{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:13:07Z","timestamp":1791839587685,"version":"4.3.4"},"reference-count":112,"publisher":"Oxford University Press (OUP)","issue":"suppl_2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1093\/neuonc\/now301","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T08:58:08Z","timestamp":1487149088000},"page":"ii38-ii49","source":"Crossref","is-referenced-by-count":128,"title":["The radiosurgery fractionation quandary: single fraction or hypofractionation?"],"prefix":"10.1093","volume":"19","author":[{"given":"John P.","family":"Kirkpatrick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott G.","family":"Soltys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon S.","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Beal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis C.","family":"Shrieve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,31]]},"reference":[{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0001","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0360-3016(99)00507-6","article-title":"Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05","volume":"47","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"key\n\t\t\t\t20170608071002_CIT0002","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3171\/jns.2006.104.6.907","article-title":"Local control of brain metastases by stereotactic radiosurgery in relation to dose to the tumor margin","volume":"104","year":"2006","journal-title":"J Neurosurg"},{"key":"key\n\t\t\t\t20170608071002_CIT0003","doi-asserted-by":"crossref","first-page":"e7765","DOI":"10.1136\/bmj.e7765","article-title":"Advances in radiotherapy","volume":"345","year":"2012","journal-title":"BMJ"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7785\/tcrt.2012.500228","article-title":"Technological advances in brain and spine radiosurgery","volume":"11","year":"2012","journal-title":"Technol Cancer Res Treat"},{"key":"key\n\t\t\t\t20170608071002_CIT0005","volume-title":"Radiobiology for the Radiologist","year":"2012","edition":"7"},{"issue":"6","key":"key\n\t\t\t\t20170608071002_CIT0006","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1080\/09553008914552491","article-title":"The 5Rs of radiobiology","volume":"56","year":"1989","journal-title":"Int J Radiat Biol"},{"key":"key\n\t\t\t\t20170608071002_CIT0007","volume-title":"The Four R\u2019s of Radiotherapy","year":"1975"},{"issue":"20","key":"key\n\t\t\t\t20170608071002_CIT0008","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.1088\/0031-9155\/49\/20\/012","article-title":"Extending the linear-quadratic model for large fraction doses pertinent to stereotactic radiotherapy","volume":"49","year":"2004","journal-title":"Phys Med Biol"},{"issue":"16","key":"key\n\t\t\t\t20170608071002_CIT0009","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1088\/0031-9155\/55\/16\/005","article-title":"Cell-survival probability at large doses: an alternative to the linear-quadratic model","volume":"55","year":"2010","journal-title":"Phys Med Biol"},{"issue":"3","key":"key\n\t\t\t\t20170608071002_CIT0010","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.ijrobp.2007.10.059","article-title":"Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapy","volume":"70","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0011","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ijrobp.2013.07.022","article-title":"The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved?","volume":"88","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"key\n\t\t\t\t20170608071002_CIT0012","first-page":"693","article-title":"Dose escalation, not \u201cnew biology,\u201d can account for the efficacy of stereotactic body radiation therapy with non-small cell lung cancer. In reply to Rao et al","volume":"89","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"8","key":"key\n\t\t\t\t20170608071002_CIT0013","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1118\/1.3157095","article-title":"Point\/Counterpoint. The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery","volume":"36","year":"2009","journal-title":"Med Phys"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0014","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ccr.2005.07.014","article-title":"Engaging the vascular component of the tumor response","volume":"8","year":"2005","journal-title":"Cancer Cell"},{"issue":"5622","key":"key\n\t\t\t\t20170608071002_CIT0015","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1126\/science.1082504","article-title":"Tumor response to radiotherapy regulated by endothelial cell apoptosis","volume":"300","year":"2003","journal-title":"Science"},{"issue":"4","key":"key\n\t\t\t\t20170608071002_CIT0016","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.semradonc.2008.04.005","article-title":"The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery","volume":"18","year":"2008","journal-title":"Semin Radiat