{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:21:39Z","timestamp":1793020899888,"version":"4.5.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This systematic review reports on outcomes and toxicities following stereotactic radiosurgery (SRS) for non-functioning pituitary adenomas (NFAs) and presents consensus opinions regarding appropriate patient management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, a systematic review was performed from articles of \u226510 patients with NFAs published prior to May 2018 from the Medline database using the key words \u201cradiosurgery\u201d and \u201cpituitary\u201d and\/or \u201cadenoma.\u201d Weighted random effects models were used to calculate pooled outcome estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 678 abstracts reviewed, 35 full-text articles were included describing the outcomes of 2671 patients treated between 1971 and 2017 with either single fraction SRS or hypofractionated stereotactic radiotherapy (HSRT). All studies were retrospective (level IV evidence). SRS was used in 27 studies (median dose: 15 Gy, range: 5\u201335 Gy) and HSRT in 8 studies (median total dose: 21 Gy, range: 12\u201325 Gy, delivered in 3\u20135 fractions). The 5-year random effects local control estimate after SRS was 94% (95% CI: 93.0\u201396.0%) and 97.0% (95% CI: 93.0\u201398.0%) after HSRT. The 10-year local control random effects estimate after SRS was 83.0% (95% CI: 77.0\u201388.0%). Post-SRS hypopituitarism was the most common treatment-related toxicity observed, with a random effects estimate of 21.0% (95% CI: 15.0\u201327.0%), whereas visual dysfunction or other cranial nerve injuries were uncommon (range: 0\u20137%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SRS is an effective and safe treatment for patients with NFAs. Encouraging short-term data support HSRT for select patients, and mature outcomes are needed before definitive recommendations can be made. Clinical practice opinions were developed on behalf of the International Stereotactic Radiosurgery Society (ISRS).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noz225","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T13:32:25Z","timestamp":1575293545000},"page":"318-332","source":"Crossref","is-referenced-by-count":85,"title":["Stereotactic radiosurgery for non-functioning pituitary adenomas: meta-analysis and International Stereotactic Radiosurgery Society practice opinion"],"prefix":"10.1093","volume":"22","author":[{"given":"Rupesh","family":"Kotecha","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Sahgal","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muni","family":"Rubens","sequence":"first","affiliation":[{"name":"Miami Cancer Institute, Baptist Health South Florida, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"De Salles","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fariselli","sequence":"first","affiliation":[{"name":"Radiotherapy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce E","family":"Pollock","sequence":"first","affiliation":[{"name":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Levivier","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Gamma Knife Center, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, University of California San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3820-8654","authenticated-orcid":false,"given":"Ian","family":"Paddick","sequence":"first","affiliation":[{"name":"Medical Physics Ltd, Reading, Cromwell Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Regis","sequence":"first","affiliation":[{"name":"Functional and Stereotaxic Neurosurgery Department, Clinical Neuroscience Federation, Timone Hospital, Aix-Marseille University, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Sheehan","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Yomo","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology, Aizawa Comprehensive Cancer Center, Aizawa Hospital, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H","family":"Suh","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"issue":"3","key":"2020030521145849100_CIT0001","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/cncr.20412","article-title":"The prevalence of pituitary adenomas: a systematic review","volume":"101","author":"Ezzat","year":"2004","journal-title":"Cancer."},{"issue":"2","key":"2020030521145849100_CIT0002","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11060-017-2370-7","article-title":"Clinical efficacy and safety of surface imaging guided radiosurgery (SIG-RS) in the treatment of benign skull base tumors","volume":"132","author":"Lau","year":"2017","journal-title":"J Neurooncol."},{"issue":"7","key":"2020030521145849100_CIT0003","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"key":"2020030521145849100_CIT0004","first-page":"48","article-title":"Conducting meta-analyses in R with the metafor package","volume-title":"J. 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