{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:57:16Z","timestamp":1792270636059,"version":"4.4.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30-CA008748"],"award-info":[{"award-number":["P30-CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1093\/neuonc\/nox066","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T08:23:34Z","timestamp":1496737414000},"page":"1248-1254","source":"Crossref","is-referenced-by-count":109,"title":["Cerebrospinal fluid circulating tumor cells: a novel tool to diagnose leptomeningeal metastases from epithelial tumors"],"prefix":"10.1093","volume":"19","author":[{"given":"Xuling","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Fleisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Rosenblum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Boire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Briggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yevgeniya","family":"Bensman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Hurtado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa","family":"Shagabayeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M","family":"DeAngelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine S","family":"Panageas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Omuro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena I","family":"Pentsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,6,21]]},"reference":[{"issue":"4","key":"key\n\t\t\t\t20170814123001_CIT0001","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/1097-0142(19820215)49:4<759::AID-CNCR2820490427>3.0.CO;2-7","article-title":"Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients","volume":"49","year":"1982","journal-title":"Cancer"},{"issue":"11","key":"key\n\t\t\t\t20170814123001_CIT0002","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s00432-010-0831-x","article-title":"Prognostic factors and treatment options in patients with leptomeningeal metastases of different primary tumors: a retrospective analysis","volume":"136","year":"2010","journal-title":"J Cancer Res Clin Oncol"},{"issue":"3","key":"key\n\t\t\t\t20170814123001_CIT0003","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.cllc.2013.12.009","article-title":"Prolonged survival of patients with non-small-cell lung cancer with leptomeningeal carcinomatosis in the modern treatment era","volume":"15","year":"2014","journal-title":"Clin Lung Cancer"},{"issue":"5","key":"key\n\t\t\t\t20170814123001_CIT0004","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.ejrad.2011.02.020","article-title":"Use of magnetic resonance imaging to detect neoplastic meningitis: limited use in leukemia and lymphoma but convincing results in solid tumors","volume":"81","year":"2012","journal-title":"Eur J Radiol"},{"issue":"4","key":"key\n\t\t\t\t20170814123001_CIT0005","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/(SICI)1097-0142(19980215)82:4<733::AID-CNCR17>3.0.CO;2-Z","article-title":"Cerebrospinal fluid cytology in patients with cancer: minimizing false-negative results","volume":"82","year":"1998","journal-title":"Cancer"},{"issue":"1","key":"key\n\t\t\t\t20170814123001_CIT0006","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.humpath.2003.08.026","article-title":"Frequent EpCam protein expression in human carcinomas","volume":"35","year":"2004","journal-title":"Hum Pathol"},{"issue":"8","key":"key\n\t\t\t\t20170814123001_CIT0007","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1056\/NEJMoa040766","article-title":"Circulating tumor cells, disease progression, and survival in metastatic breast cancer","volume":"351","year":"2004","journal-title":"N Engl J Med"},{"issue":"31","key":"key\n\t\t\t\t20170814123001_CIT0008","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1200\/JCO.2008.20.6664","article-title":"Circulating tumor cells: a useful predictor of treatment efficacy in metastatic breast cancer","volume":"27","year":"2009","journal-title":"J Clin Oncol"},{"issue":"20","key":"key\n\t\t\t\t20170814123001_CIT0009","doi-asserted-by":"crossref","first-page":"6897","DOI":"10.1158\/1078-0432.CCR-04-0378","article-title":"Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases","volume":"10","year":"2004","journal-title":"Clin Cancer Res"},{"issue":"3","key":"key\n\t\t\t\t20170814123001_CIT0010","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1470-2045(08)70340-1","article-title":"Circulating tumour cells as prognostic markers in progressive, castration-resistant prostate cancer: a reanalysis of IMMC38 trial data","volume":"10","year":"2009","journal-title":"Lancet Oncol"},{"issue":"17","key":"key\n\t\t\t\t20170814123001_CIT0011","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1212\/WNL.0b013e31828f183f","article-title":"Rare cell capture technology for the diagnosis of leptomeningeal metastasis in solid tumors","volume":"80","year":"2013","journal-title":"Neurology"},{"issue":"10","key":"key\n\t\t\t\t20170814123001_CIT0012","doi-asserted-by":"crossref","first-page":"752","DOI":"10.18632\/oncotarget.336","article-title":"Identification and enumeration of circulating tumor cells in the cerebrospinal fluid of breast cancer patients with central nervous system metastases","volume":"2","year":"2011","journal-title":"Oncotarget"},{"key":"key\n\t\t\t\t20170814123001_CIT0013","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1472-6890-12-21","article-title":"Development of a new method for identification and quantification in cerebrospinal fluid of malignant cells from breast carcinoma leptomeningeal metastasis","volume":"12","year":"2012","journal-title":"BMC Clin Pathol"},{"issue":"18","key":"key\n\t\t\t\t20170814123001_CIT0014","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1212\/WNL.0b013e3181dc1a69","article-title":"Leptomeningeal metastases in the MRI