Oncol"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0017","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ijrobp.2015.05.016","article-title":"Indirect tumor cell death after high-dose hypofractionated irradiation: implications for stereotactic body radiation therapy and stereotactic radiation surgery","volume":"93","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0018","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijrobp.2014.08.355","article-title":"A hypothesis: indirect cell death in the radiosurgery era","volume":"91","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3 Suppl","key":"key\n\t\t\t\t20170608071002_CIT0019","first-page":"S3","article-title":"Quantitative analyses of normal tissue effects in the clinic (QUANTEC): an introduction to the scientific issues","volume":"76","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3 Suppl","key":"key\n\t\t\t\t20170608071002_CIT0020","first-page":"S20","article-title":"Radiation dose-volume effects in the brain","volume":"76","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key\n\t\t\t\t20170608071002_CIT0021","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.ijrobp.2009.07.1754","article-title":"Use of normal tissue complication probability models in the clinic","volume":"76","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key\n\t\t\t\t20170608071002_CIT0022","first-page":"95","article-title":"Estimating normal tissue toxicity in radiosurgery of the CNS: application and limitations of QUANTEC","volume":"1","year":"2011","journal-title":"J Radiosurgery and SBRT"},{"issue":"4","key":"key\n\t\t\t\t20170608071002_CIT0023","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.ijrobp.2009.06.006","article-title":"Irradiated volume as a predictor of brain radionecrosis after linear accelerator stereotactic radiosurgery","volume":"77","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"9","key":"key\n\t\t\t\t20170608071002_CIT0024","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1001\/jamaoncol.2015.2756","article-title":"Role of local radiation therapy in cancer immunotherapy","volume":"1","year":"2015","journal-title":"JAMA Oncol"},{"issue":"3","key":"key\n\t\t\t\t20170608071002_CIT0025","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1667\/RR2773.1","article-title":"Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS)","volume":"177","year":"2012","journal-title":"Radiat Res"},{"key":"key\n\t\t\t\t20170608071002_CIT0026","first-page":"153","article-title":"Radiation as an immunological adjuvant: current evidence on dose and fractionation","volume":"2","year":"2012","journal-title":"Front Oncol"},{"issue":"5","key":"key\n\t\t\t\t20170608071002_CIT0027","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.ijrobp.2015.03.003","article-title":"Is less, more? The evolving role of radiation therapy for brain metastases","volume":"92","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10055","key":"key\n\t\t\t\t20170608071002_CIT0028","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/S0140-6736(16)30825-X","article-title":"Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ): results from a phase 3, non-inferiority, randomised trial","volume":"388","year":"2016","journal-title":"Lancet"},{"issue":"4","key":"key\n\t\t\t\t20170608071002_CIT0029","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1001\/jama.2016.9839","article-title":"Effect of radiosurgery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1 to 3 brain metastases: a randomized clinical trial","volume":"316","year":"2016","journal-title":"JAMA"},{"issue":"9","key":"key\n\t\t\t\t20170608071002_CIT0030","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1002\/cncr.26515","article-title":"A meta-analysis evaluating stereotactic radiosurgery, whole-brain radiotherapy, or both for patients presenting with a limited number of brain metastases","volume":"118","year":"2012","journal-title":"Cancer"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0031","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ijrobp.2014.09.004","article-title":"Defining the optimal planning target volume in image-guided stereotactic radiosurgery of brain metastases: results of a randomized trial","volume":"91","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0032","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s11060-015-1881-3","article-title":"Long-term risk of radionecrosis and imaging changes after stereotactic radiosurgery for brain metastases","volume":"125","year":"2015","journal-title":"J Neurooncol"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0033","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3171\/2014.10.JNS141610","article-title":"Adverse radiation effect after stereotactic radiosurgery for brain metastases: incidence, time course, and risk factors","volume":"123","year":"2015","journal-title":"J Neurosurg"},{"key":"key\n\t\t\t\t20170608071002_CIT0034","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1748-717X-8-135","article-title":"Hypofractionated radiosurgery