{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:57:42Z","timestamp":1786125462841,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T00:00:00Z","timestamp":1589587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>While many patients with mild traumatic brain injury (mTBI) or concussion recover completely, prolonged postconcussion symptoms remain a challenge for patients and an opportunity for clinical research. This has led to numerous research initiatives over the last 2 decades.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To review the characteristics of clinical studies on management of mTBI\/concussion; and to examine their definitions of mTBI\/concussion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This scoping review included all clinical studies on diagnosis and management of patients with mTBI\/concussion registered at www.clinicaltrials.gov from 2000 to June\/2019. The terms \u201cmild TBI\/concussion\u201d were used for the primary search. Definitions of mTBI\/concussion were obtained from the protocols. When a definition was missing in the website, the study's investigators were contacted for clarification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>There were 225 interventional and 95 observational studies. Most of the studies are focused on treatment (54.7%) or diagnosis (37.5%), while 3.4% examined preventive measures, 2.8% evaluated prognostic instruments, and 1.6% developed registries. Most of the studies in this American database were single-center initiatives led by American and Canadian institutions. The definitions of mTBI\/concussion differed widely among 109 studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The results of this review suggest that most of the clinical studies are focused on diagnosis and non-pharmacological therapies for patients with mTBI\/concussion. The large number of differing definitions of mTBI\/concussion among the studies creates significant limitations when comparing studies. The requirements for registering research protocols on mTBI\/concussion should include the necessity to state the definition being used. There is a need for consensus on a uniform definition of concussion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyaa151","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T15:14:12Z","timestamp":1586445252000},"page":"891-899","source":"Crossref","is-referenced-by-count":11,"title":["A Scoping Review of Registered Clinical Studies on Mild Traumatic Brain Injury and Concussion (2000 to 2019)"],"prefix":"10.1227","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2038-0018","authenticated-orcid":false,"given":"Julio C","family":"Furlan","sequence":"first","affiliation":[{"name":"Lyndhurst Centre, KITE \u2013 Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario, Canada"},{"name":"Department of Medicine, Division of Physical Medicine and Rehabilitation, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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