{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:12:31Z","timestamp":1793862751295,"version":"4.6.1"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NEUROSURGERY","NEUROS"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>BACKGROUND:<\/jats:bold>\n                    Early and mid-term safety and efficacy of aneurysm treatment with the Pipeline Embolization Device (PED) has been well demonstrated in prior studies.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>OBJECTIVE:<\/jats:bold>\n                    To present 5-yr follow-up for patients treated in the Pipeline for Uncoilable or Failed Aneurysms clinical trial.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>METHODS:<\/jats:bold>\n                    In our prospective, multicenter trial, 109 complex internal carotid artery (ICA) aneurysms in 107 subjects were treated with the PED. Patients were followed per a standardized protocol at 180 d and 1, 3, and 5 yr. Aneurysm occlusion, in-stent stenosis, modified Rankin Scale scores, and complications were recorded.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    The primary endpoint of complete aneurysm occlusion at 180 d (73.6%) was previously reported. Aneurysm occlusion for those patients with angiographic follow-up progressively increased over time to 86.8% (79\/91), 93.4% (71\/76), and 95.2% (60\/63) at 1, 3, and 5 yr, respectively. Six aneurysms (5.7%) were retreated. New serious device-related events at 1, 3, and 5 yr were noted in 1% (1\/96), 3.5% (3\/85), and 0% (0\/81) of subjects. There were 4 (3.7%) reported deaths in our trial. Seventy-eight (96.3%) of 81 patients with 5-yr clinical follow-up had modified Rankin Scale scores \u22642. No delayed neurological deaths or hemorrhagic or ischemic cerebrovascular events were reported beyond 6 mo. No recanalization of a previously occluded aneurysm was observed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION:<\/jats:bold>\n                    Our 5-yr findings demonstrate that PED is a safe and effective treatment for large and giant wide-necked aneurysms of the intracranial ICA, with high rates of complete occlusion and low rates of delayed adverse events.\n                  <\/jats:p>","DOI":"10.1093\/neuros\/nyw014","type":"journal-article","created":{"date-parts":[[2017,2,5]],"date-time":"2017-02-05T10:13:15Z","timestamp":1486289595000},"page":"40-48","source":"Crossref","is-referenced-by-count":412,"title":["Long-Term Clinical and Angiographic Outcomes Following Pipeline Embolization Device Treatment of Complex Internal Carotid Artery Aneurysms: Five-Year Results of the Pipeline for Uncoilable or Failed Aneurysms Trial"],"prefix":"10.1227","volume":"80","author":[{"given":"Tibor","family":"Becske","sequence":"first","affiliation":[{"name":"Rochester General Hospital, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Brinjikji","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, Minn-esota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew B.","family":"Potts","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Kallmes","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, Minn-esota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maksim","family":"Shapiro","sequence":"additional","affiliation":[{"name":"New York University Langone Medical Center, New York, New 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Minn-esota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry H.","family":"Woo","sequence":"additional","affiliation":[{"name":"Brook Hospital, Stony Brook, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrius K.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Rush University Medical Center, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan H.","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"University of Buffalo, Buffalo, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe C.","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Fiorella","sequence":"additional","affiliation":[{"name":"Brook Hospital, Stony Brook, New 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