for intact or resected brain metastases: defining the optimal dose and fractionation","volume":"8","year":"2013","journal-title":"Radiat Oncol"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0035","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.radonc.2006.08.024","article-title":"Phase II trial of hypofractionated stereotactic radiotherapy for brain metastases: results and toxicity","volume":"81","year":"2006","journal-title":"Radiother Oncol"},{"issue":"11","key":"key\n\t\t\t\t20170608071002_CIT0036","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00066-007-1714-1","article-title":"Hypofractionated stereotactic radiotherapy for brain metastases\u2014results from three different dose concepts","volume":"183","year":"2007","journal-title":"Strahlenther Onkol"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0037","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11060-012-0868-6","article-title":"Stereotactic radiosurgery and fractionated stereotactic radiotherapy: comparison of efficacy and toxicity in 260 patients with brain metastases","volume":"109","year":"2012","journal-title":"J Neurooncol"},{"issue":"5","key":"key\n\t\t\t\t20170608071002_CIT0038","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3109\/0284186X.2012.681066","article-title":"Volume specific response criteria for brain metastases following salvage stereotactic radiosurgery and associated predictors of response","volume":"51","year":"2012","journal-title":"Acta Oncol"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0039","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ijrobp.2010.05.033","article-title":"Single-dose versus fractionated stereotactic radiotherapy for brain metastases","volume":"81","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"key\n\t\t\t\t20170608071002_CIT0040","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/cncr.24082","article-title":"Hypofractionated stereotactic radiotherapy for the treatment of brain metastases","volume":"115","year":"2009","journal-title":"Cancer"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0041","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1227\/NEU.0000000000000584","article-title":"Postoperative stereotactic radiosurgery to the resection cavity for large brain metastases: clinical outcomes, predictors of intracranial failure, and implications for optimal patient selection","volume":"76","year":"2015","journal-title":"Neurosurgery"},{"issue":"3","key":"key\n\t\t\t\t20170608071002_CIT0042","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0360-3016(00)00475-2","article-title":"Hypofractionated stereotactic radiotherapy as an alternative to radiosurgery for the treatment of patients with brain metastases","volume":"47","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key\n\t\t\t\t20170608071002_CIT0043","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1748-717X-9-110","article-title":"Fractionated stereotactic radiosurgery for patients with skull base metastases from systemic cancer involving the anterior visual pathway","volume":"9","year":"2014","journal-title":"Radiat Oncol"},{"issue":"4","key":"key\n\t\t\t\t20170608071002_CIT0044","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ijrobp.2013.03.037","article-title":"Multidose stereotactic radiosurgery (9 Gy \u00d7 3) of the postoperative resection cavity for treatment of large brain metastases","volume":"86","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"key\n\t\t\t\t20170608071002_CIT0045","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.ijrobp.2016.03.013","article-title":"Single-fraction versus multifraction (3 \u00d7 9 Gy) stereotactic radiosurgery for large (>2 cm) brain metastases: a comparative analysis of local control and risk of radiation-induced brain necrosis","volume":"95","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0046","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s11060-014-1556-5","article-title":"Local control after fractionated stereotactic radiation therapy for brain metastases","volume":"120","year":"2014","journal-title":"J Neurooncol"},{"issue":"3","key":"key\n\t\t\t\t20170608071002_CIT0047","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s11060-011-0697-z","article-title":"Cyberknife hypofractionated stereotactic radiosurgery (HSRS) of resection cavity after excision of large cerebral metastasis: efficacy and safety of an 800 cGy \u00d7 3 daily fractions regimen","volume":"106","year":"2012","journal-title":"J Neurooncol"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0048","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/COC.0b013e31828aadac","article-title":"Fractionated stereotactic radiosurgery for large brain metastases","volume":"38","year":"2015","journal-title":"Am J Clin Oncol"},{"issue":"3","key":"key\n\t\t\t\t20170608071002_CIT0049","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0360-3016(93)90080-F","article-title":"The radiobiology of