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Genome-wide association studies (GWAS) have previously identified only a single risk locus for meningioma, at 10p12.31.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>To identify a susceptibility locus for meningioma, we conducted a meta-analysis of 2 GWAS, imputed using a merged reference panel from the 1000 Genomes Project and UK10K data, with validation in 2 independent sample series totaling 2138 cases and 12081 controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 \u00d7 10\u20139). A number of genes localize to the region of linkage disequilibrium encompassing rs2686876, including RIC8A, which plays a central role in the development of neural crest-derived structures, such as the meninges.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This finding advances our understanding of the genetic basis of meningioma development and provides additional support for a polygenic model of meningioma.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/neuonc\/noy077","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T15:10:48Z","timestamp":1526051448000},"page":"1485-1493","source":"Crossref","is-referenced-by-count":24,"title":["Genome-wide association analysis identifies a meningioma risk locus at 11p15.5"],"prefix":"10.1093","volume":"20","author":[{"given":"Elizabeth B","family":"Claus","sequence":"first","affiliation":[{"name":"School of Public Health, Yale University, New Haven, Connecticut, USA"},{"name":"Department of Neurosurgery, Brigham and Women\u2019s Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3966-3501","authenticated-orcid":false,"given":"Alex J","family":"Cornish","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Broderick","sequence":"additional","affiliation":[{"name":"Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joellen M","family":"Schildkraut","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, 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Yale University, New Haven, Connecticut, USA"},{"name":"Division of Neuroepidemiology, Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schramm","sequence":"additional","affiliation":[{"name":"School of Public Health, Yale University, New Haven, Connecticut, USA"},{"name":"University of Bonn Medical School, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"School of Public Health, Yale University, New Haven, Connecticut, USA"},{"name":"Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland"},{"name":"Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus 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