{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:03:01Z","timestamp":1792101781581,"version":"4.4.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The LACE+ (Length of stay, Acuity of admission, Charlson Comorbidity Index [CCI] score, and Emergency department [ED] visits in the past 6 mo) index risk-prediction tool has never been successfully tested in a neurosurgery population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To assess the ability of LACE+ to predict adverse outcomes after supratentorial brain tumor surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>LACE+ scores were retrospectively calculated for all patients (n\u00a0=\u00a0624) who underwent surgery for supratentorial tumors at the University of Pennsylvania Health System (2017-2019). Confounding variables were controlled with coarsened exact matching. The frequency of unplanned hospital readmission, ED visits, and death was compared for patients with different LACE+ score quartiles (Q1, Q2, Q3, and Q4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A total of 134 patients were matched between Q1 and Q4; 152 patients were matched between Q2 and Q4; and 192 patients were matched between Q3 and Q4. Patients with higher LACE+\u00a0scores were significantly more likely to be readmitted within 90 d (90D) of discharge for Q1 vs Q4 (21.88%\u00a0vs 46.88%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.005) and Q2 vs Q4 (27.03%\u00a0vs 55.41%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.001). Patients with larger LACE+\u00a0scores also had significantly increased risk of 90D ED visits for Q1 vs Q4 (13.33%\u00a0vs 30.00%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.027) and Q2 vs Q4 (22.54%\u00a0vs 39.44%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.039). LACE+\u00a0score also correlated with death within 90D of surgery for Q2 vs Q4 (2.63%\u00a0vs 15.79%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.003) and with death at any point after surgery\/during follow-up for Q1 vs Q4 (7.46%\u00a0vs 28.36%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.002), Q2 vs Q4 (15.79%\u00a0vs 31.58%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.011), and Q3 vs Q4 (18.75%\u00a0vs 31.25%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.047).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>LACE+ may be suitable for characterizing risk of certain perioperative events in a patient population undergoing supratentorial brain tumor resection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyaa225","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T18:21:50Z","timestamp":1589480510000},"page":"1181-1190","source":"Crossref","is-referenced-by-count":8,"title":["The LACE+\u00a0Index as a Predictor of 90-Day Supratentorial Tumor Surgery Outcomes"],"prefix":"10.1227","volume":"87","author":[{"given":"Eric","family":"Winter","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debanjan","family":"Haldar","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 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D","family":"McClintock","sequence":"additional","affiliation":[{"name":"The West Chester Statistical Institute, Department of Mathematics, West Chester University, West Chester, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Chiao Isaac","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang W","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil R","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"},{"name":"McKenna EpiLog Fellowship in 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