radiosurgery","volume":"25","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"key\n\t\t\t\t20170608071002_CIT0050","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1227\/NEU.0000000000000633","article-title":"Stereotactic radiosurgery for intracranial meningiomas: current concepts and future perspectives","volume":"76","year":"2015","journal-title":"Neurosurgery"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0051","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s11060-015-1911-1","article-title":"Post-radiosurgical edema associated with parasagittal and parafalcine meningiomas: a multicenter study","volume":"125","year":"2015","journal-title":"J Neurooncol"},{"issue":"5","key":"key\n\t\t\t\t20170608071002_CIT0052","doi-asserted-by":"crossref","first-page":"957","DOI":"10.3171\/2009.8.JNS09695","article-title":"Long-term control of petroclival meningiomas through radiosurgery","volume":"112","year":"2010","journal-title":"J Neurosurg"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0053","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3171\/jns.2002.97.1.0065","article-title":"Stereotactic radiosurgery providing long-term tumor control of cavernous sinus meningiomas","volume":"97","year":"2002","journal-title":"J Neurosurg"},{"issue":"6","key":"key\n\t\t\t\t20170608071002_CIT0054","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.3171\/2014.2.JNS13139","article-title":"Gamma Knife radiosurgery for sellar and parasellar meningiomas: a multicenter study","volume":"120","year":"2014","journal-title":"J Neurosurg"},{"key":"key\n\t\t\t\t20170608071002_CIT0055","first-page":"733","article-title":"Visual field preservation after multisession cyberknife radiosurgery for perioptic lesions","volume":"62","year":"2008","journal-title":"Neurosurgery"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0056","doi-asserted-by":"crossref","first-page":"52","DOI":"10.4103\/0973-1482.80462","article-title":"Fractionated stereotactic radiosurgery for the treatment of meningiomas","volume":"7","year":"2011","journal-title":"J Cancer Res Ther"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0057","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s11060-015-1838-6","article-title":"Hypofractionated stereotactic radiation therapy in skull base meningiomas","volume":"124","year":"2015","journal-title":"J Neurooncol"},{"issue":"5","key":"key\n\t\t\t\t20170608071002_CIT0058","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.ijrobp.2008.03.028","article-title":"Gamma knife radiosurgery for skull base meningiomas: long-term radiologic and clinical outcome","volume":"72","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0059","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3171\/2014.7.JNS131644","article-title":"Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review","volume":"122","year":"2015","journal-title":"J Neurosurg"},{"issue":"20","key":"key\n\t\t\t\t20170608071002_CIT0060","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1056\/NEJM199811123392003","article-title":"Long-term outcomes after radiosurgery for acoustic neuromas","volume":"339","year":"1998","journal-title":"N Engl J Med"},{"issue":"4","key":"key\n\t\t\t\t20170608071002_CIT0061","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.ijrobp.2010.10.010","article-title":"Radiotherapy for vestibular schwannomas: a critical review","volume":"79","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"key\n\t\t\t\t20170608071002_CIT0062","doi-asserted-by":"crossref","first-page":"885","DOI":"10.3171\/2011.6.JNS101963","article-title":"Management of large vestibular schwannoma. Part II. Primary gamma knife surgery: radiological and clinical aspects","volume":"115","year":"2011","journal-title":"J Neurosurg"},{"key":"key\n\t\t\t\t20170608071002_CIT0063","first-page":"121","article-title":"Frameless fractionated stereotactic radiosurgery for vestibular schwannomas: a single-institution experience","volume":"3","year":"2013","journal-title":"Front Oncol"},{"issue":"5","key":"key\n\t\t\t\t20170608071002_CIT0064","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/S0360-3016(03)00444-9","article-title":"Single-fraction vs. fractionated linac-based stereotactic radiosurgery for vestibular schwannoma: a single-institution study","volume":"56","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"8","key":"key\n\t\t\t\t20170608071002_CIT0065","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/jjco\/hyt082","article-title":"Hypofractionated stereotactic radiation therapy in three to five fractions for vestibular schwannoma","volume":"43","year":"2013","journal-title":"Jpn J Clin Oncol"},{"issue":"1\u20134","key":"key\n\t\t\t\t20170608071002_CIT0066","first-page":"45","article-title":"Fractionated stereotactic radiosurgery for treatment of acoustic neuromas","volume":"73","year":"1999","journal-title":"Stereotact Funct Neurosurg"},{"key":"key\n\t\t\t\t20170608071002_CIT0067","first-page":"297093","article-title":"Clinical evaluation of CyberKnife in the treatment of