{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:35:39Z","timestamp":1791599739555,"version":"4.3.4"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/ mailto:journals.permissions@oup.com"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The relationship between trans-stenotic blood flow velocity differences and the cerebral venous pressure gradient (CVPG) in transverse sinus (TS) stenosis (TSS) has not been studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To evaluate the hemodynamic manifestations of TSS and the relationship between trans-stenotic blood flow velocity differences and the CVPG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Thirty-three patients with idiopathic intracranial hypertension (IIH) or pulsatile tinnitus (PT) and TSS who had undergone diagnostic venography using venous manometry were included in the patient group. Thirty-three volunteers with no stenosis and symptoms were included in the control group. All the 2 groups underwent prospective venous sinus 4-dimensional (4D) flow magnetic resonance imaging (MRI). The average velocity (V\n                      <jats:sub>avg<\/jats:sub>\n                      ) difference and maximum velocity (V\n                      <jats:sub>max)<\/jats:sub>\n                      difference between downstream and upstream of the TS in 2 groups were measured and compared. Correlations between the CVPG and trans-stenotic V\n                      <jats:sub>avg<\/jats:sub>\n                      difference\/V\n                      <jats:sub>max<\/jats:sub>\n                      difference\/index of transverse sinus stenosis (ITSS) were assessed in the patient group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The differences in V\n                      <jats:sub>avg<\/jats:sub>\n                      difference and V\n                      <jats:sub>max<\/jats:sub>\n                      difference between the patient and control groups showed a statistical significance (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). The V\n                      <jats:sub>avg<\/jats:sub>\n                      difference and V\n                      <jats:sub>max<\/jats:sub>\n                      difference had a strong correlation with CVPG (R\u00a0=\u00a00.675 and 0.701, respectively,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) in the patient group. Multivariate linear regression using the stepwise method showed that the V\n                      <jats:sub>max<\/jats:sub>\n                      difference and ITSS were correlated with the CVPG (R\u00a0=\u00a00.752 and R\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.537, respectively;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The trans-stenotic blood flow velocity difference significantly correlates with the CVPG in TSS. As a noninvasive imaging modality, 4D flow MRI may be a suitable screening or complimentary tool to decide which TSS may benefit from invasive venous manometry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyab222","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T08:16:56Z","timestamp":1622621816000},"page":"549-556","source":"Crossref","is-referenced-by-count":37,"title":["Correlation Between Trans-Stenotic Blood Flow Velocity Differences and the Cerebral Venous Pressure Gradient in Transverse Sinus Stenosis: A Prospective 4-Dimensional Flow Magnetic Resonance Imaging Study"],"prefix":"10.1227","volume":"89","author":[{"given":"Heyu","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9559-4777","authenticated-orcid":false,"given":"Han","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshuai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guopeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusheng","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Intervention, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8190-6469","authenticated-orcid":false,"given":"Zhenchang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,10]]},"reference":[{"issue":"3","key":"bib1-20231011","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3174\/ajnr.A5055","article-title":"Transverse sinus stenosis is the most sensitive MR imaging correlates of idiopathic intracranial hypertension","volume":"38","author":"Morris","year":"2017","journal-title":"AJNR Am J Neuroradiol"},{"issue":"9","key":"bib2-20231011","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1212\/01.WNL.0000066683.34093.E2","article-title":"Idiopathic intracranial hypertension: the prevalence and morphology of sinovenous stenosis","volume":"60","author":"Farb","year":"2003","journal-title":"Neurology"},{"issue":"8","key":"bib3-20231011","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1136\/neurintsurg-2019-014725","article-title":"Endovascular treatment of debilitating tinnitus secondary to cerebral venous sinus abnormalities: a literature review and technical illustration","volume":"11","author":"Yang","year":"2019","journal-title":"J NeuroIntervent Surg"},{"issue":"5","key":"bib4-20231011","doi-asserted-by":"crossref","first-page":"581","DOI":"10.4103\/0366-6999.151648","article-title":"Incidence of vascular anomalies and variants associated with unilateral venous pulsatile tinnitus in 242 patients based on dual-phase contrast-enhanced computed tomography","volume":"128","author":"Dong","year":"2015","journal-title":"Chin Med J"},{"issue":"5","key":"bib5-20231011","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.3171\/2016.8.JNS16879","article-title":"Venous sinus stenting for reduction of intracranial pressure in IIH: a prospective pilot study","volume":"127","author":"Liu","year":"2017","journal-title":"J Neurosurg"},{"issue":"3","key":"bib6-20231011","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1212\/WNL.0b013e31827debd6","article-title":"Clinical course of idiopathic intracranial hypertension with transverse sinus