{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:49:57Z","timestamp":1786124997058,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Retrospective studies have shown high rates of sleep disordered breathing in children with myelomeningocele. However, most patients included in those studies underwent polysomnography because of symptoms, so the prevalence of sleep disordered breathing in this population is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To determine the prevalence of sleep disordered breathing in children with myelomeningocele using screening polysomnography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In this cross-sectional study, all children with myelomeningocele seen in a multi-disciplinary spina bifida clinic between 2016 and 2020 were referred for polysomnography regardless of clinical symptoms. Included children had not previously undergone polysomnography. The primary outcome for this study was presence of sleep disordered breathing, defined as Apnea-Hypopnea Index (AHI, number of apnea or hypopnea events per hour of sleep) greater than 2.5. Clinical and demographic variables relevant to myelomeningocele were also prospectively collected and tested for association with presence of sleep apnea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A total of 117 participants underwent polysomnography (age 1 mo to 21 yr, 49% male). The majority were white, non-Hispanic. Median AHI was 1.9 (interquartile range 0.6-4.2). A total of 49 children had AHI 2.5 or greater, yielding a sleep disordered breathing prevalence of 42% (95% CI 33%-51%). In multivariable logistic regression analysis, children with more rostral neurological lesion levels had higher odds of sleep disordered breathing (OR for thoracic, mid-lumbar, and low-lumbar: 7.34, 3.70, 4.04, respectively, compared to sacral level,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.043).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Over 40% of a sample of children with myelomeningocele, who underwent screening polysomnography, had significant sleep disordered breathing. Routine screening polysomnography may be indicated in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyaa507","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T15:13:00Z","timestamp":1604675580000},"page":"785-790","source":"Crossref","is-referenced-by-count":20,"title":["Prevalence of Sleep Disordered Breathing in Children With Myelomeningocele"],"prefix":"10.1227","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7333-4808","authenticated-orcid":false,"given":"Brandon G","family":"Rocque","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurosurgery, Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Halsey","family":"Maddox","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonary and Sleep Medicine. Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy D","family":"Hopson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac C","family":"Shamblin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Aban","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Department of Pediatrics, UAB School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia A","family":"Arynchyna","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey P","family":"Blount","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,4]]},"reference":[{"issue":"4","key":"bib1-20231011","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.pcl.2010.07.009","article-title":"Children with spina bifida: key clinical issues","volume":"57","author":"Sandler","year":"2010","journal-title":"Pediatr Clin North Am"},{"issue":"6","key":"bib2-20231011","doi-asserted-by":"crossref","first-page":"652","DOI":"10.3171\/2018.5.PEDS18160","article-title":"Decompression for Chiari malformation type II in individuals with myelomeningocele in the National Spina Bifida Patient Registry","volume":"22","author":"Kim","year":"2018","journal-title":"J Neurosurg Pediatr"},{"issue":"1","key":"bib3-20231011","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.cppeds.2015.10.009","article-title":"Epidemiology and diagnosis of pediatric obstructive sleep apnea","volume":"46","author":"DelRosso","year":"2016","journal-title":"Curr Probl Pediatr Adolesc Health Care"},{"issue":"2","key":"bib4-20231011","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1513\/pats.200708-135MG","article-title":"Epidemiology of pediatric obstructive sleep apnea","volume":"5","author":"Lumeng","year":"2008","journal-title":"Proc Am Thorac Soc"},{"issue":"1","key":"bib5-20231011","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3171\/2014.11.PEDS14314","article-title":"Sleep-disordered breathing in patients with myelomeningocele","volume":"16","author":"Patel","year":"2015","journal-title":"J Neurosurg Pediatr"},{"issue":"5","key":"bib6-20231011","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1378\/chest.14-0970","article-title":"International classification of sleep disorders-third edition: highlights and modifications","volume":"146","author":"Sateia","year":"2014","journal-title":"Chest"},{"issue":"2","key":"bib7-20231011","first-page":"224","article-title":"Update on paediatric obstructive sleep apnoea","volume":"8","author":"Dehlink","year":"2016","journal-title":"J Thorac Dis"},{"issue":"1","key":"bib8-20231011","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/bdra.23094","article-title":"Testing the feasibility of a National Spina Bifida Patient Registry","volume":"97","author":"Thibadeau","year":"2013","journal-title":"Birth Defects Res Part A Clin Mol