vestibular schwannomas","volume":"2013","year":"2013","journal-title":"Biomed Res Int"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0068","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/MAO.0b013e3182a435f5","article-title":"Treatment outcomes in patients treated with CyberKnife radiosurgery for vestibular schwannoma","volume":"35","year":"2014","journal-title":"Otol Neurotol"},{"issue":"5","key":"key\n\t\t\t\t20170608071002_CIT0069","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1470-2045(09)70025-7","article-title":"Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial","volume":"10","author":"European Organisation for Research and Treatment of Cancer Brain Tumour and Radiation Oncology Groups; National Cancer Institute of Canada Clinical Trials Group","year":"2009","journal-title":"Lancet Oncol"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0070","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ijrobp.2008.04.030","article-title":"Accelerated hypofractionated intensity-modulated radiotherapy with concurrent and adjuvant temozolomide for patients with glioblastoma multiforme: a safety and efficacy analysis","volume":"73","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0071","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijrobp.2011.06.1992","article-title":"Phase II study of short-course radiotherapy plus concomitant and adjuvant temozolomide in elderly patients with glioblastoma","volume":"83","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key\n\t\t\t\t20170608071002_CIT0072","article-title":"A phase III randomized controlled trial of short-course radiotherapy with or without concomitant and adjuvant temozolomide in elderly patients with glioblastoma (CCTG CE.6, EORTC 26062-22061, TROG 08.02, NCT00482677)","volume":"34","year":"2016","journal-title":"J Clin Oncol"},{"issue":"9","key":"key\n\t\t\t\t20170608071002_CIT0073","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1200\/JCO.2004.06.082","article-title":"Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial","volume":"22","year":"2004","journal-title":"J Clin Oncol"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0074","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s11060-010-0306-6","article-title":"A pilot study of hypofractionated radiation therapy with temozolomide for adults with glioblastoma multiforme","volume":"102","year":"2011","journal-title":"J Neurooncol"},{"issue":"9","key":"key\n\t\t\t\t20170608071002_CIT0075","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S1470-2045(12)70265-6","article-title":"Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial","volume":"13","author":"Nordic Clinical Brain Tumour Study Group (NCBTSG)","year":"2012","journal-title":"Lancet Oncol"},{"issue":"3","key":"key\n\t\t\t\t20170608071002_CIT0076","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0360-3016(03)01623-7","article-title":"Hypofractionated intensity-modulated radiotherapy for primary glioblastoma multiforme","volume":"58","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"key\n\t\t\t\t20170608071002_CIT0077","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.ijrobp.2010.07.021","article-title":"Phase I trial of hypofractionated intensity-modulated radiotherapy with temozolomide chemotherapy for patients with newly diagnosed glioblastoma multiforme","volume":"81","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"19","key":"key\n\t\t\t\t20170608071002_CIT0078","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.1158\/1078-0432.CCR-14-0822","article-title":"Phase II study of bevacizumab, temozolomide, and hypofractionated stereotactic radiotherapy for newly diagnosed glioblastoma","volume":"20","year":"2014","journal-title":"Clin Cancer Res"},{"issue":"35","key":"key\n\t\t\t\t20170608071002_CIT0079","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1200\/JCO.2015.62.6606","article-title":"International atomic energy agency randomized phase III study of radiation therapy in elderly and\/or frail patients with newly diagnosed glioblastoma multiforme","volume":"33","year":"2015","journal-title":"J Clin Oncol"},{"issue":"5","key":"key\n\t\t\t\t20170608071002_CIT0080","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/j.ijrobp.2010.12.074","article-title":"Safety and efficacy of stereotactic radiosurgery and adjuvant bevacizumab in patients with recurrent malignant gliomas","volume":"82","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"18","key":"key\n\t\t\t\t20170608071002_CIT0081","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1200\/JCO.2009.25.6941","article-title":"Hypofractionated stereotactic radiation therapy: an effective therapy for recurrent high-grade gliomas","volume":"28","year":"2010","journal-title":"J Clin Oncol"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0082","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijrobp.2005.05.024","article-title":"The American Society for Therapeutic Radiology and Oncology (ASTRO) evidence-based