{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:39:52Z","timestamp":1793648392146,"version":"4.5.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/ mailto:journals.permissions@oup.com"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Aneurysm recurrence after coiling has been associated with aneurysm growth, (re)hemorrhage, and a greater need for follow-up. The second-generation HydroCoil Embolic System (HES; MicroVention, Inc) consists of a platinum core with integrated hydrogel and was developed to reduce recurrence through enhancing packing density and healing within the aneurysm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To compare recurrence between the second-generation HES and bare platinum coil (BPC) in the new-generation Hydrogel Endovascular Aneurysm Treatment Trial (HEAT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>HEAT is a randomized, controlled trial that enrolled subjects with ruptured or unruptured 3- to 14-mm intracranial aneurysms amenable to coiling. The primary endpoint was aneurysm recurrence using the Raymond-Roy scale. Secondary endpoints included minor and major recurrence, packing density, adverse events related to the procedure and\/or device, mortality, initial complete occlusion, aneurysm retreatment, hemorrhage from target aneurysm during follow-up, aneurysm occlusion stability, and clinical outcome at final follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A total of 600 patients were randomized (HES, n\u00a0=\u00a0297 and BPC, n\u00a0=\u00a0303), including 28% with ruptured aneurysms. Recurrence occurred in 11 (4.4%) subjects in the HES arm and 44 (15.4%) subjects in the BPC arm (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.002). While the initial occlusion rate was higher with BPC, the packing density and both major and minor recurrence rates were in favor of HES. Secondary endpoints including adverse events, retreatment, hemorrhage, mortality, and clinical outcome did not differ between arms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Coiling of small-to-medium aneurysms with second-generation HES resulted in less recurrence when compared to BPC, without increased harm. These data further support the use of the second-generation HES for the embolization of intracranial aneurysms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Video Abstract<\/jats:title>\n                    <jats:p\/>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyaa006","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T15:10:38Z","timestamp":1581347438000},"page":"615-624","source":"Crossref","is-referenced-by-count":55,"title":["The Hydrogel Endovascular Aneurysm Treatment Trial (HEAT): A Randomized Controlled Trial of the Second-Generation Hydrogel Coil"],"prefix":"10.1227","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3506-3074","authenticated-orcid":false,"given":"Bernard R","family":"Bendok","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Mayo Clinic, Phoenix, Arizona"},{"name":"Department of Otolaryngology, Mayo Clinic, Phoenix, Arizona"},{"name":"Department of Radiology, Mayo Clinic, Phoenix, Arizona"},{"name":"Precision Neuro-therapeutics Innovation Lab, Mayo Clinic, Phoenix, Arizona"},{"name":"Neurosurgery Simulation and Innovation Lab, Mayo Clinic, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl R","family":"Abi-Aad","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Mayo Clinic, Phoenix, Arizona"},{"name":"Precision Neuro-therapeutics Innovation Lab, Mayo Clinic, Phoenix, Arizona"},{"name":"Neurosurgery Simulation and Innovation Lab, Mayo Clinic, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer D","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason F","family":"Kniss","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary J","family":"Kwasny","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudy J","family":"Rahme","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salah G","family":"Aoun","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek Y","family":"El Ahmadieh","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najib E","family":"El Tecle","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Saint Louis University Hospital, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer G","family":"Zammar","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami James N","family":"Aoun","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devi P","family":"Patra","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Mayo Clinic, Phoenix, Arizona"},{"name":"Precision Neuro-therapeutics Innovation Lab, Mayo Clinic, Phoenix, Arizona"},{"name":"Neurosurgery Simulation and Innovation Lab, Mayo Clinic, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer A","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Radiology, Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Raymond","sequence":"additional","affiliation":[{"name":"Laboratoire de Neuroradiologie Interventionnelle, Universit\u00e9 de Montr\u00e9al, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry H","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, North Shore University Hospital, Manhasset, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fiorella","sequence":"additional","affiliation":[{"name":"Department of Radiology, Stony Brook University Hospital, Stony Brook, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Dabus","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology and Neuroendovascular Surgery, Miami Cardiac and Vascular Institute, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"Milot","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chirurgie, CHU de Quebec, Quebec City, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josser E","family":"Delgado Almandoz","sequence":"additional","affiliation":[{"name":"Department of Neurointerventional Radiology, Abbott