{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:02:24Z","timestamp":1786712544618,"version":"build-2736575974"},"reference-count":4,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/ mailto:journals.permissions@oup.com"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND AND IMPORTANCE<\/jats:title>\n                    <jats:p>The Zap-X system (Zap Surgical Systems Inc, San Carlos, California) is a radically new surgical robot designed for brain and head and neck radiosurgery. It represents the first new dedicated brain stereotactic radiosurgery platform in almost half a century optimizing the goals of safety, speed, and accuracy. The Zap-X system was used in a required Chinese National Medical Products Administration clinical study. In early January 2020, 2 patients were treated with the Zap-X robot prior to a national COVID-19 lockdown. Both were closely followed via clinical exam and magnetic resonance imaging (MRI) imaging. Prospectively collected data were used to generate this report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL PRESENTATION<\/jats:title>\n                    <jats:p>\n                      Two female patients, each harboring either a trigeminal schwannoma or petroclival meningioma, were treated with the Zap-X robot. Respective tumor volumes were 2.60 and 4.02 cm\n                      <jats:sup>3<\/jats:sup>\n                      . A radiation dose of 13\u00a0Gy was prescribed to the 50% isodose line. At 8 mo of follow-up, preoperative symptoms were either resolved or stable and MRI imaging demonstrated a 31% and 56% reduction in lesion volume, respectively. In both patients, symptoms improved, and tumor volumes decreased, whereas no major complication was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Given only 2 patients and short-term follow-up, any conclusions about the safety and efficacy of the Zap-X radiosurgery robot are preliminary. However, in the absence of any other published outcomes to date, this small case series may be of interest to many radiosurgical specialists.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyaa550","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T12:52:54Z","timestamp":1605876774000},"page":"E351-E355","source":"Crossref","is-referenced-by-count":19,"title":["The Zap-X Radiosurgical System in the Treatment of Intracranial Tumors: A Technical Case Report"],"prefix":"10.1227","volume":"88","author":[{"given":"Longsheng","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolin","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmin","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangkun","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The First Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0093-8763","authenticated-orcid":false,"given":"Georg","family":"Weidlich","sequence":"additional","affiliation":[{"name":"Zap Surgical Systems Inc, San Carlos, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Adler","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,4]]},"reference":[{"issue":"3","key":"bib1-20231011","first-page":"1","article-title":"Characterization of a novel 3 megavolt linear accelerator for dedicated intracranial stereotactic radiosurgery","volume":"11","author":"Weidlich","year":"2019","journal-title":"Cureus"},{"issue":"Suppl_2","key":"bib2-20231011","doi-asserted-by":"crossref","first-page":"A14","DOI":"10.1227\/01.NEU.0000341629.57676.DB","article-title":"Cyberknife radiosurgery for trigeminal schwannomas","volume":"64","author":"Sakamoto","year":"2009","journal-title":"Neurosurgery"},{"issue":"2","key":"bib3-20231011","first-page":"1","article-title":"Characterization of a novel revolving radiation collimator","volume":"10","author":"Weidlich","year":"2018","journal-title":"Cureus"},{"issue":"11","key":"bib4-20231011","first-page":"1","article-title":"Radiosurgical treatment verification using removable megavoltage radiation detectors","volume":"9","author":"Jenkins","year":"2017","journal-title":"Cureus"}],"container-title":["Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neurosurgery\/article-pdf\/88\/4\/E351\/36592818\/nyaa550.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ovid.com\/10.1093\/neuros\/nyaa550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:46:39Z","timestamp":1786121199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1093\/neuros\/nyaa550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,13]]},"references-count":4,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1093\/neuros\/nyaa550","relation":{},"ISSN":["0148-396X","1524-4040"],"issn-type":[{"value":"0148-396X","type":"print"},{"value":"1524-4040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,13]]}}}