review of the role of radiosurgery for malignant glioma","volume":"63","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"12","key":"key\n\t\t\t\t20170608071002_CIT0083","first-page":"e413","article-title":"Stereotactic radiosurgery for glioblastoma","volume":"7","year":"2015","journal-title":"Cureus"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0084","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3171\/jns.1999.90.1.0072","article-title":"Treatment of patients with primary glioblastoma multiforme with standard postoperative radiotherapy and radiosurgical boost: prognostic factors and long-term outcome","volume":"90","year":"1999","journal-title":"J Neurosurg"},{"issue":"4","key":"key\n\t\t\t\t20170608071002_CIT0085","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3171\/jns.1995.82.4.0530","article-title":"Stereotactic radiosurgery for glioblastoma: a final report of 31 patients","volume":"82","year":"1995","journal-title":"J Neurosurg"},{"issue":"3","key":"key\n\t\t\t\t20170608071002_CIT0086","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.ijrobp.2004.04.011","article-title":"Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: report of Radiation Therapy Oncology Group 93-05 protocol","volume":"60","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"9","key":"key\n\t\t\t\t20170608071002_CIT0087","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1200\/JCO.1992.10.9.1379","article-title":"Radiosurgery as part of the initial management of patients with malignant gliomas","volume":"10","year":"1992","journal-title":"J Clin Oncol"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0088","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0167-8140(02)00386-9","article-title":"Fractionated stereotactic radiotherapy boost after post-operative radiotherapy in patients with high-grade gliomas","volume":"67","year":"2003","journal-title":"Radiother Oncol"},{"issue":"4","key":"key\n\t\t\t\t20170608071002_CIT0089","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/(SICI)1520-6823(1998)6:4<175::AID-ROI5>3.0.CO;2-V","article-title":"Accelerated radiotherapy regimen for malignant gliomas using stereotactic concomitant boosts for dose escalation","volume":"6","year":"1998","journal-title":"Radiat Oncol Investig"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0090","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1023\/A:1022985620284","article-title":"Hypofractionated stereotactic radiotherapy for malignant glioma: a phase I\/II study","volume":"2","year":"1999","journal-title":"Journal of Radiosurgery"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0091","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0167-8140(99)00183-8","article-title":"Hypofractionation in glioblastoma multiforme","volume":"54","year":"2000","journal-title":"Radiother Oncol"},{"key":"key\n\t\t\t\t20170608071002_CIT0092","article-title":"A phase III randomized controlled trial of short-course radiotherapy with or without concomitant and adjuvant temozolomide in elderly patients with glioblastoma (CCTG CE.6, EORTC 26062-22061, TROG 08.02, NCT00482677)","volume":"34","year":"2016","journal-title":"JCO"},{"issue":"1017","key":"key\n\t\t\t\t20170608071002_CIT0093","doi-asserted-by":"crossref","first-page":"e770","DOI":"10.1259\/bjr\/83827377","article-title":"Hypofractionated radiotherapy for glioblastoma: strategy for poor-risk patients or hope for the future?","volume":"85","year":"2012","journal-title":"Br J Radiol"},{"issue":"3","key":"key\n\t\t\t\t20170608071002_CIT0094","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/153303460800700311","article-title":"Survival following CyberKnife radiosurgery and hypofractionated radiotherapy for newly diagnosed glioblastoma multiforme","volume":"7","year":"2008","journal-title":"Technol Cancer Res Treat"},{"issue":"2S","key":"key\n\t\t\t\t20170608071002_CIT0095","first-page":"E131","article-title":"A phase I\/II trial of 5 fraction stereotactic radiosurgery with 5-mm margins with concurrent and adjuvant temozolomide in newly diagnosed supratentorial glioblastoma multiforme","volume":"96","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0096","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1227\/00006123-199502000-00006","article-title":"Comparison of stereotactic radiosurgery and brachytherapy in the treatment of recurrent glioblastoma multiforme","volume":"36","year":"1995","journal-title":"Neurosurgery"},{"issue":"3","key":"key\n\t\t\t\t20170608071002_CIT0097","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0360-3016(97)00843-2","article-title":"Fractionated stereotactic radiosurgery and concurrent taxol in recurrent glioblastoma multiforme: a preliminary report","volume":"40","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"7","key":"key\n\t\t\t\t20170608071002_CIT0098","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1200\/JCO.1995.13.7.1642","article-title":"Stereotactic radiosurgery for recurrent malignant