Northwestern Hospital, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Goodman Campbell Brain and Spine, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"DeNardo","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Goodman Campbell Brain and Spine, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shervin R","family":"Dashti","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Norton Neuroscience Institute, Norton Healthcare, Louisville, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"HEAT Study Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Ansari","sequence":"additional","affiliation":[{"name":"Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Deshaies","sequence":"additional","affiliation":[{"name":"SUNY Upstate Medical University, Syracuse, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Lavine","sequence":"additional","affiliation":[{"name":"Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hormozd","family":"Bozorgchami","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josser","family":"Delgado","sequence":"additional","affiliation":[{"name":"Abbott Northwestern\/Consulting Radiologists, Inc, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Veznedaroglu","sequence":"additional","affiliation":[{"name":"Capital Health Regional Medical Center, Trenton, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"St. Joseph's Hospital, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fiorella","sequence":"additional","affiliation":[{"name":"SUNY, Stony Brook, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Boulos","sequence":"additional","affiliation":[{"name":"Albany Medical College, Albany, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Cortes","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"Kanaan","sequence":"additional","affiliation":[{"name":"East Carolina University, Greenville, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Jindal","sequence":"additional","affiliation":[{"name":"University of Maryland, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Klucznik","sequence":"additional","affiliation":[{"name":"Methodist Hospital Research Institute, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Dabus","sequence":"additional","affiliation":[{"name":"Baptist Health of Miami, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kalmes","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabih","family":"Tawk","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Raymond","sequence":"additional","affiliation":[{"name":"CHUM Research Centre, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Romero","sequence":"additional","affiliation":[{"name":"UPMC Hamot, Erie, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Xavier","sequence":"additional","affiliation":[{"name":"McLaren Flint\/Wayne State University, Flint, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Hussain","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kelly","sequence":"additional","affiliation":[{"name":"University of Saskatchewan, Saskatoon, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Moran","sequence":"additional","affiliation":[{"name":"Washington University, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Chaudry","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina, Charleston, South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Pandey","sequence":"additional","affiliation":[{"name":"University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Wang","sequence":"additional","affiliation":[{"name":"MultiCare Health System, Tacoma, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"van Adel","sequence":"additional","affiliation":[{"name":"Hamilton Health\/McMaster University, Hamilton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"Milot","sequence":"additional","affiliation":[{"name":"CHU de Quebec, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Carpenter","sequence":"additional","affiliation":[{"name":"West Virginia University, Morgantown, West Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciaran","family":"Powers","sequence":"additional","affiliation":[{"name":"Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Jabbour","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Luh","sequence":"additional","affiliation":[{"name":"Mercy General Hospital, Sacramento, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai","family":"Shankar","sequence":"additional","affiliation":[{"name":"Dalhousie University, Halifax, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanchandra","family":"Tummala","sequence":"additional","affiliation":[{"name":"University of Minnesota, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athos","family":"Patsalides","sequence":"additional","affiliation":[{"name":"Weill Medical College of Cornell University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avery","family":"Evans","sequence":"additional","affiliation":[{"name":"University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Garg","sequence":"additional","affiliation":[{"name":"Oklahoma University, Oklahoma City, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shervin","family":"Dashti","sequence":"additional","affiliation":[{"name":"Norton Healthcare, Louisville, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"Queens Medical Center, Honolulu, Hawaii"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberts","family":"James","sequence":"additional","affiliation":[{"name":"University of Louisville, Louisville, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Jayaraman","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhakar","family":"Satti","sequence":"additional","affiliation":[{"name":"Christiana Hospital, Newark, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Sauvageau","sequence":"additional","affiliation":[{"name":"Lyerly