{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:48:30Z","timestamp":1786124910661,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND AND IMPORTANCE<\/jats:title>\n                    <jats:p>Ameloblastic carcinoma (AC) is a malignant neoplasm of epithelial origin that typically arises from the mandible or maxilla. It represents approximately 2% of all odontogenic tumors. Gross total resection is the surgical goal given AC\u2019s aggressiveness and propensity for recurrence. We present the first reported AC metastasis to the cervical spine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL PRESENTATION<\/jats:title>\n                    <jats:p>A 61-yr-old African American female with a history of AC of bilateral mandibles and lung metastases presented with neck pain and right arm weakness progressive over several months. Cervical spine imaging demonstrated a cervical 3 pathological fracture with severe anterior vertebral body compression and resultant cervical 2-3 kyphotic deformity and bony retropulsion causing severe cord compression. The patient underwent a cervical 3 corpectomy and cervical 2-4 anterior fixation followed by a cervical 3 laminectomy and cervical 2-5 dorsal internal fixation and fusion. Postoperatively, the patient's neurological exam remained stable and imaging showed improved spinal alignment and appropriate anterior and posterior instrumentation. Unfortunately, the patient thereafter suffered a decline in performance status and progression of lung metastatic disease. Her oncology team is considering chemotherapy and stereotactic radiosurgery, but her prognosis remains grim.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>AC is a rare and aggressive pathology with a poor prognosis despite multimodal therapy. We present the first case of AC metastatic spread to the spine. We aim to bring this pathology to the attention of our worldwide neurosurgical colleagues and share our surgical approach and multidisciplinary management to assist those who may encounter this pathology in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyab044","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T15:10:57Z","timestamp":1611760257000},"page":"E537-E542","source":"Crossref","is-referenced-by-count":0,"title":["Rare Ameloblastic Carcinoma Metastasis to the Cervical Spine: A Case Report"],"prefix":"10.1227","volume":"88","author":[{"given":"Arsalaan","family":"Salehani","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Alabama at Birmingham Hospital, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Mooney","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Alabama at Birmingham Hospital, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Lepard","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Alabama at Birmingham Hospital, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R","family":"Hackney","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham Hospital, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Harmon","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Alabama at Birmingham Hospital, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,6]]},"reference":[{"issue":"Suppl 1","key":"bib1-20231011","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4103\/jomfp.JOMFP_318_18","article-title":"Ameloblastic carcinoma: a rare case with diagnostic dilemma","volume":"23","author":"Smitha","year":"2019","journal-title":"J Oral Maxillofac Pathol"},{"issue":"6","key":"bib2-20231011","first-page":"S117","article-title":"Secondary ameloblastic carcinoma of mandible with pulmonary metastasis","volume":"28","author":"Tajammul","year":"2018","journal-title":"J Coll\u00a0Physicians\u00a0Surg Pak"},{"issue":"1","key":"bib3-20231011","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3892\/ol.2014.2654","article-title":"Primary ameloblastic carcinoma of the maxilla: a case report and literature review","volume":"9","author":"Uzawa","year":"2015","journal-title":"Oncol Lett"},{"issue":"1","key":"bib4-20231011","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.path.2016.10.006","article-title":"Odontogenic cysts and neoplasms","volume":"10","author":"Bilodeau","year":"2017","journal-title":"Surg Pathol Clin"},{"issue":"6","key":"bib5-20231011","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.3892\/ol.2016.5272","article-title":"Ameloblastic carcinoma of the maxilla: a case report and an updated review of the literature","volume":"12","author":"Moro","year":"2016","journal-title":"Oncol Lett"},{"issue":"3","key":"bib6-20231011","doi-asserted-by":"crossref","first-page":"243","DOI":"10.5114\/pjp.2018.79544","article-title":"Primary ameloblastic carcinoma: literature review with case series","volume":"69","author":"Mahmoud","year":"2018","journal-title":"Pol J Pathol"},{"key":"bib7-20231011","doi-asserted-by":"crossref","first-page":"208","DOI":"10.11604\/pamj.2018.31.208.14660","article-title":"Ameloblastic carcinoma: a clinicopathologic analysis of cases seen in a Nigerian Teaching Hospital and review of literature","volume":"31","author":"Soyele","year":"2018","journal-title":"Pan Afr Med J"},{"issue":"2","key":"bib8-20231011","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/dc.23856","article-title":"Ameloblastic carcinoma with metastasis to the parotid gland","volume":"46","author":"Alexander","year":"2018","journal-title":"Diagn Cytopathol"},{"issue":"3","key":"bib9-20231011","doi-asserted-by":"crossref","first-page":"211","DOI":"10.5582\/irdr.2017.01032","article-title":"Rare case of ameloblastoma with pulmonary metastases","volume":"6","author":"Valkadinov","year":"2017","journal-title":"Intractable Rare Dis Res"},{"issue":"6","key":"bib10-20231011","first-page":"1016","article-title":"Massive skull base ameloblastic carcinoma with intracranial extension","volume":"27","author":"Yildirim","year":"2017","journal-title":"Turk Neurosurg"},{"issue":"3","key":"bib11-20231011","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1055\/s-0032-1322531","article-title":"Ameloblastic carcinoma of the maxilla with extension into the ethmoidal air cells and close proximity to the anterior skull base: a rare case presentation","volume":"5","author":"Perumal","year":"2012","journal-title":"Craniomaxillofac Trauma Reconstr"},{"issue":"12","key":"bib12-20231011","first-page":"e6265","article-title":"A