gliomas","volume":"13","year":"1995","journal-title":"J Clin Oncol"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0099","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ijrobp.2008.10.043","article-title":"Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas","volume":"75","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0100","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0360-3016(98)00416-7","article-title":"A phase I dose escalation study of hypofractionated stereotactic radiotherapy as salvage therapy for persistent or recurrent malignant glioma","volume":"43","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"17","key":"key\n\t\t\t\t20170608071002_CIT0101","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1002\/cncr.27372","article-title":"Extended field stereotactic radiosurgery for recurrent glioblastoma","volume":"118","year":"2012","journal-title":"Cancer"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0102","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11060-012-0999-9","article-title":"Hypofractionated stereotactic radiotherapy and continuous low-dose temozolomide in patients with recurrent or progressive malignant gliomas","volume":"111","year":"2013","journal-title":"J Neurooncol"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0103","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ijrobp.2010.09.008","article-title":"Phase I dose escalation trial of vandetanib with fractionated radiosurgery in patients with recurrent malignant gliomas","volume":"82","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0104","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0360-3016(00)00688-X","article-title":"Preliminary report of a phase I study of combined fractionated stereotactic radiosurgery and conventional external beam radiation therapy for unfavorable gliomas","volume":"48","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0105","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s11060-011-0744-9","article-title":"Salvage gamma knife stereotactic radiosurgery followed by bevacizumab for recurrent glioblastoma multiforme: a case-control study","volume":"107","year":"2012","journal-title":"J Neurooncol"},{"issue":"1","key":"key\n\t\t\t\t20170608071002_CIT0106","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11060-013-1044-3","article-title":"Re-irradiation with and without bevacizumab as salvage therapy for recurrent or progressive high-grade gliomas","volume":"112","year":"2013","journal-title":"J Neurooncol"},{"issue":"5","key":"key\n\t\t\t\t20170608071002_CIT0107","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.ijrobp.2009.12.061","article-title":"Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the central nervous system","volume":"79","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"key\n\t\t\t\t20170608071002_CIT0108","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.ijrobp.2013.04.029","article-title":"Concurrent stereotactic radiosurgery and bevacizumab in recurrent malignant gliomas: a prospective trial","volume":"86","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"key\n\t\t\t\t20170608071002_CIT0109","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11060-015-1791-4","article-title":"Hypofractionated-intensity modulated radiotherapy (hypo-IMRT) and temozolomide (TMZ) with or without bevacizumab (BEV) for newly diagnosed glioblastoma multiforme (GBM): a comparison of two prospective phase II trials","volume":"123","year":"2015","journal-title":"J Neurooncol"},{"issue":"4","key":"key\n\t\t\t\t20170608071002_CIT0110","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.semradonc.2014.06.006","article-title":"Recurrent malignant gliomas","volume":"24","year":"2014","journal-title":"Semin Radiat Oncol"},{"issue":"4","key":"key\n\t\t\t\t20170608071002_CIT0111","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.prro.2016.03.007","article-title":"Radiation therapy for glioblastoma: executive summary of an American society for radiation oncology evidence-based clinical practice guideline","volume":"6","year":"2016","journal-title":"Pract Radiat Oncol"},{"issue":"6","key":"key\n\t\t\t\t20170608071002_CIT0112","first-page":"835","article-title":"Mean apparent diffusion coefficient values in defining radiotherapy planning target volumes in glioblastoma","volume":"5","year":"2015","journal-title":"Quant Imaging Med Surg"}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/19\/suppl_2\/ii38\/17677580\/now301.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T18:10:32Z","timestamp":1568830232000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-lookup\/doi\/10.1093\/neuonc\/now301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,31]]},"references-count":112,"journal-issue":{"issue":"suppl_2","published-online":{"date-parts":[[2017,3,31]]},"published-print":{"date-parts":[[2017,4]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/now301","relation":{},"ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,31]]}}}