Neurosurgery, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Fields","sequence":"additional","affiliation":[{"name":"Kaiser Permanente, Clackamas, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Grobelny","sequence":"additional","affiliation":[{"name":"Advocate Health, Park Ridge, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnathan","family":"Hartman","sequence":"additional","affiliation":[{"name":"Kaiser Permanente, Sacramento, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,5]]},"reference":[{"issue":"4","key":"bib1-20231011","doi-asserted-by":"crossref","first-page":"656","DOI":"10.3171\/jns.1999.90.4.0656","article-title":"Five-year experience in using coil embolization for ruptured intracranial aneurysms: outcomes and incidence of late rebleeding","volume":"90","author":"Byrne","year":"1999","journal-title":"J Neurosurg"},{"issue":"5","key":"bib2-20231011","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S1474-4422(09)70080-8","article-title":"Risk of recurrent subarachnoid haemorrhage, death, or dependence and standardised mortality ratios after clipping or coiling of an intracranial aneurysm in the International Subarachnoid Aneurysm Trial (ISAT): long-term follow-up","volume":"8","author":"Molyneux","year":"2009","journal-title":"Lancet Neurol"},{"issue":"9778","key":"bib3-20231011","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0140-6736(11)60408-X","article-title":"Hydrogel-coated coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms (HELPS): a randomised controlled trial","volume":"377","author":"White","year":"2011","journal-title":"Lancet North Am Ed"},{"issue":"7","key":"bib4-20231011","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.3174\/ajnr.A4175","article-title":"Mechanisms of healing in coiled intracranial aneurysms: a review of the literature","volume":"36","author":"Brinjikji","year":"2015","journal-title":"Am J Neuroradiol"},{"issue":"3","key":"bib5-20231011","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3171\/2010.6.JNS091058","article-title":"Sixteen-year single-surgeon experience with coil embolization for ruptured intracranial aneurysms: recurrence rates and incidence of late rebleeding","volume":"114","author":"Plowman","year":"2011","journal-title":"J Neurosurg"},{"issue":"5","key":"bib6-20231011","doi-asserted-by":"crossref","first-page":"935","DOI":"10.3174\/ajnr.A3857","article-title":"Bioactive versus bare platinum coils in the treatment of intracranial aneurysms: the MAPS (Matrix and Platinum Science) trial","volume":"35","author":"McDougall","year":"2014","journal-title":"Am J Neuroradiol"},{"issue":"10","key":"bib7-20231011","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1161\/STROKEAHA.112.657254","article-title":"Cerecyte coil trial: angiographic outcomes of a prospective randomized trial comparing endovascular coiling of cerebral aneurysms with either cerecyte or bare platinum coils","volume":"43","author":"Molyneux","year":"2012","journal-title":"Stroke"},{"issue":"10","key":"bib8-20231011","first-page":"2053","article-title":"Cerecyte coils in the treatment of intracranial aneurysms: a preliminary clinical study","volume":"27","author":"Bendszus","year":"2006","journal-title":"Am J Neuroradiol"},{"issue":"5","key":"bib9-20231011","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3174\/ajnr.A1021","article-title":"Results of 101 aneurysms treated with polyglycolic\/polylactic acid microfilament nexus coils compared with historical controls treated with standard coils","volume":"29","author":"Van Rooij","year":"2008","journal-title":"AJNR Am J Neuroradiol"},{"issue":"3","key":"bib10-20231011","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1148\/radiol.2313030460","article-title":"Relation between aneurysm volume, packing, and compaction in 145 cerebral aneurysms treated with coils","volume":"231","author":"Sluzewski","year":"2004","journal-title":"Radiology"},{"issue":"9","key":"bib11-20231011","first-page":"1580","article-title":"New expandable hydrogel-platinum coil hybrid device for aneurysm embolization","volume":"23","author":"Kallmes","year":"2002","journal-title":"Am J Neuroradiol"},{"issue":"1","key":"bib12-20231011","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/neurintsurg-2016-012915","article-title":"GEL THE NEC: a prospective registry evaluating the safety, ease of use, and efficacy of the HydroSoft coil as a finishing device","volume":"10","author":"Brinjikji","year":"2018","journal-title":"J Neurointervent Surg"},{"issue":"6","key":"bib13-20231011","doi-asserted-by":"crossref","first-page":"996","DOI":"10.3171\/jns.2004.101.6.0996","article-title":"Endovascular treatment of intracranial aneurysms: comparative evaluation in a terminal bifurcation aneurysm model in dogs","volume":"101","author":"Yoshino","year":"2004","journal-title":"J Neurosurg"},{"issue":"6","key":"bib14-20231011","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1136\/neurintsurg-2013-010867","article-title":"Reactive tissue proliferation and damage of elastic lamina caused by hydrogel coated coils in experimental rat aneurysms","volume":"6","author":"Zhang","year":"2014","journal-title":"J Neurointervent Surg"},{"issue":"2","key":"bib15-20231011","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/jbm.b.31443","article-title":"A comparison of experimental aneurysm occlusion determination by angiography, scanning electron microscopy, MICROFIL\u00ae perfusion, and histology","volume":"91","author":"Cruise","year":"2009","journal-title":"J Biomed Mater Res"},{"issue":"9","key":"bib16-20231011","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.3174\/ajnr.A4035","article-title":"Patients prone to recurrence after endovascular treatment: periprocedural results of the PRET randomized trial on large and recurrent aneurysms","volume":"35","author":"Raymond","year":"2014","journal-title":"Am J