rare presentation of ameloblastic carcinoma of the sinus cavity and skull base","volume":"11","author":"Landeen","year":"2019","journal-title":"Cureus"},{"issue":"4","key":"bib13-20231011","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1055\/s-2005-918621","article-title":"Ameloblastic carcinoma arising from anterior skull base","volume":"15","author":"Ozlugedik","year":"2005","journal-title":"Skull Base"},{"issue":"1","key":"bib14-20231011","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4103\/0975-5950.102169","article-title":"Ameloblastic carcinoma of maxilla","volume":"3","author":"Bedi","year":"2012","journal-title":"Natl J Maxillofac Surg"},{"issue":"9","key":"bib15-20231011","first-page":"5","article-title":"Ameloblastic carcinoma: case report and literature review","volume":"69","author":"Avon","year":"2003","journal-title":"J Can Dent Assoc"},{"issue":"6","key":"bib16-20231011","first-page":"799","article-title":"Ameloblastic carcinoma: an analysis of 14 cases","volume":"103","author":"Hall","year":"2007","journal-title":"Oral\u00a0Surg\u00a0Oral\u00a0Med\u00a0Oral\u00a0Pathol\u00a0Oral\u00a0Radiol"},{"issue":"2","key":"bib17-20231011","doi-asserted-by":"crossref","first-page":"e0117789","DOI":"10.1371\/journal.pone.0117789","article-title":"Incidence and overall survival of malignant ameloblastoma","volume":"10","author":"Rizzitelli","year":"2015","journal-title":"PLoS One"},{"issue":"12","key":"bib18-20231011","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1002\/hed.25926","article-title":"Ameloblastic carcinoma: clinicopathological analysis of 18 cases and a systematic review","volume":"41","author":"Deng","year":"2019","journal-title":"Head Neck"},{"issue":"10","key":"bib19-20231011","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1007\/s00405-017-4631-7","article-title":"Pattern of care and impact of prognostic factors in the outcome of ameloblastic carcinoma: a systematic review and individual patient data analysis of 199 cases","volume":"274","author":"Giridhar","year":"2017","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"2","key":"bib20-20231011","doi-asserted-by":"crossref","first-page":"914","DOI":"10.3892\/ol.2014.2230","article-title":"Ameloblastic carcinoma: an analysis of 12 cases with a review of the literature","volume":"8","author":"Li","year":"2014","journal-title":"Oncol Lett"},{"issue":"9","key":"bib21-20231011","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.joms.2009.09.028","article-title":"Ameloblastic carcinoma: a multicenter Nigerian study","volume":"68","author":"Ndukwe","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"issue":"1","key":"bib22-20231011","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5125\/jkaoms.2016.42.1.43","article-title":"Ameloblastic carcinoma of the maxilla: a report of two cases and a review of the literature","volume":"42","author":"Fomete","year":"2016","journal-title":"J Korean Assoc Oral Maxillofac Surg"},{"issue":"2","key":"bib23-20231011","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bjoms.2018.12.005","article-title":"Huge ameloblastic carcinoma of the mandible with metastases treated in several different ways","volume":"57","author":"Kikuta","year":"2019","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"4","key":"bib24-20231011","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/his.12995","article-title":"Ameloblastic carcinoma: a Brazilian collaborative study of 17 cases","volume":"69","author":"Loyola","year":"2016","journal-title":"Histopathology"},{"issue":"1","key":"bib26-20231011","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1053\/ajot.2003.15","article-title":"Ameloblastic carcinoma: report of an aggressive case with multiple bony metastases","volume":"24","author":"Datta","year":"2003","journal-title":"Am J Otolaryngol"},{"issue":"1","key":"bib27-20231011","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4103\/2231-0746.133070","article-title":"Ameloblastic carcinoma: a clinicopathologic dilemma\u2014report of two cases with total review of literature from 1984 to 2012","volume":"4","author":"Kar","year":"2014","journal-title":"Ann Maxillofac Surg"},{"issue":"2","key":"bib28-20231011","first-page":"e56","article-title":"The use of radiation therapy in the definitive management of ameloblastic carcinoma: a case report","volume":"127","author":"Aoki","year":"2019","journal-title":"Oral\u00a0Surg\u00a0Oral\u00a0Med\u00a0Oral\u00a0Pathol\u00a0Oral\u00a0Radiol"},{"issue":"10","key":"bib29-20231011","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1007\/s00405-016-3899-3","article-title":"Treatment of ameloblastoma and ameloblastic carcinoma with radiotherapy","volume":"273","author":"Kennedy","year":"2016","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"bib30-20231011","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/1748-717X-9-157","article-title":"Prominent response with helical tomotherapy in recurrent ameloblastic carcinoma of maxillary sinus: a case report","volume":"9","author":"Koca","year":"2014","journal-title":"Radiat Oncol"},{"key":"bib31-20231011","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1748-717X-6-13","article-title":"Carbon ion therapy for ameloblastic carcinoma","volume":"6","author":"Jensen","year":"2011","journal-title":"Radiat Oncol"},{"issue":"4","key":"bib32-20231011","first-page":"34","article-title":"Proton beam therapy combined with retrograde intra-arterial infusion chemotherapy for an extremely rapid growing recurrent ameloblastic carcinoma: a case report","volume":"13","author":"Takayama","year":"2020","journal-title":"Mol Clin Oncol"}],"container-title":["Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neurosurgery\/article-pdf\/88\/6\/E537\/37927229\/nyab044.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ovid.com\/10.1093\/neuros\/nyab044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:47:09Z","timestamp":1786121229000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1093\/neuros\/nyab044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,20]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1093\/neuros\/nyab044","relation":{},"ISSN":["0148-396X","1524-4040"],"issn-type":[{"value":"0148-396X","type":"print"},{"value":"1524-4040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,20]]}}}