stenosis","volume":"80","author":"Riggeal","year":"2013","journal-title":"Neurology"},{"issue":"8","key":"bib7-20231011","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.3174\/ajnr.A2575","article-title":"Transverse sinus stenting for idiopathic intracranial hypertension: a review of 52 patients and of model predictions","volume":"32","author":"Ahmed","year":"2011","journal-title":"AJNR Am J Neuroradiol"},{"issue":"10","key":"bib8-20231011","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11936-019-0758-8","article-title":"Clinical applications of MRA 4D-Flow","volume":"21","author":"Sierra-Galan","year":"2019","journal-title":"Curr Treat Options Cardiovasc Med"},{"issue":"1","key":"bib9-20231011","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12968-015-0174-5","article-title":"4D flow cardiovascular magnetic resonance consensus statement","volume":"17","author":"Dyverfeldt","year":"2015","journal-title":"J Cardiovasc Magn Reson"},{"issue":"6","key":"bib10-20231011","doi-asserted-by":"crossref","first-page":"e586","DOI":"10.1212\/WNL.0000000000005948","article-title":"Hemodynamic assessments of venous pulsatile tinnitus using 4D-flow MRI","volume":"91","author":"Li","year":"2018","journal-title":"Neurology"},{"issue":"10","key":"bib11-20231011","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1007\/s00330-015-4181-6","article-title":"Four-dimensional flow MRI for evaluation of post-stenotic turbulent flow in a phantom: comparison with flowmeter and computational fluid dynamics","volume":"26","author":"Kweon","year":"2016","journal-title":"Eur Radiol"},{"issue":"5","key":"bib12-20231011","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/neuros\/nyz314","article-title":"Role of resistivity index analysis in the prediction of hemodynamically significant venous sinus stenosis in patient with idiopathic intracranial hypertension","volume":"86","author":"Mohammaden","year":"2020","journal-title":"Neurosurgery"},{"issue":"13","key":"bib13-20231011","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1212\/WNL.0b013e3182a55f17","article-title":"Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children","volume":"81","author":"Friedman","year":"2013","journal-title":"Neurology"},{"issue":"2","key":"bib14-20231011","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1136\/neurintsurg-2016-012605","article-title":"A new index for the assessment of transverse sinus stenosis for diagnosing idiopathic intracranial hypertension","volume":"9","author":"Carvalho","year":"2017","journal-title":"J Neurointerv Surg"},{"issue":"4","key":"bib15-20231011","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1067\/mva.2002.121127","article-title":"Intravascular ultrasound scan evaluation of the obstructed vein","volume":"35","author":"Negl\u00e9n","year":"2002","journal-title":"J Vasc Surg"},{"issue":"5","key":"bib16-20231011","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0741-5214(03)01020-6","article-title":"Venous outflow obstruction: an underestimated contributor to chronic venous disease","volume":"38","author":"Negl\u00e9n","year":"2003","journal-title":"J Vasc Surg"},{"issue":"1","key":"bib17-20231011","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1136\/neurintsurg-2018-014004","article-title":"Correlation between angiographic stenosis and physiologic venous sinus outflow obstruction in idiopathic intracranial hypertension","volume":"11","author":"West","year":"2019","journal-title":"J Neurointerv Surg"},{"issue":"6","key":"bib18-20231011","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1055\/s-0039-3399506","article-title":"Men are from mars, idiopathic intracranial hypertension is from venous: the role of venous sinus stenosis and stenting in idiopathic intracranial hypertension","volume":"39","author":"Dinkin","year":"2019","journal-title":"Semin Neurol"},{"issue":"5","key":"bib19-20231011","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1007\/s00330-020-07415-2","article-title":"CT venography correlate of transverse sinus stenosis and venous transstenotic pressure gradient in unilateral pulsatile tinnitus patients with sigmoid sinus wall anomalies","volume":"31","author":"Zhao","year":"2021","journal-title":"Eur Radiol"},{"issue":"4","key":"bib20-20231011","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.mri.2015.11.010","article-title":"Post-stenotic plug-like jet with a vortex ring demonstrated by 4D flow MRI","volume":"34","author":"Kim","year":"2016","journal-title":"Magn Reson Imaging"},{"issue":"5","key":"bib21-20231011","doi-asserted-by":"crossref","first-page":"849","DOI":"10.3174\/ajnr.A6043","article-title":"Reduced jet velocity in venous flow after CSF drainage: assessing hemodynamic causes of pulsatile tinnitus","volume":"40","author":"Haraldsson","year":"2019","journal-title":"Am J Neuroradiol"},{"issue":"4","key":"bib22-20231011","first-page":"635","article-title":"Four dimensional magnetic resonance velocimetry for complex flow in the jugular vein","volume":"5","author":"Acevedo-Bolton","year":"2015","journal-title":"Quant Imaging Med Surg"},{"issue":"11","key":"bib23-20231011","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.3174\/ajnr.A5833","article-title":"MR venous flow in sigmoid sinus diverticulum","volume":"39","author":"Amans","year":"2018","journal-title":"Am J Neuroradiol"}],"container-title":["Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neurosurgery\/article-pdf\/89\/4\/549\/40348112\/nyab222.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ovid.com\/10.1093\/neuros\/nyab222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:59:15Z","timestamp":1786121955000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1093\/neuros\/nyab222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,25]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1093\/neuros\/nyab222","relation":{},"ISSN":["0148-396X","1524-4040"],"issn-type":[{"value":"0148-396X","type":"print"},{"value":"1524-4040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,25]]}}}