Neuroradiol"},{"issue":"2","key":"bib17-20231011","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00234-006-0166-0","article-title":"HydroCoil as an adjuvant to bare platinum coil treatment of 100 cerebral aneurysms","volume":"49","author":"Fanning","year":"2007","journal-title":"Neuroradiology"},{"issue":"10","key":"bib18-20231011","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s00234-018-2074-5","article-title":"New generation Hydrogel Endovascular Aneurysm Treatment Trial (HEAT): a study protocol for a multicenter randomized controlled trial","volume":"60","author":"Abi-Aad","year":"2018","journal-title":"Neuroradiology"},{"issue":"9","key":"bib19-20231011","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1161\/hs0901.095600","article-title":"Endovascular treatment of unruptured aneurysms","volume":"32","author":"Roy","year":"2001","journal-title":"Stroke"},{"issue":"5","key":"bib20-20231011","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1161\/STROKEAHA.108.527572","article-title":"Reporting standards for endovascular repair of saccular intracranial cerebral aneurysms","volume":"40","author":"Meyers","year":"2009","journal-title":"Stroke"},{"key":"bib21-20231011","year":"2013"},{"issue":"1","key":"bib22-20231011","doi-asserted-by":"crossref","first-page":"40","DOI":"10.7326\/M17-0046","article-title":"CONSORT statement for randomized trials of nonpharmacologic treatments: a 2017 Update and a CONSORT extension for nonpharmacologic trial abstracts","volume":"167","author":"Boutron","year":"2017","journal-title":"Ann Intern Med"},{"issue":"3","key":"bib23-20231011","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3171\/jns.1997.86.3.0475","article-title":"Guglielmi detachable coil embolization of acute intracranial aneurysm: perioperative anatomical and clinical outcome in 403 patients","volume":"86","author":"Vi\u00f1uela","year":"1997","journal-title":"J Neurosurg"},{"issue":"3","key":"bib24-20231011","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1148\/radiol.2273020656","article-title":"Endovascular treatment of ruptured intracranial aneurysms with detachable coils: long-term clinical and serial angiographic results","volume":"227","author":"Sluzewski","year":"2003","journal-title":"Radiology"},{"issue":"7","key":"bib25-20231011","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3174\/ajnr.A0542","article-title":"Complex-shaped platinum coils for brain aneurysms: higher packing density, improved biomechanical stability, and midterm angiographic outcome","volume":"28","author":"Wakhloo","year":"2007","journal-title":"Am J Neuroradiol"},{"issue":"7","key":"bib26-20231011","first-page":"1446","article-title":"Increasing the packing of small aneurysms with complex-shaped coils: an in vitro study","volume":"24","author":"Piotin","year":"2003","journal-title":"Am J Neuroradiol"},{"issue":"1","key":"bib27-20231011","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/neurintsurg-2011-010118","article-title":"Complex shaped detachable platinum coil system for the treatment of cerebral aneurysms: the Codman Trufill DCS and Trufill DCS orbit detachable coil system COMPLEX registry final results","volume":"5","author":"Bendok","year":"2013","journal-title":"J Neurointervent Surg"},{"issue":"12","key":"bib28-20231011","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.jvir.2007.07.020","article-title":"Midterm clinical experience with a complex-shaped detachable platinum coil system for the treatment of cerebral aneurysms: Trufill DCS Orbit detachable coil system registry interim results","volume":"18","author":"Hirsch","year":"2007","journal-title":"J Vasc Interv Radiol"},{"issue":"2","key":"bib29-20231011","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1136\/jnis.2010.004390","article-title":"The impact of coil shape design on angiographic occlusion, packing density and coil mass uniformity in aneurysm embolization: an in vitro study","volume":"3","author":"Mehra","year":"2011","journal-title":"J Neurointervent Surg"},{"issue":"1","key":"bib30-20231011","first-page":"152","article-title":"HydroCoil for Endovascular Aneurysm Occlusion (HEAL) study: 3\u20136 month angiographic follow-up results","volume":"28","author":"Cloft","year":"2007","journal-title":"Am J Neuroradiol"},{"issue":"3","key":"bib31-20231011","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3174\/ajnr.A5101","article-title":"Hydrogel versus bare platinum coils in patients with large or recurrent aneurysms prone to recurrence after endovascular treatment: a randomized controlled trial","volume":"38","author":"Raymond","year":"2017","journal-title":"AJNR Am J Neuroradiol"},{"issue":"3","key":"bib32-20231011","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1161\/STROKEAHA.117.018707","article-title":"Second-generation hydrogel coils for the endovascular treatment of intracranial aneurysms","volume":"49","author":"Taschner","year":"2018","journal-title":"Stroke"},{"issue":"Suppl 2","key":"bib33-20231011","first-page":"S40","article-title":"Timing of retreatment for patients with previously coiled or clipped intracranial aneurysms: analysis of 156 patients with multiple treatments","volume":"7","author":"Okada","year":"2016","journal-title":"Surg Neurol Int"}],"container-title":["Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neurosurgery\/article-pdf\/86\/5\/615\/33040150\/nyaa006.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ovid.com\/10.1093\/neuros\/nyaa006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:59:59Z","timestamp":1786121999000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1093\/neuros\/nyaa006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,17]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1093\/neuros\/nyaa006","relation":{},"ISSN":["0148-396X","1524-4040"],"issn-type":[{"value":"0148-396X","type":"print"},{"value":"1524-4040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,17]]}}}