era","volume":"74","year":"2010","journal-title":"Neurology"},{"issue":"1","key":"key\n\t\t\t\t20170814123001_CIT0015","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ana.410380111","article-title":"Neuroimaging and cerebrospinal fluid cytology in the diagnosis of leptomeningeal metastasis","volume":"38","year":"1995","journal-title":"Ann Neurol"},{"issue":"9","key":"key\n\t\t\t\t20170814123001_CIT0016","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1007\/s004150050459","article-title":"The diagnostic accuracy of magnetic resonance imaging and cerebrospinal fluid cytology in leptomeningeal metastasis","volume":"246","year":"1999","journal-title":"J Neurol"},{"issue":"5","key":"key\n\t\t\t\t20170814123001_CIT0017","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1093\/clinchem\/47.5.948","article-title":"Cerebrospinal fluid cytokeratins for diagnosis of patients with central nervous system metastases from breast cancer","volume":"47","year":"2001","journal-title":"Clin Chem"},{"issue":"7","key":"key\n\t\t\t\t20170814123001_CIT0018","first-page":"874","article-title":"Intrathecal synthesis of tumor markers is a highly sensitive test in the diagnosis of leptomeningeal metastasis from solid cancers","volume":"47","year":"2009","journal-title":"Clin Chem Lab Med"},{"issue":"8","key":"key\n\t\t\t\t20170814123001_CIT0019","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1212\/WNL.54.8.1670","article-title":"Vascular endothelial growth factor in CSF: a biological marker for carcinomatous meningitis","volume":"54","year":"2000","journal-title":"Neurology"},{"issue":"2","key":"key\n\t\t\t\t20170814123001_CIT0020","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/sj.bjc.6601953","article-title":"Vascular endothelial growth factor (VEGF) in leptomeningeal metastasis: diagnostic and prognostic value","volume":"91","year":"2004","journal-title":"Br J Cancer"},{"issue":"2","key":"key\n\t\t\t\t20170814123001_CIT0021","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3233\/CBM-130338","article-title":"The concentration of CYFRA 21-1, NSE and CEA in cerebro-spinal fluid can be useful indicators for diagnosis of meningeal carcinomatosis of lung cancer","volume":"13","year":"2013","journal-title":"Cancer Biomark"},{"issue":"23","key":"key\n\t\t\t\t20170814123001_CIT0022","doi-asserted-by":"crossref","first-page":"7134","DOI":"10.1158\/0008-5472.CAN-13-2051","article-title":"Molecular profiling of tumor cells in cerebrospinal fluid and matched primary tumors from metastatic breast cancer patients with leptomeningeal carcinomatosis","volume":"73","year":"2013","journal-title":"Cancer Res"},{"issue":"2","key":"key\n\t\t\t\t20170814123001_CIT0023","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s10549-015-3610-1","article-title":"Detection of cerebrospinal fluid tumor cells and its clinical relevance in leptomeningeal metastasis of breast cancer","volume":"154","year":"2015","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"key\n\t\t\t\t20170814123001_CIT0024","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.lungcan.2015.09.008","article-title":"CellSearch technology applied to the detection and quantification of tumor cells in CSF of patients with lung cancer leptomeningeal metastasis","volume":"90","year":"2015","journal-title":"Lung Cancer"},{"issue":"4","key":"key\n\t\t\t\t20170814123001_CIT0025","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s10585-015-9716-3","article-title":"Diagnostic and prognostic significance of flow cytometry immunophenotyping in patients with leptomeningeal carcinomatosis","volume":"32","year":"2015","journal-title":"Clin Exp Metastasis"},{"issue":"6","key":"key\n\t\t\t\t20170814123001_CIT0026","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1093\/neuonc\/nov273","article-title":"EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors","volume":"18","year":"2016","journal-title":"Neuro Oncol"},{"issue":"5","key":"key\n\t\t\t\t20170814123001_CIT0027","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1080\/15384047.2015.1026508","article-title":"Circulating tumor cell levels are elevated in colorectal cancer patients with high tumor burden in the liver","volume":"16","year":"2015","journal-title":"Cancer Biol Ther"},{"issue":"9","key":"key\n\t\t\t\t20170814123001_CIT0028","first-page":"3905","article-title":"Circulating tumor cell (CTC) count and epithelial growth factor receptor expression on CTCs as biomarkers for cetuximab efficacy in advanced colorectal cancer","volume":"33","year":"2013","journal-title":"Anticancer Res"},{"issue":"7","key":"key\n\t\t\t\t20170814123001_CIT0029","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1634\/theoncologist.2012-0048","article-title":"Circulating tumor cell count is a prognostic factor in metastatic colorectal cancer patients receiving first-line chemotherapy plus bevacizumab: a Spanish Cooperative Group for the Treatment of Digestive Tumors study","volume":"17","year":"2012","journal-title":"Oncologist"},{"key":"key\n\t\t\t\t20170814123001_CIT0030","doi-asserted-by":"crossref","first-page":"now183","DOI":"10.1093\/neuonc\/now183","article-title":"Leptomeningeal metastases: a RANO proposal for response criteria","year":"2016","journal-title":"Neuro Oncol"}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/19\/9\/1248\/19516970\/nox066.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T14:30:32Z","timestamp":1602253832000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/neuro-oncology\/article\/19\/9\/1248\/3883642\/Cerebrospinal-fluid-circulating-tumor-cells-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,21]]},"references-count":30,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,6,21]]},"published-print":{"date-parts":[[2017,9]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/nox066","relation":{},"ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,21]]}}}