superoxide by live cell imaging","volume":"3","author":"Robinson","year":"2008","journal-title":"Nat Protoc"},{"issue":"4","key":"key\n\t\t\t\t20170508175126_NOR068C38","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cell.2010.01.029","article-title":"Merlin\/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus","volume":"140","author":"Li","year":"2010","journal-title":"Cell"},{"issue":"9","key":"key\n\t\t\t\t20170508175126_NOR068C39","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/j.ejca.2009.03.013","article-title":"Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells","volume":"45","author":"Lee","year":"2009","journal-title":"Eur J Cancer"},{"issue":"8","key":"key\n\t\t\t\t20170508175126_NOR068C40","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/mc.20348","article-title":"The functional contrariety of JNK","volume":"46","author":"Bode","year":"2007","journal-title":"Mol Carcinog"},{"issue":"5467","key":"key\n\t\t\t\t20170508175126_NOR068C41","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1126\/science.288.5467.870","article-title":"Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway","volume":"288","author":"Tournier","year":"2000","journal-title":"Science"},{"issue":"5","key":"key\n\t\t\t\t20170508175126_NOR068C42","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1101\/gad.13.5.607","article-title":"Control of cell cycle progression by c-Jun is p53 dependent","volume":"13","author":"Schreiber","year":"1999","journal-title":"Genes Dev"},{"issue":"1","key":"key\n\t\t\t\t20170508175126_NOR068C43","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/sj.cr.7290262","article-title":"Role of JNK activation in apoptosis: a double-edged sword","volume":"15","author":"Liu","year":"2005","journal-title":"Cell Res"},{"issue":"3","key":"key\n\t\t\t\t20170508175126_NOR068C44","first-page":"199","article-title":"Role of JNK in tumor development","volume":"2","author":"Kennedy","year":"2003","journal-title":"Cell Cycle"},{"issue":"5","key":"key\n\t\t\t\t20170508175126_NOR068C45","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.molcel.2006.01.018","article-title":"Chemical genetic analysis of the time course of signal transduction by JNK","volume":"21","author":"Ventura","year":"2006","journal-title":"Mol Cell"},{"issue":"1","key":"key\n\t\t\t\t20170508175126_NOR068C46","first-page":"250","article-title":"Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors","volume":"63","author":"Tsuiki","year":"2003","journal-title":"Cancer Res"},{"issue":"6","key":"key\n\t\t\t\t20170508175126_NOR068C47","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.freeradbiomed.2005.10.056","article-title":"JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species","volume":"40","author":"Shen","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"key\n\t\t\t\t20170508175126_NOR068C48","volume-title":"Free Radicals in Biology and Medicine","author":"Halliwell","year":"1999","edition":"3rd ed."},{"issue":"3","key":"key\n\t\t\t\t20170508175126_NOR068C49","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0891-5849(02)00905-X","article-title":"Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression","volume":"33","author":"Zelko","year":"2002","journal-title":"Free Radic Biol Med"}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/13\/9\/961\/16663540\/nor068.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T05:14:32Z","timestamp":1637903672000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-lookup\/doi\/10.1093\/neuonc\/nor068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,22]]},"references-count":49,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2011,6,22]]},"published-print":{"date-parts":[[2011,9]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/nor068","relation":{},"ISSN":["1523-5866","1522-8517"],"issn-type":[{"value":"1523-5866","type":"electronic"},{"value":"1522-8517","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6,22]]}}}