Teratol"},{"issue":"2","key":"bib9-20231011","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000028836","article-title":"Measurement of ventricular size: reliability of the frontal and occipital horn ratio compared to subjective assessment","volume":"31","author":"Kulkarni","year":"1999","journal-title":"Pediatr Neurosurg"},{"issue":"4","key":"bib10-20231011","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S0022-3476(98)70359-2","article-title":"Sleep-disordered breathing in children with myelomeningocele","volume":"132","author":"Waters","year":"1998","journal-title":"J Pediatr"},{"issue":"1","key":"bib11-20231011","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1017\/S0012162299000079","article-title":"Sleep\u2010disordered breathing in patients with myelomeningocele: the missed diagnosis","volume":"41","author":"Kirk","year":"1999","journal-title":"Dev Med Child Neurol"},{"issue":"5","key":"bib12-20231011","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1442-200X.2012.03660.x","article-title":"Sleep-disordered breathing in children with Chiari malformation type II and myelomeningocele","volume":"54","author":"Alsaadi","year":"2012","journal-title":"Pediatr Int"},{"issue":"1","key":"bib13-20231011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2016.7.PEDS16218","article-title":"Treated hydrocephalus in individuals with myelomeningocele in the National Spina Bifida Patient Registry","volume":"34","author":"Kim","year":"2018","journal-title":"J Neurosurg Pediatr"},{"issue":"4","key":"bib14-20231011","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1001\/archotol.132.4.432","article-title":"Obstructive sleep apnea: Should all children with Down syndrome be tested","volume":"132","author":"Shott","year":"2006","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"1","key":"bib15-20231011","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1542\/peds.88.1.132","article-title":"Obstructive sleep apnea in children with Down syndrome","volume":"88","author":"Marcus","year":"1991","journal-title":"Pediatrics"},{"issue":"5","key":"bib16-20231011","doi-asserted-by":"crossref","first-page":"e12826","DOI":"10.1111\/jsr.12826","article-title":"Screening for sleep-disordered breathing with Pediatric Sleep Questionnaire in children with underlying conditions","volume":"28","author":"Pabary","year":"2019","journal-title":"J Sleep Res"},{"issue":"2","key":"bib17-20231011","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.chest.2019.02.011","article-title":"OSA and cardiovascular risk in pediatrics","volume":"156","author":"Smith","year":"2019","journal-title":"Chest"},{"issue":"4","key":"bib18-20231011","first-page":"30","article-title":"Cognitive and behavioral consequences of sleep disordered breathing in children","volume":"5","author":"Trosman","year":"2017","journal-title":"Med Sci"},{"issue":"5","key":"bib19-20231011","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/ppul.20981","article-title":"Neurocognitive and behavioral impact of sleep disordered breathing in children","volume":"44","author":"Owens","year":"2009","journal-title":"Pediatr Pulmonol"},{"issue":"4","key":"bib20-20231011","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3233\/PRM-160399","article-title":"Factors associated with parent depressive symptoms and family quality of life in parents of adolescents and young adults with and without Spina Bifida","volume":"9","author":"Ridosh","year":"2016","journal-title":"J Pediatr Rehabil Med"},{"issue":"8","key":"bib21-20231011","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/jpepsy\/jsm042","article-title":"Attention and executive functions in adolescents with Spina Bifida","volume":"32","author":"Rose","year":"2007","journal-title":"J Pediatr Psychol"},{"issue":"3","key":"bib22-20231011","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/PHM.0b013e3182a92b03","article-title":"Young adults with spina bifida may have higher occurrence of prehypertension and hypertension","volume":"93","author":"Stepanczuk","year":"2014","journal-title":"Am J Phys Med Rehabil"},{"issue":"4","key":"bib23-20231011","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1310\/sci2204-253","article-title":"ADHD and attention problems in children with and without Spina Bifida","volume":"22","author":"Wasserman","year":"2016","journal-title":"Top Spinal Cord Inj Rehabil"},{"issue":"1","key":"bib24-20231011","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/ddrr.89","article-title":"The cognitive phenotype of spina bifida meningomyelocele","volume":"16","author":"Dennis","year":"2010","journal-title":"Dev Disabil Res Rev"},{"issue":"2","key":"bib25-20231011","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3171\/2011.11.PEDS11269","article-title":"Risk factors of sudden death in young adult patients with myelomeningocele","volume":"9","author":"Jernigan","year":"2012","journal-title":"J Neurosurg Pediatr"}],"container-title":["Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neurosurgery\/article-pdf\/88\/4\/785\/36592762\/nyaa507.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ovid.com\/10.1093\/neuros\/nyaa507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:48:39Z","timestamp":1786121319000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1093\/neuros\/nyaa507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,28]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1093\/neuros\/nyaa507","relation":{},"ISSN":["0148-396X","1524-4040"],"issn-type":[{"value":"0148-396X","type":"print"},{"value":"1524-4040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,28]]}}}