{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:58:07Z","timestamp":1791824287573,"version":"4.3.4"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Else Kr\u00f6ner-Fresenius Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This study aims to evaluate the impact of tumor location on key molecular alterations on a single voxel level in patients with newly diagnosed glioma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A consecutive series of n = 237 patients with newly diagnosed glioblastoma and n = 131 patients with lower-grade glioma was analyzed. Volumetric tumor segmentation was performed on preoperative MRI with a semi-automated approach and images were registered to the standard Montreal Neurological Institute 152 space. Using a voxel-based lesion symptom mapping (VLSM) analysis, we identified specific brain regions that were associated with tumor-specific molecular alterations. We assessed a predefined set of n = 17 molecular characteristics in the glioblastoma cohort and n = 2 molecular characteristics in the lower-grade glioma cohort. Permutation adjustment (n = 1000 iterations) was used to correct for multiple testing, and voxel t-values that were greater than the t-value in &gt;95% of the permutations were retained in the VLSM results (\u03b1 = 0.05, power &gt; 0.8).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Tumor location predilection for isocitrate dehydrogenase (IDH) mutant tumors was found in both glioblastoma and lower-grade glioma cohorts, each showing a concordant predominance in the frontal lobe adjacent to the rostral extension of the lateral ventricles (permutation-adjusted P = 0.021 for the glioblastoma and 0.013 for the lower-grade glioma cohort). Apart from that, the VLSM analysis did not reveal a significant association of the tumor location with any other key molecular alteration in both cohorts (permutation-adjusted P &gt; 0.05 each).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our study highlights the unique properties of IDH mutations and underpins the hypothesis that the rostral extension of the lateral ventricles is a potential location for the cell of origin in IDH-mutant gliomas.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/neuonc\/noy134","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T23:28:46Z","timestamp":1533684526000},"page":"1517-1524","source":"Crossref","is-referenced-by-count":54,"title":["Voxel-wise radiogenomic mapping of tumor location with key molecular alterations in patients with glioma"],"prefix":"10.1093","volume":"20","author":[{"given":"Miguel Angel","family":"Tejada Neyra","sequence":"first","affiliation":[{"name":"Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Neuberger","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annekathrin","family":"Reinhardt","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, University of Heidelberg Medical Center, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Brugnara","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bonekamp","sequence":"additional","affiliation":[{"name":"Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Sill","sequence":"additional","affiliation":[{"name":"Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany"},{"name":"Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany"},{"name":"German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Wick","sequence":"additional","affiliation":[{"name":"Neurology Clinic, University of Heidelberg Medical Center, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T W","family":"Jones","sequence":"additional","affiliation":[{"name":"Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany"},{"name":"Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany"},{"name":"German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Radbruch","sequence":"additional","affiliation":[{"name":"Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Unterberg","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Heidelberg Medical Center, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Debus","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Heidelberg Medical Center, Heidelberg Institute of Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Pfister","sequence":"additional","affiliation":[{"name":"Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany"},{"name":"Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany"},{"name":"German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany"},{"name":"Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"von Deimling","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, University of Heidelberg Medical Center, Heidelberg, Germany"},{"name":"DKTK, Clinical Cooperation Unit Neuropathology, DKFZ, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Wick","sequence":"additional","affiliation":[{"name":"Neurology Clinic, 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