{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:58:26Z","timestamp":1786125506093,"version":"build-2736575974"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas. Their resection may lead to serious morbidity. Incidence of postoperative motor and sensory deficits is unknown, and reconstruction aimed at restoring such deficits is infrequently carried out.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To identify the incidence and risk factors of postoperative morbidity in MPNST as well as the use and outcomes of functional reconstructions in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Postoperative function and treatment of MPNSTs diagnosed from 1988 to 2019 in 10 cancer centers was obtained. Two models were constructed evaluating factors independently associated with postoperative motor (&lt;M3) or critical sensory loss. Critical sensation was defined as partial or complete loss of hand, foot, or buttocks sensation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A total of 756 patients (33.4% neurofibromatosis type 1, NF1) were included. MPNSTs originated in 34.4% from a major nerve. Of 658 surgically treated patients, 27.2% had &lt;M3 muscle power and 24.3% critical sensory loss. Amputations were carried out in 61 patients. Independent risk factors for motor and sensory loss included patients with NF1, symptomatic, deep-seated, extremity, or plexus tumors originating from major nerves (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05). A total of 26 patients underwent functional reconstructions. The majority (64%) of these patients regained at least M3 muscle power and 33% M4 despite 86% receiving multimodal therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Resection of MPNSTs commonly results in motor and sensory deficits. Patients with NF1, symptomatic, deep-seated tumors, arising from major nerves were associated with a higher risk for developing postoperative morbidity. Functional reconstructions are infrequently performed but can improve functional outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyab342","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T07:41:57Z","timestamp":1631086917000},"page":"354-364","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Morbidity and Function Loss After Resection of Malignant Peripheral Nerve Sheath Tumors"],"prefix":"10.1227","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8678-9203","authenticated-orcid":false,"given":"Enrico","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University Medical Center Utrecht, the Netherlands;"},{"name":"Department of Surgical Oncology, Erasmus Medical Center, Rotterdam, the Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7717-2068","authenticated-orcid":false,"given":"Courtney","family":"Pendleton","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9980-8613","authenticated-orcid":false,"given":"Cornelis","family":"Verhoef","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Erasmus Medical Center, Rotterdam, the Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0443-7763","authenticated-orcid":false,"given":"Robert J.","family":"Spinner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1921-9737","authenticated-orcid":false,"given":"J. Henk","family":"Coert","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University Medical Center Utrecht, the Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"issue":"6","key":"R1-20250819","first-page":"2597","article-title":"Incidence and survival in sarcoma in the United States: a focus on musculoskeletal lesions","volume":"33","author":"Ng","year":"2013","journal-title":"Anticancer Res"},{"issue":"5","key":"R2-20250819","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/cncr.22098","article-title":"Malignant peripheral nerve sheath tumors: prognostic factors and survival in a series of patients treated at a single institution","volume":"107","author":"Anghileri","year":"2006","journal-title":"Cancer"},{"key":"R3-20250819","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejca.2019.10.014","article-title":"A nationwide cohort study on treatment and survival in patients with malignant peripheral nerve sheath tumours","volume":"124","author":"Martin","year":"2020","journal-title":"Eur J Cancer"},{"key":"R4-20250819","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.radonc.2019.03.015","article-title":"Radiation-induced and neurofibromatosis-associated malignant peripheral nerve sheath tumors (MPNST) have worse outcomes than sporadic MPNST","volume":"137","author":"Miao","year":"2019","journal-title":"Radiother Oncol"},{"key":"R5-20250819","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejca.2015.12.015","article-title":"Management and prognosis of malignant peripheral nerve sheath tumors: the experience of the French Sarcoma Group (GSF-GETO)","volume":"56","author":"Valentin","year":"2016","journal-title":"Eur J Cancer"},{"issue":"6","key":"R6-20250819","doi-asserted-by":"crossref","first-page":"758","DOI":"10.6004\/jnccn.2016.0078","article-title":"Soft tissue sarcoma, version 2.2016, NCCN clinical practice guidelines in oncology","volume":"14","author":"von Mehren","year":"2016","journal-title":"J Natl Compr Canc Netw"},{"issue":"19","key":"R7-20250819","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1200\/JCO.19.03289","article-title":"Neoadjuvant chemotherapy in high-risk soft tissue sarcomas: final results of a randomized trial from Italian (ISG), Spanish (GEIS), French (FSG), and Polish (PSG) Sarcoma Groups","volume":"38","author":"Gronchi","year":"2020","journal-title":"J Clin Oncol"},{"key":"R8-20250819","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/8685638","article-title":"SARC006: phase II trial of chemotherapy in sporadic and neurofibromatosis type 1 associated chemotherapy-naive malignant peripheral nerve sheath tumors","volume":"2017","author":"Higham","year":"2017","journal-title":"Sarcoma"},{"issue":"4","key":"R9-20250819","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1096-9098(200004)73:4<206::AID-JSO4>3.0.CO;2-5","article-title":"Predictors of functional outcomes following limb salvage surgery for lower-extremity soft tissue sarcoma","volume":"73","author":"Davis","year":"2000","journal-title":"J Surg Oncol"},{"issue":"358","key":"R10-20250819","first-page":"90","article-title":"Evaluating functional outcome in patients with lower extremity sarcoma","author":"Davis","year":"1999","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"R11-20250819","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s11552-013-9567-9","article-title":"Concomitant upper extremity soft tissue sarcoma limb-sparing resection and functional reconstruction: assessment of outcomes and costs of surgery","volume":"9","author":"Mundinger","year":"2014","journal-title":"Hand"},{"issue":"6","key":"R12-20250819","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/jso.20486","article-title":"Reconstruction of the hand and upper extremity after tumor resection","volume":"94","author":"Saint-Cyr","year":"2006","journal-title":"J Surg Oncol"},{"issue":"10","key":"R13-20250819","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.ejso.2019.05.024","article-title":"Resuscitating extremities after soft tissue sarcoma resections: are functional reconstructions an overlooked option in limb salvage? 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